http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오우용(Woo Yong Oh),주상섭(Sang Sup Jew),박형근(Hyeung Geun Park),함광수(Kwang Su Ham),조장섭(Jang Sup Cho),이선미(Sun Mee Lee) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.3
(R)-JG-381, a R form of alkylglycidic acid derivative, was examined for mutagenicity in the reverse mutation test on bacteria, chromosomal aberration test on cultured mammalian cells and micronucleus test in mice. In the reverse mutation test on bacteria using Salmonella typhimurium strain TA98, TA100, TA102, TA1535, TA1537 with or without a metabolic activation system (S9 mix), (R)-JG-381 did not affect the revertant colonies but significantly increased revertant colonies in one test strain, TA98, compared with the vehicle control. In the chromosomal aberration (CA) test using cultured Chinese Hamster Lung fibroblast(CHL) cells, the number of aberrant cells was not increased in the presence or absence of S9 mix at concentration of the (R)-JG-381 0.025㎕/㎖ to 0.1 ㎕/㎖, compared with vehicle control. In the micronucleus (MN) test, micronucleated polychromatic erythrocytes in the (R)-JG-381-treated mice were not different from those of the vehicle-treated mice.
오우용(Woo Young Oh),이상호(Sang Ho Lee),김형진(Hyung Jin Kim),주상섭(Sang Sup Jew),박형근(Hyeung Geun Park),함광수(Kwang Su Ham),조장섭(Jang Sup Cho),이선미(Sun Mee Lee) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.3
N/A The single oral toxicity of JG-381 was studied in Sprague-Dawley rats of both sexes. In this study, rats were administrated orally with dosages of 267, 400, 600, 900 and 1350 ㎎/㎏ of JG-381. We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days after JG-381 administration. When we administered different doses of 267, 400, 600, 900 and 1350 ㎎/㎏, we found 1, 4, 4, 5 and 5 male rats died and 3, 5, 4, 5 and 5 female rats died within 1 day after administration, respectively. Some clinical signs (decrease locomotor activity, salivation, soft stool, prone position, lacrimation, crouching position, convulsion, ataxic gait, incontinence of urine) were also observed during the experimental period. Our findings suggest that oral LD_(50s) (95% confidence limit) for male and female rats are 327 ㎎/㎏ (270∼396 ㎎/㎏) and 250 ㎎/㎏ (236∼264 ㎎/㎏), respectively.
오우용(Woo Yong Oh),이상호(Sang Ho Lee),주상섭(Sang Sup Jew),박형근(Hyeung Geun Park),함광수(Kwang Su Ham),조장섭(Jang Sup Cho),이선미(Sun Mee Lee) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.1
N/A General pharmacological properties of (R)-JG-381 were examined in laboratory animals to investigate its safety profile. Administration of (R)-JG-381 (50 and 100 mg/kg) in mice and rats had no effects of general behaviors, central nervous system of the animals in test systems of pentobarbital-induced sleeping time, writhing syndromes induced by 0.7% acetic acid, chemo-shock produced by pentylenetetrazole, and, however, had mild effects on motor coordination. Heart rate and blood pressure were not changed by (R)-JG381 treatment. (R)-JG-381 also showed mild effects on intestinal propulsion and gastric secretion. These results suggest that (R)-JG-381 dose not exert serious pharmacological effects.
SD 랫드에서 ( R ) - JG - 381 의 단회경구독성시험
오우용(Woo Young Oh),주상섭(Sang Sup Jew),함광수(Kwang Su Ham),이상호(Sang Ho Lee),김종춘(Jong Chun Kim),박형근(Hyeung Geun Park),조장섭(Jang Sup Cho),이선미(Sun Mee Lee) 한국응용약물학회 2002 Biomolecules & Therapeutics(구 응용약물학회지) Vol.10 No.1
N/A A single administration toxicity of (R)-JG-381 was studied in Sprague-Dawley rats of both sexes. In this study, rats were administered orally with dose of 50, 100, 200, 400 and 800 ㎎/㎏ of (R)-JG-381. We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days after (R)-JG-381 administration. When we administered different doses of 100, 200, 400 and 800 ㎎/㎏, we found 5, 3, 5 and 5 male rats and 1, 4, 4 and 5 female rats dead within 1 day after administration, respectively. Some clinical signs(decrease of locomotor activity, decreased respiration rate, lacrimation, prone position) were observed during the experimental period. Our findings suggest that oral LD_50s(95% confidence limit) for male and female rats are 93.8 ㎎/㎏ (28.8∼161.6 ㎎/㎏) and 166.3 ㎎/㎏ (89.1∼284.8 ㎎/㎏), respectively.
최기환,박인숙,임화경,오우용,왕소영,김소희,김주일,김동섭 대한약학회 2003 약학회지 Vol.47 No.2
The present paper reviews the notion and comparison of the Korea Food and Drug Administration(KFDA) general pharmacology and the International Conference on Harmonisation (ICH) safety pharmacology. General pharmacology or safety pharmacology is termed the study to determine the potential of a compound to induce adverse pharmacological effects. KFDA general pharmacology studies have been considered an important component in drug safety assessment and these were originally referred to those designed to examine effects other than the primary therapeutics effect of a drug candidate. The KFDA notified the Guideline for General Pharmacology in 1997. Safety pharmacology studies were focused on identifying adverse effects on physiological functions. In the ICH came into place S7A Safety Pharmacology Studies for Human Pharmaceuticals in 2001. A new chemical entity should be assessed for its side effects, initially in those physiological systems which are generally agreed to be the key systems that are essential for life; these "core system" include the central nervous system, cardiovascular system and respiratory system in safety pharmacology studies. These studies should be performed in compliance with Good Laboratory Practice (GLP).
급성 허혈성 뇌졸중에서의 뇌 영상 검사의 최신 지견과 역할
조세진,정승채,서종현,김경원,우동철,오우용,이종구,김병준 대한영상의학회 2019 대한영상의학회지 Vol.80 No.6
Neuroimaging plays a key role in assessing the detection of acute hemorrhage, diagnosis of infarct core, detection of steno-occlusive arteries, mismatch between infarct core and penumbra, and collateral circulation in patients with acute cerebral ischemic stroke. The recent announcement of randomized clinical trials that demonstrated the usefulness of intra-arterial mechanical thrombectomy and the guidelines of 2018 Guidelines for the Early Management of Patients with Acute Ischemic Stroke from American Heart Association/American Stroke Association led to a larger role of neuroimaging and required new neuroimaging strategy for acute cerebral ischemic stroke. In this review, we summarize the recommendation on neuroimaging from the 2018 Guidelines, and review pros and cons between CT and MR and fast scanned stroke MR. Based on the new guidelines and recent research, we discuss the appropriate neuroimaging strategy for acute cerebral ischemic stroke patients. 뇌 영상 검사는 급성 허혈성 뇌졸중 환자의 뇌출혈 배제, 뇌경색 진단, 폐색 혈관의 검출, 관류상태와 뇌경색 간의 불일치 정도, 측부 순환 상태를 평가하는 핵심적인 역할을 한다. 최근 동맥 내 재개통술의 효용성을 증명한 무작위 배정 임상시험과 함께 이를 반영한 2018년 미국뇌졸중협회 가이드라인이 발표되면서 급성 허혈성 뇌졸중 환자의 진단과 치료 대상 선별을 위한 뇌 영상 검사의 역할은 더욱 커졌고 이에 시간에 따라 다른 영상의학적 전략이 중요해졌다. 이에 2018년 미국뇌졸중협회 가이드라인의 영상의학적 권고안을 요약하고 주요 뇌 영상검사인 CT와 MR의 역할과 장·단점 및 MR의 단점 극복을 위한 고속촬영 기법에 대해 기술하고자 한다. 아울러 새로운 가이드라인과 최근의 연구를 바탕으로 급성 허혈성 뇌졸중 환자를위한 적절한 영상의학적 전략에 대해 논하고자 한다.