소장에 발생한 신경형의 소화관 간질성종양 [증례]

김철남,장석효 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3

A new type of neurogenic gastrointestinal stromal tumours(GIST) was described. This neoplasm represents a newly described entity that grossly and histologically resembles leiomyomas and showed neurogenic differentiation. Neural type of gastrointestinal stromal tumors contains neuroaxonal and Schwann cell elements arranged in a way that differs from the usual schwannoma orneurofibroma. The clinicopathologic, histologic, immunohistologic characterisctics of neural type of gastrointestinal stromal tumors are similar to GIST. Ultrastructural examination provides the definitive distinguishing criteria for diagnosing a neural type of gastrointestinal stromal tumor. The presence of electron-dense granules or small vesicles suggests the presence of post-ganglionic neurotransmitter vesicles. We experienced a 65-year-old female patient who complained bloody diarrhea. She was diagnosed as neural type of gastrointestinal stromal tumor by abdominal CT and operation. Thus we report a case of neural type of gastrointestinal stromal tumor with a review of relevant literatures.

뜻 바뀜과 어휘소되기

김철남 한글학회 1999 한글 Vol.- No.244

제31차 학술대회 : 90. 위장관계 암환자에 있어서의 혈청 CEA ( Carcinoembryonic Antigen ) 치 변동에 관한 임상적 연구

김철남,이용우 () 대한외과학회 1979 대한외과학회 학술대회자료집 Vol.- No.-

함백산의 식물상과 식생

김철남 강원과학교육연구회 2001 강원과학교육연구회지 Vol.6 No.1

본 연구는 1999년 5월부터, 2000년 5월에 걸쳐 함백산 일대에서 채집한 양치 식물 이상의 관속 식물을 대상으로 식물상과 식생을 조사하였다. 함백산 일대에 자생하는 관속식물은 79과 261속 365종 75변종 11품종 2아종으로 총 453종류이며 양치식물계수(Pte-Q)는 0.99로 나타났다. 한국특산식물은 16과 25속 18종 9변종 1품종, 총 28종류이고, 환경부지정 특정야생식물은 관찰되지 않았다. 귀화식물은 5과 11속 12종 1변종, 총 13종류였다. 조사지역의 생활형조성은 H-D4-R5-e type으로 온대의 전형적인 생활형을 보였으며, 자원식물의 유용도는 식용식물이 21.5%로 가장 많았고, 목초용식물이 21.1%, 약용식물 14.1%, 관상용 8.4%, 목재용 1.5%, 섬유용 0.7%의 순으로 나타났고, 용도가 아직 밝혀져 있지 않은 식물도 32.7%로 나타났다. 함백산 일대의 산림식생에 대하여 Z-M방식에 의한 식물사회학적 조사방법으로 분석한 결과 1개의 군목, 1개의 군단, 4개의 군락으로 분류되었다. 이 곳의 산림식생의 층상구조는 교목층의 피도가 76%로 비교적 높은 반면에 아교목층과 관목층은 35%, 32%로 낮고 초본층은 82%로 다소 안정된 층상구조를 보이고 있다. 방형구당 평균 출현 종 수가 33종이며 신갈나무-철쭉군목은 24종, 조릿대-신갈나무군락 20종, 대사초-신갈나무군락 50종, 사스래나무-신갈나무군락 44종으로 신갈나무-철쭉군목과 조릿대-신갈나무군락을 제외하고는 비교적 풍부한 종 조성을 나타내고 있다.

`-이` 파생명서의 통시성

김철남 동남어문학회 1993 동남어문논집 Vol.3 No.-

조어론 연구의 계승과 발전 : 주시경·최현배·허 웅을 중심으로

김철남 동아대학교 어학연구소 1994 언어와 언어교육 Vol.9 No.-

This thesis is the study on succession and development process of Korean word-formation theory. The subject of study is on word-formation study of Ju Si-Gyeong, Choe Hyeon-Bae, Hur Ung. Ju Si-Gyeong is the first scholar that established Korean word-formation theory and he set up derivation and compound. But he didn't distinguish between derivation and inflection because he established grammar system in terms of syntax. Choe Hyeon-Bae explained the type and function of derivative affix and classified the type of compound word systematically. But he didn't have the concept of morpheme, because he considered derivative word as slmple Word. Hur Ung distinguished derivation from inflection by objective standard, and discriminated compound word from phrase. These three scholars above made great contribution to the study of Korean and their word-formation study can serve the study of Korean word-formation theory.

脾臟損傷後의 治癒過程에 關한 實驗的 硏究

金哲男,全奎榮 한양대학교 의과대학 1983 한양의대 학술지 Vol.3 No.1

When the splenic injury, even the trival injury, was occured, splenectomy has been considered a choice of treatment. Recently the fact has been clarified that OPSI (over-wheliming postsplenectomy infection) was occured in children as well as adult after splenectomy. So, the efforts directed toward the splenic preservation such as nonoperative management, methods using hemostatic agents, repair and closure of splenic capsule, partial splenectomy, autotransplantation and reimplantation. The author selected 14 weeks old, weighing 280±3gm, 107 rats as experimental animal. The standardized splenic trauma was performed in each rat's spleen with specific designed equipment and also performed wedge resection following various surgical procedures, postoperatively, all rats were observed for mortality during 1 week. RBC, WBC, platelet, Hb, and Hct. were obtained on postoperative 1,2,3,4,6, and 8 weeks and then observed relationship to retained amount of the splenic tissue. Postoperatively 4 weeks, each rat was challenged with 3x10?/ml of Escherichia coli intraperitoneally, and rats were observed for mortality during 1 week. The results were as following; 1) Following the splenic trauma, even though no repair was attemped, most cases were appeared spontaneous hemostasis and mortality was 22%. 2) Following the splenic trauma, if the adequate operative procedures including repair, hemisplenectomy, primary closure were performed, the mortakity due to bleeding was none. 3) The microscopic findings following splenorrhaphy were demonstrated the normal splenic architecture. 4) After each rat was challenged with 3x10?/ml organisms of Escherichia coli intraperitoneally, the mortality was 80% in total splenectomy, 30% in hemisplenectomy, 10% in no repair cases, 0% in splenic tissue normally preserved cases. So the incidence of sepsis was proportioned to amount of the preserved splenic tissue. 5) In the case of which the splenic tissue was retained normally by repair and primary closure, increased WBC and platelet values returned to preoperative levels within 4 weeks, within 6 or 8 weeks for the hemisplenectomy, whereas the values for the total splenectomy were still abnormally increased state after 8 weeks. So the increased and decreased values of WBC and platelet were proportioned to the amount of preserved splenic tissue.

위장관계 암환자에 있어서의 혈청 CEA (Carcinoembryonic antigen)치의 변동에 관한 임상적 연구

김철남(Chul Nam Kim),이용우(Yong Woo Lee) 대한외과학회 1980 Annals of Surgical Treatment and Research Vol.22 No.5

비장손상후의 치유과정에 관한 실험적 연구

김철남 전규영 대한외과학회 1983 Annals of Surgical Treatment and Research Vol.25 No.11

HER-2/neu유전자 과발현 유방암의 임상병리학적 특성

김철남 ( Chul Nam Kim ) 대한임상종양학회 2009 Korean Journal of Clinical Oncology Vol.5 No.1

서론: 유방암은 다양한 임상경과를 보이는 질환으로 예후 인자의 역할이 매우 중요하다. 현재까지 유방암의 예후 인자로 액와부 림프절의 전이 상태, 원발 종양의 크기, 에스트로겐 수용체와 프로게스테론 수용체 발현 유무, HER-2/neu유전자 과발현 유무 등이 잘 알려져 있다. 본 연구에서는 유방암의 예후 예측에 중요한 역할을 담당하는 HER-2/neu 유전자의 과발현을 면역조직화학염색법을 통해 확인하고 그 결과와 기타 임상병리학적 인자와의 연관성을 알아보고자 하였다. 방법: 1999년 12월부터 2003년 10월까지 유방암으로 수술 받은 119예를 대상으로 하였다. 모든 환자의 유방암 진료기록을 검토하여 진단 당시 나이, 종양의 크기, 조직학적 등급, 핵등급, 림프절 전이여부, 분자생물학적 특성(호르몬수용체, p53, Ki-67, HER-2/neu, 림프혈관침윤)들을 조사하여 분석하였다. 결과: 환자의 평균 나이는 50.3세였으며 전체 119예 중 HER-2/neu 과발현이 있는 경우는 32예(26.9%)였다. 액와 림프절 병기에 따른 HER-2/neu 과발현율이 통계적인 유의성을 보였고(p=0.036), 에스트로겐 수용체나 프로게스테론 수용체는 HER-2/neu 과발현과 관계가 있었으며(p=0.001, p=0.004), p53 단백 발현 유무와 ki-67 지수는 유의한 상관관계가 없었다. 조직학적 소견 중에서는 림프혈관침윤 유무와 조직등급, 핵등급 등이 HER-2/neu 과발현과 통계적으로 연관성이 있는 것으로 나타났다(p=0.029, p=0.041, p=0.001)(Table 1). 다변량 분석을 시행한 결과 핵등급만이 독립적으로 HER-2/neu 과발현과 연관성이 있는 것으로 나타났다(p=0.014)(Table 2). 결론: HER-2/neu유전자 과발현 유방암은 액와림프절 전이, 림프혈관침윤, 조직학적 등급, 핵등급, 호르몬 수용체 발현 정도와 연관성이 있는 것으로 나타났으며, 향후 생존율, trastuzumab 사용 유무 등에 대한 분석을 통해 예후에 미치는 독립적인 영향에 대해 연구되어야 할 것으로 생각된다. Purpose: Clinicopathologic factors associated with prognosis in breast cancer patients have varied. HER-2/neu gene amplification and/or protein overexpression occur in 14-30% of all cases of breast cancer. Among clinicopathologic factors, HER-2/neu gene status has been suggested to be a significant prognostic indicator for breast cancer. The objective of this study was to determine whether HER-2/neu gene expression is associated with other clinicopathologic factors in breast cancer. Methods: The expression of HER-2/neu, Ki-67, p53, estrogen receptor and progesterone receptor was determined immunohistochemically and medical records were reviewed in 119 breast cancer patients, including 87 patients that demonstrated the absent of HER-2/neu expression and 32 patients with the present of HER-2/neu expression. Results: HER-2/neu expression was noted in 32 patients (26.9%) of the 119 breast cancer patients. Of the 87 patients(73.1%) with absent of HER-2/neu expression. There was a significant correlation between HER-2/neu expression and the nodal status (p=0.023), lymphovascular invasion(p=0.029), histologic grade(p=0.041), nuclear grade(p=0.001), estrogen receptor status(p=0.001) and progesterone receptor status(p=0.004). Nuclear grade was statistically significant association factor with HER-2/neu expression status independently in multivariate analysis.(p=0.041, relative risk 0.177, 95% CI 0.043-0.733) Conclusion: This study demonstrates the potential value of the lymph nodal status, lymphovascular invasion, histologic grade, nuclear grade and hormonal receptor status correlating with the status of HER-2/neu expression in human breast cancer.