서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

흰쥐에서 음경발기 평가의 척도로서 음경해면체내압측정술 확립

송윤섭,김용준,이광우,김준모,문기혁,박영호,민영기,유형균,김형건 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Because studies about the control of penile erection at the entral nervous system was dependent on the animal experiments, establishment of measuring penile erection is important to evaluate the effects changes at the central nervous system on the penile erection. Intracavernous pressure measurement in rats has been introduced as a suitable index for the evaluation of penile erection but this method is invasive and technically difficult. So, we established the intracavernous pressure measurement in rats as the experimental index for penile erection. Materials and Methods: 42 male adult Sprague-Dawley rats (250-300gm) were divided to saline or papaverine treated group. Rats were placed on a heating table to maintain their body temparature and anesthetized with 50mg/kg of pentobarbital sodium by intraperitoneal injection. A cannula was inserted to the left carotid artery to measure systemic blood pressure. Saline (0.05, 0.1ml), papaverine(0.05, 0.1, 0.25, 0.5, 1.0, 2.0mg) were injected intracavernously via 26 guage needle filled with saline or papaverine which connected to pressure transducer and polygraph was inserted into the corpus cavernosum on one side to inject the drug and to measure intracavernous presure. Results: Properly executed insertion and intracavernous administration produced a instantaneous but transient rise in intracavernous pressure that substantially stabilized and maintained at 5.4±0.4mmHg. Intracavernous pressure and duration of penile blood flow following intracavernous injection of papaverine are increased comared to those of saline. Conclusions: Monitoring intracavernous pressure in rats represents a suitable index for the evaluation of penile erection in small laboratory animals.

입원 중인 베트남 참전 군인의 삶의 만족도와 관련된 요인

김애리,박종,김율,노희송,박광희,김은숙,김형철,홍강식,류소연,강명근,김기순 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background and Objectives: The aim of the study was to identify the factors associated with life satisfaction of hospitalized Vietnam veterans. Material and Methods: The data were collected from 200 hospitalized Vietnam veterans of 5 veterans hospitals in Korea from September 13 to 23, 2004. Information of general characteristics, health behavior, disease history, family function, depression and life satisfaction were collected by structured questionnaire. Results: The mean of life satisfaction was 21.48(±6.03), and the mean of depression was 53.10(±9.64). The prevalence of depression was mild depression 24.0%, moderate depression 43.5% and severe depression 25.0%. Depression was associated with life satisfaction and depression was higher, life satisfaction was lower. Family function and age were positively associated with life satisfaction, Conclusion: Life satisfaction was affected by depression and family function in hospitalized Vietnam veterans. Therefore, it was thought that psychosocial approaches such as improve depression and family function in care of hospitalized Vietnam veterans is required.

담낭암의 발생에서 담췌관합류이상의 역할 규명과 암화과정에 관한 연구

한기준,송시영,정재복,이세준,김호근,강진경 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.4

전선 : 사학분쟁조정위원회의 대법원 판례 해석과 정이사 선임원칙 등의 문제점 -상지학원의 정이사 선임 사례를 중심으로-

송기춘 ( Ki Choon Song ),김명연 ( Myoung Youn Kim ) 민주주의법학연구회 2011 민주법학 Vol.0 No.46

2010년 사학분쟁조정위원회(이하 "사분위")는 상지학원의 ``정상화``를 위하여 과거 교육비리로 이사에서 해임되었고 형벌까지 받았던 김문기 씨쪽이 추천한 인사를 정이사로 선임하고 교육과학기술부는 이를 승인하였다. 사분위는 이 결정이 대법원의 판결을 충실하게 따른 것이라고 강변하고 있지만, 사분위가 만든 정이사 선임기준은 이 대법원 판결을 자의적으로 왜곡한 것일 뿐 아니라 사립학교법이나 민법의 일반원칙에 비춰 봐도 받아들이기 힘든 것이다. 사분위의 결정은 대법원의 다수의견이 아닌 다수의견에 대한 보충의견을 다수의견인 양 인용하면서 자신들의 정이사 선임원칙을 정당화하고 있을 뿐이다. 또한 사학의 정상화를 위한 기준은 심의 당시의 민법, 사립학교법 등의 일반원칙에 따라 결정되어야 한다는 판결에도 불구하고 현행 사립학교법의 취지와 전혀 반대되는 결정을 하고 있다. 이 글은 사분위가 대법원 판결을 어떻게 왜곡하고 있는지, 정이사 선임원칙은 어떠한 문제가 있는지를 종합적으로 평가하고 아울러 사분위의 권한남용의 원인이라 할 수 있는 사립학교법의 사분위 심의기준에 대한 입법적 보완 또는 사분위의 폐지를 주장하고 있다. The Private School Dispute Resolution Committee has the power to appoint the ad-hoc directors, discharge them or appoint the regular directors to normalize private schools. It made a decision regarding Sangji Educational Foundation last year. The decision is to appoint the directors recommended by the ex-director Moonki Kim who was discharged because of his crime regarding illegal operations of the Foundation as a director. The Committee says that the decision is based on the judgement of the Supreme Court relating to the Sangji Educational Foundation in 2007. But the Committee distorted the judgement to justify its own decision. It regards the concurring opinion of two Associate Justices as the binding opinion of the Supreme Court. Only the opinion of the Court has the binding power, but the concurring one does not. The Committee even made its decision arbitrarily because there is no regulation on the way and scope to normalize private schools. The power of regulation is delegated to the Committee too comprehensively. It`s the defect of the legislation which should be corrected by the legislative body. It was wrong for the Committee to appoint the crime-related people as directors of Sangji Educational Foundation. It should have considered the moral aspects of the ex-director Kim. He has the critical defect to become an educator.

퇴행성 요추 질환에서 후측방 유합술과 후방 추체간 유합술의 비교

송경진(Kyung-Jin Song),김기남(Ki-Nam Kim),송광훈(Kwang-Hun Song),이준모(Jun-Mo Lee) 대한정형외과학회 2006 대한정형외과학회지 Vol.41 No.4

목적: 이분절 이하의 퇴행성 요추부 질환에서 후측방 유합술과 후방 추체간 유합술의 임상적, 방사선학적 결과를 분석하여 두 수술을 비교해 보고자 하였다. 대상 및 방법: 이분절 이하의 요추 유합술 및 척추경 나사못 고정술, 감압술을 시행받고 추시관찰이 가능하였던 90명을 대상으로 하였으며 이 중 요추 후측방 유합술을 실시한 환자 45명을 Ⅰ군, 요추체간 유합술을 실시한 환자 45명을 Ⅱ군으로 분류하였다. 결과: 요추 전만도는 Ⅰ군에서 술 전 36.84±8.31°, 술 후 40.58±7.61°, 최종 추시 시 35.73±7.61°이었고, Ⅱ군에서는 31.53±7.09°, 39.11±7.21°, 35.47±7.76°이었다. 골유합은 Ⅰ군에서 45예 중 41예(91.1%), Ⅱ군에서는 45예 중 43예(95.6%)에서 얻었다. 합병증은 Ⅰ군에서 11예(24.4%), Ⅱ군에서는 1예(2.2%)에서 발생하였다. 결론: 이분절 이하의 퇴행성 요추부 질환에서 실시한 후측방 유합술과 후방 추체간 유합술 모두에서 만족할 만한 골유합률과 임상적 결과를 보였고, 두 군 사이의 유의한 차이는 없었다. 요추 전만도와 합병증에서는 후방 추체간 유합술에서 더 좋은 결과를 얻었으나, 임상과 방사선적 결과에 대해서는 좀 더 장기적인 연구가 필요하리라 생각된다. Purpose : This study compared the surgical treatment results between posterior lumbar interbody fusion (PLIF) and posterolateral fusion (PLF) with pedicle screw fixation in degenerative lumbar spinal disorders. Materials and Methods : In 45 cases of PLF (group Ⅰ) and 45 cases of PLIF (group Ⅱ), lumbar lordosis, segmental lordosis, bone union and complications were considered to be an evaluation criterion. Kim's functional evaluation scale was used for the clinical results. Results : The average lumbar lordosis in group I was 36.84±8.31° preoperatively, 40.58±7.61° postoperatively and 35.73±7.61o at the last follow up. On the other hand, the respective changes in the average lumbar lordosis were 31.53±7.09°, 39.11±7.21°, and 35.47±7.76° in group Ⅱ. Definitive solid union was obtained in 41 cases in group Ⅰ (91.1%) and 43 cases in group Ⅱ (95.6%). The rate of complications was 24.4% (11 cases) in group I and 2.2% (6 cases) in group II, and a satisfactory functional outcome were obtained in 43 cases (95.6%) in group Ⅰ and 41 cases (91.1%) in group Ⅱ. Conclusion : Both PLF and PLIF on short segment fusion provided satisfactory bone union and clinical results. In segmental lordosis, there were no significant differences between the two groups. However, PLIF was more effective in preventing lumbar lordosis and complications than PLF. A longer term follow up will be needed to evaluate the adjacent segmental degeneration and maintenance of the sagittal balance.

방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

1995년 및 1996년에 국내에서 분리된 풍진바이러스의 염기서열 및 계통분석

백락주,송기준,정재희,정희진,김우주,김민자,송진원,김세연,이용주,박광숙,강주일 대한감염학회 1997 감염 Vol.29 No.3

목적: 유소아에서 경한 발진성 질환을 일으키는 풍진바이러스는 토가바이러스과에 속하며 일회 감염으로 평생면역을 획득하는 것으로 알려져 왔다. 그러나 1960년대 후반 풍진예방접종이 시행된 이후 선진국의 경우 풍진 호발 연령이 유소아에서 청소년 층으로 변화하는 양상을 나타내었으며 우리 나라의 경우에도 1995년에서 1996년도 사이에 발생한 풍진대유행기에 주로 중 고등학생층에서 풍진이 호발하였다. 주기적인 풍진의 유행에도 불구하고 우리 나라에서는 최근까지도 풍진 바이러스의 분리나 유전정보에 대한 연구보고가 없어 이에 대한 연구를 시행하였다. 방법: 1995년에서 1996년에 발생한 풍진 환자의 인후분비물을 채취하여 세포배양법으로 풍진바이러스 분리를 시도하였으며, 분리된 풍진바이러스의 RNA를 추출하여 역전사 중합효소연쇄반응법으로 증폭한 후 염기서열 및 아미노산 서열을 결정 분석하였다. 결과: 세포배양을 통해 7주의 풍진바이러스를 분리하였으며 국내 풍진바이러스주들은 염기서열상 92.5-100%의 동질성을 나타내었고, 백신주 RA27/3과는 2.2-6.4%의 차이를 보였다. 아미노산서열상에서는 국내에서 분리된 풍진바이러스주들은 98.3-100%의 동질성을 나타내었고, 백신주 RA27/3과는 1.7%이하의 차이를 보였다. 계통분석 결과 국내에서는 최소한 2가지 유형의 풍진바이러스가 유행하였다. 결론: 국내에서 유행한 풍진바이러스주의 E1 gene 부위를 기존에 알려진 외국의 분리주나 백신주와 비교시 의미있는 차이는 관찰되지 않았으며 Vero E6 세포는 풍진바이러스의 분리배양에 유용함을 알수 있었다. 그러나 풍진바이러스의 지속적인 변이 양상이 관찰된 사실은 체계적이고 지속적인 풍진바이러스 감시체계의 필요성을 제시하였다. Background: The age group of Rubella virus (RV) infection in most industrialized nations located in temperate climates, has in large part shifted from children to young adults since introducing of the RV vaccine in late 1960's. Interestingly, there were rubella outbreakes from 1995 through 1996 in Korea, and middle and high school students were mostly affected during that time. Although continued of genetic information of rubella viruses circulated in Korea. Method: To isolate RV circulated in Korea, and determine the phylogenetic relationship between RV strains in Korea and RV isolates from other geographic regions including vaccine strains, we inoculated nasopharyngeal secretion samples from clinically diagnosed rubella patients to Vero E6 cells, and sequenced corresponding region of the 5' EL encoding genomic regions of RV isolates. Result: Seven RV strains isolated from Korea showed 93.6 to 97.8% and 98.3 to 100% sequence homologies in nucleotide and amino acid levels, respectively, compared to RA27/3 vaccine strain. Phylogenetic tree based on 359bp of RV indicated that at least two different groups of RV circulated in Korea during 1995-1996 epidemics. Conclusion: Our data suggested that mutant RV strains were possiblely not the cause of recent rubella epidemics in Korea.