정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

부산지역 수돗물과 지하수의 중금속 농도

김준연,손지언,김형수,김두희,원미숙,김인식,이혜령 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

This study investigated mean airborne CO concention of 15 workplaces, suspected of CO exposure and conducted self-reported questionnaire completion and indirect COHb concentration measure using Micro II Smokerlyzer to healthy 702 adult subjects from 1999 May to 1999 September in order to find a relation of CO exposure and occupational factors, socioeconomic factors, and health related behaviors and confirm the related conditions in the screening test for CO exposure. The results of this study were summarized as follows : 1. In the CO exposed and non exposed group, COHb concentrations of the smokers were 2.55±0.96% and 2.21±0.97% and that got a statistically significant difference, There were not statistically significant differences in the age and total smoking index. Passed times after the last smoking, Working time/day, and working duration were statistically significant difference (p〈0.05). 2. In the CO exposed and non exposed group, COHb concentrations of non-smoking group were 0.94±0.35% and 0.68±0.47% and that got a statistically significant difference. There were not statistically significant differences in the age and working duration but Working time/day was a statistically significant difference(p〈0.05). 3. In the CO exposed group, r-square of multiple regression of the smokers was 38.5 % and passed time after the last smoking, working time/day, and job category were statistically significant differences (p〈0.05). And r-square in the CO non-exposed group was 38.3 % and age, passed time after the last smoking, and total smoking index were statistically significant difference. 4. In the CO exposed group, r-square of multiple repression of the non-smokers was 66.3% and job category and airborne CO concentration were statistically significant differences(p〈0.05). But r-square of non-smokers in the CO non-exposed group was 1.0% and there was not a statistically significant difference(p〈0.05). 5. In the smokers of CO exposed and non exposed groups, relation of COHb concentration and passed time after the last smoking was expressed as exponential function, Y = 2.9182e-0.0083x and r-square of this function was 37.4%. Therefore it was more than 150 minutes that passed time after the last smoking was when COHb concentrations were measured as less than 1%. In conclusion, variable, that was statistically significant to COHb concentraion in the both CO exposed and non-exposed smokers, was a passed time after the last smoking. We suggest that you have to restrict the smoking of smokers at least 150 minutes in the exposed and non exposed group before COHb concentration measure in order to exclude smoking effects

가정 환경적 요인이 배드민턴 선수의 역할 사회화에 미치는 영향

두만균,김연수 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

This study is aimed at providing basic data for scouting for and training skilled badminton players by investigating the extent of influence that such home background factors as subjective social class, educational level of parents, family income, job authority and seniority of brotherhood upon the role socialization of badminton players. For this purpose, a sampling framework was prepared out of the male and female badminton players at middle and high schools who are registered as of 2002 with the Korea Badminton Association affiliated with the Korea Sports Council and have participated in the national badminton championships by category in summer this year. By means of random sampling, a total of 222 players including 100 males and 122 females were selected randomly. From the investigation into the hypothesis on the influence of home backgrounds upon the role socialization of badminton players in line with the above-mentioned purpose and research method, following conclusions could be drawn: 1. The influence of family environment(education of father) upon the role socialization(position in the team) of a badminton player (p<.05). 2. The family environment(job authority of father) appeared to affect the role socialization(career as player) of a badminton player (p<.05). 3. The family environment(job authority of father) seemed to influence upon the role socialization(prize career) of a badminton player (p<.05). 4. The influence of family environment(job authority of mother) upon the role socialization(prize career) of a badminton playe(p<.05).

축구선수들의 정신력 요인에 관한 연구 : 중·고등학교 축구선수들을 중심으로 Centering on the Middle and High School Soccer Athletes

두만균,김연수 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

The present study is designed to provide basic data for psychological training programs to improve athletic strength of middle and high school soccer players by comparing and analyzing the levels of psychological sub-factors in terms of their team, position and status within their teams, and athletic and skill level. For this purpose, 427 soccer players including 139 middle and 288 high schoolers who are registered with the Korea Football Association in 2003 were sampled out as population from across male soccer teams of the country's whole middle and high schools. A test was conducted with the test paper designed by Loehr(1982) for measurement of psychological ability which was modified into somewhat unified format in a try to simplify answering by Korea Sport Science institute. The questionnaires were composed of 7 items of sub-factors. The filled-in questionnaires were collected and put to analysis after screening out those that were thought to be insincerely or unreliably replied. Frequencies, independent sampling t-test and one-way ANOVA were conducted to process the selected data which were put in computer by using SPSS 10.0 program From the findings, following conclusions could be drawn: First, ace players revealed higher sub-actors of psychological strength in terms of their status within the team than substitute players. Moreover, there was a significant difference in self-confidence, visualization image control ability and motive level modulation ability; Second, in terms of lengthy of sports career, players with longer than 6 years of experience showed higher sub-factors of psychological strength than those with less than 3 years of career. Furthermore, a significant difference was demonstrated in self-confidence, visualization and image control ability; Third, players of higher rank showed higher sub-factors of psychological strength depending on the technical level than those of lower rank, with a significant difference detected in stimulation and behavior level control abilities.

Retinoic Acid가 흰쥐 태자 혀조직의 분화와 Laminin 합성에 미치는 영향에 대한 연구

김혜주,정호삼,서윤경,백두진,김원규,윤지희,이방헌 대한췌담도연구회 2000 대한췌담도연구회지 Vol.5 No.4

도서관리 종합 정보 시스템 설계 및 구현

윤선심,김영준,유재중,이호근,김영현,임한수,박두순 순천향대학교 부설 산업기술연구소 2002 순천향 산업기술연구소논문집 Vol.8 No.1

There has been a sizable growth in the use of rich media over the World Wide Web(WWW) as more individuals and institutions realize rich-media's potential in a broad range of applications, including electronic commerce, education and training, news, etc. Internet and WWW technologies provide the information of the web. Libraries are systems that carry out interactions among information and knowledge seekers. Library become more and more important for the provision of data. Total information system for books management exist in many forms. We present total information system for books management which is applied to several different sources, e.g., administrator security login, statistics about the present state of lending, printing management, and convenient GUI(Graphic User Interface) environment.

배드민턴 선수의 경쟁상태불안이 경기력에 미치는 영향

두만균,김연수,이호성 圓光大學校 附設 體力科學硏究所 2002 體力科學硏究 Vol.25 No.1

The purpose of this study was to determine the relationship of competition anxiety of badminton players, including physical competition anxiety, cognitive competition anxiety, and competition confidence, to their athletic capabilities to help them get better record. The subjects in this study were 100 selected male and female badminton players. The statistical techniques employed in this study were t-test, one-way ANOVA, correlation analysis and stepwise multiple regression procedures. After the collected data were analyzed, the following findings were given; First, the physical and cognitive competition anxieties of the badminton players investigated didn't significantly vary with their gender. But their competition confidence was different according to gender. Second, the player career made a significant difference to their physical and cognitive competition anxieties The physical and cognitive competition anxieties of the players were on the decrease with age. Their competition confidence didn't differ with player career. Third, the athletic capability of the players was affected by their own competition anxiety. Specifically, the physical competition anxiety, one of the competition anxiety subfactors, and competition confidence had more effect on improving their athletic capabilities.

흰쥐 입천장발생중 laminin의 발현에 관한 연구

김원규,황우열,윤지희,백두진,정호삼 대한췌담도연구회 2000 대한췌담도연구회지 Vol.5 No.3

우라늄 分離定量에 있어서 Amberlite LA-2의 利用

尹鉉勝,鄭昌雄,金演斗 충남대학교 자연과학연구소 1980 學術硏究誌 Vol.7 No.2

The liquid anion exchanger, Amberite LA-2, has been used to separate the trace amount of uranium from synthetic graphite in sulfuric acid solution As reducing the impurity metals with NaHSO_(3) the complete extraction of uranium has been made successfully in organic phase. The mixed solution, NaOH-HClO_(4)-H_(2)O_(2), was found to be good solution for stripping and developing of the uranium complex.

키레이트 滴定法에 의한 물중 칼슘, 마그네슘 定量에 있어서 Amberlite LA-2의 利用

김연두,배준현,김학수 충남대학교 1985 忠南科學硏究誌 Vol.12 No.2

This study is on the determination of calcium and magnesium in water at very low concentration. Iron(Ⅲ) was added to the sample, and calcium and magnesium were precipitated with iron by adding sodium carbonate and ammonia water. The precipitates were dissolved in conc-HCI and then Fe(Ⅲ) was removed by extraction with Amberlite LA-2. The residual aqueous solution containing calcium and magnesium were determined. Calcium and magnesium are determined by EDTA method respectively after separating them with sodium oxalate. This method, showing the small average relativity of error (less than 3.0%), is very useful to determine low concentration of calcium and magnesium in the water.