정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

隔壁의 傾斜에 따른 箱子桁의 硏究

鄭熺孝,安光列,李承烈,朴泳珏 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-

The box girder has became a popular bridge type for long span or curved bridges because of its structural advantage of torsional stiffness. Generally box girder have inner diaphragms. The purpose of diaphragms is to prevent the deformation of cross section shape. Most diaphragms are parallel to cross section but it is necessary at present to adapt the design of bridge structures to transport requirement and the restrictive conditions of environment. City bridges, bridges spanning railway lines and stations, skew crossing of streets and highways, etc., require an irregular arrangement of internal supports. If diaphragms are applied, they are usually skew. It is advantageous to use a box girder as the basic component for a bridge of this kind because the box girder provides a high torsional stiffness, a favorable stresses, and due to the small shear stresses arising due to torsion. This paper deal with the analysis of the function of irregularly situated support and skew diaphragms and with their influence on the resulting state of stress of the box girder and compare with vertical deflections, horizontal deflections, longitudinal stresses, distortional stresses according to the angle of diaphragms.

중간스프링을 가진 개선된 탄성지반상(彈性地盤上) 보의 휨해석

鄭熺孝,李承烈,安光列 慶尙大學校 經營行政大學院 2004 工學硏究院論文集 Vol.20 No.-

While the BEF(Beam on Elastic Foundation, Wright et al, 1968) analogy has been widely used in straight and simple supported box girder analysis, the EBEF(Equivalent Beam on Elastic Foundation, Yao. T. Hsu et al, 1995) analogy has been made possible in curved and continuous box girder. Instead of using the traditional trigonometric foundation to solve a BEF problem, EBEF analogy used stiffness matrix considering bending, shear, elastic foundation and defined middle diaphragms in box girder as middle supports of continuous beam. In this study, for the comparison with BEF analogy, the element length of beam is determined first and infinity support stiffness corresponding to dimensionless middle diaphragm stiffness is determined in EBEF analogy. Two approaches, BEF and EBEF analogy are compared in the beam on elastic foundation.

Sezary증후군과 병발된 용혈성 빈혈 1예

유광하,진춘조,김홍승,이종인,심영학,정순희,이창훈 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.- No.7

DC 편의된 다상 전원에 의한 횡자속 선형 유도 구동기 자기력의 왜곡 분석

鄭光碩,韓英喜 충주대 2004 産業科學論文集 Vol.12 No.-

The magnetic force across the air-gap between primary and secondary part in linear induction motor is in most part constrained by bearing or linear guide. But, the existence of the normal force gives us a possibility to levitate and drive the secondary part of the linear motor stably without the bearing. Therefore, to control the normal force and the thrust force on the secondary part independently, the various methodologies have been presented. As one of the solutions, we suggest the decouple control by DC-biased multi phase input, in which the biased DC is modulated to control the normal force and the multi phase AC to control the thrust force. To guarantee the method, the distortion of the magnetic force is intensively analysed using the distributed parameter magnetic field theory for the transverse flux linear induction motor.

하악 고정성 임프란트를 이용한 퇴축된 하악골의 수복

정영진,박원희,안원준,이명렬,이영수,유광희,심광섭 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

Transmandibular implants are used limitedly such as on remaining symphyseal basal bone of atrophic mandible, on the bony defect of symphyseal area due to trauma or tumor as surgical implants. Among the more recent advances in oral implantology are the Fixed Mandibular Implant (FMI)based on the pioneering studies and clinical applications by Irwin Small of the USA and the development very high success rates for providing attachments and abutments in areas of the oral cavity severely compromised by either atrophy or surgical loss of osseous tissues. We will present a case report of regabilitation of totally edentulous mandible with advanced alveolar atrophy using Fixed Mandibular implant (F.M.I).

거더의 單純化 解析에 관한 硏究

鄭熺孝,安光列 慶尙大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.15 No.-

A simplified method to analyze pin-ended girders under uniform load is presented. This method is shown to estimate the maximum moment, shear and deflection of the girder without calculating any of the beam reactions it supports. If exact solutions for the maximum moment, shear and deflection are needed, they can be easily found by multiplying the approximate results by a tabulated constant. Results are valid for any type of pin-ended girder, provided structures are made by uniformly spaced beams or trusses. This method can easily be programmed into a spreadsheet, calculated by hand or incorporated into an existing software package.

여성들의 자기효능감과 건강증진행위에 관한 연구

정숙희,하안례,심선녀,이용환,김광혁 고신대학교보건과학연구소 2003 보건과학연구소보 Vol.13 No.-

The results were as follows : The higher the degree of self-efficacy feeling, one of the recognition factor was the more did they do health-promoting activities (γ=0.48, p=0.00). The conducting degree of health-promotion activities resulted in 3.79 points in the perfect score of 6point, which was a quiet high result. The subordinate areas under the health-promoting activity were adjustment of personal relationshiP (4.42), nutrition (3.93), stress control (3.87), self-realization (3.64), alcoholic drink/smoking (3.38), and responsibility for health. As for the differences of self-efficacy feeling according to subjects general characters, significant differences were found in the areas of age, occupation, whether or not they have taken healthrelated lectures, family and geriatric diseases of family members or relatives. The above study results tell that the self-efficacy feeling has a great effect on their putting the health-promoting activities into practice, in daily life.

경동맥 내막 절제술 후 발생한 과관류 증후군 1예

송희정,박광열,정진상,조수진,이순정,허승,김동익,이광호,이병붕 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

경사격벽을 가진 상자형의 해석

鄭熺孝,安光列,李承烈,朴泳珏 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

It is necessary at present to adapt the design of bridge structures to transport requirement and the restrictive conditions of environment. City bridges, bridges spanning railway lines and stations, skew crossing of streets and highways, etc., require an irregular arrangement of internal supports. If diaphragms are applied, they are usually skew. It is advantageous to use a box girder as the basic component for a bridge of this kind because the box girder provides a high torsional stiffness, a favorable stresses, and due to the small shear stresses arising due to torsion. This paper deal with the analysis of the function of irregularly situated support and skew diaphragms and with their influence on the resulting state of stress of the box girder. The solution is shown for a box girder under eccentric load and according to the length of skew diaphragms.