정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

태권도 품새 수련이 아동의 심박수, 심근산소소비량, 에너지 대사에 미치는 영향

정성태,전태원,박익렬,정덕조,우재홍,이광희,이동기,강현주 서울대학교 체육연구소 2000 서울大學校 體育硏究所論集 Vol.21 No.1

The Taegeuk Poomse 1 through 8 of Taekwondo are based upon eight major branches of philosophical theories. The propose of this study was to investigate the nfluence of Taekwondo poomse trainning on heart rate, MVO2, energy metabolism in primary school students. Subjects for this study were eight male the fifth∼sixth grades students who participated in exercise program consist of Taekwondo poomse trainning in dojang which is located in Shinlim-2dong, Kwanak-Gu, Seoul(12.7± 0.5years, 150.8 ±4.6cm, 45.1 ± 9.4kg, 24.9 ± 9trainning length). The results of thet this study are as follows: 1) The average of heart rate was Taegeuk Poomse 1 through 8 of Taekwondo 90.57± 4.gbeats/min in rest and 139.7 ± 17.5beats/min in exercise. The minimum heart rate was 89.0±2.8, peak heart rate was 167.1 ±6.4 in exercise. It was ranged from 42% to 80% 2) of the max heart rate and ranged 42 to 65%HRmax. Taegeuk 1 Jang was differenced with others Jangs significantly(p<0.05), 2) The time of the Taegeuk 1 through 8 Jang of Taekwondo was 5minutes 12seconds. Heart rate was ranged from 90.6 ± 7.85beats/min to 171.8 ±8.Ibeats/min and increased linearly. 3) The average of the MVO2 was 11.1 ±0.78mmHg · bpm-3 in rest and 19.1 ± 1.2mmHg ㆍbpm-3 in exercise. MVO2 was ranged from 10.5mmHg · bpm-3 to 20.3mmHg · bpm-3. There were not difference between Taegeuk Poomses(p<0.05). 4) The energy metabolism was as follows: Mean VO2 Respiratory exchange ratio, energy consumption were 0.51(V02L/min),0.71(RQ),2.32Ckca1/min) in rest respectively. but In exercise Mean VO2 Respiratory exchange ratio, energy consumption were 0.89 ± 0.18( V 02L/min), 0.79±0.08(RQ), 4.26±0.51(kcal/min) respectively . The difference was only between Taegeuk 1 Jang and Taegeuk 3 Jang(p<0.05). This study showed that the Taekwondo Poomse trainning was proper exercise for fitness, body composition and weight control in normal, abnormal(obese) children because the Taekwondo trainning are dynamic and exciting sport.

농촌인의 건강실태에 관한 연구

정동춘,정성태,장창현,전태원 師範大學 體育硏究所 1993 서울大學校 體育硏究所論集 Vol.14 No.2

The purpose of this study was to investigate the health condition of rural area adults. To accomplish this purpose 98 adults were drawn from 2 different rural areas such as Chungnam and Junbook, and their health condition were examined. The data from these people were compared with those of 108 Seoul residents. The main findings of this study were as followings; 1. Neuralgia was the commonest disease in rural area adults, followed by Rheumatism, waist pain, and heart problem. 2. About 62% of rural area adults indicated that their average sleeping time was less than 7 hours per day. 3. About 48% of rural area male adults indicated that their daily labor was generally “severe,”while 61.3% of female adults said in the same way. 4. The blood pressure value of rural area males was 124/73 ㎜Hg, while that of urban area males was 114/77 ㎜Hg. 5. The values of GOT and GPT were higher in rural area males than in rural area females. 6. the value of cholestrol was lower in rural area adults than in urban area adults.

木花의 二面交雜에 의한 遺傳力 및 雜種强勢의 程度

鄭元福,金京泰 東亞大學校生命資源科學大學附設 農業資源硏究所 1992 農業生命資援硏究 Vol.1 No.1

육지면 7개 품종을 이면교배하여 얻은 F₁42 개 조합을 재료로 각 형질에 대한 유전력 및 교배집단에 따른 잡종강세의 정도를 산출한 결과는 다음과 같다. 유전력은 개화일수, 개서일수, 초장, 경직경, 절간장, 주당삭수, 삭중, 삭당 종자수, 삭당 실면중, 삭당 조면비율, 삭당 조면중, 종자 100립중, 섬유장, 종자장, 실면중에 대한 조면비율이 72.71%이상으로 높았다. 잡종강세는 주당삭수, 삭중, 삭당 실면중, 삭당 조면중이 정·역 교배 I·II집단에서 각각 正으로 유의하였고, 개화 일수, 개서일수, 초장이 각각 負 로 유의하였다. 형질에 따른 각 교배조합을 보면 삭당 실면중, 삭당 조면중, 주당삭수는 4×5(목포 7호×Stoneville 2-B)조합이 heterosis 나 heterobeltiosis에서 비교적 높았다. A seven parent diallel study was conducted to determine the inheritance of the heritability and heterosis in cotton(Gossypium hirsutum L.). Broad-sense heritability estimates were from 40.41 to 95.89%. In F₁ generation, days to flowering, days to maturity, plant height, stem diameter, length of stem internode, number of bolls per plant, boll weight, number of seeds per boll, seeds and lint weight per boll, lint percentage per boll, lint weight per boll, 100-seed weight, staple length, length of seed and lint percentage vs. seed and lint were over 72.71%. The degrees of positive heterosis of number of bolls per plant, boll weight, seeds and lint weight per boll, and lint weight per boll were higher, while days to flowering, days to maturity and plant height showed negative heterosis in the F₁ generation. Based on the degrees of heterosis and heterobeltiosis the crossed of Morpo #7×Stoneville 2-B showed high potential for yield.

醱酵食品添加物의 能力 및 安全性確認 硏究 : -第二報 乳酸菌製劑食品의 活性能力試驗- -PartⅡ Activity Test of Lactic Acid Bacterial Food and Drugs-

鄭鎬權,姜孝源,權泰鍾 건국대학교 1978 學術誌 Vol.22 No.1

This work was carried out to investigate the acid producing activity, tolerance and other important characteristics of the strains isolated from the market yogurt drinks (fermented milk or fomented milk drinks) and lactic bacterial drugs (control agent of entero-bacteria). And obtained results were as in the followings. 1. Almost of the strains isolated from market yogurt drinks were identified as Lactobacillus bulgaricus and two of them were Lactobacillus acidophillus. The specially aerobic strains isolated from lactic acid bacterial drugs were identified as Bacillus subtilis and anaerobics were Clostridium butylicum, Sporolactobacillus inulinus, Streptococcus faecalis and Bifidobacterium bifidum. 2. Concentration of active lactic acid bacteria of the market yogurt drinks was found almost as same level, and decreasing tendency of the concentration was commonly seen in every samples during hot summer (high temperature over 35℃). Acid producing activity of some stronger strains continued for 10 days and weak strains for 6 days in summer. 3. During 6 months of the test period, not any contamination case of pathogenic enter-obacteria was found in market yogurt drink samples. 4. But yeast contamination was so aboundantly seen that the ratio of contaminated case was attained to about 20% in fermented milk and to 80% in fermented drink samples. 5. Maximum acid production of the strains isolated from market yogurt drinks was attained to almost 2.0%, but that of the strains from tactic acid bacterial drugs was less than 0.7% except the Str. faecalis strain. 6. Curd forming and acid producing activities of both L. bulgaricus strains and L. acidophillus strains were almost as same level. And the activities continued for 15 days at temperature of 5℃ and pH of 4.0, but for 7 days at high temperature of 35℃. 7. In high temperature (over 35℃) and loll pH condition (less than 3.6), the old culture of homo fermentative lactic acid bacterial strains isolated from market yogurt drinks were more easily changed to hetero fermentative strains than the young culture of the strains.

농촌인의 체격 및 체력 실태에 관한 연구

정성태,장창현,전태원 師範大學 體育硏究所 1993 서울大學校 體育硏究所論集 Vol.14 No.2

The purpose of this study was to investigate the physique and physical fitness of the rural area adults. To accomplish this purpose 202 adults were drawn from 4 different rural areas such as Chungnam, Junbook, Kyoungbook, and Chungbook, and their physique and physical fitness were measured. The data from these people were compared with those of 114 Seoul residents. The findings of this study were as followings; physique 1. The heights of rural area adults were shorter than those of urban area adults by about 4cm, and their heights tended to reduce by 2cm every 10 year as they got older. 2. The weights of rural area male adults were lighter that those of their urban counterparts by about 6kg ; rural area female adults were also lighter than their urban counterparts by 10kg. 3. The sizes of waist girths of both the rural area adults and urban area adults tended to increase after their 40s. physical fitness 1. There was no significant difference of grip strengh between rural and urban area male adults; rural area female adults exhibited stronger grip strengh than their urban area counterparts by about 4kg. 2. There was no significant difference of sit-up performance between rural and urban area male adults; rural area female adults showed weaker sit-up performance than their urban counterparts. 3. There was no significant difference of trunk bending performance between rural and urban area male adults; rural area female adults showed more flexible trunk bending performance than their urban counterparts.

인천경제자유구역 물류용지 규모산정 및 역할에 관한 연구 : 영종지구 공항물류단지를 중심으로 Incheon Free Economic Zone

정태원,박영태 한국물류학회 2006 물류학회지 Vol.16 No.1

전류 제어형 PWM 인버어터에 의해 구동되는 유도전동기 서어보 운전시스템의 고성능 제어에 관한 연구

元忠淵,金泰勳 成均館大學校 科學技術硏究所 1989 論文集 Vol.40 No.1

In this paper, the vector control or the field oriented control system of current controlled PWM inverter fed induction motor servo drive system is proposed to obtain good dynamic response. The good dynamic response, however, depends on the controllability of the stator current. In this paper, an optimum current control strategy is proposed, which provides better dynamic response for current control. In order to realize this aim, the authors are adopted the current controlled PWM inverter with hysteresis controller. The controller produces a PWM Voltage waveform based on a comparison of the actual phase currents with a reference current. The time optimal controller is used as a outer loop of the vector control loop to regulate position and/or speed of induction motor. A simple set of switching trajectory is easily obtained by solving a second order state equation. The validity of the optimal control strategy is verified by digital simulation.

氣象環境이 잎담배 生産에 미치는 影響에 關한 硏究

鄭元采,鄭泰益,申周植 충북대학교 엽연초연구소 1980 煙草硏究 Vol.7 No.-

This study was conducted to study the effects of meteorological elements on the yield and quality of flue-cured tobacco. Data for this study was collected in Cheongju, Chungju and Taejeon districts during the period from 1967 to 1979. 1.There was positive correlation between yield and air temperature from maximum growth stage to harvesting time. And there was positive correlation also between quality and air temperature at maximum growth stage, but not significant relationship at the other growing stage. 2.The re were negative correlation between yield and precipitation at harvesting time and between quality and topping time, respectively. 3.There were positive correlations between yield and quality and percentage of possible sunshine at and after topping time. 4.Early and long range weather forecast will be efficiently employed for tobacco cultivation. It is considered that the study on the early and long range weather forecast and on the hastening and/or delaying the planting and maturing of tobacco plants ought to be studied together.

은행의 부실채권 처리 방안에 관한 연구

정수원,박태진 東西大學校 1998 동서논문집 Vol.4 No.-

The purpose of this paper is to examinate of the Financial Structure Reform in Korea and Japan. Through examination of the Financial Structure Reform in Japan, the suggestions to Korea is as follows. 1. To securitization of insolvency assets is better than injection of government fiscal funds. 2. We have to establish rule of the Financial Structure Reform. 3. We have to stop "too big to fail" and have to readjust insolvency big banks. 4. We have to strengthen of supervisory function on an enterprise by banks.