농아에서의 측두골 전산화 단층촬영 소견과 다른검사 요인과의 연관성

조태환,이상흔,권대구,엄규상,성창섭,김용선,한기원 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

Temporal bone high resolution computed tomogram(TBHRCT)is a essential diagnostic tool in considering for cochlear implantation in patients with profound sensorineural hearing loss. This study was designed for an effort to provide and efficacy of TBHRCT in determination of inner ear malformations for the patients who have profound sensorineural hearing loss and to examine the relationships between TBHRCT findings and other preoperative evalutions for cochlear implantation in that patients. Authors examined 68 deaf patients to provide fundamental data for cochlear implantation. Inner ear abnormalities were founded in 13(19%) patients, among which 10(14.7%) patients had Mondini'dysplasia in which 5 patients were hypoplastic type and 5 patients were hydrops type. Other inner ear abnormalities were as follows : lateral semicircular canal hypoplasia ; internal auditory canal abnormality ; cochlear aqueduct widening ; vestibular aqueduct widening. No relationships were found between TBHRCT findings and other test results. : promontory test, K-WISC cognitive test etc.(Korean J Otolaryngol 39 : 8, 1996)

안와를 침범한 상악동 악성종양에서 안구 보존을 위한 내시경의 역할

조규섭,노환중 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

Background and Objectives: The periorbita has been regarded as the crucial structure in decision of orbital exenteration in the patients with paranasal malignancies. The mass beyond the thickened periorbita on T2-weighted images was considered to be a positive finding of orbital invasion. The purpose of this study is to evaluate the oncological safety of endoscopic removal of infiltrated tumor onto the periorbita but not transgress into orbital fat. Patients and Methods: Five patients of advanced maxillary cancer, showing bony orbital wall destruction and infiltration onto the periorbita but not transgress into orbital fat, underwent partial or total maxillectomy. Preoperative Cl and MRI were performed in all cases and compared with intraoperative findings. The successful dissection between tumors and periorbita using bipolar nasal coagulation forceps and tumor forcep was performed under endoscopy. Results: The mean age was 54.4 (41-74) years. All tumors of five patients originated from maxillary sinus and extended to involve multiple different subsites according to AJCC (2002, 6^(th) ed.) Histopathology included four squamous cell carcinomas and one adenoid cystic carcinoma. Follow-up ranged from 30 to 121 months (mean 53.6 months). All cases showed no local recurrence on the periobita after endoscopic removal. One patient had local recurrence in the pterygopalatine fossa and the other had in the neck. Conclusion: Endoscopic removal of infiltrated tumor onto the periorbita using microdebrider, bipolar nasal coagulation forceps and tumor forceps can be oncologically safe technique in advanced maxillary cancer infiltrated onto the periorbita but not invaded into orbital fat.

실험적 구루병에서 백서 치아조직 및 하악골의 무기질함량에 관한 연구

박규섭,조재오 대한구강생물학회 1988 International Journal of Oral Biology Vol.12 No.1

Richets is not the deposit of mineral in the skeletal tissue and is the retardation of skeletal growth in growing animals. In the skeletal disease such as rickets, vitamin D was known the most effective element. The purpose of this study was to investigate mineral changes induced by rachitogenic diet No. 2, which was high in calcium but low in phosphorus and deficient in vitamin D upon the dental structures and mandibular bone of rats. For this study, 48 albino rats were used and divided into two groups. While 24 rats of experimental group were maintained rachitogenic diet, 24 rats of control group were maintained normal diet for experimental period. For observation, animals were killed at 7 days intervals during the 42 days period and obtained specimen of teeth and mandibular bone. After both materials were powdered, Ca content determined by atomic absorption spectrophotometer (Shimadju Co, Flame Emission Spectrophotometer : AA-640-18) and P content determined by UV-spectrophotometer (Bausch and Lomb, Spectrophotometer 21) The results were as follows : 1. The Ca content in incisor of control group rose from 19.0% of dry weight in 7 days to 19.8% in 42 days while that of experimental group fell from 18.6% in 7 days to 17.8% in 42 days. 2. The P content in incisor of control group rose from 9.8% dry weight in 7 days to 10.7% in 42 days while that of experimental group fell from 9.6% in 7 days to 8.8% in 42 days. 3. The Ca content in molar of control group rose from 19.0% of dry weight in 7 days to 19.8% in 42 days while that of experimental group fell from 18.8% in 7 days to 18.3% in 42 days. 4. The P content in molar of control group rose from 10.0% dry weight in 7 days to 10.7% in 42 days while that of experimental group fell from 9.9% in 7 days to 9.4% in 42 days. 5. The Ca content in mandibular bone of control group rose from 14.2% of dry weight in 7 days to 15.0% in 42 days while that of experimental group fell from 14.0% in 7 days to 11.5% in 42 days. 6. The P content in mandibular bone of control group rose from 7.5% of dry weight in 7 days to 8.7% in 42 days while that of experimental group 7.4% in 7 days to 6.2% in 42 days.

포도상구균 초항원과 연관된 만성 비·부비동염의 병인에서 감마 인터페론 생산 T세포의 역할

김창수,조규섭,이현순,박희영,노환중 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

Background and Objectives: The etiology and pathogenesis of chronic rhinosinusitis (CRS) is multifactorial and the role of infectious agents in CRS is not clear. S. aureus is the most frequent cultured pathogen in CRS and it expresses toxin, SEA, SEB and TSST-l, with superantigen (SAG) activity. Recently an importnat role of these staphylococcal toxins in CRS with nasal polyposis (CRSwNP) has been suggested. CRSwNP is a severe chronic inflammation characterized by massive infiltration of lymphocytes and eosinophils in the sinonasal mucosa and nasal polyp. However, there has been no further studies evaluating the properties of infiltrating T lymphocytes in CRSwNP and the cytokine profiles in activated T-Iymphocyte relating with SAGs. The aims of this study was to know what kind of T lymphocytes infiltrates in nasal mucosa and polyp tissue of CRSwNP, to analyze the cytokine profiles in infiltrating T cells, and to determine whether infiltrating T lymphocytes are specific for SAGs. Patients and Methods: Ethmoid sinus mucosa and polyp tissue samples were collected from 13 patients with CRSwNP and control sinus mucosa were obtained from 10 patient without CRS. Tissue infiltrating cells and T cells were isolated from tissue samples and flow cytometry, enzyme-linked immunosorbent assay, reverse transcriptase-polymerase chain reaction, in vitro T lymphocyte stimulation with S. aureus toxin were performed. Results: The mean total CD3+ T cell count was significantly higher in the mucosa and polyp tissue of patients with CRSwNP compared with control mucosa. Most infiltrating T cells in mucosa and polyp tissue were activated type, expressing CD45RO. CD8+ T cells were significantly increased in mucosa and polyp tissue of patients with CRSwNP compared with CD4+ cells IFN-γ was highly expressed in infiltrating T cells in both mucosa and polyp tissue, whereas IL-10 was expressed a small amount and IL-4 was not expressed. IFN-γ levels were significantly higher than IL-4 and IL-10 when isolated T cells were stimulated with SAGs in vitro. Conclusion: CD8+ T-cytotoxic and IFN-γ producing Th1 cells could paly an important role in the CRSwNP if sinonasal chronic inflammation is induced by SAGs.

소양호 부영양학의 연변화 추이

김범철,조규송,허우명,김동섭 江原大學校 附設 環境硏究所 1989 環境硏究 Vol.6 No.-

The trend of trophic status change in Lake Soyang from 1981 to 1989 was studied by the measurement of chlorophyll a concentration, transparaency, total phosphorus concentration, and the rate of hypolimnetic oxygen deficit rate. And the phosphorus loading from the watershed was measured monthly at the main inflowing river, Soyan River. The increasing trend of chlorophyll was clear at the rate of 0.4 /￡㎍/l/yr. The advent and expansion of Anabaena bloom was the major cause of chlorophyll, increase and transparency reduction. The rate of hypolimnetic oxygen deficit also increased from 0.032 mg Ο_(2)/cm^(2)/day in 1986 to 0066 in 1988. The trophic state of Lake Soyang can be assessed as oligotrophy before 1983, mesotrophy from 1984 to 1988, and eutrophy since 1989. Phosphorus loading from floating net fishfarms was estimated to be larger than 45% of total. The phosphorus loading from only watershed is smaller than the dangerous critical loading, but, if the fishfarms loading added, it exceeds the critical loading.

내시경부비동수술후 비음형대, 스펙트럼 및 비·부비동의 용적변화의 분석

김창수,공수근,이현순,조규섭,왕수건,노환중 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.11

플레이트를 이용한 냉간성형 각형강관 T형 접합부에 관한 실험적 연구

석희원,박금성,정상민,조성식,배규웅,문태섭 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

The purpose of this paper is to investigate experimentally the strength and deformation of T-joints to evaluate the structural behavior of truss connection consisted in square hollow steel section with plate. There are the branch plate type in T-joint shapes. Principal parameters are the ratio of the chord width to thickness(2ν=31.3, 22.2, 16.7) and the ratio of branch plate thickness to chord width(βp=0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.75, 0.85). The most important result obtained from this experiment is as follows; The ultimate strength of T-joints increase proportionally as the 2ν ratio decrease, and the βp ratio increase. The others, experimental results are summarized for ultimate strength to displacement, initial stiffness and failure mode of each T-joints.

Differential Diagnosis of Primary Nasopharyngeal Lymphoma and Nasopharyngeal Carcinoma Focusing on CT, MRI, and PET/CT

Cho, Kyu-Sup,Kang, Dae-Woon,Kim, Hak-Jin,Lee, Jong-Kil,Roh, Hwan-Jung SAGE Publications 2012 Otolaryngology-head and neck surgery Vol.146 No.4

<P>No study has done a comparative analysis of radiologic imaging findings between primary nasopharyngeal lymphoma (PNL) and nasopharyngeal carcinoma (NPC). The purpose of this study was to analyze computed tomography (CT) and magnetic resonance (MR) images and to evaluate the maximum standardized uptake value (SUV max) of positron emission tomography (PET)/CT between PNL and NPC, knowing the imaging features that distinguish PNL from NPC.</P>

IFATS Collection: Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells in an Allergic Rhinitis Mouse Model

Cho, Kyu-Sup,Park, Hye-Kyung,Park, Hee-Young,Jung, Jin Sup,Jeon, Seong-Gyu,Kim, Yoon-Keun,Roh, Hwan Jung Wiley (John WileySons) 2009 Stem Cells Vol.27 No.1

<P>Adipose tissue-derived stem cells (ASCs) exhibit immunosuppressive effects in allogeneic transplantation. However, there is no report that evaluates the in vivo immune-modulating effect of ASCs in an experimental allergic rhinitis (AR) model. We investigated whether ASCs migrate to the nasal mucosa in an AR mouse model and evaluated the immune-modulating effect of ASCs in the AR mouse model. Cultured ASCs (2 x 10(6)) were injected i.v. before the first allergen challenge in the AR mouse model. Migration of ASCs to the nasal mucosa was evaluated by immunofluorescence. The immunomodulatory effects of ASCs were evaluated by nasal symptoms, histology, serum ovalbumin (OVA)-specific antibody, and the cytokine profile of the spleen. ASCs migrated to the nasal mucosa in the AR mouse model. ASCs significantly reduced allergic symptoms and inhibited eosinophilic inflammation in the nasal mucosa. ASCs significantly decreased the serum allergen-specific IgE level and the IgG(1)/IgG(2a) ratio and significantly increased the IgG(2a) level in the AR mouse model. ASCs inhibited interleukin (IL)-4 and IL-5 production from OVA-incubated splenocytes, but enhanced interferon-gamma production. In conclusion, ASCs can migrate to the nasal mucosa in the AR mouse model and inhibit eosinophilic inflammation partly via shifting to a T-helper 1 (Th1) from a Th2 immune response to allergens.</P>

한국의 발톱진균증 환자의 삶의 질에 관한 연구

조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]