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RISS 인기검색어
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- 저자 : Su-Taek Uh (검색결과 4 건)
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해외에서 유입된 정상 면역 성인의 Varicella 폐렴 1예
조영관,박은경,김양기,이영목,어수택,김태형 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Varicella-zoster virus, an unusual pathogen of community acquired pneumonia in adult, may causes respiratory distress and death. Since the first description by Waring et al. in 1942, the disease has been recognized by roentgenography, pathologic study, and virus studies as a special syndrome of the varicella virus. Immunocompromized conditions such as leukemia, malignant lymphoma and corticosteroid therapy predispose patients to varicella pneumonia. It occurs rarely in immunocompetent patients. The clinical manifestations of varicella zoster pneumonia exhibit a wide spectrum of disease from asymptomatic to death. Acyclovir is the recommended treatment and corticosteroid can be used in severe varicella pneumonia. We report a case of varicella pneumonia developed in a immunocompetent patient.
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Nam-Su Lee,Hee-Sook Park,Jong-Ho Won,Dae-Sik Hong,Su-Taek Uh,이상재,Joo-Hang Kim,Se-Kyu Kim,Myung-Ju Ahn,최정혜,Suk-Chul Yang,Jung-Ae Lee,Keun-Seok Lee,Chang-Yeol Yim,Yong-Chul Lee,Chul-Soo Kim,Moon-Hee Lee 대한암학회 2005 Cancer Research and Treatment Vol.37 No.6
Purpose: We prospectively conducted a multi-center,open-label, randomized phase II trial to compare the efficacy and safety of docetaxel plus cisplatin (DC) and etoposideplus cisplatin (EC) for treating advanced stage non-small cell lung cancer (NSCLC).Materials and Methods: Seventy-eight previously untreated patients with locally advanced, recurrent or metastatic NSCLC were enrolled in this study. The patientsreceived cisplatin 75 mg/m2 on day 1 and either docetaxel 75 mg/m2 on day 1 or etoposide 100 mg/m2 on days 1 to 3 in the DC or EC arm, respectively, every 3 weeks.Results: The objective response rate was 39.4% (15/38) and 18.4% (7/38) (p=0.023) in the DC and EC arms, respectively. The median time to progression (TTP) was5.9 and 2.7 months (p=0.119), and the overall survival was 12.1 and 8.7 months (p=0.168) in the DC and EC arms, respectively. The prognostic factors for longer survival were an earlier disease stage (stage III, p=0.0095), the responders to DC (p=0.0174) and the adenocarcinoma histology (p=0.0454). The grades 3 and 4 toxicities were similar in both arms, with more febrile neutropenia (7.9% vs. 0%) and fatigue (7.9% vs. 0%) being noted in the DC arm.Conclusion: DC offered a superior overall response rate than does EC, along with tolerable toxicity profiles, although the DC drug combination did not show significantlyimproved survival and TTP.
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성인성 호흡장애 중후군에서 혈청 Fibronectin 의 변화
양동호,어수택,이성희,박춘식,김무원,김치환,오상권,홍원기 대한내과학회 1986 대한내과학회지 Vol.30 No.4
Plasma fibronectin(FN) is known to play a central role in the host defense system, where it acts as nonimmunologic opsonin for the removal of different degradation products by the reticuloendothelial system. Decrease in plasma FN may prolong the survival time of tissue or fibrin (ogen) degradation products with a possible deleterious effect on alveolar permeability. In human studies, plasma FN level is a reliable index of severity and prognosis in septic patients. We measured the ratio of arterial oxygen partial pressure to inspired oxygen fraction(PaO2/FiO2) and FN levels in 16 patients with adult respiratory distress syndrome(ARDS) from day 1 to 9 on ventilator to study correlation between serum FN and PaO2/FiO2,. Also we measured serum FN levels in 9 patients with sepsis and 7 patients with high pressure pulmonary edema and studied value of serum FN in differential diagnosis bet- ween sepsis with or without ARDS and ARDS and high pressure pulmonary edema. The results as follows; 1) 16 ARDS patients showed no statistically significant difference in daily evolution of serum FN levels. 2) 5 Recovered ARDS patients showed statistically signficant elevation(p$lt;0.005) in daily evolution of serum FN levels, but 11 nonrecovered ARDS patients showed elevated tendency but no statistically significant difference in daily evolution of serum FN levels. 3) There was statistically significant decrease (p$lt;0.005) in daily evolution of serum FN levels in 7 septic ARDS patients, however 9 aseptic ARDS patients showed elevated tendency but no stasistically signficant difference in daily evolution of serum FN levels. 4) There was no signficant correlation between serum FN and PaO2/FiO2, in all ARDS patients. 5) Serum FN in 9 septic patients without ARDS showed lower tendency than that of all ARDS, high pressure pulmonary edema patients and normal control, hut there is no statistically signficant difference. In conclusion, serum FN is not valuable to differentiate ARDS from high pressure pulmonary edema, but valuable to predict the course of ARDS.
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기포성 말기 폐질환에서 발생한 allergic bronchopulmonary aspergillosis (ABPA) 1 례
김동원,이영목,한상훈,홍기영,이준혁,김용훈,박춘식,차건영,어수택 대한알레르기학회 2001 천식 및 알레르기 Vol.21 No.3
Allergic bronchopulmonary aspergillosis(ABPA) is a syndrome seen in patients with asthma and cystic fibrosis. It is characterized by chronic cololinization of the airways with a ubiquitous fungus, Aspergillus fumigatus. Clinically, it is a syndrome characterized by recurrent episodes of wheezing, mucus production, pulmonary infiltrates, and elevated levels of serum IgE. ABPA patients are also accompanied with bronchiectasis in 89% and observed in 10% of cystic fibrosis that show the features of end-stage lung pattern. There are few reports of ABPA associated with bullae. We will report here a case of ABPA developing in an old cicartrical and bullous lesion of a lung.
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