일차성 식도이완불능증의 풍선확장술후 치료효과의 객관적 평가지표

손영해,나호영,조성범,주영은,김현수,최성규,유종선,김세종 全南大醫大 2001 전남의대학술지 Vol.37 No.2

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

경남 일부 지역 간흡충 감염 주민에 대한 혈청 생화학검사 소견 분석

손운목,조영표,김기진,김미영,이종욱,박도흠 한국건강관리협회 1999 건협 Report Vol.2 No.-

THI에 의한 서울시 지하철 역사 근로자의 신체 및 심리적 증상에 관한 연구

손종렬,김선철,변상훈,문경환,김영환 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

This paper reports an investigaion for the health status of subway workers in the 67 subway stations in the Seoul area during from September 15th to Nobimber 15th, 2002 . Prevalence of subuective complaints was surveyed of 400 subway workers applied by a general health questionnaire-the Todai Health index(THI). The basic tool employed in this present study was the THI which is modified Comell Medical Index(CMI) and was developed by Tokyo University Research Team in Japan, and had been used to evaluate manufacturing workers, iron workers and other workers by Kim(1979), Chung(1982), Lym(1987), Lee(1996) in Korea. The results were summarized as follows; 1. The physical and psychological complaints were much higher in the 20~29 age group than other age groups. 2. The physical and psychological complaints showed a high tendency of increased incidence in all items as length of service decreased, and the 3~5 years group was higher than less 1 year group with regard to the symptoms of Digestive(C), Aggressiveness(F), Nervousness(E). 3. The physical and psychological complaints showed much higher tendency in the station staff(S?S) group than other groups. 4. The physical and psychological complaints showed much higher tendency in the under station(Un.S) and upper station (Un.S) groups than other groups. 5. The responses of physical and psychological complaints by monthly pay showed much higher tendency in he income of 10.1~1.50 millions won group than other groups. 6. The responses of physical and psychological complaints by smoker or non-smoker showed much higher tendency in the smoker group than non-smoker group. Therefore, it can be concluded that the worker of subway studied was perceived as acceptable the importance of health status, and suggested that the goverment of related subway need to be effort to control the health of subway workers in environment of indoor.

Job shop에서 지체작업수 성과를 고려한 작업배정 규칙

손영진,우종선,문석환 한국의사결정학회 2001 경영과학연구 Vol.10 No.-

Scheduling techniques and dispatching rules are widely studied because of their simulation-based analysis of dispatching rules for scheduling in dynamic job shops taking into account of utilization on the shop floor and due-date tightness. This research proposed new dispatching rules for a job shop that are expected to minimizes the proportion of tardy jobs. With respect to the proportion of tardy jobs objectives, the relative performance of the proposed dispatching rules were evaluated against that of the well-known ones.

매켈게실의 신티그래피 진단

손명희,한영민,김종수,최기철 의과학연구소 1990 全北醫大論文集 Vol.14 No.2

Meckel's diverticulum is one of the most frequent congenital malformations of the gastrointestinal tract in man and found in approximately 1 to 3% of the general population. This remnant of the omphalomesenteric duct gives rise to symptoms of primarily rectal bleeding in the young. The customary radiographic approach to the gastrointestinal bleeder ususally fails to identify this lesion. Most of the symptomatic Meckel's diverticula are lined with ectopic gastric mucosa. Therefore Tc-99m pertechnetate which is concentrated by the gastric mucosa has been found to be useful in localizing these divertecula. The authors described a case of bleeding Meckel's diverticulum whose pathologic diagnosis was expected preoperatively with Tc-99m pertechnetate abdominal scintigraphy and confirmed postoperatively.

서울 북부지역의 생활폐기물 발생량 및 조성 분석

손종렬,배은상,김영환,문경환 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

This study was carried out to investigate on the generation and composition of municipal waste in north area of Seoul. The results was as follows: 1. The generation and composition of municipal waste was investigated foods> papers> glasses> plastics> metals(cans)> textiles> leaches> woods> ashes> rubbers> ceramics> leathers in residential area, that was investigated papers> foods> plastics> glasses(bottles)> textiles> metals> ashes> leaches> rubbers> ceramics> leathers in nonresidential area. 2. The recycling generation of municipal waste was investigated papers> glasses> plastics> metals> textiles> woods in residential and nonresidential areas. 3. The three components(water, combustion & ash) was analysed in each composition of municipal waste for the deciding treatment methods of waste in residential and nonresidential areas. The water component of each composition was analysed foods> papers> woods> textiles> rubbers > ashes in residential area, which analysed foods> papers> ashes> woods> textiles> rubbers in nonresidential area. The combustible component was analysed plastics> textiles> woods> rubbers>papers in residential and nonresidential area. The ash component was analysed nonferrous metals> ferrous metals> ceramics> ashes in residential area, that was analysed ceramics> ferrous metals> nonferrous metals> ashes in nonresidential area. Conclusively, in order to treat municipal waste the separated collection system should be systematically performed, the next improvable proposal of the detailed methods should be prepared.

통조림罐의 內面腐蝕에 미치는 有機酸의 影響

孫泰華,崔鍾旭,權榮澤,金聲達 경북대학교 1981 새마을 硏究論叢 Vol.1 No.-

This experiment was carried out to research the effect of kinds and concentration of organic acid food component on the internal can corrosion, stored at room temperature (25℃) and low temperature (0℃). The criterion for the degree of the internal can corrosion was tin contents in the pure acid solution. The result of this research can be summarized as followes. The intension which effect the rate of the tin dissolution was furmaric>malic>citric, were respectively. The rate of the dissolution were increased rapidly at 30days after treatment, and the higher concentration of malic acid, the more dissolved of tin from the can body. The amounts of tin dissolved from can body at room temperature were slightly stronger than low temperature.

피혁슬러지 고형화시 시멘트 혼화제의 영향

주소영,박상찬,전태성,손종렬,김태영 대한위생학회 2003 대한환경위생공학회지 Vol.18 No.4

The cement-based system among S/S(Solidification/Stabilization) is widely used to treat hazardous wastes. In this study, tannery sludge was solidified to evaluate the stabilization effects of using admixtures in the cement-based S/S. Fly ash as substitute also used to increase the strength of the S/S of hazardous waste. The compressive strength measurement and leaching experiment of chromium metal of solidified mortar were carried out to compare and evaluate the physical and chemical characteristics of solidified hazardous waste sludge. From the result of this study, there was increased of compressive strength by using AEW-3(early-hardening AE water reducing agent), and leaching concentration of chromium became low enough to satisfy the regulatory criteria. The successful solidification for the organic contaminant and heavy metal in hazardous waste should enable to treat by cement-based system using early-hardening AE water reducing admixture and fly ash as substituted cement.

기관지 방선균증의 임상 1례

이은영,장태원,정만홍,옥철호,이규원,손창배,이지숙,신은경,서정아,백종현,김영옥 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Actinomycosis is a chronic suppurative infection, whitch infiltrates mucosa-associated tissues. Thoracic, pelvic and cervicofacial infections of actinomyces are not uncommon, but endobronchial actinomycosis is rarely reported. We report a case of a 29 year old man who presented with a recurrent pneumonia and chronic cough. Fiberoptic bronchoscopy revealed occlusion of the right. lower medio-basal segment bronchus with exophytic endobronchial mass. The diagnosis was confirmed histologically by demonstration of sulfur granules in the bronchoscopic biopsy of the mass. Intravenous administration of amoxacillin and clindamycin followed by oral amoxacillin and clindamycin therapy resulted in complete recovery.