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박재선 고신대학교 의학부 1993 高神大學校 醫學部 論文集 Vol.9 No.1
During the past two decades, a dramatic progress has been made in the treatment of childhood acute lymphoblastic leukemia(ALL). The long-term survival of childhood ALL has been improved from around 20% in the beginning of 1970' to as high as 60-70% currently. It is largely due to the improved combination chemotherapy, preclinical treatment of the most sanctuary area, the central nervous system, improved survival of poor-prognosis subgroup by intensive chemotherapy and salvage of relapsed patients with better chemotherapy regimens and with bone marrow transplantation. To date, the use of other therapeutic approach than multiple combination chemotherapy has been unconceivable. Consequently, review of important outocmes of the recent chemotherapeutic regimens will give us a future direction and help to refine present treatment protocol.
사염화규소 누출사고지점 주변 식물에 대한 노출지표 평가
박재선,김지영,김명옥,박현우,정현미,최종우 한국환경농학회 2017 한국환경농학회지 Vol.36 No.4
BACKGROUND:Silicon tetrachloride reactswithmoisture in the atmosphere to generate hydrogen chloride, which affects the environment. Since silicon tetrachloride and its by-products are dispersed in the atmosphere in a short time after the silicon tetrachloride release into the atmosphere, it is difficult to directly assess the extent of environmental impact. In the present study, the exposure test of silicon tetrachloride or hydrogen chloridewas examined in order to establish the criterion of the range affected by the silicon tetrachloride release, and the actual crops in the area exposed to silicon tetrachloride leakage were analyzed. METHODSANDRESULTS:For the experiment of exposure to silicon tetrachloride or hydrogen chloride, the leaves of red-pepper and cornwere used in glass sealed containers. In the actual accident area, 59 samples from10 different kinds of cropswere collected. The pretreatment of the samplewas performed by freezing and grinding, and then extracted using distilledwater. The pHand concentration of chloride (Cl-) ion of the extracted solution weremeasured using pH meter and ion chromatograph, respectively. CONCLUSION: Exposure to silicon tetrachloride caused visible damage, increasing the concentration of chloride ion, and decreasing the pH as well as hydrochloric acid. In the actual crops of the affected area, the tendency was the same as the result of the laboratory test, and the range of influence could be estimated through the concentration of Cl- ion over 2,000 mg/kg, and the correlation evaluation between the concentration of Cl- and pH. Therefore, the concentration of Cl- ion and the correlation betweenCl- and pH would be considered as the factors to estimate the influence range of silicon tetrachloride release. .