동결온도가 해동 쇠고기의 품질에 미치는 영향

남주현,송형익,김미숙,문윤희,정인철 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.5

동결온도가 해동우육의 품질에 미치는 영향을 검토하였다. 해동드립감량은 -3℃ 동결이 30일째에 3.4%, -20℃ 동결이 60일째에 1.8%로 높았으며, -3℃가 -20℃보다 드립량이 많았다. 가열감량은 water bath와 pan 가열 모두 저장초기보다 동결저장중에 현저하게 높았으나, 동결온도에 의한 차이는 없었다. 염용성 단백질의 추출성은 동결기간이 경과함에 따라 감소하였고, -20℃에서 동결한 것이 -3℃에서 동결한 것보다 추출성이 높았다. 수용성 단백질의 추출은 -3℃의 경우 동결기간에 따라 현저한 변화가 없었으나, -20℃에서 동결한 것은 동결기간에 따라 증가하는 경향을 보였다. 명도(L)는 동결초기가 높았고 적색도(a)는 동결기간에 따른 변화가 없었으며, 황색도(b)는 동결초기보다 동결중에 더 높았다. Myoglobin의 변성율은 -3℃의 경우 45일째, -20℃의 경우 15일째 각각 94.4%와 94.0%로 가장 높았다. 전단력가는 동결초기보다 저장기간이 경과함에 따라 높아졌으며, 근원섬유의 소편화도는 동결저장중 현저한 변화가 없었다. pH는 -3℃와 -20℃ 모두 30일째까지 높아지다가 그 이후 낮아지는 경향을 나타내었다. This study was carried out to investigate the effects of freezing temperature on quality of thawed beef loin. In case of thaw drip loss, the freezing of -3℃ and -20℃ were higest by 3.4% to 30 days and by 1.8% to 60 days, respectively. And the thaw drip loss of -3℃ freezing was more than -20℃ freezing. The cooking loss of water bath and pan boiling were increased significantly during freezing than the beginning of freezing, but were not different -3℃ and -20℃. The salt soluble protein extractability was decreased during freezing, the -20℃ freezing was higher than -3℃ freezing. The water soluble protein extractability of -3℃ freezing was not significant different during freezing storage, that freezed at -20℃ was increased during freezing. The "L" value of the beginning of freezing was higher than during freezing, the "a" value was not different during freezing, and the "b" value during freezing was higher than the beginning of feezing. The myoglobin denatured percentaged of the -3℃ and -20℃ freezing were highest by 94.4% to 45 days and by 94.0% to 15 days, respectively. The shear force value during freezing was higher than the beginning of freezing, the myofibrillar fragmentation index was not significant different during freezing. The pH was increased to freezing 30 days, after that was decreased.

만성폐색성 폐질환과 위식도 역류질환과의 관계

김영철,오재희,변주남 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.1

In order to investigate the factors influencing the chronic obstructive pulmonary disease (COPD), especially for the relationship between gastroesophageal reflux disease(GERD) and COPD, a case-control study was conducted in chonnam area. Data were obtained from hospital records and interview survey from Jan. to Dec. 1991. Final 64 cases with COPD(case group) were compared with 83 cases of normal lung(control group 1) and 45 cases of non-COPD lung disease (control group 2) The results were as follows. 1. Smoking status, history of adulthood pulmonary infection and frequent history of URI, socioeconomic status and GERD were significantly different between COPD group and control group 1. 2. Drinking status, physical height of the subjects and GERD were significantly different between COPD group and control group 2. 3. If control group 1 was used, odds ratio of GERD and COPD was 5.68(95% confidence interval, 95% CI: 2.59-12.45) and 4.81(95% CI: 1.89-10.53) when adjusted by age and smoking status. 4. If contol group 2 was used, odds ratio of GERD and COPD was 4.22(95% CI: 1.69-10.56) and 4.59(95% CI: 1.64-12.86) when adjusted by alcohol and adulthood respiratory infection status. 5. This results suggested that GERD might play a causative role in the development of COPD.

장시간 불가피한 공복(fasting)후 인체의 내분비 변화 : 삼풍백화점 붕괴 사고후 구조된 3인의 증례 THREE CASES IN COLLAPSE OF SAMPOONG DEPARTMENT STORE

박규남,황주일,박조현,오동렬,이원재,오승택,김세경,김인철 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

The interactions between nutrition and the endocrine system are more intimate and complex that previously thought. Nutrition modulates secretion and activity of many hormones, as part of the stress adaptation process. Fasting, in particular, produces a number of important changes in the endocrine system, with teleological purpose of helping the body tolerate the lack of food ingestion. These changes are therefore beneficial and protective, although at times they may not appear to be that way. The endocrine changes of fasting mediate the metabolic response. We must emphasize that these changes are completely reversible when appropriate nutrition is established. These changes are as followes: 1) decreased insulin and increased glucagon levels, 2) decreased thyroid effect, 3) decreased sympathetic activity, 4) hypothalamic hypogonadism, 5) decreased growth, 6) altered glucocorticoid secretion and metabolism, 7) impaired mineralocorticoid response, 8) decreased ADH secretion and effect. We experienced three cases of involuntary prolonged fasting after collapse of Sampoong department store. They were released from collapsed field after 11(case Ⅰ), 13(case Ⅱ), 17days(case Ⅲ) respectively. In each case, the endocrine changes of plasma levels were as followes: decrease of cortisol in case Ⅰ, increase of GH in case Ⅱ, decrease of free T3, T3, cortisol and increase of reverse T3, insulin in case Ⅲ. Each one did not show the same endocrine changes of plasma levels. But we think these changes of fasting are beneficial in metabolic response of human.

정신분열병 환자의 말초 임파구에서 도파민 수용체 mRNA의 변화

곽용태,최철희,김옥준,주연호,김형섭,강성숙,구민성,선우일남 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 정신분열병은 주로 청소년기에 발병하는 정신과에서 가장 흔한 질환 중의 하나이다. 이 질환의 원인이나 병인은 아직 불확실하지만 뇌 도파민계의 기능장애가 중요한 기전으로 생각되고 있으나 부검없이 뇌 도파민계를 직접 관찰할수 없으므로 많은 혼란이 있어왔다. 이를 극복하기 위하여 최근에 발견된 말초 임파구의 도파민 수용체를 이용하여 정신분열병에 있어서 말초 임파구 도파민 수용체가 뇌 도파민계의 기능을 반영하는 말초표식인자일 가능성이 있는지를 규명한다. 방 법 : 3년 이상 항정신병 약물을 복용중인 정신분열병 환자(약물투약군) 44명, 최근 3개월 이상 항정신병 약물을 복용하지 않은 환자(약물비투약군) 43명, 정상대조군 31명을 대상으로 말초 임파구의 D3, D5 도파민 수용체를 정량적 역전사 중합효소 연쇄반응(quantitative reverse transcritpase polymerase chain reaction)을 이용하여서 정량 비교하였고, 또한 항정신병 약물을 복용하지 않은 환자들에 있어서 약물 투여 후 도파민 수용체의 변화 및 임상양상의 변화를 관찰하였다. 결 과 : 1) 말초혈액 임파구의 D3R/βA는 약물비투약군에서 정상대조군이나 약물투약군에 비하여 통계적으로 유의하게 있게 증가되어 있었다. D5R/βA의 경우 약물비투약군이 약물투약군에서만 비하여 유의하게 증가되었다. 그러나 약물투약군과 정상대조군 간에는 도파민 수용체 mRNA(D3R/βA, D5R/βA)양에 있어서 차이가 없었다. 2) 항정신병 약물을 새로 투여하는 환자에서 항정신병 약물을 투여 후 임파구 도파민 수용체의 변화를 추적 관찰한 결과 증가하는 경향을 보였다. 3) 약물비투약군을 정상 대조군과 비교하여 D3R/βA mRNA가 정상범위에 속하는 군과 높은 군으로 나누어서 임상척도와 비교 분석한 결과 임파구 도파민 수용체가 증가한 군에서 다음과 같은 임상특징을 관찰할 수 있었다. (1) 정신병리증상이(BPRS) 현저하였다. (2) 약물치료에 대해 양성 정신병리증상(pBPRS)의 호전도가 낮았다. (3) 약물치료시 추체외로 부작용이 심하였다. 결 론 : 이상의 연구결과로 말초 임파구에서 발현되는 도파민 수용체는 정신분열병의 소군 분류 및 예후 예측에 있어서 임상적 의의가 있는 것을 알 수 있었다. 따라서 말초임파구에서 발현되는 도파민 수용체는 비록 이에 상응하는 뇌의 해부학적 위치는 알 수 없지만 중추신경계의 도파민 수용체의 기능을 반영할 가능성이 높다고 생각되었다. Objectives : Schizophrenia, commonly developed in adolescence and young adulthood, is one of the most common mental diseases in psychiatry. The etiology or pathogenesis of this disease is uncertain yet, but the dysfunction of dopaminergic system in the brain has been proposed. However, there is no direct evidence of dysfunction of brain dopaminergic systems in schizophrenic patients because the direct assessment of brain dopaminergic systems is almost impossible at present. To overcome this problem, recently founded dopamine receptors and their mRNAs in peripheral lymphocytes was used. The purpose of this study was to define whether the dopamine receptors of peripheral lymphocytes can be the peripheral markers of schizophrenia or not. Methods : The total numbers of subjects are 87 schizophrenic patients. Among them 44 patients were schizophrenics who had been taking antipsychotic drugs for more than 3 years(medicated patients), 43 schizophrenics who recently are not taken antipsychotic drugs for more than 3 months(drug-free patients). For controls age and sex matched 31 healthy persons were enrolled. Sequential reverse transcription and quantitative polymerase chain reaction of the mRNA were used to investigate the expression of dopamine receptors in peripheral lymphocytes. The gene expression of dopamine receptors were compared in each groups and after starting antipsychotic medicines in drug-free patients, the clinical scales and the dopamine receptors of peripheral lymphocytes were sequentially studied before, 2 weeks after and 8 weeks after medication. Results : 1) In drug-free schizophrenics, D3 dopamine receptor mRNA expression of peripheral lymphocytes was significantly increased comparing with that of controls and drug-medicated schizophrenics and D5 dopamine receptor mRNA expression was increased comparing with only that of drug-medicated schizophrenics. There was no difference between controls and drug-medicated schizophrenics. 2) After antipsychotic medication, dopamine receptors of lymphocytes were increased tendency. 3) Drug-free patients were divided into two groups according to dopamine receptor expression in controls to evaluate the significance of increased dopamine receptor expression. The group of patients with increaseddopamine receptor expressio had following clinical characteristics. (1) More severe psychiatric symptoms (2) Poor pharmacological response of pBPRS on medicines (3) Severe extrapyramidal side effects after pharmacological treatment Conculsion : These results revealed that the molecular biologically determined dopamine receptors of peripheral lymphocytes were reactive, and increased expression of dopamine receptor in peripheral lymphocyte had clinical significance for subgrouping and prognostication. These findings suggested that dopamine receptors of peripheral lymphocyte may represent dopamine receptors of the brain, even the location cannot be determined.

췌장의 대낭성 장액성 낭선종 : 2예 보고

김한성,최현준,주미,장선희,곽지은,김철남 인제대학교 2006 仁濟醫學 Vol.27 No.-

Typical serous cystadenoma of pancreas is formed by many microcysts, of which diameter are less than 2cm. Recently, rare variants are also reported as macrocystic, unicystic, or multicentric. Macrocystic serous cystadenoma is diffcult to differentiate from pseudocyst, mucinous cystadenoma and other cystic mass having macrocysts. As these lesions have different symptoms, methods of treatment, and prognoses, it is important to diagnose and treat correctly. We report 2 cases which diagnosed as macrocystic serous cystadenoma with stressing scarcity value and clinical importance.

조혈모세포이식을 받은 급성 골수 백혈병 환자에서 발생한 cyclosporine에 의한 양측 시신경병증

정진권,김한조,박명진,하승주,최경식,이성진,박성희,이상철,이남수,박희숙,원종호 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

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Randomized, Multi-center Phase II Trial of Docetaxel Plus Cisplatin Versus Etoposide Plus Cisplatin as the First-line Therapy for Patients with Advanced Non-small Cell Lung Cancer

Nam-Su Lee,Hee-Sook Park,Jong-Ho Won,Dae-Sik Hong,Su-Taek Uh,이상재,Joo-Hang Kim,Se-Kyu Kim,Myung-Ju Ahn,최정혜,Suk-Chul Yang,Jung-Ae Lee,Keun-Seok Lee,Chang-Yeol Yim,Yong-Chul Lee,Chul-Soo Kim,Moon-Hee Lee 대한암학회 2005 Cancer Research and Treatment Vol.37 No.6

Purpose: We prospectively conducted a multi-center,open-label, randomized phase II trial to compare the efficacy and safety of docetaxel plus cisplatin (DC) and etoposideplus cisplatin (EC) for treating advanced stage non-small cell lung cancer (NSCLC).Materials and Methods: Seventy-eight previously untreated patients with locally advanced, recurrent or metastatic NSCLC were enrolled in this study. The patientsreceived cisplatin 75 mg/m2 on day 1 and either docetaxel 75 mg/m2 on day 1 or etoposide 100 mg/m2 on days 1 to 3 in the DC or EC arm, respectively, every 3 weeks.Results: The objective response rate was 39.4% (15/38) and 18.4% (7/38) (p=0.023) in the DC and EC arms, respectively. The median time to progression (TTP) was5.9 and 2.7 months (p=0.119), and the overall survival was 12.1 and 8.7 months (p=0.168) in the DC and EC arms, respectively. The prognostic factors for longer survival were an earlier disease stage (stage III, p=0.0095), the responders to DC (p=0.0174) and the adenocarcinoma histology (p=0.0454). The grades 3 and 4 toxicities were similar in both arms, with more febrile neutropenia (7.9% vs. 0%) and fatigue (7.9% vs. 0%) being noted in the DC arm.Conclusion: DC offered a superior overall response rate than does EC, along with tolerable toxicity profiles, although the DC drug combination did not show significantlyimproved survival and TTP.

경량 식혈기의 스크류 형상에 따른 회전력에 관한 연구(1) - 스크류 형상에 따른 이론 회전력-

조남철 ( Nam Chul Joo ),김동근 ( Dong Gun Kim ),김기동 ( Ki Dong Kim ),김진현 ( Jin Hyun Kim ) 한국농업기계학회 2016 한국농업기계학회 학술발표논문집 Vol.21 No.1

Glucomannan이 노인성 제2형 당뇨병 환자의 당질 및 지질 대사에 미치는 영향

김철식(Chul-Sik Kim),박종숙(Jong-Suk Park),남주영(Joo-Young Nam),남지선(Ji-Sun Nam),조민호(Min-Ho Cho),박진아(Jina Park),김똘미(Dol-Mi Kim),안철우(Chul-Woo Ahn),차봉수(Bong-Soo Cha),임승길(Sung-Kil Lim),김경래(Kyung-Rae Kim),이현철(Hyun 대한임상노인의학회 2004 대한임상노인의학회지 Vol.5 No.4

연구배경: 본 연구자들은 소장에서 당분과 지방질의 흡수를 저해하는 효과가 있는 것으로 알려져 있는 glucomannan을 노인성 제2형 당뇨병 환자에게 투여하여 혈당, 지질 및 인슐린저항성에 어떠한 영향이 있는지 조사하고자 하였다. 방법: 연세대학교 의과대학 내분비내과에 내원한 혈청 총콜레스테롤 농도가 높은 당뇨병 환자 중 60세 이상의 76명을 대상으로 실험군 39명, 대조군 37명으로 나누어 실험군에게는 하루 glucomannan을 대조군에게는 placebo 약제를 총 8주간 투여하였다. 공복혈당과 식후 2시간 혈당은 치료 0, 4, 8주에 측정하였으며, 치료 0, 8주에는 당화혈색소 및 총콜레스테롤, 중성지방, 고밀도 지단백 콜레스테롤, 저밀도 지단백 콜레스테롤을 측정하였으며 혈청 인슐린, C-peptide를 측정하고 인슐린저항성을 파악하기 위해 HOMA score를 산출하였다. 결과: 본 연구를 시행한 결과 다음과 같은 결과를 얻었다. 1) 공복혈당은 glucomannan을 8주간 투여한 후에 유의한 감소를 나타내었으며 식후 2시간 혈당은 glucomannan을 투여한 후 4주부터 감소하였으며 8주째에도 유의한 감소를 보였다. 2) 혈청 총콜레스테롤, 중성지방, 저밀도 지단백 콜레스테롤은 glucomannan 투여 후에 유의한 감소를 보였으나 고밀도 지단백 콜레스테롤은 유의한 변화가 없었다. 3) glucomannan을 8주간 투여한 후 HbA₁c는 투여 전에 비하여 유의하게 감소하였다. 4) HOMA-IR 값은 glucomannan 투여 후에 감소하였으며, HOMA-β 값은 투여 8주에 유의한 증가를 나타내었다. 5) glucomannan 투여가 간기능, 신장기능 및 전해질에는 특별한 영향을 미치지 않았다. 결론: 이상의 연구 결과를 통하여, 노인성 제2형 당뇨병 환자에게서 glucomannan은 혈당 및 지질대사 개선에 효과가 있는 것으로 확인되었다. glucomannan의 작용기전은 식후 고혈당 개선을 통한 인슐린저항성 감소 및 인슐린분비능의 개선으로 생각된다. Background: Glucomannan is known to be effective in reducing glucose and lipid absorption from small intestine. In this study, we tried to investigate the relationship between glucomannan and glucose, lipid profile, and insulin resistance in the elderly type 2 diabetes patients. Method: We have taken 76 type 2 diabetes patinets with hypercholesterolemia, aged over 60 years old, who have visited our endocrine clinic of Yonsei University of Medical College and categorized them into two groups. The experimental group, which consisted of 39 subjects, received daily glucomannan, while the control group, which consisted of 37 patients, received daily placebo for 8 weeks. We have measured fasting glucose, 2hr post-prandial glucose at 0, 4, 8 weeks and HbA1C, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, insulin, c-peptide levels at 0, 8 weeks, and calculated HOMA score in order to determine insulin resistance. Results: The following results were obtained. 1) 2hr postprandial glucose level was significantly reduced after taking glucomannan for 4 and 8 weeks, and fasting glucose level declined after taking glucomannan for 8 weeks. 2) Serum total cholesterol, triglyceride, LDL-cholesterol levels were significantly lowered after treatment. Serum HDL-cholesterol level had a tendency to increase in the experimental group, but was not statistically significant. 3) HbA₁c was significantly decreased after taking glucomannan for 8 weeks. 4) HOMA-IR was reduced at 8 weeks, and HOMA-β showed a significant increase at 8 weeks. 5) Glucomannan did not have adverse effects on CBC, liver function, renal function, and electrolyte levels. Conclusion: The above study results demonstrate that glucomannan is effective in improving glucose and lipid metabolism in elderly type 2 diabetes patients. Glucomannan enhances insulin resistance by lowering postprandial gluocse level and stimulating insulin secretion.

원저 : Rosiglitazone 치료 후 Adipocytokine 농도와 저밀도 근육량의 변화를 통한 인슐린 저항성의 개선정도

남주영 ( Joo Young Nam ),박종숙 ( Jong Suk Park ),김철식 ( Chul Sik Kim ),조민호 ( Min Ho Cho ),박진아 ( Jin A Park ),김똘미 ( Dol Mi Kim ),안철우 ( Chul Woo Ahn ),김경래 ( Kyung Rae Kim ),임승길,이현철,허갑범 ( Kap Bum Huh ) 대한비만학회 2004 The Korean journal of obesity Vol.13 No.2