High-sensitivity C-reactive Protein Can Predict Major Adverse Cardiovascular Events in Korean Patients with Type 2 Diabetes

이상흔,김인태,박형복,현유경,김윤지,송선옥,김형진,성주헌 대한의학회 2011 Journal of Korean medical science Vol.26 No.10

Inflammation is thought to play a role in the pathogenesis of major adverse cardiovascular events (MACE). It has been suggested that the measurement of markers of inflammation may aid in predicting the risk of such events. Here, the relationship between highsensitivity C-reactive protein (hs-CRP) levels and MACE in Korean patients with type 2diabetes is assessed. A retrospective cohort study was conducted as a follow-up among 1,558 patients with type 2 diabetes and without cardiovascular diseases over a mean period of 55.5 months. A Cox proportional-hazards model was used to determine whether increased hs-CRP levels are useful as a predictor for future MACE. The hazard ratio of MACE was 1.77 (95% CI; 1.16-2.71) in subjects who had the highest hs-CRP levels ( > 0.21 mg/dL) compared to subjects who had the lowest hs-CRP levels ( < 0.08 mg/dL),after adjusting for age, regular physical activity, current smoking, and duration of diabetes. The present results indicate that high hs-CRP levels can act as a predictor for the MACE occurrence in Korean patients with type 2 diabetes.

초고출력 안테나 시스템 급전용 다중 모드 혼 안테나 설계에 관한 연구

이상흔,윤영중,이병무,소준호,Lee Sang-Heun,Yoon Young-Joong,Lee Byoung-Moo,So Joon-Ho 한국전자파학회 2006 한국전자파학회논문지 Vol.17 No.5

In this paper, a multimode feed horn antenna is suggested for a high power microwave(HPM) antenna system. The proposed HPM feed horn antenna which is connected with a mode converter is located between source and reflector antenna. A multimode feed horn antenna which has reduced -25 dB beamwidth is designed and fabricated for miniaturization of reflector antenna because -25 dB beamwidth which is determined by considering spillover of feed horn antenna decides a size of reflector in case of HPM. As a result, feed system which uses the multimode feed horn antenna has high gain about 27 dBi and return loss is less than -22 dB at 10 GHz. The measured -25 dB beamwidths of the radiation pattern at vertical, horizontal-plane equal to $20.24^{\circ},\;28.92^{\circ}$ which is less than about $10^{\circ}$ beamwidth of conventional feed system. Thus the suggested feed hem antenna is suitable to feed horn for miniaturization of HPM antenna system. 본 논문에서는 초고출력 안테나 시스템의 급전용 다중 모드 혼 안테나를 제안한다. 제안된 초고출력용 급전 혼 안테나는 모드 변환기와 연결되며, 전원부와 반사판 안테나의 사이에 위치한다. 초고출력 시스템의 경우 급전 안테나의 spillover를 고려한 -25 dB 빔 폭이 반사판 안테나의 크기를 결정하므로 반사판 안테나의 소형화를 위해 -25 dB 빔 폭을 줄인 급전용 다중 모드 혼 안테나를 설계 및 제작하였다. 그 결과 제안된 다중 모드 혼 안테나를 이용한 급전 시스템의 이득은 27 dBi이며 반사 손실은 10 GHz에서 -22 dB 이하의 값이 측정되었다. 또한 -25 dB 범 폭은 수직 평면과 수평 평면에서 각각 $20.24^{\circ}$와 $28.92^{\circ}$로 측정되었고 이는 기존의 혼 안테나를 이용한 급전 시스템의 빔 폭보다 약 $10^{\circ}$가량 작은 값으로, 제안된 혼 안테나는 초고출력 안테나 시스템 소형화에 적합한 형태임을 확인하였다.

Child-Pugh Score Is an Independent Risk Factor for Immediate Bleeding after Colonoscopic Polypectomy in Liver Cirrhosis

이상흔,홍성필,박수정,천재희,김태일,김원호,강대룡 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.5

Purpose: Post-polypectomy bleeding is the most common colonoscopic polypectomycomplication. However, the risk of post-polypectomy bleeding in liver cirrhosisis unknown. We aimed to evaluate the risk of post-polypectomy bleeding in patients with liver cirrhosis. Materials and Methods: We included 89 patients with liver cirrhosis who received colonoscopic polypectomy between January 2006 and October 2012. Three hundred forty-eight subjects without liver disease who underwent colonoscopic polypectomy comprised the control group. Risks of post-polypectomy bleeding were analyzed according to patient- and polyp-related factors. Results: Among 89 patients, 75 (84.3%) were Child-Pugh class A, 10 (11.2%) were class B, and 4 (4.5%) were class C. Incidence of immediate post-polypectomy bleeding was significantly increased in cirrhosis with Child-Pugh class B or C compared to liver cirrhosis with Child-Pugh class A or control group [hazard ratio (HR) 3.5; p<0.001]. Polyp size (HR 3.6; p=0.032) and pedunculated polyps (HR 2.4; p=0.022) were also significant risk factors for immediate post-polypectomy bleeding in multivariate analysis. Conclusion: Cirrhotic patients with Child-Pugh class B or C have a high risk of immediate post-polypectomy bleeding. Thus, endoscopists should be cautious about performing colonoscopic polypectomy in patients with Child-Pugh class B or C.

선천성 고도 난청에서 Connexin 26의 유전자 변이의 형태분석

이상흔,이정래,이지은,김태정,강봉석 대한청각학회 2001 Journal of Audiology & Otology Vol.5 No.2

원발성 비루관 폐쇄환자에서 누낭의 병리학적 소견

이상흔,유혜린,심정연 대한안과학회 2004 대한안과학회지 Vol.45 No.2

목적 : 원발성 비루관 폐쇄 환자에서 다양한 임상적 특징과 누낭점막의 병리학적 소견과의 관계를 알아보고자 하였다. 대상과 방법 : 경피적 누낭비강문합술을 시행한 21명 23안의 의무기록을 후향적으로 분석하였고 비루관 폐쇄의 양상과 위치를 누낭조영술 결과에 따라 분류하고, 누낭의 특징적 병리소견 4가지 항목(염증, 섬유화, 술잔세포, 상피화생)의 정도를 점수화하였으며 다양한 임상적 특성과 병리학적 소견과의 상관관계를 조사하였다. 결과 : 누낭의 염증, 술잔세포, 상피화생의 정도는 인구학적 특성이나 임상적 특성과 통계학적으로 유의한 차이가 없었다(P>0.05). 누낭조영술상 완전폐쇄일 때 섬유화 점수가(1.95±0.62) 부분폐쇄일 때(1.00±0.82) 보다 유의하게 증가되어 있었다(p=0.015). 폐쇄위치가 누낭인 경우 섬유화 점수가(2.20±0.63) 총누소관의 경우와(1.57±0.53) 비루관의 경우(1.33±0.82)보다 유의 하게 증가되어 있었다(p=0.041). 섬유화와 환자의 성별, 나이, 유병기간, 누석유무와 병리소견 사이에 통계학적으로 유의한 차이는 없었다(P>0.05). 결론 : 누낭의 섬유화는 비루관 폐쇄의 주요한 병리 소견이며 특히 누낭 폐쇄 환자에서 특징적 이었다. 향후 비루관 폐쇄의 병태생리를 알기 위해 비루관에 대한 연구와 초기 비루관 폐쇄 환자에 대한 연구가 필요 할 것이다. Purpose: The purpose of this study is to find out the relationship between clinical characteristics and pathologic findings of lacrimal sac in patients of primary acquired nasolacrimal duct obstruction. Methods: This study reviewed medical records of 23 eyes of 21 patients who were received external dacryocystorhinostomy, and analyzed patients according to the obstruction patterns and locations on dacryocystography. The relationship between the pathologic degrees of lacrimal sac (inflammation, fibrosis, presence of goblet cells and squamous metaplasia) and clinical characteristics of the patients, was also evaluated. Results: There were no significant relation between the pathologic degrees of lacrimal sac and clinical characteristics. From dacryocystography, the degree of fibrosis was 1.95±0.62 in complete obstruction, which was significantly higher than 1.00±0.82 in partial obstruction (p=0.015). In addition, the degree of fibrosis (2.20±0.63) was different depending on the location of the obstruction. In common canaliculus-obstruction group, it was 1.57±0.53 and in the nasolacrimal duct-obstruction group, it was 1.33±0.82 (p=0.041). However, there was no significant statistical difference between the patient's demographics and pathologic findings of lacrimal sac. Conclusions: The fibrosis of lacrimal sac mucosa is a major pathological finding of nasolacrimal duct obstruction and in particular, it is the characteristic of patients with lacrimal sac obstruction.

다중 모드 간섭 현상을 이용한 변형도 측정 실험

이상흔,한영근 한국통신학회 2009 한국통신학회 기타 간행물 Vol.2009 No.12

안검에 발생한 원발성 피부 세포표면항원무리 30 양성 림프구증식 질환1예

이상흔,유혜린,심정연.Sang-Hun Lee. M.D.. Helen Lew. M.D.. Jeong-Yun Shim. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.7

Purpose: To report one case of lymphoproliferative disorder on the upper eyelid. Methods: Primary CD30+ lymphoproliferative disorder on the skin is very rare. A 31-year-old female patient visited our clinic complaining of red, erosive papules on the right upper eyelid and on the left flank for two weeks. A 2.0 cm erythematous papule showed central ulceration. A 1.5 cm lymph node enlargement was palpated on the left groin. There was no abnormal finding on the slit-lamp test. Computed tomography showed a subcutaneous nodule on the anterolateral aspect of the flank and a lymph node enlargement on the left inguinal area. There was no evidence of other visceral involvement. Histopathologic finding showed diffuse infiltration of atypical cells with lobated nuclei showing multifocal positivity to CD30; a finding consistent with primary cutaneous CD30+ T-cell lymphoproliferative disorder and borderline lesion. Results: This case seems to be a borderline case between CD30+ T-cell large cell lymphoma and lymphoid papulodesis. We are conducting conservative care and observing the progress on the skin lesion for further evaluation.

지방족 폴리에스터 / 글루텐 블랜드의 몰폴로지와 물성연구

이상흔,정인권,이광희 한국고분자학회 1996 한국고분자학회 학술대회 연구논문 초록집 Vol.1996 No.10

갑상샘눈병증 환자에서 보툴리눔독소를 이용한 위눈꺼풀뒤당김 치료의 결과

이상흔,유혜린,윤영수,Sang Hun Lee,Helen Lew,Young Soo Yun 대한안과학회 2006 대한안과학회지 Vol.47 No.8

Purpose: This study is to determine the effects of botulinum toxin injection on patients who suffer from upper eyelid retraction caused by thyroid ophthalmopathy. Methods: We injected 10-15 units botulinum toxin (Botox?, Allergan, USA) on the upper tarsus of 12 eyes of 12 thyroid ophthalmopathy patients and compared duration of disease, clinical activity scores (CAS), intraocular pressures (mmHg), exophthalmometry (mm), upper eyelid retraction (mm), marginal reflex distance1 (MRD1, mm), levator function test (mm), lid lag (mm), limitation of ocular movement (mm), lid tension test results, phenylephrine test results, and orbital computed tomography results before and after the injection. Results: The patient group with smaller-sized cross section of superior rectus/levator complex before the injection showed a greater decrease of upper eyelid retraction after the injection (p=0.04). Other clinical parameters showed no significant relations on the effect of the toxin injection. Conclusions: Botulinum toxin injection can have variable effects on the upper eyelid retraction of thyroid ophthalmopathy patients. The patients who had smaller volume of superior rectus/levator complex measured in orbital cross sections on CT, could expect good results after botulinum toxin injection.

간헐외사시 환자에서 사시의 자연 퇴행

이상흔,유혜린,윤영수 대한안과학회 2006 대한안과학회지 Vol.47 No.8

Purpose: To compare the characteristics of the intermittent exotropia patients with spontaneous regression to the surgically corrected group. Methods: Twenty-five patients who had exodeviation of around 25 prism diopters (PD). Visual acuity and best corrected visual acuity were measured. The latter was obtained by using cycloplegic refraction. Far and near deviation angles were measured through alternating prism cover test. Stereo acuity was measured using a Titmus stereo acuity test chart and occlusion was performed for those who had more than 2 lines of difference between the best corrected visual acuity of the left and right eyes on the Snellen E chart. We divided the patients into two groups. The first group is the spontaneous regression group (SRG), who showed declining deviation angles and maintained less than 10 PD for more than 3 months. The second group is the surgically corrected group (SCG), showed the same or increasing deviation angle and underwent operation. Results: There was no difference in the age or observation period between the two groups. The prevalence period was significantly higher in the SRG than in the SCG. The deviation angle from a distance at the first visit was not different for the SCG from that of the SRG. However, the deviation angle at near was significantly larger for the SCG than that of the SRG and increased at the last examination. Stereo acuity of the SRG was better than that of the SCG at the first visit. Conclusions: Deviation angle could be reduced in the mild intermittent exotropia patients with relatively small deviation angle at near or with good stereo acuity.