근린공원 환경의 만족도가 신체활동과 건강에 미치는 영향 - 창원시 성산구와 의창구를 대상으로 -

박경훈,이우성,김태환,김은정,Park, Kyung-Hun,Lee, Woo-Sung,Kim, Tae-Hwan,Kim, Eun-Jung 한국조경학회 2014 韓國造景學會誌 Vol.42 No.3

본 연구의 목적은 경상남도 창원시를 대상으로 근린공원 환경에 대한 만족도가 신체활동과 건강증진 목적의 공원이용횟수와 체질량지수(BMI)에 의한 건강수준에 미치는 영향을 분석하는 것이다. 설문조사는 창원시 성산구와 의창구 도심지역에 분포하는 8개 근린공원의 이용자와 그 주변에 거주하는 429명의 주민들을 대상으로 실시하였고, 설문분석은 근린공원 환경에 대한 만족도가 신체활동과 건강에 미치는 영향을 분석하기 위해 일대일대응 선형회귀분석을 활용하였다. 연구결과를 요약하면, 공원을 이용하지 않는 주된 이유는 시간적 여유의 부족, 공원까지의 이동거리와 소요시간, 공원 내 이용시설의 부족 등이고, 공원을 이용하는 주된 이유는 공원까지의 접근성, 걷기 또는 산책, 휴식시설, 수목이나 그늘, 운동공간의 다양성 등으로 나타났다. 공원 이용자의 경우, 공원에서 걷기나 산책을 가장 많이 하고, 주 2회 이상 평균 10분 정도 걸어가서 1시간 정도 운동을 하는 것으로 나타났다. 공원과 그 주변의 물리적 환경 중에서 집에서 공원까지의 거리와 이동하는 가로 환경에 대한 만족도가 높았고, 공원 내 수공간이나 볼거리 등에 대한 만족도가 낮게 나타났다. 다음으로, 운동목적의 공원이용 여부, 공원이용시간, 공원이용의 만족도와 건강증진 효과, 공원까지의 거리, 따른 건강증진 효과만이 유의수준 10% 이내에서 상호관련성이 있는 것으로 나타났다. 향후에도 공원의 신체활동과 건강 증진 효과에 대한 실증적 사례노약자들의 공원이용 편이성 등이 유의수준 5% 이내에서 신체활동과 건강증진 목적의 공원이용횟수에 긍정적인 영향을 보였고, 체질량지수와는 공원이용에 를 지속적으로 축적해 나갈 필요가 있으며, 이를 통해서 각종 개발용도로 전환되거나 그 면적이 축소되고 있는 도시지역의 공원 및 녹지공간을 보전 확대시켜 나가고, 신체활동 및 건강증진 장소로서의 기능을 제고하기 위한 공원계획 설계 요소를 도출하는데 근거 자료를 제공하는 것이 가능할 것으로 판단된다. The purpose of this study is to analyze the effects of satisfaction in neighborhood park environments located in the Changwon-si of Gyeongsangnam-do, South Korea, on physical activity, the number of parks used for health improvement, and health levels based on Body Mass Index(BMI). Accordingly, a survey was conducted of 429 nearby residents and users of eight neighborhood parks located in urban areas of Seongsan-gu and Uichang-gu in the Changwon-si. The correlation between the environmental perception of neighborhood parks and physical activity and health, which was observed in the survey results, was analyzed using one-by-one linear regression analysis. By summarizing the study results, it was found that the primary reasons for avoiding park use were lack of time, time and effort required to reach the park(i.e., distance from the park), and lack of facilities within the park. Conversely, the primary reasons for using the park included accessibility, walking or strolling, leisure facilities, trees or shade, and diversity in exercise areas. In the case of park users, walking or strolling was the most common activity in the park. On average, park users walked to the parks for 10 minutes and exercised for an hour at least twice per week. With respect to the physical environment of the parks and surrounding areas, park users showed a high level of satisfaction with the distance between their houses and parks and the street environment. On the contrary, they exhibited low levels of satisfaction with water spaces and sightseeing within the parks. Subsequently, it was shown that the number of people using the parks for physical activities and health improvement was positively influenced(within a 5% significance level) by the intent to use the park for exercise, time spent in the park, satisfaction with park use and health improvement, distance to the park, and the convenience of using the park for the elderly. However, only the health improvement gained from park use was found to exhibit a correlation with BMI at the 10% significance level. Continuous accumulation of practical case studies on physical activities in parks and their health improvement effects is required. Through this, park spaces that are under the threat of reduction or elimination owing to various development plans can be conserved and expanded. Furthermore, such case studies can be used to provide data as the basis for deriving park plans and designs that improve parks' functions as sites of physical activity and health improvement.

근린공원에 대한 환경지각이 이용자의 건강증진인식에 미치는 영향 - 창원시의 8개 근린공원을 대상으로 -

박영은,이우성,정성관,박경훈,Park, Young-Eun,Lee, Woo-Sung,Jung, Sung-Gwan,Park, Kyung-Hun 한국조경학회 2015 韓國造景學會誌 Vol.43 No.1

본 연구는 근린공원에 대한 이용자의 공원지각환경이 건강증진인식에 미치는 영향을 분석하기 위해 경상남도 창원시의 8개 근린공원을 대상으로 공원별 현장조사 및 설문조사를 실시하였다. 연구결과에 따르면, 먼저 공원별 공원지각환경에서는 대부분의 공원이 집에서 공원까지의 거리와 집에서 공원까지의 길 환경이 높게 평가된 반면, 수공간과 공원 내 다양한 볼거리는 충분하지 못한 것으로 분석되었다. 다음으로 23개의 지각환경 변수들을 요인분석한 결과, 경관성, 안락성, 접근성, 활동성, 편의성, 쾌적성의 6개 요인으로 분류되었다. 이를 토대로 건강증진인식과 지각환경요인과의 관련성을 분석한 결과, 8개 공원 중 4개 공원에서 지각환경요인이 신체적 건강증진인식에 유의한 영향을 주는 것으로 나타났다. 특히, 접근성과 활동성이 3개의 공원에서 영향력이 있는 변수로 분석되었다. 또한, 심리적 건강증진인식의 경우, 8개 공원 중 5개 공원에서 유의한 영향을 주는 것으로 나타났으며, 접근성이 4개의 공원에서 영향력이 있는 변수로 평가되었다. 이상과 같은 결과들은 기존의 공원 환경을 개선하고, 새로운 공원을 조성하고자 할 때 효율적인 기초자료로 활용될 수 있을 것으로 판단된다. The purpose of this study was to analyze the effect of environmental perception in neighborhood parks on user's recognition of health improvement. This study used objective field survey data and subjective user survey data at 8 neighborhood parks in Changwon City. According to the results, the perceptions of distance and street environment from home to park were evaluated highly but the perception of water spaces and various attractions within the parks were rated lowly in most of parks. As a result of factor analysis, 23 environmental perception variables were classified into 6 factors such as scenery, comfort, accessibility, activity, convenience and amenity. For the result of regression analysis between environmental perceptions and user's recognition of health improvement based on 6 factors, the recognition of physical health improvement was significantly influenced from environmental perception factors in 4 parks among 8 parks. 'Accessibility' and 'activity' were analyzed as the meaningful factors in 3 parks. Also, recognition of mental health improvement was significantly influenced from environmental perception factors in 5 parks among 8 parks and especially 'accessibility' was showed as the significant factor in 4 parks. The findings from this study can contribute to improve the physical environments of the present parks and can be a basic data for new park development.

DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals

Kyung, Jae Won,Kim, Jin-Mo,Lee, Wongyoung,Ha, Tae-Young,Cha, Seon-Heui,Chung, Kyung-Hwun,Choi, Dong-Joo,Jou, Ilo,Song, Woo Keun,Joe, Eun-Hye,Kim, Sung Hyun,Park, Sang Myun National Academy of Sciences 2018 Proceedings of the National Academy of Sciences Vol.115 No.7

<P>Mutations in DJ-1 (PARK7) are a known cause of early-onset autosomal recessive Parkinson's disease (PD). Accumulating evidence indicates that abnormalities of synaptic vesicle trafficking underlie the pathophysiological mechanism of PD. In the present study, we explored whether DJ-1 is involved in CNS synaptic function. DJ-1 deficiency impaired synaptic vesicle endocytosis and reavailability without inducing structural alterations in synapses. Familial mutants of DJ-1 (M26I, E64D, and L166P) were unable to rescue defective endocytosis of synaptic vesicles, whereas WT DJ-1 expression completely restored endocytic function in DJ-1 KO neurons. The defective synaptic endocytosis shown in DJ-1 KO neurons may be attributable to alterations in membrane cholesterol level. Thus, DJ-1 appears essential for synaptic vesicle endocytosis and reavailability, and impairment of this function by familial mutants of DJ-1 may be related to the pathogenesis of PD.</P>

의약품의 효능별 안전성·유효성 평가에 관한 조사연구(Ⅰ) : 항균제 Antiboiotics

박윤주,최기환,김동섭,박인숙,정면우,임화경,오우용,강주희,박찬웅,김주일 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

새로운 물질이 개발되어 신약으로 탄생하기까지 많은 시간과 노력, 예산이 필요하다. 최근, 우리 나라에서도, 신약캐발이 어릴고 힘든 분야이지만 새로운 신약개발을 총해 얻어지는 분가가치가 막대함을 인식, 연구에 박차를 가하 있는 실정이다. 본 연구는, 의약품 개발 선진국인 미국 FDA에서 발행하는 참고자료 중 항균제 임상편가에 대한 가이드라인 및 주요 임상적응증별 항균제 기발(지역사획회득성 폐렴, 원내감염성 계렴, 급성기관지염의 2차세균감염, 만성기지염의 급성세균성 악화, 연쇄구균에 의한 인두영 및 편도염 , 단순성 요로감염증, 복합성 요로감염증 및 신우신영, 급성 세균성 부비동옆, 항 바이러스제 개발시 전임상단계에서 고려사항, 항 바이러스제 허가와 된련 잉상적 고려사항, 카레타 괸련 혈류감염)에 있어서의 파이드라인 등의 자료를 소개함으로져, 향후 제약사의 항균제 신약개발 및 허가 신청된 의악품의 전임상차료 및 잉상시험자료의 검토 평가업무에 참고자료로 활용될 수 있을 것이다. Changing or unclear interpretations of clinical trial data needed to demonstrate the effectiveness and safety of antimicrobial drug products have a times led to confusion and frustration on the part of both applicants and division of these drug products reviewers. The FDA published guidance on desing clinical protocols, implementing, and analyzing data from clinical trials for antimicrobial drug products has been presented and additional companion guidances introduced specific issues to individual infections. This document provides applicants and reviewers with minimal information appropriate for the clinical development of routine antimicrobial drug products and identifies issues common to many antimicrobial drug applications. The agency can use the kind of information to determine whether the antimicrobial drug product under study is safe and effective in the treatment of the specific infection studied.

슬관절 골관절염 증상이 환자에게 미치는 우울 효과

박영규,이윤영,이계우,김정아,윤도경,박승회,조경환,홍명호,박용규 대한노인병학회 2001 대한노인병학회지 Vol.5 No.4

사망진단서(사체검안서) 상의 선행사인으로부터 사망통계의 원사인이 선정되는 비율 : 3개 대학병원에서 교부된 사망진단서를 중심으로

박우성,박석건,정철원,김우철,탁우택,김부연,서순원,김광환,서진숙,부유경 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Background : To exatnine the problems intolved in writing practice of death certificates, we cotnpated the determination of underlying cause of death for wital statistics using recorded underlying cause of death in issued death statistics. Methods : We collected 688 rnortality certificates issue in year of 2,000 from 3 university hospitals. And we also collected vital statistics from ministry of statistics. The causes of death were coded by experienced medical record wpecialists. And causes of death determined at ministry of statistics for national vita statistics were mapped to causes of death recorded at each death certificates. The rate that underlying causes of death for vital statistics were derived from underlying causes of death recorded at issued death certificaties sere analysed. Results : 64.5% of underlying cause of death for could be derived from underlying cause of death recorded at issued death certificates, 8.6% derived from intermediate cause of death, and 3.9% derived from direct cause of death. In 23% of cases, underlying cause of death could not be derived using issued death certificates. The rate that underlying cause of death for vital statistics could be derived from underlying cause of death recorded at death certificates was different between 3 university hospitals. Ane the rate was also different between death certificates and postmortem certificates. We classified the causes of death using 21 major categories. The rate was different between diseases or conditions tha caused death too. Conclusion : When we examined the correctness of death certificate writing practice using abpve methods, cortectness of writing could not be told as satisfactory. There was difference in correctness of writing between hospotals, between death certificates and postmortem certificates, and between diseases and conditions that caused death. With this results, we suggested some strategy to improve the correctness of death certificate writing practice.

각종 소화성질환에서의 Campylobacter Pylori의 검출에 관하여

허정욱,강영우,박준호,박승국,하경임,김재룡,안성훈,박선우 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

Peptic disorders are among the most common maladies in korea as the world. In most cases their etiologies not be established and their pathophysioolgy remain obscure. Although the persence of fastric bacteria has been logn established, recently campylobacter pylori seems to be etiologic agent of peptic disorders. Campylobacter pylori is visualized in most cases of peptic disorders and not visualized after treatment of bctericidal agents, bismuth compound or metronidazole. We had a following results for identification of campylocacter pylori in stomach and duodenal mcuosa via endoscipc biopsy. 1. We studied 54 patients who had dyspeptic symptoms, 29 males. 2. Most patients are in 5th decades, next in 3rd and 6th in order. 3. Ptients were composed of 27 peptic ulcer, 22 gastitis and 5 gastric carcinoma. 4. Campylobacter pylori was identified in 69% of total patients, peptic ulcer 63%, gastritis 77%, stomach carcinoma leastly.

내사시에서 양안 내직근후전술 시 기능적적도부 및 팍스의 수술양을 고려한 군 간 수술성적비교

강병완,박상우,윤경철,허환,Byung Wan Kang,MD,Sang Woo Park,MD,PhD,Kyung Chul Yoon,MD,PhD,Hwan Heo,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.1

Purpose: To compare the surgical outcomes of functional equator-considering and Parks’ methods in infantile esotropia and partially accommodative esotropia. Methods: The medical records of 96 patients with infantile esotropia and partially accommodative esotropia who underwent bilateral medial rectus muscle recession by functional equator-considering and Parks’ methods were reviewed retrospectively. The surgery success rate at 1 month, 3 months, 6 months and 12 months was compared by the deviation angle measurement. Results: Overall success rates were not statistically different between the 2 groups. Additionally, there were no differences in surgical success rate of functional equator-considering and Parks’ methods in infantile esotropia and partially accommodative esotropia. When the patients were divided into 2 groups based on 40 PD, no significant difference in success rate between the 2 groups was observed. When patients were divided into 2 groups based on 22 mm of axial length, there was no statistical difference observed. Postoperative overcorrection was 2 (4%) in the functional equator group and 3 (6.5%) in Parks’ method group and postoperative undercorrection was 9 (18%, 19.6%) in each group. The incidence of undercorrection in the Parks’ method group was significantly higher in the greater than 22 mm axial length group (7, 35.0%) than in the less than 22 mm group (2, 7.7%) (p = 0.029). Conclusions: There was no statistically significant difference in surgical success rate between the functional equator and Parks’ methods in infantile esotropia and partially accommodative esotropia. J Korean Ophthalmol Soc 2012;53(1):138-144

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.