정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

아랍어의 분사형과 활용에 관하여

이두선 한국외국어대학교 중동연구소 1996 중동연구 Vol.15 No.2

This paper analyzes participles with a focus on their forms and capacities. 1) As for the forms, ① active participle 《??》 only derives from transitive verbs 《??》and 《??》② The active participle coming from hollow verbs is 《??》 in this case, weak letters turn into Hamza when following long vowel 《??》 ③ When two weak letters are in adjacency, a stong vowel is generated in the preceding vowels, are changed 《??》 turns into 《??》 and 《??》 into 《??》. 2) Regarding the capacities, ① capacities modify nouns. ② When used as verbal adjectives, participles can have different tenses. ③ They can also be used as nouns, serving as subjects, objectives and complements. ④ When a participle is derived from a transitive verb and act as a noun, it can have objectives, just as gerunds.

원격진료 서비스를 위한 서버 구축

이병수,이순흠,안영두 순천향대학교 부설 산업기술연구소 2000 순천향 산업기술연구소논문집 Vol.6 No.1

본 논문에서는 인터넷에서 보다 빠른고 효율적인 원격 진료 서비스를 지원할 수 있는 서버를 설계, 구현하였다. 인터넷에서 본 원격 진료 서비스 서버에 접속해서 의료영상 및 정보를 검색, 열람할 수있으며, 관리자는 의료영상 획득장치를 통해 획득된 영상을 가공하고 의료정보를 첨부하여 데이터베이스에 저장할 수 있다. 본 시스템은 ASP를 통해 데이터베이스를 효율적으로 관리하여 사용자에게 편리한 인터페이스를 제공하며, XML을 통해 같은 형태의 데이터를 볼 수 있도록 하여 이기종 간의 호환성 문제를 해결하였다. 그리고 의료영상 획득장치를 통해 획득된 영상을 JPEG, GIF, PNG 압축을 사용하여 적은 용량으로 양질의 이미지를 통해 이미지로 인한 속도 저하 문제를 해결하였다.

황룡강에 서식하는 어류의 중금속 레벨에 관한 연구

이두표,고선근 호남대학교 산업기술연구소 1997 산업기술연구논문집 Vol.5 No.-

황룡강에서 서식하는 어류의 중금속 오렴레벨을 알아보기 위하여 1995년 상류와 하류에서 총 15종 47개체의 어류를 채집하여 Pb, Cd, Mn, Cu, Zn, Fe의 6개 원소의 농도를 측정하여 비교ㆍ분석하였다. 원소별 농도는 Fe>Zn>Mn>Cu>Pb>Cd의 순으로 나타났으며 각 원소의 농도레벨은 전반적으로 낮아 Background레벨을 반영하였다. 상류와 하류의 지역간에는 대부분의 원소에서 농도차이는 없었으나 Cd의 경우 상류가 하류보다 2배이상 높게 나타났다. 어류의 식성간에는 오염원소인 Pb과 Cd만 평균농도에서 차이가 있었고 나머지 필수원소들은 모두 차이가 없었다. Pb은 육식성>초식성>잡식성의 순을 나타내었고, Cd는 육식성이 가장 높았고 초식성과 잡식성은 비슷하게 낮았다. 각 어종별 원소농는 세계 각 국에서 설정한 어류에 대한 식품으로서의 최대 허용 레벨을 기준으로 하여 비교ㆍ검토하였다. Analyses of 6 heavy metals in 15 species of freshwater fish from Hwangryong River, 1995, were presented. Heavy metal levels were generally low and within the range of values previously reported from non-polluted regions. A rank of heavy metal level was Fe>Zn>Mn>Cu>PB>Cd. The mean metal levels in upper stream and down stream were not different except Cd level. It is two times higher in upper than in down. Pb and Cd levels of carnivorous fish were significantly higher than those of herbivorous and omnivorous. Some metal levels in fish species were discussed in the view of their consumption by humans.

미취학 아동의 우유병 우식증 유병률과 세균학적 우식활성도에 관한 연구

이광희,유두선 大韓小兒齒科學會 1994 大韓小兒齒科學會誌 Vol.21 No.1

The purpose of study was to survey the prevalence of the nursing bottle caries and bacteriologic caries activity in preschool children. Dental caries experience of 690 preschool children in Iri city and Cheonju city was examined. Subjects were grouped by the pattern of their caries experience: Group 1-no caries, Group 2-no caries in the upper arch,Group 3-no caries among the upper incisors, Group 4-dmft in the lower arch ?? dmft in upper arch, Group 5-dmft among the upper posterior teeth > dmft among the upper incisor, Group 6- the rest, Groups 5 and 6 were regarded as the group which had experienced nursing bottle caries. The prevalence of the nursing bottle caries of the present study was 15.6% (4.6% for Group 5 and 11.0% for Group 6). dmft index of Group5 was 9.16 and the highest, and the next was 7.89 of Group 6. The prevalence of the individual tooth in Group 6 was in order as follows: the upper incisors, the lower posterior teeth the upper posterior teeth, the upper cuspids, the lower incisors. The prevalence of the upper central incisors was the highest (89.5-94.7%), and that of the lower central incisor was the lowest (1.3%). The composition of the bacteriological caries activity test medium was 20% sucrose, 2% tryptose, 0.5% sodium chloride, 5% bromcresol green solution, 0.213 units/ml bacitracin. The medium was incubated by the dental plaque and incubated for 72 hours and the PH was measured after 48 hours and 72 hours. Although Groups 5 and 6 showed the high caries activity tendency, there was no significant difference among the group.

진행성 위암에 동반된 위 칸디다증 1예

이두영,김성호,선제형,박진석,손존광,선홍주,이승,박찬국 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Gastric candidiasis is an uncommon disorder. It is an opportunistic pathogen in immune compromised individuals, alcoholics, persons treated with broad-spectrum antibiotics, immunosuppressive and chemotherapeutic agents. Besides, the use of drugs that reduce the gastric acid production may be a cause of gastric candidiasis. We experienced a case of gastric candidiasis following advanced gastric adenocarcinoma. A 85-year-old woman was admitted to our hospital because of epigastric soreness. Endoscopic findings revealed a large ulcero-infiltrating mass with yellow exudate at cardia of the stomach, which suggested an advanced gastric cancer. Endoscopic biopsy revealed spores and pseudohyphae infiltrating through the ulcerated stomach wall, diffuse infiltration of tumor cells and abortive tumor glands. After treatment with fluconazole 100 mg daily for 21 days, no evidence of the gastric candidiasis was seen on endoscopic biopsy and pathologic findings. The case is herein reported of gastric candidiasis following advanced gastric adenocarcinoma along with a review of corresponding literature.

기종성 방광염을 동반한 기종성 신우신염 1예

김선두,김순제,이길도,김정수,김지훈,윤호상,송종오,문언수 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

정신과 입원 환자의 직종별 불안 성향에 관한 연구

박재선,박두병,이길홍 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.4

The present study was to examine the relationship between psychiatric inpatients' occuputions and their anxiety level. The sampling subjects were randomly selected by 3 stage probability proportional culster extraction method among psychiatric who were admitted to the psychiatric clinics and hospitals nationwide. Four hundred and twenty eight subjects including 249 males and 179 females were undergone by questionnaire survey while measurement of anxiety was done by using Zung's self-rating anxiety scale. Collected data were processed by IBM PC AT computer using SPSS program and statistically analyzed by chi-square test and analysis of variance. 1) It was revealed that these psychiatric inpatients showed relatively higher rates of the unemployed (34.6%), single(43.2%), and divorce(5.1%). 2) Patients with higher classes of occupation such as administrative, managerial or clerical workers showed higher rate of divorce. 3) In the occupational distribution of psychiatric disorders, psychotic disorders were more prevalent among high or low occupational classes, neurotic disorders more prevalent among middle occupational classes, while psychoactive substance use disorder more prevalent among farmers and sales workers. 4) Overall the mean anxiety score of the whole subjects is 39.28 ±14.67. The mean anxiety score (39.71±14.89) of the pschiatric inpatients with job is higher than that (36.59±14.20) of the unemployed. 5) In the anxiety tendency according to occupational classification, the unemployed showed less anxiety compared with the employed. Patients with middle occupational classes such as fishing workers and sales workers showed higher levels of the cardiovascular, musculoskeletal, respiratory and skin system anxiety, while patients with higher or lower occupational classes showed lower anxiety. In the relationship between occupational classes and level of anxiety, it showed profiles of inverted V curve. 6) The lower occupational classes such as sales workers showed higher anxiety level, while the higher occupational classes such as clerical workers showed lowest one. Particularly the fishing group exposed in the higher stress situation showed the highest level of anxiety.

도서관리 종합 정보 시스템 설계 및 구현

윤선심,김영준,유재중,이호근,김영현,임한수,박두순 순천향대학교 부설 산업기술연구소 2002 순천향 산업기술연구소논문집 Vol.8 No.1

There has been a sizable growth in the use of rich media over the World Wide Web(WWW) as more individuals and institutions realize rich-media's potential in a broad range of applications, including electronic commerce, education and training, news, etc. Internet and WWW technologies provide the information of the web. Libraries are systems that carry out interactions among information and knowledge seekers. Library become more and more important for the provision of data. Total information system for books management exist in many forms. We present total information system for books management which is applied to several different sources, e.g., administrator security login, statistics about the present state of lending, printing management, and convenient GUI(Graphic User Interface) environment.

水球選手의 無酸素性 파워에 관한 硏究

최선용,이병두,이규성 韓國體育大學校附屬 體育科學硏究所 1990 韓國體育大學校附屬 體育科學硏究所論文集 Vol.9 No.1

The purpose of this study was to analyze the Anaerobic Power and Blood lactate concentration of Water-polo players (University and high school) in incremental load exercise. Subjects were selected from Korean National College of Physical Education and Seoul High School, whose careers had been 3 to 4 years in water-polo. The study utilized isokinetic muscle contraction test and Wingate test by Cybex-Ⅱ and computerized bicycle-ergometer. The results of the study were as follows : 1. Anaeroble powers of water-polo players of the university and high school respectively were 57.62±3.99%, 48.8±8.74% in Extensor and were 45.5±7.30, 39.0±6.96% in Flexor by Cybex-Ⅱ. 2. Anaerobic powers between two groups by wingate test were 57.62±3.99KPM/S in College group, 50.58±3.17PM/S in High School group with a mean power and 68.49±6.19KPM/S in College group, 61.32±3.64KPM/S in High School group with maximal state. But It was a statistically significant differences (p <.001) between two group. Fatigue index of water-polo players of College and high school saparately were 31.14±2.36% and 37.96±4.56%. These data showed a statistically significant difference (p<.001). 3.Maximal blood lactate concentrations between College players and High School Players were 8.6±0.73mmoles/1 and 7.4±1.88 mmoles/1, revealing a statistically significant difference (p< .01) in 3 minute recovery. And recovery ratio respectively are 64.4%, 62.9% in not statistically significant difference at 10 minute of recovery. 4. Correlation coefficients between endurance ratio of extensor, flexor and maximal blood lactate respectively showed 0.872, 0.804 for water-polo player of univ. and high school. Between means, maximal values of wingate test and maximal blood lactate are 0.849, 0.860.