腫瘍의 화학요법과 放射線療法의 副作用에 대한 韓方藥物療法

곽계호,김성훈,임낙철 대한동의병리학회 1995 동의생리병리학회지 Vol.9 No.2

연구배경 : 국내 질병에 의한 사망률중 암에 의한 것이 최상위를 차지하고 있으며 또한 그 비율이 점차 증가추세에 있다. 지금까지 국내외에서 암의 예방과 치료법에 대하여 대규모 연구가 진행되어 많은 함암제가 개발되었으나 여러 부작용이 나타나면서 최근에는 암의 치료를 극대화하면서 여러 항암치료의 부작용을 감소시키기 위한 생약 및 한약에 대한 연 구가 활발히 진행되고 있어, 저자는 향후한약을 이용한 실험연구와 임상에 기여하고자 제 관련 문헌을 정리 조사하여 보고하게 되었다. 방법 : 한의학에서의 연구동향과 암치료에 널리 활용되고 있는 화학료법 및 방사선료법의 부작용감소를 위한 한방약물료법에 관해 한의학의 중요서적과 잡지를 중심으로 정리하고 비교 고찰하였다. 결과 : 종양치료에 활용된 치법으로는 부정법(扶正法)과 거사법(祛邪法)으로 크게 나눌수 있는데 부정법에 활용된 약물로는 삼류와 백출, 황기, 복령, 감초, 자감초, 당귀, 백작약, 생지황, 숙지황 등의 약물이 선용되었으며, 거사약물로는 백화사설초, 반지련, 석상백외 18종 이 주로사용되었고, 종양치료에 실험 및 임상에서 유효하였던 처방은 화류탕등을 비롯 다 양한 처방이 면역 기능을 증강시켜 부작용감소 및 병용투여에서 상승효과를 나타냈다. To be helpful to the treatment of cancer with oriental medicine, we got clinical report together and analyzed the data. The results were obtained as follows; 1. The treating methods could be summarized as two methods that were reinforcing vital energy and eliminating harmful Qi; The methods of reinforcing vital energy were reinforcing spleen and increasing Qi; reinforcing spleen and harmonize stomach, aid virility and nourishing blood, nourishing stomach and incresing body fluid, reinforcing kidney and strength the basic energy, warmth kidney and aid virility. The other methods of eliminating poison were transforming pathological fluid and softening activating blood, transforming pathological blood, guiding Qi, take off and harmonize harmful body fluid, disperse Qi and dry the dampness, transforming pathological blood and harmonize moisture. 2. The oriental herbs used for reinforcing vital energy were Radix Ginseng, Codonops is Pilosulae Radix, Radix Pseudostellariae, Adenophorae Radix, Scrophulariae Radix, Astractylodis Macrocephalae Rhizoma, Astragali Radix, Poria, Gylcyrrhizae Radix, Angelicae Gigantis Radix, Paeonilae Radix Alba, Rehmanniae Radix and used for eliminating harmful Qi were Oldenlindiae Diffusae Herba, Herba Scutellariae Barbatae, Paridis Rhizoma, Verbenae Herba, Smilacis Chlnae Rhizoma, Radix Semiaquilegiae, Houttuynae Herba et. 3.The useful prescriptions used for cancer therapy were Hwalyutang Yukmijihwangtang, Yonghosinchonghwan, Bokbangkyokolamtang, Yikki-sojeungbang, Samchobujeonhangamchungjye and Bokbangkyokolamtang, Yikksojeungbang were reported to be effective in immunodulatory reaction and Bokbangsamsahapjye, Sibjeondaeboang, Gagyulpijukyeotang, Hwayebokwontang showed the combined treatment with anticancer drug was effective and Hangamlyeong(抗癌靈) was effective for pain caused by cancer. 4.The useful antitumor effective prescriptions in experimental investi-sation were Yikikeonbihabjye, Keon biiksinchungjye, Bisinbang, Sankyeol pyeolpyeon, Hangamdanhyeokkeombokbang, Janglyupyeong, HangamIIho, Keonbiyikitang, Yikkiisojingbang, Sakunjatang, Bokbanggyongkyejusayek, Bujeonghangambang, Bokbangjungyakjusayek, Yukmijihwangtang, Samchobujeonghangamchungjae, Samkijusayek, Yikkiyanghyeolbowonkyonang, Samyongtang-Bojungikkitang, Soyinibo-jungikang among them Bisinbang, keonbiiksinchungjye, Janglyup-yeong, Keonbiyikitang, Yikkisojingbang, Yukmijihwangtang, Keumku-esinkihwan were showed antitumor effect by regulate immunity function. 5. The main treatment for the side effect by chemotheraphy was reinforcing Qi, spleen and harmonize stomach and Omisodokyeum, Hyangsaynkkunjatang, Yijintang, Kamlosodokdan, Silbiyeum, Hageojye-johwan, Sibjeondaebotang, Olyeongsan, Sobanhakaboklyeongtang, seung-baektang, Bisinbang, Keonbiyiksinbang, Sambaekdangjang, Bokbang-samsahabjye, Keonbiyikitang, Janganseungbaekchungjye, Kobonkeoe I ho, Bokihwawejikubang, Bokbangsaenghyeolyeng, Keonbiyikkibosinbang, Hwangbaekhabjye, Yukkunjatang, Seonbokdaejatang, Bangdoktang, Hwangjeongomibang, seunghyeoltang, Kilpijukyetang, Sakunjatang, Yikkibohy-eolkeonbitang, Kangyeoktang,Samkijusayaek, Bujeongseungbaektang, Yukmijihwanghwan, were suggested for the side effect by chemotheraphy. 6. The main treatment for the side effect by radiotheraphy was increasing Yin and clarifying heat, Sasammaekmundongtang, Boyeum-jeon, Maekmundongyeum, Dangkwibohyeltang, Paljintang, Bowontang, Yukkunjatang, Pyeongwesan, samintang, Kwakrakhalywongtang, Cheon-keumwekyeongtang, Sohamhamhyungtang, Paljeongsan, Sokyeoyeumja, Kalkeunkeumlyeongtang, Yeonlitang, Yilkwanjeon Oklyeojeon, Yukmijihwangtang, Hwangiyeontang, Hwanglyeonhaedoktang, Yangyeumcheongpyeoko, Yidongko, Chuliko, Cheongpyeotang, Jayeumkanghwatang, Hangbiyinam I ho, Hangbiyinam II ho, Hangbiyinam III ho, Hangbyinam IV ho, Jukyeoseokkotang, Samsatang I ho, Samsatang II ho, Samsatang, Bokbanggsaenghyeollyeng, Bujeongsaengjintang, Yikkiyangyeumbang, Sinlibpyeon, Sakunjatang, Sakunjatang, Kobonyik-kitang, keoehaedoktang, Bujeongjeunghyohabjye, were suggested for the side effect by radiotheraphy. 7. The useful prescription for the side effect by chemotheraphy and radiotherapy in experimental investigation were Hwangbaekhabjye, Sakunjatang, Yikkibohyeolkeonbitang, Bujeongsaengjintang, Samchobu

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

광대역 종합정보통신망에서의 관리 요구사항 도출에 관한 연구

林海鎭,黃盛晧 三陟大學校 1998 論文集 Vol.31 No.1

In parallel with rapid advances and increased reliance on telecommunication services, network technologies continue to evolve. In addition, the advanced switching technologies required for ATM technology and switched multimegabit digital service(SMDS) are now being deployed. Considering the rapid deployment of new services and technologies, escalating competive pressures, and the broadening demands of customers, service providers face an immediate and pressing need to streamline, simplify, and automate network management operations. This research provides the first step in the requirements process for a new type o network operations capability. The logical model of this research describes a set of functions that could be assigned to either physical standalone components, operations systems, or network elements. This research should help facilitate consistency in the way the operations for different new technologies are specified.

표준 셀 라이브러리 P&R 포팅과 테스트 칩의 설계

임호민,김남섭,김진상,조원경 한국항행학회 2003 韓國航行學會論文誌 Vol.7 No.2

본 논문에서는 최신의 미세공정인 0.18㎛ CMOS 공정을 이용한 표준 셀 라이브러리를 설계하고, 이를 P&R(Placement and Routing) CAD 틀에 사용할 수 있도록 포팅한다 제작결과를 검증하기 위하여 간단한 테스트칩을 제작하였으며 설계에 사용된 표준 셀 라이브러리는 0.18㎛ 아남반도체의 공정이다. 이러한 설계 및 제작과정을 통하여 최신의 미세공정을 이용하여 디지털 시스템의 자동설계가 가능함을 확인하였다. In this paper, we design standard cell libraries using the 0.18um deep submircom CMOS process, and port them into a P&R (Placement and Routing) CAD tool. A simple test ship has been designed in order to verify the functionalities of the 0.18um standard cell libraries whose technical process was provided by Anam semiconductor. Through these experiments, we have found that the new 0.18um CMOS process can be successfully applied to automatic digital system design.

영역 특수적인 입장에서의 과학적 창의성에 대한 정의, 구성요인에 대한 탐색

임성만,양일호,임재근 경북대학교 과학교육연구소 2009 科學敎育硏究誌 Vol.33 No.1

본 연구는 창의성의 영역 특수적인 입장에서 과학적 창의성을 다룬 논문들을 내러티브 리뷰의 방법을 사용하여 탐색한 것이다. 창의성을 바라보는 2가지 입장 중에서 한 가지인 영역 특수적인 입장은 창의성에 대해 “그 아동이 얼마나 창의적인가?”라는 창의성의 일반적인 입장에서 “그 아동은 어느 영역에서 창의적인가”라는 영역 특수적인 접근방법으로 창의성을 바라보는 것이다. 이러한 관점에서 본 연구는 과학을 바라보았을 때, 과학적 창의성은 어떻게 정의될 수 있으며, 또 어떤 구성 요인들로 이루어졌는가를 탐색해 본 연구이다. 과학적 창의성 관련 논문들에 대한 리뷰를 통해 본 연구는 과학적 창의성은 과학적인 지식을 바탕으로 논리적이고 분석적인 사고를 통해 새롭고 적절한 것을 찾아내는 능력으로 정의할 수 있었으며, 과학적 창의성의 구성 요인은 정의적, 인지적, 환경적 요인으로 나눠 살펴본 결과, 영역 특수적인 관점에서 가장 두드러지게 차이를 보이는 과학적 창의성의 인지적 요인은 과학 관련 지식, 과학 탐구과정, 문제 발견력, 문제 해결력 등으로 구성되어짐을 알 수 있었다. 이러한 과학적 창의성에 대한 논의는 보다 과학적 창의성에 대한 실증적인 연구에 대한 좋은 길잡이가 될 것으로 사료된다. The purpose of this study is to identify a domain-specificity of the scientific creativity and the component of scientific creativity. Conducted from theoretical study, this study suggests that a domain-specific view of creativity offers a more useful and constructive components of scientific creativity based on the literature associated with the component of scientific creativity. Scientific creativity has a domain-specific component and so there is need to distinguish scientific creativity from creativity in general. As a result, scientific creativity is different from other creativity it is concerned with scientific knowledge, science process skill, creative scientific problem finding and solving and so on. And since scientific creativity is a kind of ability, it is possible to improve through a scientific creativity program.

Comb 형 전극구조를 갖는 AC 플라즈마 디스플레이 패널의 전기, 광학적 특성

임성규,장호정,김동수,이순석 단국대학교 1999 論文集 Vol.34 No.-

The electrical and optical characteristics of comb type AC-PDP fabricated by the screen printing method were measured. The charge-voltage (Q-V), capacitance-voltage(C-V) and current-voltage (I-V) characteristics were also measured. The Q-V curve showed the firing voltage and transferred conduction charges and wall charges. The capacitance charge due to the charge of applied voltage was also observed from the C-V curve and it was shown that the air gap could not be considered 100% shorted during the discharge. It can be concluded that the increase of the discharge space by the comb type electrode structure reduces the firing voltage and the internal physical characteristics of the AC PDP cell can be understood by measuring various electrical characteristics.

항진균성 항생물질을 생산하는 Streptoverticillium sp. NA-4083의 분리 및 동정

임대석,윤상균,이명섭,윤원호,김창한 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.6

전국 각지의 토양에서 441균주의 방선균을 분리한 결과 Trichophyton mentagrophytes, Trichophyton rubrum, Nanniza otae 및 Pyricularia oryzae 등의 진균에 광범위한 항진균활성을 나타내는 방선균 NA-4803을 선발하여 그 균주의 동정을 실시하였다. 분리균주 NA-4803은 Gram 양성세균 4균주, Gram 음성세균 2균주, 효모 2균주, 곰팡이 5균주, 조류 1균주에 대해 약한 항균활성을 보이는 반면, 곰팡이 Trichophyton mentagrophytes, Trichophyton rubrum, Nanniza otae 및 Pyricularia oryzae에 대해서는 비교적 강한 항진균활성을 나타내었다. 분리균주 NA-4803은 생리적 특성, 항균활성, lectithinase 및 lipolytic 활성, 각종 유기물의 분해력, 항생물질에 대한 저항성, 온도, pH 및 화학저해제의 첨가에 따른 생육, 질소원의 이용성 및 탄소원의 이용성 등에 있어서 cluster group F에 속하며 Cluster No. 58에 해당하는 Streptoverticillium blastmyceticum과 가장 유사하게 비교·동정되었으나 nitrate 환원성의 양성반응, L-tyrosine 분해력의 음성반응 및 cephaloridine에 대한 저항성에 음성반응을 보였고, 탄소원 중 L-rhamnose와 inulin을 이용하는 것으로 보아 Streptoverticillium blastmyceticum과 다른 특성을 나타내었다. 따라서 분리균주 NA-4803은 Streptoverticillium sp. NA-4803으로 동정되었다. The aim of the present research program was to develop a strain of actinomycetes producing antifungal substance. Soil samples were collected from various sites in Korea and a number of actinomycetes were isolated from the soil samples by applying selective agar for actinomycetes. Among over 440 isolates, a strain (NA-4803) producing antifungal substance against Trichophyton spp. Nannizzia otae and Pyricularia oryzae was selected. The strain NA-4803 was identified as strain similar to Streptoverticillium blastmyceticum with respect to morphological and physiological characteristics, lecithinase and lipolytic activity, degradation of organic compounds, resistance to antibiotics and utilization of carbon and nitrogen sources. But it showed some differences such as positive reaction of nitrate reduction, negative reaction of L-tyrosine degradation, resistance to cephaloridine, and utilization of I rhamnose and inulin. The strain NA-4803 was named as Streptoverticillium sp. NA-4803.

鐵骨 半剛接 보-기둥 接合部의 回轉擧動에 관한 比較硏究

임호섭,윤성기 부산대학교 1995 生産技術硏究所論文集 Vol.48 No.-

철골 구조물에서, 보-기둥 접합부의 설계와 구조해석은 건물 전체의 안정성 확보와 경계성에 큰 요인으로 작용한다. 일반적인 보-기둥 접합부의 해석은 완전한 강접합이나 핀 접합으로 가정하여 수행하고 있으나 실제적으로는 휨에 대하여 어느 정도의 강성을 갖고 있는 반강접 접합부가 자주 적용되고 있다. 이 연구에서는 비선형 구조해석 프로그램인 ADINA에 적용하여 반강접 접합부의 강성을 밝혀내며, 7가지 형태로 분류된 접합방법에 대해 강성을 비교 분석하고 실험결과로 검증하여 ADINA의 적용방법의 제시와 함께 그 타당성을 입증하였다. The conventional analysis and design of steel frameworks usually carried out under the assumption that the connections joining the beams to the columns are either fully rigid or ideally pinned. In practice, the most steel frames have been composed of the semi-rigid connections because the most connections exhibit a certain degree of flexibility under loads. In this research, the prediction of rotational stiffness of semi-rigid connection using common structural analysis program, ADINA(Automatic Dynamic Incremental Nonlinear Analysis) can be performed, without carrying out experiment or analytical model. The comparison of rotational rigidity about for seven types of connection was shown, also, the connection types using both angle and end-plate, are testified by test data and analytical model.

치수절단 후 접착레진 도포에 대한 잔존치수조직 반응에 관한 연구

임성삼,박동성,손호현 大韓齒科保存學會 1997 Restorative Dentistry & Endodontics Vol.22 No.2

This study was performed to observe the histopathological response to the bonding resin directly applied on the remaining pulp tissuse. 40 teeth from 3 adult dogs were pulpotomized with a sterile round but and sharp excarvater. In the control group, Ca(OH)_2 powder was applied on the pulp tissue and the cavities were sealed with IRM cement. In the experimental group 1, Superbond C&B was applied on the remaining pulp and the cavities conditioned with 10-3 solution were filled with the mixture of the MMA liquid, PMMA powder and Catalyst. Multi-purpose adhesive was used on the remaining pulp tissue in the experimental group 2 and Z-100 was filled in the cavities. In the experimental group 3, Clearfil photobond applied and directly photo=cured on the pulp tissue, then the cavitieswere treated wit CA agent (10% citric acid and 20% CaCl_2 aqueous solution) for 20 seconds, washed and applied with Clearfil photobond then filled with Protect liner. The experimental animals were sacrified at the 1st, 2nd, and 4th week. The specimens were routinely processed and stained with H-E for light microscopic observation. The results were as followed : 1. In the experimental group 1, the number and characteristics of the dentin bridge formation case was similar to those in the control group and less cases were observed in the experimental group 2 and 3 than experimental group 3. The inflammatory response in experimental group 1 was less than that in the control group at 1st week but there had been little difference at between 2nd and 4th week. 2. The number of the dentin bridge in experimental group 2 was less than that in control group and experimental group 1. The inflammatory response of the experimental group 1 was similar to that of experimental group 1 but less than that of the control group. A number of bleeding and vascular congestion were observed. The least inflammatory response was seen in the experimental group 2 among all groups. 3. In the experimental group 3. one case of the dentin bridge formation was observed and that was the same as that in the experimental group 2 but smaller than that of the control and experimental group 1. The inflammatory response of the experimental group 3 was least at the 1st week and most at the 4th week in the all group.

Pb(Sn_½Sb_½)O₃-PbTiO₃-PbZrO₃계 압전 세라믹의 필터로서의 응용

임진호,조상희 경북대학교 공과대학 1987 工大硏究誌 Vol.16 No.-

The effect of the size of sintered body on the resonant characteristic of the Pb(Sn_½Sb_½)O_3-PbTiO_3-PbZrO_3 ceramics was investigated. The attenuation characteristics of ring-dot type and ladder type filter were also investigated. As the sintered body are small, the resonant characteristic (f_γ, f_α) and the center frequency are increased. The big difference between the ring-dot type and ladder type filter was the sharpness of bandwidth and the movement of center frequency. As the poling field increased, the K_p and bandwidth were also increased.