Cytokine and Tumor Environments

Jin Tae Hong1*, Ju Kyung Song, Sun Mi Kwon, Byung Woo Ahn, Youngsoo Kim, Sang Bae Han 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1

Cytokines are known to function as regulatory molecules that can be produced by virtually every nucleated cell type in the body, including lymphocytes, monocytes/macrophages, epithelial cells, fibroblasts, and many others. Cytokines include lymphocyte-derived factors (lymphokines), monocyte-derived factors (monokines), hematopoietic factors (colony-stimulating factors), connective tissue/growth factors, and chemotactic chemokines. Cytokines released in response to infection can affect tumor development in different ways. When exposed to infectious agents, cytokines are secreted by sentinel cells, such as macrophages and dendritic cells. These cytokines include interleukin 1 (IL-1) and tumor necrosis factor-α, as well as others, such as IL-6, IL-12, and IL-18. When released in sufficient quantities, these molecules can cause inflammation. Chronic inflammation is highly associated with tumor initiation, promotion, and progression. In this article, we review the roles and mechanisms of cytokines in tumor development.

Association of 20 potential ATP2B1‐interacting genes with blood pressure in Koreans

Kyung‐Won Hong,Hyun‐Seok Jin,Ji‐Eun Lim,Bermseok Oh 한국유전학회 2011 Genes & Genomics Vol.33 No.3

Plasma membrane calcium‐transporting ATPase 1 (ATP2B1)is associated significantly with blood pressure in Caucasians and Asians. ATP2B1 regulates calcium homeostasis and belongs to the P‐type calcium pump family; several studies have identified diverse proteins that bind to ATP2B1. We hypothesized that ATP2B1 regulates blood pressure through ATP2B1‐interacting genes. To this end, 20 potential ATP2B1‐interacting genes were selected, 197 SNPs of which were analyzed for their association of systolic and diastolic blood pressure. These 20 genes were categorized into 2 groups: ATP2B1‐binding genes and ATP2B1‐cleaving calpain family members. Three ATP2B1‐binding genes (CALM1, NOS1, and PDLIM1)were associated with blood pressure, and a SNP in CALM1(rs2401887) generated the strongest association signal (beta=‐3.60±0.92, p=8.9×10^(‐5) for systolic blood pressure and beta=‐1.40±0.62, p=0.02 for diastolic blood pressure). Of the calpain family members, 3 genes (CAPN6, CAPN9, and CAPN10)were associated with blood pressure, and the CAPN10 SNP rs4676348 yielded the strongest association signal (beta=‐0.88±0.27, p=0.001 for systolic blood pressure and beta=‐0.58±0.18, p=0.015 for diastolic blood pressure). Further, the interaction of CALM1 to ATP2B1 was examined using the blood pressure of individuals who carried both variants of CALM1and ATP2B1 genes. Similarly the interaction of CAPN10 to ATP2B1 was also examined. The CALM1 variant (rs2401887)and CAPN10 variants (rs4676348) appear to decrease blood pressure further in addition to the decrease by the variant (rs17249754) of ATP2B1, which suggests that ATP2B1 might regulate blood pressure through the ATP2B1‐interacting genes CALM1 and CAPN10.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

A Study on the appropriate herbal medicine according to Sasang constitution using EAV

Choi,Jin-Wook,Lee,Su-kyung,Hong,Suck-chull,Koh,Byung-hee INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 1997 JOURNAL OF ORIENTAL MEDICINE Vol.2 No.1

1. Objective This is a basic study about the response of herbal medicine to EAV. The purpose was to investigate how the meridian of EAV responded to herbal medicine and how EAV was applied to the diagnosis of Sasang constitution. 2. Materials & Methods The subjects of this study were patients who were being treated in the Dept. of Constitutional Medicine ot Kyung-Hee Medical Center. The study examined how herbal medicine affected the maximum value and the indicator drop and how each constitution responded differently to the constitutional herb medicine. 3. Results & Conclusions 1) When comparing the maximum value and ID of the worst BAP before and after the experiment with herbal medicine, the maximum value significantly went up and the ID significantly went down in all the herbal medicines. So we confirmed that all the herbal medicines positively affected the change of the maximum value and ID. 2) The changes in the maximum value induced by herbal medicines were significantly different according to the constitution of Dokhual Jihwang Tang, and Hyangbuja Palmul Tang. Although Dokhual Jihwang Tang was soyangin's herb medicine in Sasang constitutional medicine, it raised the value of soeumin higher than that of soyangin. Hyangbuja Palmul Tang which was soeumin's herb medicine raised the value of soeumin higher than that of the other constitution. 3) The changes of ID were not significantly different in the constitution.

사람 태아 간의 과립백혈구 형성에 관한 전자현미경적 연구

홍진숙,김경용,이원복,김동창 대한해부학회 1992 Anatomy & Cell Biology Vol.25 No.4

상치와 부추의 구조탄수화물의 정량분석 방법간의 비교연구

홍상식,윤수현,김경자,김대진 東亞大學校 附設 生活科學硏究所 1998 생활과학연구 논문집 Vol.6 No.-

This study was conducted to determine several analytical methods to quantitative structural carbohydrate(dietary fiber). Two kinds of vegetables(lettuce and leek) with each, having several components-dietary fiber(DF, includ nondigestible component), total dietary fiber(TDF), neutral detergent fiber(NDF), protein corrected NDF(c-NDF), indigestible dietary fiber(IDF) and acid detergent fiber(ADF) were compared in this study. Two kinds of vegetable components were calculated to the regression equation and correlation coefficients between them-Y=39.955+0.37X(r=0.27) between DF(Y) and NDF(X), Y=53.346+0.12(r=0.08) between DF(Y) and c-NDF(X), Y=30.519+0.80X((r=0.81, p<0.05) between DF(Y) and ADF(X), Y=65.097-0.128X(r=0.26, p<0.01) between TDF(Y) and IDF(X), and Y=47.89+0.2X(r=0.49, p<0.05), between DF(Y) and TDF(X), respectively.

관광성향 비교를 통한 지역관광 특화방안에 관한 연구

홍윤순,이경진 公州大學校 産業開發硏究所 1999 産業開發硏究 Vol.7 No.-

The purpose of this study to search regional tourism strategy planning for comparing travel attitudes; Chungchengnam-do and Yesan. Tourism development program of regional operation base was as follows - Green & natural tourism development in Chungnam agricultural techno-park. - Resort development in Duksan spa area and Duksan province national park - Historical-cultural tourism route development in Sudukas, Chunguisa, Chusa-gotaek. - Edu-cultural private Museum development in Yedang water front.

관광호텔의 리더쉽 유형이 조직유효성에 미치는 영향

홍경욱 ; 박진영 ; 이현정 김천대학교 2000 김천대학교 논문집 Vol.21 No.-

The Leadership is very important for organizational behavior in every organization. Excellent leadership guide an organization to achievement. The leadership is more important in hotel organizations because which are highly dependent on human resources compare with other organizations. The Purpose of this research is to examine what influence leader-ship has on organizational performance. The variables of leadership are initiation structure leadership and consideration leadership. And the factors of organizational effective-ness are job satisfaction and job commitment. The results of this study revealed the followings : First, the initiation structure leadership and consideration leader-ship both effect on job satisfaction and the consideration leadership is more influence than initiation structure leadership. Second, the consideration leadership has positive effect on organi-zational commitment, but initiation structure leadership has not positive. This results means employees recognize more important the consideration leadership consist of friendship. confidence and respect.

현장실무 인증제 도입을 위한 기초적 연구

홍경옥 ; 김정호 ; 권창오 ; 박진영 김천대학교 2004 김천대학교 논문집 Vol.25 No.-

As the society becomes diverse and specialized, industrial corporations require much more than before to their applicant, in order to accept rapid technological change. Moreover, they request practical education of colleges to increase students' work ability. In order to create human resource who has official ability corresponding to the change and demand of industry and improve the results, the introduction of college educational quality certification policy is urgently requested for develop ing and managing the human resource of college graduator. Therefore, this study analyzed the sort of qualification policy which is practically required and recognition and necessity of a spot business certification recognized by industrial corporations, as a basic stage to strengthen work place adaptability and basic work ability of college graduator. This study also researched the method to improve the quality of college edu-cation on the purpose of providing basic research materials for buildinga foundation of this college certification system.

여성상품 판매원의 판매방법이 고객만족과 판매 성과에 미치는 영향에 관한 연구

홍경옥 ; 전기환 ; 박진영 김천대학교 2002 김천대학교 논문집 Vol.23 No.-

The sales method of sales person can be strategic service activity concept that produce superior value and maintain it in the market by responding for the customer's 'need'.