Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

정형외과 영역에서 Sulperazon(Sulbactam/cefoperzon)의 Non-Comparative study

신현대,임상덕,안상로,이준규,이광진,윤승호 최신의학사 1989 最新醫學 Vol.32 No.2

옥수수 種實 形質의 遺傳分析

申昌浩,鄭丞根,車善佑 충북대학교 농업과학기술연구소 1990 農業科學硏究 Vol.8 No.1

Five inbreds and 20 F1s form a 5×5 diallel cross were used to obtain genetic informations on kernel characters in corn, which are necessary to improve seeds more adaptable to mechanical planter and to produce higher yielding hybrids with greater kernel dimension. Both general combining ability (GCA) and specific combining ability (SCA) were significant for kernel length (L), kernel width (W), kernel thickness (T), kernel weight, L/W, L/T and W/T. Greater GCA mean squares indicated additive effects were more important for W and L/W, while non-additive effects were more important for other characteristics. Significant reciprocal effects showed that female parents had greater effect on kernel dimension. Heterosis and heterobeltiosis were 14-43% and 8-31%, respectively, for all characteristics except T. GCA effects indicated that inbreds FR25 and KS42 increased L, KI16A increased W and WT, FR14A increased T, while FR2A decresed L, W, T, and WT. Genetic analysis also indicated the dominance and additive effect for W/T. No interactions between non-allelic genes and overdoinance were indicated for L, W and WT. Narrow sense heritability (0.29) indicated that selection for only W would be effective, although broad sense heritabilities for L, W and WT were 0.78-0.87

천정 크레인 시스템의 위치제어와 진동저감에 관한 연구

신승권,이한석,조영호,안두수 成均館大學校 科學技術硏究所 1998 論文集 Vol.49 No.1

Overhead crane systems are widely used for material transportation in many industrial fields. However, undesired swing can always be found during the moving progress, especially at the end location of the transport. The swing may increase the carrying time and cause safety problems. In order to achieve the target position, this paper used a PD controller and used a fuzzy controller to reduce swing angles found during the moving progress. The performance of controller was verified through the experimental results and the simulation results by MATLAB.

전신성 홍반성 낭창의 임상적 고찰

신영태,이정호,신승훈,이강욱 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

To elucidate the clinical feature and clinicopathologic correlation of systemic lupus erythematosus(SLE), the authors analized symptoms and signs, laboratory findings and kidney pathology in 25 patients with SLE who were admitted to the Department of Internal Medicine, Chungnam National University Hospital from My 1985 to October 1989. Kidny biopsy was performed in 15 patients out of 19 patients who showed lupus nephritis. The results were as follows: 1. The ratio of male of females was 1:11.5. They were 14 to 53 years old and mean age was 30.2 years old. The peak age incidence was 3rd and 4th decades. 2. The most frequent chief complaint on admission was fever and chills. Most patients had two or more symptoms such as arthralgia, malar rash, generalized edema or weakness. 3. In 84% of the patients, duration from onset of the disease to diagnosis of SLE was longer than 1 month, which suggested that diagnosis of SLE is not easy in early stage of SLE. 4. The positive anti -DNA was the most frequently observed ARA criteria of SLE. And positive ANA, malar rash, persistent proteinuria, leukopenia, positive LE cell preparation, arthritis and oral ulcer were observed in order of frequency. 5. The frequent and pertinent general symptoms, not included in ARA criteria were fever and chills, arthralgia and abdominal pain which were observed in more than half of the patients. 6. On immunologic test, serum concentrations of C3 and C4 were decreased in 96% of the patients, serum concentration of Ig G, Ig A were increased in 65%, 36.8% and 26.3% of the patients respectively. The RA test was positive in 25% of the patients. 7. Lupus nephritis represented 76% of all SLE patients and pathological classification on 15 patients with lupus nephritis revealed class IV lupus nephritis in 9 patients(60%), class II n 3 patients (21%), class V in 2 patients(13.3%) and class III in 1 patient. 8. 7 out of 9 patients with class IV lupus nephritis and 1 out of 2 patients with class V lupus nephritis showed nephrotic syndrome. Progressive azotemia were observed in 3 out of 9 patient with class IV lupus nephritis and in 1 out of 2 patients with class V lupus nephritis. There were no nephrotic syndroms or azotemia in class II and class III lupus nephritis. 9. Of 17 patients who can be followed up, 9 patients were improved, 5 patients became progressive azotemia and 3 patients resulted in death. The causes of death were myocarditis with pericarditis in 1 patients, pneumonia with acute respiratory failure in 1 patient and CNS involvement of SLE in 1 patient.

XML 문서의 효율적인 구조 검색을 위한 동적 색인 모델

신승호,손충범,유재수 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.2

XML문서는 정보 표현의 기본 단위인 엘리먼트로 구성되어져 있다. 이러한 정보 표현의 기본 단위인 엘리먼트가 XML문서 내에서 구조 변정 이 발생 할 경우 보다 빠른 검색을 위해 기존의 색인 구조 정보의 변경 없이 효율적으로 처리 되어져야 한다. 이를 위해 본 논문에서는 XML 문서의 구조 변정 시 기존의 색인 구조에 효을적으로 수용될 수 있는 동적 색인 모뗄을 제안한다. 본 논문에서 제안 하는 동적 색인 모뗄을 위한 구조정보는 기존의 EID(Element Id), ETID(Element TrPe Id), SORD(Sibling ORDer) SSORD(Same Sibling ORDer), Ccount 구조정보 추출 방법에 SSORD를 대신한 STSOL(Same TyPe Sibling ORDer List). Scount (STSOL내의 SORD 개수). 그리고 COL(Child ORDer List)을 추가함으로써 구성된다. 이러한 구조정보를 이용해 효율적인 검색을 지원하기 위한 동적 색인 구성 알고리즘을 기술하고 제한하는 색인 기법이 기존의 동적 색인을 지원하는 기법 보다 내용 색인, 구조 색인, 애트리뷰트 색인 측면에서 우수함을 성능 평가를 통해 보인다. XML documents consist of elements that are basic units of information. When the structure of XML documents is changed dynamically, we need to update structure information efficiently without changing the information of an index structure for fast retrieval In this Paper, we propose a dynamic index modelling scheme that update index struoture in real time as the structure of XML documents is changed by insertion and deletion of elements. In recent, for indexing XML documents. we have proposed a structural information representation method such as element ID(EID), element type ID(ETID), sibling order(SORD). same sibling order(SSORD) and child count(Ccount). Besides them, our proposed dynamic index modelling method in this paper extracts additional structural information, such as same type sibling order list(STSOL) that substitutes for SSORD. Scount that is the number of SORDS in STSOL. and child order Bist(COL). We design a dynamic indexing technique with our structural information. We show through various experiments that our method outperforms existing enes in processing various types of queries such as content based queries, structural queries and hybrid queries.

제7차 고등학교 체육과교육과정에 대한 인식

신승호,한상준 江原大學校附設體育科學硏究所 2003 江原大學校附設體育科學硏究所論文集 Vol.- No.26

The purpose of this study was to examine how much the high school students understand the 7th physical education curriculum, to find out the better teaching method for physical training class and to give basic data needed for using selection focused curriculum. To attain this purpose, this paper dealt with the survey with the 1st-2nd grade students, 1173 students who live in cities and counties whose population is more than 200,000 and less than 100,000. The results are as follows. Most students felt positive about the structures and class aims of the 7th curriculum in high school physical education. boy students and high graded group had relatively higher regards and participation of the 7th physical education curriculum. They also had positive regards about the present physical training evaluation. In other words, boy students, high graded group and county's group had more positive thought about the evaluation process and results of the physical training class than girl students, low graded group and city's group.

Newton-Raphson 방법에 기반한 공개키의 암호화 전달

신승호,노희영 강원대학교 정보통신연구소 2009 정보통신논문지 Vol.13 No.-

It is necessary to cipher for secrete of public key in processing of the certification for secrete key. Hence, this paper offers a method based on Newton-Raphson for encryption transmission of public keys that are generated by Diffi-Hellman cipher algorithm.

프로젝트관리 시스템을 위한 범위관리 알고리즘 개발

신호균,전승호,김만균 대한설비관리학회 2004 대한설비관리학회지 Vol.9 No.2

This study present the method to cope with the limitations of the existing study that has uniformly been customizing the methodology by only project's complexity. We show how the applied model(ODW) is implemented in PMS using knowledgebase and modelbase which are designed for a scope management algorithm. An ODW model is used for implementation of a WBS identification module and regression model is used for measuring project's complexity. Scope management algorithm is simulated in MS-Excel for estimating its effectiveness and the interrelationship among the knowledgebase, modelbase and database is derived.