농아에서의 측두골 전산화 단층촬영 소견과 다른검사 요인과의 연관성

권대구,엄규상,한기원,이상흔,조태환,성창섭,김용선 대한이비인후과학회 1996 대한이비인후과학회지 두경부외과학 Vol.39 No.8

표면 근전도 센서 기반 Ptosis 진단 시스템 및 알고리즘 개발

권미성(Mi Sung Kwon),이종하(Jong-Ha Lee),손대구(Dae Gu Son),김아람(A Ram Kim) 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.6

If the lifting power of eyelid from the levator palpebrae muscle becomes weak, eyelid is drooped and the edge of eyelid cannot be lifted on normal level. This phenomenon is called the ‘Ptosis’. If the person has the ptosis, they use the forehead muscle when the eyes open. In this research, the frontalis EMG was measured for the gaze angle. People with the ptosis was confirmed for the use frontalis muscle more than normal people. Therefore, we propose a system to quantify the presence the ptosis as EMG levels of frontalis muscle.

표준화된 화상 모델에서 화상 후 첫 24시간 내의 화상 깊이의 변화

손대구,최태현,권선영 대한성형외과학회 2008 Archives of Plastic Surgery Vol.35 No.4

Purpose: In full thickness burn, the depth of burn is known to increase until around 1-3 days after the burn. However, no study on how the depth increase during the first 24 hours has been conducted. Therefore, the authors investigated how the depth of burn changes within the first 24 hours after the burn by using the standardized burn model. Received April 8, 2008 Revised May 6, 2008 Accepted May 22, 2008 Address Correspondence: Dae Gu Son, M.D., Department of Plastic and Reconstructive Surgery, Keimyung University, Dongsan Medical Center, 194 Dongsan-dong, Jung-gu, Daegu 700-712, Korea. Tel: 053)250-7636/Fax: 053)255- 0632/E-mail: handson@dsmc.or.kr * 본 연구는 2005년도 계명대학교 삼성안과 연구비로 이루어졌음. * 본 논문은 2007년 제 63차 대한성형외과학회 학술대회에서 포스터 발표되었음. Methods: A total of four experiments on pigs were carried out for this study. Experiment 1 was performed to examine how temperature affects the depth of burn. The digitally controlled aluminum thermal block was set at different temperatures-80, 90 and 100 degrees in Celsius, respectively. Then the pig was exposed to the block for 15 seconds each time. The time exposed to heat was set as a variable for the Experiment 2. The temperature was maintained at 80 degrees Celsius, and the pig was contacted with the thermal block for 5, 10 and 20 seconds, respectively. The biopsy of the tissues were performed in one hour, 6 hours, 24 hours, and 7 days after the burn. After hematoxylin and eosin staining a percentage of the depth from a basement membrane of epidermis to the deepest tissue damaged by the burn against total dermal thickness was measured. Results: In Experiment 1, the depth of burn increased considerably as time passed by. At all three temperatures, differences in depths measured in 6 and 24 hours, and in 1 hour and 7 days were both significant. In addition, the depth deepened as the temperature went higher. In the case of Experiment 2, the depth of burn also increased significantly as time passed by. At all three times, differences in depth measured in 6 and 24 hours, and in 1 hour and 7 days were also significant. Moreover, the depth extended with longer contact time when it was compared according to the time. Conclusion: Full thickness burn progressed rapidly from 6 to 24 hours after the burn and the depth of burn was almost decided within the first 24 hours after the burn. On the other hand, partial thickness burn also advanced from 6 to 24 hours after the burn but the depth deepened at slower level.

돼지모델에서 상처의 모양과 부위에 따른 상처수축의 특성

추호준,손대구,권선영,김준형,한기환 대한성형외과학회 2011 Archives of Plastic Surgery Vol.38 No.5

Purpose: The shape and location, the amount of the wound and the characteristics of the remaining tissues are known to influence wound contraction. The previous studies using small animals have not been an appropriate model because the wound healing mechanisms and skin structures are different from those of the human. The purpose of this study is to evaluate wound contraction according to the shape and location of the wound using a Micropig . Methods: Four Micropigs (Medikinetics, Pyeongtaek, Korea) that were 10 months of age weighed 25 kg were used. Full thickness skin defects were made by clearing all the tissues above the fascial layer in the shape of square, a regular triangle and a circle of 9 cm2 each on the back around the spine. Eight wounds were created on the back of each pig, 50 mm apart from each other. The randomly chosen wound shapes included 11 squares, 11 regular triangles, and 10 circles. Wound dressing was done every other day with polyurethane foam. The wound size was measured using a Visitrak Digital (Smith & Nephew, Hull, UK) on every other day after surgery from day 2 to day 28. A biopsy was performed on day 3, and 1, 2, 3 and 4 weeks to investigate the degree of acute and chronic inflammation, the number of microvesssel and myofibroblast density using H & E stain and immunohistochemistry. The wound contraction rate was calculated to figure out the differences among each of the shapes and the locations. Results: The ultimate shape of the circle wound was oval, and that of the regular triangle and square were stellate. The maximum contraction rate was obtained on 8 to 10 days for all the shapes, which corresponds with the immunohistochemical finding that myofibroblast increases in the earlier 2 weeks whereas it decreases in the later 2 weeks. Epithelialization was seen in the wound margin on day 7 and afterwards. The final wound contraction rates were highest for the regular triangle shapes; however, there were no statistically significant differences. The wound contraction rates by locations showed statistically significant differences. The wound in the cephalic area presented more contractions than that of the wounds in the caudal area. Conclusion: The location of a wound is more important factor than the wound shape in wound contraction.

돼지를 이용한 만성피부결손상처의 모델

손형빈,손대구,김준형,한기환,류남희,권선영 대한성형외과학회 2006 Archives of Plastic Surgery Vol.33 No.5

Purpose: Animal models of a chronic wound are yet to be fully developed, and animal studies on this subject has yet to take place. The purpose of this study is to create the foundation for research on chronic wound healing based on a swine model, the most similar to that of a human. Methods: Three female 2-3 month old 'yolkshires' were used. Total of eight full thickness skin defects, 6 × 3 cm sized, were created on the back of each pigs. Three groups were created for comparison; Group I (n=4) was left as they were after full skin thickness excision, while the excised tissues of Group II (n=3) were turned inside out and sutured so that the epidermis would come in contact with the fascia. Group III (n=3) were excised full skin thickness in depth and silicone blocks were implanted in them. Dressing was not practised so that the wounds would be vulnerable to infection. Results: In Group III, the skin contraction rate was the least among the three groups for each three weeks of observation respectively. Also during the three weeks, bacteral colonization was at the highest among the comparison. On the third week, inflammatory cells were still active, but the generations of epidermis and collagen synthesis were detected minimally.Conclusion: The Group III was relatively the most similar model of chronic wounds. and modification of the silicone blocks, could provide us with a very effective chronic skin wound model similar to human.

Apocrine Carcinoma of the Axilla Associated with Extramammary Paget’s Disease: A Case Report and Review of the Literature

정혜라,권선영,손대구 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.6

외음부에 발생한 원발성 피부 선상 낭종성 암의 치험례

정회준,손대구,권선영 대한성형외과학회 2008 Archives of Plastic Surgery Vol.35 No.3

Purpose: Adenoid cystic carcinoma is a rare type of eccrine sweat gland carcinoma. Although it is mostly known as a neoplasm of the salivary gland, it could occur as a primary skin tumor. We present a patient with a primary cutaneous adenoid cystic carcinoma at the genital area.Methods: A 60-year-old man had a slowly growing 1 cm sized single tender mass near the left scrotum and he underwent excisional biopsy at a local clinic. A diagnosis of adenoid cystic carcinoma was made and thus he was transferred to our hospital. In physical examination, other specific findings were not detected except a linear scar caused by a previous skin biopsy near the left scrotum. In CT scan, PET-CT scan and endoscopy, there was no evidence of neoplasm in other organs. It was diagnosed as the primary cutaneous adenoid cystic carcinoma and then wide excisions were performed including total 4.5cm margin of normal skin.Results: Microscopic findings revealed proliferation of tumor cell islands with cribriform or tubular patterns containing several round, pseudocystic structures. The tumor cells showed basaloid cells with uniform and small nuclei. Tumor cells infiltrated into the dermis and upper portion of subcutaneous tissue. There was multifocal perineural invasion of tumor cells. In postoperative 6 months, we found no recurrence and other complications.Conclusion: Herein we found a rare case of primary cutaneous adenoid cystic carcinoma at the genital area.

Vessel Remodeling after Intima-to-Intima Contact Anastomosis

여현정,김효동,손대구,홍창배,권선영 대한성형외과학회 2017 Archives of Plastic Surgery Vol.44 No.2

Background Intima-to-intima microanastomotic vascular remodeling was explored, utilizing a polylactide-caprolactone absorbable vein coupler model (PAVCM), which was designed to simulate a non-absorbable counterpart system with the sole exception of being absorbable. Methods Six New Zealand white rabbits were used. After transection of the jugular vein, 2 PAVCMs were placed, 1 at each transected end. The stumps were slipped through the PAVCMs, and the venous wall was everted 90° to achieve intima-to-intima contact. Reanastomosis of the transected jugular vein was performed bilaterally in 3 rabbits. In the other 3 rabbits, the jugular vein (20 mm) harvested from one side was interpositionally grafted to the jugular vein on the opposite side to ease the anastomotic tension. Patency testing, ultrasonography, and histologic assessments were conducted postoperatively at weeks 2, 4, 12, 16, 22, and 26. Results All anastomotic sites were patent, without stenosis, occlusion, or dilatation. In the histologic sections, immature endothelial regeneration was observed at week 2, which was completed by week 4. Regeneration of the tunica media was noted at week 12. Between week 22 and week 26, the tunica media fully regenerated and the coupler dissipated entirely. Conclusions Despite the absence of a coupler to act as an anastomotic buttress, the structure and function of all the vessels appeared normal, even histologically. These outcomes are true milestones in the development of an absorbable vein coupler.

공음성 난청에서의 순음청력역치와 DPOAE의 연관성

엄규상,조경제,권대구,이상흔,성창섭 대한이비인후과학회 1995 대한이비인후과학회지 두경부외과학 Vol.38 No.12

농아에서의 측두골 전산화 단층촬영 소견과 다른검사 요인과의 연관성

조태환,이상흔,권대구,엄규상,성창섭,김용선,한기원 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

Temporal bone high resolution computed tomogram(TBHRCT)is a essential diagnostic tool in considering for cochlear implantation in patients with profound sensorineural hearing loss. This study was designed for an effort to provide and efficacy of TBHRCT in determination of inner ear malformations for the patients who have profound sensorineural hearing loss and to examine the relationships between TBHRCT findings and other preoperative evalutions for cochlear implantation in that patients. Authors examined 68 deaf patients to provide fundamental data for cochlear implantation. Inner ear abnormalities were founded in 13(19%) patients, among which 10(14.7%) patients had Mondini'dysplasia in which 5 patients were hypoplastic type and 5 patients were hydrops type. Other inner ear abnormalities were as follows : lateral semicircular canal hypoplasia ; internal auditory canal abnormality ; cochlear aqueduct widening ; vestibular aqueduct widening. No relationships were found between TBHRCT findings and other test results. : promontory test, K-WISC cognitive test etc.(Korean J Otolaryngol 39 : 8, 1996)