유치거리 분석을 통한 도시공원의 적정배치에 관한 연구

류연수,나정화,도후조 慶北大學校農業科學技術硏究所 2002 慶北大農學誌 Vol.20 No.-

The purpose of this study is to analysis of disposition distance of city park for the plan of suitable arrangement of city park based on the date examining Daegu Metropolitan City. The results of this study are as follows. 1) The result of analysis of population density as the case of districts, it appeared highly in city center area which Seo-Gu district and Nam-Gu district besides Jung-Gu district. However, it apperared in a low Buk-Gu district, Dong-Gu district and Salseong-Gun. 2) The result of analysis of population density as the case of regions, it appeared very highly Joukjun-Dong of Dalseo-Gu district(31,554per/㎢), Naedang-Dong of Seo-Gu district(29,922per/㎢). However it appeared in a low YeugaoMaen(85per/㎢) and Gachang-Maen(94per/㎢) of Dalseong-Gun. The regions where the population density is high have very low green space and live a lot of low income layer. 3) The result of analysis of disposition distance, in the case of children park, it appeared an intensive distribution in Dongcheon-Dong and Guam-Dong of Buk-Gu district, Whanggm-Dong and Dusan-Dong of Suseong-Gu district, Sangin-Dong and Yeongasn-Dong and Walsung-Dong of Dalseo-Gu district. however, it appeared in a low in Jung-Gu district. The case of urban park of the neighboring area, it appeared the most in Dalseo-Gu district except 2 parks in Jung-Gu district, the case of urban park of the walking area, it apperared in equality in city. 4) In conclusion, the area have population density and lots of low income layer, is in out of disposition distance should be considered in first for city park plan.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

아미노산 투여가 중장거리 운동선수의 최대 및 최대하운동시 젖산생성에 미치는 영향

이정수,윤탁영,김문희,이선장,김완조 韓國體育大學校附屬 體育科學硏究所 1992 韓國體育大學校附屬 體育科學硏究所論文集 Vol.11 No.1

The Purpose of the Study was to determine whether the glutamate ingestion prior to exercise would reduce the lactat formation and its clearance in exercising mscle tisue during Submaximal and maximal execise. Six elite distance rummers particapated in this study. The Subjects had a half dose of glutamale(15.6mg .Kg?? ??) at 45min and ingested rest dose at prior to exerise. The test Performed twice. One was Performed in the track and the other was in the Lab. Blood Smples were obtained from catheter which was placed in the antecubital vein (Lab test) and finger tip Samples (Feld test) Unaltered blood lactate was observed in both trials, but, tended to less lactate concentration with glutamate ingestion than that of without glutamate ingestion. The recovery rate of blood lactate was markely rapid with glutamate ingestion in the field test. Unchanged in heart rate was founded in both trials. It many Suggest that, the additional supplement st of glutamate can improve execise performance limiting lactate formation or induce its rapid clearance from the muscle fissue.

혈관중심성 T세포/자연살상세포 림프종의 임상적 고찰

이정찬,박수진,박상은,곽승근,신현영,김성은,이정호,윤환중,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Although the Working Formulation is commonly used to classify NHL in Korea, it has been recognized as imperfect for primary extranodal lymphoma, expecially for patients with nasal, paranasal disease because of their histological characteristics. Angiocentric T/NK cell lymphoma remains rare clinical presentation in North America and Europe but is more common in Asia and Latin America. The optimal mode of treatment has also not been decided on, probably because of their rarity and limited understanding of its natural course. The aim of this study was to analyze our experience with 14 patients with angiocentric lymphoma seen at the Chungnam Natioanl University Hospital over the last 5 years. We reviewed the records of 14 patients who were treated at the Chungnam National University Hospital between January, 1996 and December, 2000. The angiocentric T/NK cell lymphoma accounted for about 8.2% of NHL. The median age was 52.5 (range 36-71) years. Sex ratio was equal. According to the Ann Arbor staging system, disease was classified as stage Ⅰin 3 patients, stage Ⅱ in 8 patients and stage Ⅳ in 3 patients. Systemic B symptoms were present in only four patients in only four patients. All patients has extranodal involvement. The most frequently involved extranodal sites were nasal cavity followed by paranasal sinuses and orpharynx. The most common presenting symptoms were nasal obstruction with purupent rhinorrhea followed by dysphagia. According to the International prognostic index (IPI), most patients was in low-risk group (11 patients). Nine patients responded completely. Seven patients were received combination chemotherapy and 2 patients had radiation therapy as a initial treatment. Five patients were relapsed. After a median follow-up of 660.5 days, the overall survival and disease-free survival rates at 3 years was 56.8% and 42.9% respectively. The median survival time was not yet reached. The median overall survival time was 1338.5 (range 1212-1564) days for non-relapsed and 733.4 (range 302-1008) days for relapsed patients. The median time from CR to relapse was 100.5 (range, 39-159) days. There were limitations to know enough about the characteristics of angiocentric T/NK cell lymphoma because of a small number of patients. In the future, multicenter trials will be neccesary to identify clinical characteristics, optimal treatment mordalities and their responses, and prognostic factors.

人工湖를 利用한 淡水魚類(Blugill sunfish-Lepomis macrochirus macrochirus Rafiusesque)의 養殖에 關한 硏究

孫賢秀,曺鍾澤,韓熙世,裵泰雄 東亞大學校 1972 東亞論叢 Vol.9 No.-

本試驗은 九德貯水池의 環境要因 調査와 Blue gill sunfish의 粗放的 養殖試驗과 新農藥이 淡水魚類에 미치는 영향등을 調査하였던 바 얻어진 結果를 要約하면 다음과 같다. 試驗Ⅰ. 九德 貯水池의 環境要因 調査 1. 營養鹽과 水溫, pH, 透明度 等을 調査하여 試驗池의 生産力에 對하여 究明하였다. 2. 調査期間동안 水溫은 13.0℃∼27.0℃ 였으며 透明度는 40cm∼130cm, pH는 6.8∼8.0 溶存酸素 5.4cc/l∼7.9cc/l를 나타냈다. 3. 營養鹽에 있어서는 全窒素量과 全憐酸鹽은 plankton 生産에 充分한 量이 溶存되어 있으며 腐食性 營養湖에 해당되었다. 특히 규산염은 댜른 湖沼에 比해 대단히 높은 量的分布를 보였다. 4. phyto plankton은 17種이 出現하였으며 Ulthrix, Fragilaria, Desmipseud, Pediastrum 等이 量的 우세를 보였다. 5. Zooplankton은 Crustacea 幼生을 除外하고 15種이 出現하였으며, Cyclops Branchionus, Daphnia Eudiaptomus 等이 우세하였다. 試驗Ⅱ Blue gill sunfish의 粗放的 養殖試驗 1. Blue gill sunfish의 調査期間동안 增重量은 平均 7.64g 이었으며 잉어는 18.8g의 增重量을 나타냈다. 2. Blue gill의全長 및 體高의 比는 1 : 2.6∼2.8로써 餌料를 준 試料를 준 試驗과의 差異는 없었다. 3. 粗放的 養殖試驗의 結果 Blue gill sunfish는 二年魚가 飼育試驗한 1年魚의 約1/2에 가까운 增重量을나타내어 天然餌料만으로 飼育試驗으로는 좋은 結果를 보였다. 試驗Ⅲ 毒性調査 1. Blue gill sunfish와 잉어 稚魚에 대한 新農藥의 영향을 조사하여, 供試魚種間이 感受性의 差異에 대하여 比較檢討하였다. 2. Blue gill sunfish가 잉어에 비하여 感受性이 높은 農藥은 Diazinon乳劑, Birlane乳劑, Saturn-S粒劑등이 였고. 3. 잉어가 Blue gill sunifish보다 높은 感受性을 나타낸 것은 Kasugamin乳劑, Blasticidine-S乳劑, Sevin 水和劑, Kitazin乳劑, Lasso乳劑등이였다. 4. Blue gill sunfish의 養殖上 극히 注意를 要하는 毒性이 강한 農藥과 48時間後의 TLm値를 보면 Diazinon乳劑…0.08ppm, EPN乳劑-0.9ppm, Birlane乳劑…0.005ppm, Saturn-S粒劑…0.5ppm였다. The following are some results obtained from a series of research environmental factors and experiments in Blue gill sunfish culture, and effect of the new agricultural pesticides on fresh water fishes. Experiment Ⅰ. Research of environmental factors in Ku Dork Reservoir The work has been done as one of the basic study to productivity of Ku Doek Reservoir in Busan. The range of the water temperature was 13.0℃∼27.0℃ and maximum temperature was shown in late August. The values of the disolved oxygen were 5.4cc/l∼7.9cc/l and pH range was 6.8∼8.0, and the range of transparency was 40cm∼130cm. Total amounts of nitrogen ion and phosphorus ion were very abundant, moreover Sio?-Si amounts was higher concentration than other reservoirs. Phytoplankton was observed 17 species and dominant species were Ulthrix, Fragilaria, Desmipseud and Pediastrum. Zooplankton was observed 15 species except Crustacea larva and dominant species were Cyclops, Branchionus, Daphnia and Eudiaptomus. Total numbers of the phytoplankton and zooplankton were proportional to temperature. Experiment Ⅱ. Realing Blue gill sunfish. The work wa conducted by rearling Blue gill sunfish and Carp in Ku Doek Reservoir. Bluegill sunfishes body weight were increased 7.64g per one individual number and Carps were increased 18.8g during experiment period. A ratio relatived to total length(cm) and body depth(cm) were 1 : 2.6∼2.8 in this culture and no differnce was convinced between this culture and artifical culture. Experiment Ⅲ. Effect of the new agricultural pesticides on fresh water fish TLm velues of the new agricultural pesticides on Bluegill sun fish and Carp was investigated. Blue gill sunfish was more sensitive than Carp in Diazinon(E.C), Birlane(E.C), Saturn-S(G). Carp was more sensitive than Blue gill sunfish in Kasugamin(E.C), Blasticidin-s (E.C), Sevin(W.P), Kitazin(E.C), Lasso(E.C). Higher toxic pesticides on Blue gill sunfish were Diazinon(E.C), E.P.N(E.C), Birlane(E.C), Saturn-S(G), TLm values(after 48 hours) of these pesticides on Bluegill sunfish was as follows; Diazinon……0.8ppm, E.P.N……0.9ppm Birlane……0.005ppm, Saturm-S……0.5ppm.

여드름 환자에서 adapalene 겔과 tretinoin 크림의 split-face 비교 연구

김영조,선정우,정병수,최규철 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background : Adapalene is a new synthetic naphtholic acid derivative with potent retinoid and antiinflammatory properties, developed for the topical treatment of acne vulgaris. Objective : This study was designed to compare the efficacy and safety of 0.1% adapalene gel with tretinoin cream(0.025% and 0.05%) in the treatment of grade I to V facial acne vulgaris. Methods : Forty acne patient volunteers were enrolled in this investigatormasked, left-right comparison, randomized, controlled, intraindividual study. 0.1% adapalene gel and tretinoin cream(0.025% or 0.05%) were applied once a day to one halfface by the volunteers for 30 consecutive days. Efficacy and cutaneous tolerance were accessed at baseline and week 1, 2, 3, and 4. Efficacy was determined by investigator counts of inflammatory papules and pustules, and non-inflammatory open and closed comedones, as well as global improvement. Clinical signs(erythema, desquamation, dryness) and subjective symptoms(pruritus, burning) were evaluated and scored weekly. Result : 0.1% Adapalene gel was more effective in treating acne lesions than tretinoin cream(p<0.05). Cutaneous side effect was limited to a mild retinoid dermatitis occurring in all treatment groups. However, patients treated with adapalene gel tolerated this therapy significantly better than those treated with tretinoin cream. Conclusion : 0.1% adapalene gel applied once daily was significantly more effective in reducing acne lesions and was better tolerated than tretinoin cream in the treatment of acne vulgaris.

모반세포성 모반과 악성 흑색종의 CD44 발현에 관한 면역조직화학적 연구

김정수,김영조,최규철,정병수 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

모반세포성 모반과 악성 흑색종의 CD44 발현에 관한 면역조직화학적 연구

김정수,김영조,최규철,정병수 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

CD44 is the major human cell surface receptor for hyaluronate and mediate cellmatrix and cell-cell interactions involved in the mechanisms of tumor invasion and metastasis. Typical acquired melanocytic nevi appear to follow a life cycle characterized by active growth, maturation, and progressive involution, In contrast, congenital melanocytic nevi have a different course and prognosis with potential for development of melanoma, and metastatic spread is very common in malignant melanoma. We investigated the expression of CD44 in acquired and congenital melanocytic nevi, and malignant melanoma by immunohistochemical technique. Formalin-fixed and paraffin-embeded tissue from 5 compound nevi, 6 intradermal nevi, 5 congenital melanocytic nevi, and 5 malignant melanoma were immunolabeled with monoclonal antibodies directed against CD44. All acquired melanocytic nevi showed negative or weak staining for CD44. However, all congenital melanocytic nevi exhibited positive staining for CD44 with minimal irregularities according to location. In malignant melanoma, there was variable intensity of staining for CD44 in different areas of the tumor. These findings suggest that the different expression of CD44 in melanocytic nevi may contribute to different biological behavior between acquired and congenital meanocytic nevi. and CD44 seems to be related to metastasis and tumorigenesis of the malignant melanoma.

Cone-beam CT를 이용한 안면비대칭자에서 이부편위에 따른 치성보상의 양상분석

박수병,박정희,정연화,조봉혜,김용일 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.5

Objective: The purpose of this study was to evaluate the correlation between menton deviation and dental compensation in facial asymmetry. Methods: Tooth axis and distance of first molar and canine to the reference plane were investigated by cone-beam computerized tomography. The subjects consisted of 50 patients with asymmetric mandibles (male 21, female 29, mean age 24.3 years). Control groups were also assessed (male 11, female 9, mean age 25.6 years). Nine measurements (5 linear measurements and 4 angular measurements) were measured in order to evaluate the correlation between menton deviation and the linear and angular difference of first molar and canine in the deviated and none-deviated sides using the defined MPR images. The differences between deviated and non-deviated side, according to menton deviation, were statistically analyzed using stepwise multiple regression analysis. Results: From the result, Menton deviation was negatively correlated with mandibular first molar's angular measurement (Δ∠LM6-Mn plane (dev.-ndev.)) and positively with maxillary fist molar's angular measurement (Δ∠UM6-FH plane (dev.-ndev.)) (p < 0.01). Two angular measurements (Δ∠ LM6-Mn plane (dev.-ndev.), Δ∠UM6-FH plane (dev.-ndev.)) explained the variability in menton deviation with a significant r² value of 0.589. Conclusions: This study suggests that the tooth axis of upper and lower first molars leans towards the deviated side of Menton when there is mandibular asymmetry with Menton deviation. 본 연구는 Cone-beam CT의 MPR이미지상에서 하악골 평면에 대한 하악 제1대구치와 견치의 편위측과 비편위측의 높이와 각도차이 그리고 FH 평면에 대한 상악 제1대구치와 견치의 편위측과 비편위측의 높이와 각도차이를 계측함으로써 안면비대칭자에서 이부편위에 따른 편위측과 비편위측의 제1대구치와 견치의 높이와 협설측 경사도를 CBCT를 이용하여 분석하고 그 관련성을 알아보는 데 있다. 연구대상은 하악골의 이부편위를 동반한 안면비대칭 환자 50명(여자 29명, 남자 21명, 평균나이 24세 4개월)으로 하였다. 대조군으로 평균나이 25세 7개월인 20명(남자 11명, 여자 9명)을 분석하였다. 결과는 이부편위에 대해 FH 평면에 대한 상악 제1대구치의 편위측과 비편위측의 길이 및 각도 차이(편위측 - 비편위측)는 대조군에 대해 통계적으로 유의한 차이가 존재하였다 (p < 0.01). 비대칭군에서 상악 제1대구치 각도는 편위측이 비편위측보다 평균 8.62 ± 5.95˚ 컸다 (p < 0.01). 상악 견치의 경우에도 편위측과 비편위측의 각도차이가 평균 4.48 ± 5.05˚로 통계적으로 유의한 차이가 존재하였다 (p < 0.01). 하악골 평면에 대한 하악 제1대구치의 수직 길이와 각도는 편위측과 비편위측에서 통계적으로 유의할 만한 차이가 존재하였다 (p < 0.01). 각도의 차이는 평균 -11.92 ± 5.79˚로 나타났다. 이부편위에 대한 상하악 제1대구치와 견치의 수직거리 및 각도의 Pearson 상관분석 및 회귀분석 결과, FH 평면에 대한 상악 제1대구치의 편위측과 비편위측의 각도차이(Δ∠ UM6-FH plane (dev.-ndev.))는 통계적으로 유의한 양의 상관관계를 나타내었고, 하악골 평면에 대한 하악 제1대구치의 편위측과 비편위측의 각도차이(Δ∠LM6-Mn plane (dev.-ndev.))는 통계적으로 유의한 음의 상관관계를 나타내었다. 이상의 결과에서 이부편위를 동반한 하악골 비대칭이 존재하는 경우, 이부가 편위되는 방향으로 상하악 제1대구치의 치아장축의 각도가 변화되는 것으로 나타났다.

職場人의 健康維持ㆍ增進을 위한 運動處方 模型開發에 關한 硏究

金正幸,金秉洙,陸調永 龍仁大學校 1993 용인대학교 논문집 Vol.9 No.-

We measured rest HR blood pressure, boots lactate, blood fat in male 132, female 98, total 230 on purpose of developement of exercise prescription model to improve and maintain the health, physical strength and our altimate goal is to increase work efficiency and occupational persons condition. To evaluate exorcise function and work capacity we did exercise test using exercise program and measured maximun oxygen up take and simultaneously individual physical constitution and physical strength was meassural. "There for in the course of scientific systematic efficiert program and efficient exercise prescription model studying" "We tried analysis of working jogging terdmil test cycle ergometar physical condition, physical strength of sexs and ages for adapt to individual health and exercise capacity. The HR was dicreased in proportion to inclosing blood pressure and blood pressure was higher in male but incresing rate was higher in female." All so cholesterol and triglycerine were higher in male and incresing rate was higher in female. Body fat was relatively higher in female but incresing corpare to other physical strength but paralleisem and flexibility showed large, dicreasement, physical strength was showed in sexual differences in proportion to ageing. This study's significance is basic guide for further study by conpare to occupational person's health state and phsycial strength in sexes, ages. Particulary we sertain that this model minized chronic hypokinetic phenomenon and various pathologic phenomenon for the maintenance of all occupational persons.