神門穴 鍼刺戟이 母性分離 스트레스로 야기된 攝食 障碍와 시상하부 neuropeptide Y 발현에 미치는 영향

박히준,류연희,홍미숙,김승태,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : The purpose of this study is to find out the effect of acupuncture at HT7(Shinmun) on the feeding behavior and hypothalamic neuropeptide Y(NPY) expression in the maternally separated rat pups. Methods : To show the effect of acupuncture, we performed maternal separation(MS) for 7 days beginning on postnatal day 14, and observed body weight, food intake, and NPY immunoreactivity in the paraventricular nucleus(PVN) of hypothalamus after acupuncturing at HT7, the end of the transverse crease of the ulnar wrist of the forepaw. Results : MS induced a significant decreases in body weight and food intake, while acupuncture treatment at acupoint HT7 showed much more improvement in those evaluations. NPY-immunoreactivity in area PVN were decreased in the MS group, but significantly increased in the HT7 group. Conclusions : These findings suggest that acupuncture has an effect on the feeding disorders caused by MS, possibly by modulating NPY expression in the PVN.

유세포측정기에 의한 소화기간엽종양의 DNA 분석

조미연,홍순원,정순희,김호근,박찬일 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.7

백금(Ⅳ)착체의 약리학적 연구

박은희,임경화,신윤진,박미화 숙명여자대학교 약학연구소 1994 약학논문집-숙명여자대학교 Vol.10 No.-

The platinum complex, PtCl₄(2-CEen), was previously synthesized and shown to have anti-tumor activity. In the present study, toxicologic profile of PtCl₄(2-CEen) and its acute anti-inflammatory activity on carrageenin edema was observed with oral administration. The ef-4feet of this agent on acetic acid-induced writhing in mice were also examined. In male and female mice given a single intragastrical dose of PtCl₄(2-CEen), we determined that LD_(50) values were over lOOOmg/kg B.W. In the method of carrageenin edema and writhing test, the PtCl₄(2-CEen), orally administered in a single dose, tended to inhibit the development of hind paw edema in rats, and the number of writhing induced by acetic acid in mice. These facts suggest that PtCl₄(2-CEen) may have weak anti-inflammatory effect.

Head-Space SPME에 의한 생체시료 중 메스암페타민류 분석(Ⅲ)

박미정,최상길,손행자,최화경,최영남,허상철,박종서,정희선 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

MathML에 기반한 수학식 생성 웹사이트의 설계 및 구현

박정희,이미정 한국컴퓨터교육학회 2003 컴퓨터교육학회 논문지 Vol.6 No.3

인터넷이 널리 보급되면서 웹을 이용한 이러닝 교육방법이 활성화되고 있다. 웹 기반 교육에 있어서 수학도 예외는 아니다. 그런데 수학식을 웹 마크업 언어 HTML의 이미지 태그를 이용하여 표현하면 구조적 특징을 가지는 수학식의 1)표현과 검색이 어렵게 되고, 수학 관련 어플리케이션에서의 재사용이 어렵게 된다는 문제가 발행한다. 그래서 본 논문은 MathML에 기반하고, ActiveX 컨트롤 기술을 이용한 수학식 생성 웹사이트를 설계하고 구현한다. 본 시스템은 ActiveX 컨트롤 기술을 이용하기 때문에 웹상에서 시공간 제약 없이 수학식 생성을 할 수 있고, 프로그램의 최신 버전 관리가 가능하다. 또한 본 시스템에서 생성한 수학식을 저장 가능하게 하여 차후에 재사용이 가능하도록 하였다. E-learning education methodology using the web has been as much activated with the introduction of the internet to our society. As for the web-based education, there is no exception in case of mathematics. However, when it comes to representing math equations by using HTML image tags, a type of web marked-up language, it can be hard to represent math equations that have structural features, and to do the search, resulting in the difficulty in reusing math related applications. Therefore, based on MathML and using ActiveX control technology, a math equation generating website was designed and implemented in this study. Since this system employed ActiveX control technology, it is possible to generate math equations without the limit of time and place on the web, and to manage the program with the most up-to-date version. And in this system, it is also possible to save the math equations generated in this system to be referred to for their reuse in the future.

비알콜성 지방간 : 임상소견과 초음파소견의 비교

채희복,김미성,박선미,성노현,윤세진 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.1

연구목적 : 최근 건강검진이 널리 시행됨에 따라서 지방간 환자가 많이 발견되고 있으며 이에 대한 사람들의 관심이 증대되고 있다. 본 논문에서는 지방간 환자의 임상적인 특징을 살펴보고 위험요인과 예후에 관련된 인자들을 규명해 보고자 하였다. 연구대상 및 방법: 1998년 2월부터 2000년 3월까지 충북대학교 병원에 내원한 환자 중 초음파로 지방간을 진단받은 65명의 환자를 대상으로 하였다. 후향적으로 진료기록을 검토하였으며, 전화로 체중, 키, 음주력, 약물복용력, 관련증상 유무를 확인하였다. 초음파상 지방간의 중증도와 대상환자들의 체질량지수, 혈청 ALT치의 상승, 기저질환, 관련 임상 증상들간에 상관성이 있는지를 비교분석 하였다. 결과: 체질량지수와 초음파상 지방간의 중증도간에는 유의한 상관관계가 관찰되었다. 혈청 ALT치를 80 IU/L를 기준으로 두 군으로 나누어 지방간의 중증도와 비교하여 본 결과 중증도가 심할수록 혈청 ALT치의 이상소견이 더 높은 빈도로 관찰되었다. (P < 0.01) AST/ALT비는 초음파상 중증도와 역의 상관관계를 나타내었다. (P < 0.01) 소량음주군과 비음주군의 두 군으로 나누었을 때 지방간의 중증도가 심한 군에서 소량음주군이 보다 더 많이 포함되는 경향을 보였다 (P = 0.052) 첫 초음파 검사 시행 시점부터 평균 32개월의 기간이 경과한 뒤 추적검사가 가능하였던 9명의 환자 중 6명에서 무변, 3명에서 호전이 관찰되었다. 결론: 본 연구의 결과 초음파상 지방간 중증도가 심한 환자에서 더 자주 혈청 ALT치의 상승이 관찰되었다. 지방간 환자 중에서 간내 지방축적이 심할수록 염증을 동반할 기회가 많아진다고 생각된다. 이러한 간내 염증괴사소견의 동반은 좋지 않는 예후를 시사하므로 간조직검사등의 적극적인 진단과 비 알콜성지방간염에 대한 조기대응이 필요하다고 생각된다 아울러 지방간 이환기간과 간내 염증과의 상관성을 증명하기 위한 후속연구가 더 필요하다고 생각된다. Background/purpose : Nonalcoholic fatty liver disease can be found more frequently than before due to a high fat diet and a sedentary life style. The aim of this study was to compare clinical characteristics and outcomes of patients with different sonographical grade of the nonalcoholic fatty liver. Methods : 65 patients were diagnosed as nonalcoholic fatty limier patients by abdominal solography from Feb. 1998 to Mar. 2000. We reviewed medical records and confirmed the clinical data by phone. We compared the sonographical grade of the fatty liver with such clinical data as BMI, serum ALT level, underlying diseases and associated symptoms. Results: 1) There was a significant correlation between the BMI and the sonographical grade of the fatty liver . 2) The more severe the sonographical grade of the fatty liver, the higher the serum ALT level was. 3) There were significant inverse correlations between the AST/ALT ratio and the sonographical grade of the fatty liver. 4) Out of the 9 patients whose status could be assessed by sonography or biochemical tests after about 3 years, 3 patients improved and the other 6 patients showed no interval change. Conclusion : Both the amount of excessive fat and the duration of the fatty liver are considered to be the risk factors of nonalcoholic steatohepatitis. We confirmed the association between the sonographical grade of the fatty liver and the serum ALT level by this study, but the association between the duration of the fatty liver diesease and the nonalcoholic steatohepatitis needs to be studied more in the future. The nonalcoholic steatohepatitis showing necrosis or a Mallory body may take an aggressive course leading to cirrhosis and liver related death. Therefore, a liver biopsy and active therapeutic intervention is necessary, early and properly

농촌지역 영유아 보육의 문제점

김경희,박분희,양미경 목포대학교 여성문제연구소 2000 여성연구 Vol.8 No.-

병원간호사의 노동조합에 대한 태도와 간호전문직관에 관한 연구

주미경,박성희 서울대학교 간호대학 간호과학연구소 1997 간호학 논문집 Vol.11 No.1

In studies on the hospital labor-management relations, research about the attitudes of workers and management toward unions was relatively untouched in Korea. This study was investigated to identify the relation between attitudes toward unions and views on nursing profession among unrses. Data was obtained from a convenience sample of 285 nurses in different positions, education, career, status of union member. The results of this study were as follows: 1. There were significant differences between nurses' position and status of union member and attitudes toward unions(p<.05) 2. Nurses with master's degree had significantly lower views on nursing profession(p<.05). 3. There were significant differences between nurses' employed hospital and attitudes toward union(p<.05). 4. There were correlation between attitudes toward unions and views on nursing profession(r=.16). The findings of this study suggest that antecedents and moderating variables of attitudes toward unions and views on nursing profession need to be explored for further theoretical specification and empirical evaluation. As the results, it is important that lablr and management make a reciprocal relations. And labor-management relations will be stabilized and more cooperative.

재가노인들을 위한 무료급식소의 식단 평가

한경희,채인숙,박정숙,최미숙,정순둘 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.5

The purpose of this study was to evaluate the diet quality of the menus delivered by 17 free meal service centers for the low-income home-bound elderly in Chung- cheong buk-Do. Statistical data analysis was compleleted using the SPSS package program for descriptive analysis, T-test, and ANOVA. The meals offered by free meal service centers were not met the 1/3 recommended dietary allowances in calcium and vitamin B_2. There were significant differences between dependent variables(nutrient content, nutrient density, nutrient deficiency, NAR, MAR, food group intake patterns) and independent variables (operation type, operation status, operation period, nutritionist, food cost).

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.