Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

홍민어 Sciaenops ocellatus에서의 바이러스성 신경괴사증 viral nervous necrosis

김진도,김석렬,정성주,김영진,정태성,최태진,박성우,오명주 한국어병학회 2001 한국어병학회지 Vol.14 No.2

1999년 10월에서 11월 사이에 남해안 일대의 홍민어 종묘 생산장에서 20~30열령의 치어가 척추만곡 및 이상유영을 하며 대량 폐사하였다. 병어는 특이 외부 증상이 없었고, 높은 누적폐사량이 바이러스 질병으로 의심되어, 조직학적 및 분자생물학적인 검사를 행하여 폐사원인을 확인하였다. 폐사개체의 조직을 H-E 염색하여 관찰한 결과 뇌와 안구의 신경세포에서 공포와 괴사가 관찰되었고, 전자현미경 관찰에서는 안구와 뇌에서 바이러스 입자가 관찰되었다. RT-PCR 결과에서는 ≒426 bp의 DNA 단편을 확인할 수 있었다. 이러한 결과로 홍민어에서 발생한 대량폐사는 바이러스성 신경괴사증(VNN)으로 진단되었다. Mass mortalities occurred among red drum lavae, 20 to 30 days old, culturing at hatcheries on southern costal area. No specific external signs were observed except abnormal swimming and spinal deformity. It was, however, suspected as a viral etiology due to high mass mortalities so that histopathological and molecular biological study was performed to evaluate the agent. Both vacuoles and necrosis were observed on nerve cells of brain and eye by H-E staining, and viral particles were observed on electronmicroscopic examination. On the other hand, DNA fragment, approximately 426 bps, was amplified with RT-PCR. The above results were able to diagnosis the etiological agent of mass moralities in red drum larvae as VNN(viral nervous necrosis)virus.

모 제약회사 근로자들의 직업성 천식 유병률과 약제 분말 노출수준

오성수,최용휴,김은아,이영목,장재길,유장진,박승현,김태균,정수영,김규상,강성규 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 제약회사에서 직업상 천식의 유병 규모를 파악하고 작업공정에 대한 작업환경 측정을 통해 제약회사의 약제 분말에 대한 노출수준을 평가하고자 하였다. 방법: 제약회사에서 약제 분말에 노출되는 근로자를 대상으로 천식을 선별하기 위하여 설문조사 및 진찰, 혈액검사, 폐기능 검사 그리고 피부단자시험을 실시하였고, 각 부서별 공정에 따라서 총분진과 항생제 또는 효소제 분말에 대한 작업환경 측정을 실시하였다. 직업상 천식이 의심되는 근로자에 대하여 기관지과민성에 대한 검사(메타콜린을 이용한 비특이 기관지유발시험)와 약제 분말 기관지유발시험을 실시하여 확진하였다. 결과: 설문조사 및 진찰에서 작업 관련 천식 증상이 있는 근로자는 11명(34.4%)이었고, 약제 분말을 이용한 피부단자시험에서 1+ 이상 반응을 보인 근로자 10명(31.2%)이었다. 비특이 기관지유발시험 결과 8명(25.0%)이 양성(PC20 ≤16 mg/ml)이었다. 약제 분말 기관지유발시험을 통해 직업상 천식으로 확진된 근로자는 5명(15.6%)이었다. 작업환경 측정에서 원료를 충진하거나 투입하는 작업 그리고 정립작업에서 약제 분말에 대한 노출이 많았다. 결론: 제약회사에서 직업상 천식은 주로 제조공정 중 약제 분말에 노출된 근로자에서 발생하여, 증상 및 직업성 천식의 유병률이 높았다. 따라서 원료를 충진 또는 투입하는 작업과 정립작업 등 제조과적에서 약제 분말 노출을 줄이기 위한 세심한 주의가 필요하여, 약제 분말을 취급하는 근로자에 대해서는 천식 증상 조사뿐 아니라 정기적으로 피부단자시험, 비특이 기관지유발시험 등을 실시하여야 할 것이다. Objectives: After the investigation of one worker with occupational asthma, we surveyed the preva- lence of occupational asthma and the exposure level of pharmaceutical dust of 32 workers in a pharmaceutical company. Methods: Thirty-two of the 90 employees participated in the survey which consisted of questionnaire, blood sampling, spirometry and skin prick tests with 8 common allergens as well as 9 antibiotics and 2 enzymes. Various indices of the working environment were also measured. Subjects who had a symptom suggestive of work-related asthma or positive skin prick test were further investigated by PC20 methacholine. Nine subjects who had a PC20 result of 16 mg/ml or less (n=7) or had work-related symptoms and positive skin prick test (n=2) were referred to undergo a specific bronchial provocation test to phar- maceutical dust in an academic allergic disease center. Results: Eleven of 32 workers (34.4%) had a work-related symptom suggestive of occupational asthma. Ten (31.2%) showed positive skin prick test. 8 (25.0%) had a PC20 result of 16 mg/ml or less (indicative of significant bronchial hyperresponsiveness), and 5 (15.6%) had a positive result on the specific bronchial provocation test. Exposure levels of stuffing, input of raw materials and screening process were relatively high. Conclusions: This survey showed that pharmaceutical workers have an increased risk of occupational asthma. Although pharmaceutical factories maintain a relatively good working environment, careful control of respiratory tract exposures, especially during stuffing, input or raw materials and screening process, is important to prevent occupational asthma. Pharmaceutical workers need to undergo regular skin prick and methacholine bronchial provocation tests, as well as asthmatic symptom survey, to ensure the early detection and prevention of occupational asthma.

결핵 환자의 치료 순응도 향상을 위한 자기 간호교육의 효과

오영주,전진호,손혜숙,이종태 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objectives : Good compliance to standard guideline might be the most important factor for success of tuberculosis treatment. This study was performed to propose the way to promote the compliance through evaluating the effect of self-care education in pulmonary tuberculosis treatment. Methods : The subjects were 100 patients(male 82, female 18) admitted in the national tuberculosis hospital, and study period was from December 1, 2000 to March 31, 2001. Study method was a direct interview survey with questionnaire that consisted of knowledges, attitudes, compliances about tuberculosis treatment, and some characteristics of subjects. The pre- and post-educational data were compared by chi-square test and paired t-test using SPSS(ver 10.0) with α-error=0.05. Results : The mean age of the subjects was 41.8±12.8years, and most of them was male. Half of them was still drinking and smoking, and the tuberculosis treatment categories of WHO was categoryⅢ 42%, categoryⅣ 22%, categoryⅡ 21%, categoryⅠ 15% when admitted. Average prevalent period was 56.8 months, and 68% of them showed positive sputum smear test. The average knowledge level was increased from 6.88±1.85 when admitted, and 8.02±1.57 when two months after(p〈0.001), that means, the effect of education was recognized. In contrast, recognition and attitudes showed no difference. And, the frequency of subjective aggravation was higher in the group of low compliance: voluntary medication stop(p=0.022). Conclusions : This study had some limitations; lack of representativeness because the subjects were limited to the patients in one tuberculosis hospital, and, not sufficient sample size etc. Nevertheless, because the effect of the education was partly recognized, to enhance the effect of tuberculosis treatment, the contents of self-care education would be changed toward the practice with a close monitoring of the patients' compliance.

만화 과제를 이용한 정신분열병 환자의 사회인지 능력의 측정

오정은,나명현,하태현,신용욱,노규식,홍순범,이경진,신민섭,이영호,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : This study is to investigate the hypothesis that schizophrenic patients have difficulty in inferring mental state of others. Methods : Twenty schizophrenic patients and twenty normal subjects were administered to the Cartoon Task required inferring the character's intention in a given context. Results : The schizophrenic patients showed a statistically significant impairment in the Cartoon Task. Both groups chose the card depicting a frequent everyday action significantly more rather than the similar card to the last picture in each story for wrong answers. Conclusion : These preliminary results suggest that schizophrenia is associated with a specific deficit of the cognitive ability referred to as social cognition, and this deficit can be detected not only in the acute phase as found in previous research studies, but also in remission. Also when subjects fail to appreciate what is going on in the minds of other people, they seem to rely on a socially familiar experience.

國民學校 自然科實驗學習 指導 : 플라나리아의 실험

吳鎭泰 부산교육대학교 과학교육연구소 1984 科學敎育硏究 Vol.9 No.-

This study is to suggest the teaching method of the experimental material "Planaria" in primary school science course. This is as follows, 1. Collection and breeding methods of planaria 2. Observation of external structure and gut branch 3. Irritability and taxis of planaria. 4. Observation of regeneration. autotomy and diminution.

유치우식의 관련요인에 대한 연구

오명희,김진태 大韓小兒齒科學會 1982 大韓小兒齒科學會誌 Vol.9 No.1

The author has compared and analized contributing factors which affect 155 5-year-old childrens who reside in SEOUL with caries involvement by means of oral inspection and questionaire. The results are as follows. 1. Children sucking human milk had more decayed teeth than those who sucking bovine milk. (P<0.05) 2. Children performing the toothbrushing everyday had fewer decayed teeth than those who performing that occasionally. (P<0.05) 3. Children eating the weaning diet late had more decayed teeth than those who eating that earlier. (P>0.05) 4. Children sucking milk bottle besides milk had more decayed teeth than those who sucking milk bottle only with milk. (P>0.05) 5. Children not using milk bottle had more decayed teeth than those who always using that. (P>0.05) 6. Children eating between meals up to time has fewer decayed teeth than those who eating between meals whenever possible. (P>0.05) 7. Children eating the sugar containing food well had more decayed teeth than those who eating the meal ordinarily. (p>0.05)

鷄胚의 十二指腸 粘液細胞에 미치는 4 Nitroquinoline 1-Oxide의 影響

吳鎭泰,韓春培,河在淸 부산교육대학교 과학교육연구소 1982 科學敎育硏究 Vol.7 No.-

This experiment was performed to observe the histochemical properties of the mucosubstances in the duodenum of chick embryos and the effect of 4NQO 5x10^-6M and 4NQO 5x10^-7M on the goblet cells of the chick embryo's duodenum. The chick embryos, which was used for this experiment, was seperated into five stages in the process of their developing; 16 day-embryos, 18 day-embryos, 20 day-embryos, 21 day-embryos and 9 day hatched chick. The mucosubstances were stained with Alcian blue pH2.5-PAS, Periodic Acid Schiff(PAS) and Alcian blue pH2.5-Azure. The obtained results were as follows; 1. The histochemical compositions and amounts of mucosubstances in the goblet cells of Chick embryo's duodenum were observed to consist of acid and neutral mucins. 2. The acid neutral mucin's cells were observed to increase in number more in the others long-day chick embryo than 16 day chick embryo in the process of their developing. 3. The histochemical compositions and amounts of mucosubstances in the goblet cells were didn't have the portion differences, but were showed less in the crypt goblet cells. 4. Though 4NQO 5x10^-6M and 4NQO 5x10^-7M had been injected into chick embryo, the histochemical compositions and amounts of mucosubstances in the goblet cells, and their structure of villi were not varied in particular.

수학과 그룹별 자기 주도 학습이 문제해결능력 신장에 미치는 영향 : 중학교 2학년 과정을 중심으로 Gentered to the 2nd Grade curriculum of Middle School

오후진,김태흥 한국학교수학회 2001 韓國學校數學會論文集 Vol.4 No.2

In its seventh revision to start in 2001, mathematics will have a new emphasis in the middle school curriculum. Mathematics subject is now composed of practical things in the use of mathematics. Also, the future of new generation, which has been known as the information age, places much focus on problem-solving in order to collect, analyze, synthesize, and judge various kinds informations. This demand of problem-solving ability is not only related with mathematical education but, along the entire educational process, its related to actual life. With this change of social structure, the importance of school education is increasing rapidly. Therefore, in order to grow abilities and create new knowledge, adapted this new method of self-oriented learning in groups to middle school 2nd graders for one year, the results were as follow : 1. Students developed their ability of the use of mathematical terms and signs correctly. 2. Students' mathematical knowledge and problem-solving ability improved as they had increased interest in mathematics. 3. Students' peership was enhanced through their communication and cooperative activities in groups during the class. 4. Students themselves were more willing to volunteer and participate during the class.

Identification of a Gene Cluster in Streptomyces spectabilis-spectinomycin producer

오태진,김형준,송재경 선문대학교 대학원 2000 대학원학술논문집 Vol.2 No.-

Spectinomycin (Spc) is an aminoglycoside antibiotic which shows remarkable broad-spectrum. From a chromosomal cosmid library of Streptomyces spectabills, a Spc producer, a clone (pSPM8) was isolated by homology to the dTDP-glucose 4,6-dehydratase and aminotransferase genes which obtained from S. spectabilis genome using a polymerase chain reaction. From this clone, a 5.8-kb DNA region was sequenced and found to encode four open reading frames and one Incomplete reading frame. The putative orfl protein reveals 29% amino acid sequence homology of putative myo-inosltol-2-dehydrogenase from Vibrio anguillarnm. The orf2 is about 46% homologous to putative myo-inositol-1-monophosphotase of Mycobacterium leprae. The orf3 showed strong homology (67.4%) to putative export protein (spcT) from S. flavopersicus. The amino acid sequence deduced from 0114 showed a high similarity (70.8%) to a spectinomycin resistance gene (spcN) from S. flavoperslcus. Expression of orf4 in E. coti BL21 showed the spectinomycin resistance.