정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

Sezary증후군과 병발된 용혈성 빈혈 1예

유광하,진춘조,김홍승,이종인,심영학,정순희,이창훈 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.- No.7

기업의 시장가치비율 측정에 관한 연구

이광조 건국대학교 사회정책연구소 1999 사회과학연구 Vol.12 No.-

활주형선의 고속어선 적용에 관한 연구

이귀주,이광일,이조원 朝鮮大學校 機械技術硏究所 1999 機械技術硏究 Vol.2 No.2

본 연구는 25노트급 활주형 어선의 기본선형을 도출하기 위해 수행되었다. 대상선형은 총톤수 10톤급으로 자료조사 결과로부터 길이 15m, 폭 3.5m, 깊이 1.32m로 정하였다. 총 5척의 선형에 대하여 저항 및 트림, 침하량 계측시험을 수행하였다. 15노트까지와 저속역에 대한 모형시험은 조선대학교 회류수조에서 수행되었고, 이로부터 3척의 선형에 대하여 서일본유체기술연구소 고속회류수조에서 고속역에 대한 모형시험을 수행하였다. 연구결과 볼록-오목 단면형 선형의 선수를 DeeP V 형으로 개선한 P-4선형이 저항 및 기타 성능 면에서 가장 우수한 결과가 나왔다. This study was carried out to get a basic hull form planning fishing boat. Some principal characteristics of the object hull form of G/T 10ton class are selected as length 15m, breadth 3.5m, depth 1.32m from a result of data research. For 5 models, resistance, trim and sinkage were tested. The model tests at low speed zone were performed in Chosun University, and at high speed zone were performed in CWC at WJFEL. From test results, P-4 which inverted-bell type modified to deep V type was the most excellent with respect to resistance and the other performance

실크의 방염약제 (DPBAP) 처리에 관한 연구

이광우,이기조 한국의류산업학회 2001 한국의류산업학회지 Vol.3 No.1

The study was conducted to find out suitable flame proofing on silk fabrics and to examine closely the flame retardancy effect and the physical properties changes of the silk, which was dyed by natural dyes and synthetic dyes, treated with agent (Diphenylbutylamidophasphte (DPBAP)). The results of the study were as followes: 1) Silk could be treated with DPBAP easily soluble in water by means of simple Pad-Dry-Cure. 2) The add-on of silk fabrics dyed by natural dyes was more than that of silk fabrics dyed by synthetic dyes. 3) The silk fabrics dyed by India ink among natural dyes has more flame retardancy effect in before treating with flame proofing agent than in after treating with it. 4) The physical properties (stiffness and tensile strength) of the silk fabrics treated with flame retardancy agent were little changed.

마이크로 엔드밀링 공정의 절삭계수 모델링 및 최적 공정 설계

이광조,정성종 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

Micro end-milling process is applied to fabricate precision mechanical parts cost-effectively. It is a complex and time-consuming job to select optimal cutting conditions with high productivity and quality. To consider the productivity and quality of precision mechanical parts, micro end-mill wear and cutting force characteristics should be studied exactly. In this paper, high speed machining experiments are studied for optimum process design and modeling of cutting parameters in micro ball end-milling processes. Cutting force and wear characteristics under various cutting conditions are investigated through the condition monitoring system and Taguchi method. Mathematical models for the cutting forces are derived from the response surface method. Optimal milling database has been constructed through experimental models.

MoSi_2기 복합재료의 소결온도에 따른 미끄럼마모 특성

이광영,박원조,허선철,김형진,박성호 경상대학교 해양산업연구소 2002 해양산업연구소보 Vol.15 No.-

Molybdenum disilicide(MoSi_2) is considered to be a promising high temperature material for turbojet anhypersonic engines in aerospace and various industrial applications, because of a high melting point(2030℃),adequate density(6.3g/cm^3) and an excellent oxidation resistance. Mosi2 powder was evaluated from the variation of fabricating such as preparation temperature 1250℃, 1350℃ and 1500℃ respectively. Abrasion tester used a pin-on-disk type and a Si3N4 ceramic ball which used as machine structural materials. The test condition apply to load of 8kgf at 7.5rpm for 6 hours and the effect of hardness is also discussed. As a result of the tests, the friction coefficient was decreased with sintered MoSi_2 of increasing temperature but the function coefficient did not vary much for all specimens at all temperatures.

스테레오 비젼과 레이저포인터를 이용한 거리 측정 시스템

조현,진광식,윤태성,이용중 國立 昌原大學校 産業技術硏究所 1999 産技硏論文集 Vol.13 No.-

In this paper, we studied on the environment map building for the autonomous mobile robot navigation using the vergence controllable stereo camera system. First of all, distance measurements are necessary to build the environment map. So, we present the distance measurement method using the stereo camera system and a laser pointer. To measure the distance using the stereo camera system, finding the common points in the left and the right images are needed. In this study, we use a laser pointer to solve this problem. Secondly, we present the method how to obtain the 3-dimension position information using 3-D geometric schematic of the stereo camera and the measured distance information. This information is essential to the mobile robot navigation. Finally, we prove the presented method experimentally. An image of a corridor is taken by the stereo camera. The door and pillar in this image are landmarks. Therefore, we find such landmarks in the image and measure the 3-D position information for those landmarks. And the, we construct the environment map for the navigation of the mobile robot.

불소가 함유된 세마제가 법랑질의 내산성에 끼치는 영향에 관한 생체외 연구

조중한,김대업,이광희 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

The purpose of study was to know the effect of addition of fluoride to prophylaxis paste on caries prevention. 2% sodium fluoride solution and 8% stannous fluoride solution were applied topically to enamel blocks made from human teeth. Also, 2% sodium fluoride-containing pumice and 8% stannous fluoride-containing pumice was applied to enamel blocks using rubber cup for ten seconds. Enamel surface hardness was measured before and after demineralization by 0.01 N lactic acid. The results were as follows ; 1. Enamel solubility was increased in NaF group and nearly unchanged in SnF₂group by prophyaxis with plain pumice after fluoride application. 2. Enamel solubility was increased in NaF group and decreased in SnF₂group by prophylaxis with fluoride-containing pumice after fluoride application. 3. Enamel solubility was lower in case of prophylaxis with fluoride-containing pumice after fluofied application and after no fluoride application than in case of prophyalxis with plain pumice after fluoride application. 4. Enamel solubility was lower incase of no prophylaxis after fluoride application than in case of prophylaxis with fluoride-containing pumice in NaF group, and vice versa in SnF₂group.