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      • KCI등재

        A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma Co-existing with Mucinous Carcinoma - A Case Report -

        장선희,심상화,주미,김한성,김용규 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.1

        An endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare skin tumor that most commonly occurs on the eyelids of elderly women. This tumor is morphologically analogous to endocrine ductal carcinoma in situ and solid papillary carcinoma of the breast. We describe one case of a 51-year-old male with an EMPSGC co-existing with mucinous carcinoma of the eyelid. The tumor was composed of dilated ducts with a smooth border and was partially filled with a papillary proliferation. Tumor cells were uniform, small-to-medium in size, and oval-to-polygonal with light eosinophilic cytoplasm. Nuclei were bland with diffusely stippled chromatin and inconspicuous nucleoli. Tumor cells expressed chromogranin, synaptophysin, estrogen and progesterone receptors, cytokeratin 7, and epithelial membrane antigen.

      • KCI등재

        피부 콕시디오이데스 진균증 - 1예 보고 -

        장선희,심상화,곽지은,주미,김한성,박혜진,곽이경,지제근 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.4

        Coccidioidomycosis, which results from inhaling the spores of Coccidioides species, is endemic in the southwestern United States. The primary infection site is the lung, and dissemination of the disease can occur. We report a case of cutaneous coccidioidomycosis in a 79-year-old Korean woman who presented with purpura on both lower extremities, but no pulmonary symptoms and no history of visiting an endemic area. Microscopically, skin biopsy showed multiple aggregates of granulomas in the dermis. Numerous multinucleated giant cells were associated with the granulomas. Mature and immature fungal spherules, which were 20 to 30 μm in diameter, were present inside and outside the multinucleated giant cells.

      • KCI등재

        A Diagnostically Challenging Case of an Infarcted Adenomatoid Tumor of the Epididymis

        장선희,심상화,곽지은,주미,김한성,지제근,이건철 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.4

        We describe a case of an infarcted adenomatoid tumor of the epididymis that was challenging to diagnose. A 20-year-old man presented with acute left scrotal pain. He was found to have a 2×1.5×1 cm tumor that was relatively well circumscribed on gross examination. There was a central necrotic area that exhibited gaping spaces and ghost outlines of epithelial cells. The periphery of the necrotic lesion showed focally viable adenomatoid tumor. The majority of the tissue adjacent to the necrosis consisted of granulation tissue, fibroblastic and myofibroblastic proliferation, and neutrophils. The fibroblasts and myofibroblasts showed plump nuclei, often with small nucleoli. No mitotic activity was present. The differential diagnosis for an infarcted adenomatoid tumor includes malignant mesothelioma, inflammatory myofibroblastic tumor, and inflammatory conditions. The key to diagnosing an infarcted adenomatoid tumor is to consider it in the differential diagnosis of any spindle cell tumor with necrosis occurring in the genital tract. We describe a case of an infarcted adenomatoid tumor of the epididymis that was challenging to diagnose. A 20-year-old man presented with acute left scrotal pain. He was found to have a 2×1.5×1 cm tumor that was relatively well circumscribed on gross examination. There was a central necrotic area that exhibited gaping spaces and ghost outlines of epithelial cells. The periphery of the necrotic lesion showed focally viable adenomatoid tumor. The majority of the tissue adjacent to the necrosis consisted of granulation tissue, fibroblastic and myofibroblastic proliferation, and neutrophils. The fibroblasts and myofibroblasts showed plump nuclei, often with small nucleoli. No mitotic activity was present. The differential diagnosis for an infarcted adenomatoid tumor includes malignant mesothelioma, inflammatory myofibroblastic tumor, and inflammatory conditions. The key to diagnosing an infarcted adenomatoid tumor is to consider it in the differential diagnosis of any spindle cell tumor with necrosis occurring in the genital tract.

      • KCI등재

        Fibrovascular Polyp of the Hypopharynx - A Case Report -

        장선희,심상화,곽지은,주미,김한성,정범조,신중욱,박시영,조경자,지제근 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.4

        We report here on a case of fibrovascular polyp arising in the hypopharynx of a 62-year-old man. Laryngomicroscopic surgery with laser ablation was performed to excise the mass. Histopathologically, the surface of the polyp was covered with mature squamous epithelium. The polyp showed a characteristic lobular proliferation of mature adipose tissue that was separated by myxoid or collagenous connective tissue. Some scattered skeletal muscle bundles were seen in the central portions of the polyp and these bundles were surrounded by a concentric proliferation of the spindle cells; this was reminiscent of Pacinian corpuscles. Regarding their location and the intermingled pattern of proliferating tissues, it is more plausible that the skeletal muscle is a hamartomatous component rather than entrapped, preexisting tissue. We report here on a case of fibrovascular polyp arising in the hypopharynx of a 62-year-old man. Laryngomicroscopic surgery with laser ablation was performed to excise the mass. Histopathologically, the surface of the polyp was covered with mature squamous epithelium. The polyp showed a characteristic lobular proliferation of mature adipose tissue that was separated by myxoid or collagenous connective tissue. Some scattered skeletal muscle bundles were seen in the central portions of the polyp and these bundles were surrounded by a concentric proliferation of the spindle cells; this was reminiscent of Pacinian corpuscles. Regarding their location and the intermingled pattern of proliferating tissues, it is more plausible that the skeletal muscle is a hamartomatous component rather than entrapped, preexisting tissue.

      • 류마티스관절염의 야누스인산화효소억제제 치료

        장선희,주지현 대한의사협회 2021 대한의사협회지 Vol.64 No.2

        Rheumatoid arthritis is a chronic inflammatory destructive disorder that affects the joints, muscles, and tendons accompanying various extra-articular manifestations. Traditional disease-modifying anti-rheumatic drugs (DMARDs) represent the basic treatment for rheumatoid arthritis. Over the last 20 years, biologic DMARDs (tumor necrosis factor inhibitors, interleukin-1 inhibitors, interleukin-6 inhibitors, T cell inhibitors, and B cell inhibitors) have been widely used as a novel class of DMARDs that have efficacy and efficiency. Discovery of the underlying pathogenesis of autoimmune disease enables us to develop new target therapies such as a Janus kinase (JAK) inhibitor. Activated JAK is known to activate signal transducers as well as activators of transcription (STAT) signaling. A JAK inhibitor is a type of medication that functions by inhibiting the JAK-STAT signaling pathway. In addition, it is easy to take a JAK inhibitor orally. In Korea, several JAK inhibitors have been approved. This review describes the types of JAK inhibitors, recommended doses, side effects, and updated European Alliance of Associations for Rheumatology guidelines. Clinicians should more often consider JAK inhibitors in the treatment of refractory rheumatoid arthritis in current rheumatology clinics

      • KCI등재

        대학생의 자기결정성, 우울, 자아존중감, 충동성이 스마트폰 과의존에 미치는 영향

        장선희,하영미 한국디지털정책학회 2019 디지털융복합연구 Vol.17 No.1

        The purpose of this study was to identify the influencing factors on smartphone overdependence by examining the relationships between smartphone overdependence, self-determination, depression, self-esteem, and impulsivity in male and female college students. The self-reported questionnaires were administered to 263 students from two colleges. As results of multiple regression analysis, the factors affecting smartphone overdependence in male students were the perception of smartphone importance (β=.411, p<.001), impulsivity (β=.204, p=.007), and depression (β=.200, p=.040). In female students, influencing factors were the perception of smartphone importance (β=.630, p<.001) and impulsivity (β=.185, p=.010). Based on the findings, a tailored smartphone overdependence prevention program is needed by controlling impulsivity and changing distorted perceptions of smartphone. 본 연구의 목적은 남녀 대학생의 자기결정성, 우울, 자아존중감, 충동성, 스마트폰 과의존간의 관계를 탐색함으로써 이들 요인이 대학생의 스마트폰 과의존에 미치는 영향을 규명하기 위함이다. 2개 대학교에 재학중인 남녀 대학생 263명을 대상으로 자가보고형 설문조사를 실시하였다. 연구결과 남학생의 스마트폰 과의존에 영향을 미치는 요인은 스마트폰의 중요성에 대한 인식(β=.411, p<.001), 충동성(β=.204, p=.007)과 우울(β=.200, p=.040)인 것으로 나타났다. 여학생의 스마트폰 과의존에 영향을 미치는 요인은 스마트폰의 중요성에 대한 인식(β=.630, p<.001)과 충동성(β=.185, p=.010) 이었다. 본 연구결과를 바탕으로 남녀 대학생의 충동성 조절 및 스마트폰에 대한 왜곡된 인식 변화를 통해서 남녀 대학생의 스마트폰 과의존을 예방하기 위한 맞춤형 프로그램 개발이 필요하다.

      • 교사 수업전문성 계발에 영향을 미치는 학교조직문화 요인 분석

        장선희,추지윤 한국교원교육학회 2015 한국교원교육학회 학술대회자료집 Vol.2016 No.11

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        학생들의 학업 성취를 향상시키기 위한 노력은 교육에서의 중요한 관심사였다. 이러한 교육적 성과를 내기 위해 많은 연구들이 진행되어 왔으며, 그중에서도 교사의 전문성은 교 육적 성과를 높이기 위한 노력의 일환으로 지속적으로 연구되어 왔다. 학생의 학업성취에 영향을 미치는 중요한 요인 중 하나로 교사의 전문성이 보고되고 있으며, 교사의 전문성을 계발하기 위한 노력들이 요구되고 있다(정제영?이희숙?김수지, 2014). 특히 교사의 전문 성을 잘 보여주는 영역은 교사의 수업이라고 할 수 있다. 학생을 가르치는 것은 교사의 중 요한 업무이면서 교사에게 전문적인 자기 이해를 할 수 있도록 기회를 제공하기 때문이다 (손승남, 2005). 즉, 교사의 수업전문성은 교사에게 요구되는 전문성 중 가장 핵심적인 부분 이라고 할 수 있다(김찬종, 2009; 손승남, 2005).

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