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신현영,이석민 대한의사협회 2018 대한의사협회지 Vol.61 No.4
Although the enclosed rate of death certificates has steadily improved when domestic death notification to the government, the percent of well-certified causes of death is still 29th among the 35 Organization for Economic Cooperation and Development countries. The death certificate is a medical diagnosis how the deceased died, however, it is difficult to identify the causes of death such as cardiopulmonary arrest, unknown, and death due to old age were up to about 11%. The Statistics Korea selects the final cause of death by linking administrative records such as national health insurance records and national cancer registry data. The World Health Organization's the international statistical classification of diseases and related health problems, 10th revision, volume 2 manual, provides standard forms of death certificate and guidelines for how to write death certificates. It is necessary to provide the education materials or programs to the clinical doctors such as how differentiate the concepts of the underlying cause of death which is the basis of the death cause statistics, originating antecedent cause, main condition and the direct diagnosis of the death. Statistics on the causes of death are continuously needed to improve for the people’s perception of death and to upgrade the quality of health care research and policy development.
신현영,김훈,신지영,이수정,유광원,Shin, Hyun-Young,Kim, Hoon,Shin, Ji-Young,Lee, Sue Jung,Yu, Kwang-Won 한국식품영양학회 2021 韓國食品營養學會誌 Vol.34 No.1
After ethanol (BM-E and RW-E) and hot-water (BM-HW and RW-HW) extracts were fractionated from two herbal mixtures (BM and RW), their physiological activities were investigated. All extracts consisted of more than 50% of neutral sugar, with their total polyphenol levels higher than flavonoid levels. Radical scavenging activities of EtOH extracts remained significantly higher compared to that of hot-water extracts, and in particular, RW-E showed consistently higher antioxidant activity than BM-E. When anti-inflammatory activities of the extracts were evaluated by LPS-stimulated RAW 264.7 cells at 10~500 μg/mL non-cytotoxicity doses, BM-E showed significantly higher levels of TNF-α, IL-1β, IL-6, and nitric oxide inhibitory activity than those of hot-water extracts and RW-E. Murine peritoneal macrophage cells were shown to be enhanced in crude polysaccharides (BM-CP and RW-CP fractionated from BM-HW and RW-HW) compared to hot-water extracts and polysaccharide K (PSK, positive control). Especially, RW-CP exhibited higher activity than BM-CP, and component sugar analysis showed that BM-CP mainly contained galacturonic acid, glucose, arabinose, galactose, and xylose (34.5%, 33.9%, 16.1%, 7.1%, and 6.3%, respectively), whereas RW-CP showed different measurements (29.5%, 59.2%, 5.0%, 4.5%, and 0.2%). In conclusion, two herbal mixtures could contain varying sets of physiological activities dependent on different extraction and fractionation methods.
Adiponectin in Women with Polycystic Ovary Syndrome
신현영,이덕철,이지원 대한가정의학회 2011 Korean Journal of Family Medicine Vol.32 No.4
Background: Though adiponectin has been associated with insulin resistance and cardiovascular risk factors, the relationship between adiponectin and polycystic ovary syndrome (PCOS) remains controversial. The aim of this study was to compare adiponectin level in women with PCOS and without PCOS, and to investigate the relationship between adiponectin level and metabolic variables including insulin resistance. Methods: 60 women with PCOS were enrolled along with a control group of 80 healthy women, matched for age and body mass index (BMI). We measured hormonal and metabolic parameters, as well as the plasma adiponectin concentration of each participant. We estimated the insulin sensitivity according to the quantitative insulin sensitivity check index (QUICKI). Results: The PCOS group displayed significantly lower level of adiponectin (P < 0.001) after adjustment for age, BMI, mean blood pressure, fasting glucose, fasting insulin, and several metabolic parameters. Adiponectin levels were positively correlated with QUICKI in the PCOS group (P < 0.001) and the control group (P = 0.03). Following step-wise multiple regression analysis, however, adiponectin level was positively correlated with QUICKI in the control group only (P = 0.03). In addition, adiponectin level was found to be independently associated with HDL-cholesterol level (P < 0.001) and BMI (P = 0.02) in the PCOS group and independently associated with HDL-cholesterol (P = 0.02) in the control group. Conclusion: We report decreased adiponectin level in PCOS patients in relation to controls independently of insulin resistance or other metabolic factors. And adiponectin is associated with both lipid metabolism and obesity, which,in turn, is related to insulin resistance in PCOS. Further studies are needed to clarify the mechanism of adiponectin in PCOS.
신현영,지영미,박경아,김봉옥 대한의사협회 2018 대한의사협회지 Vol.61 No.2
Korean women doctors have expanded their activities globally in various fields within the international community. This study conducted face-to-face interviews or e-mail surveys of representatives among internationally active women doctors with experience in working with the Medical Women’s International Association and the World Health Organization. Conveying the activities of these senior women doctors will be valuable to the younger generation of doctors who are interested in international health and who aspire to become potential leaders in the international health care scene in the future.
신현영,이지연,송주화,이석민,김혜란,임병선,이정훈,허선 대한의사협회 2016 대한의사협회지 Vol.59 No.3
This article presents recent trends and statistical indicators related to mortality in the Republic of Korea by analyzing the 2014 cause-of-death statistics. Specifically, we assessed the number of deaths, the crude death rate, the ranking of causes of death, and trends in the death rate from the major causes of death. Causes of death were classified according to the International Statistical Classification of Diseases and Related Health Problems, 10th revision, as recommended by the World Health Organization. In order to determine the ranking of causes of death, Statistics Korea used the selection list of 56 causes of death from the 80 causes of death list for tabulation mortality statistics recommended by World Health Organization to better fit the Korean situation. The 10 leading causes of death were, in order, cancer, heart disease, cerebrovascular disease, suicide, pneumonia, diabetes mellitus, chronic lower respiratory disease, liver disease, transport accidents, and hypertensive diseases. The top 10 causes of death accounted for 70.5% of all Korean deaths. The ranking of cancer types as causes of death was lung, liver, stomach, colon, and pancreatic cancer. Death rates for heart disease increased from the third in 2013 to the second leading cause in 2014 and the rank of pneumonia moved up from the sixth in 2013 to the fifth in 2014. The mortality rate due to stomach cancer has decreased continuously over time.. This finding may reflect changes in Korean society involving population structure, epidemiological patterns, and lifestyles, including dietary habits.