간단한 인증키 동의 프로토콜인 Kim-Kim-Hwang 방법의 안전성 고찰

김윤정;김영신;황준 서울여자대학교 컴퓨터과학연구소 2004 정보기술논문지 Vol.2 No.-

The Diffie-Hellman Key Exchange scheme can produce a common session key between the two communicators, but its problem is that it makes a man-in-the middle attack possible. To solve problems like these, several protocols have been put forward, and the Simple Authenticated Key Agreement (SAKA) Protocol is among them. Seo-Sweeney suggested a SAKA protocol initially and the protocol has weakness that a malicious 3rd party can masquerade a valid user. Tseng suggested another protocol that advances this problem but this protocol can still be attacked when the messages in key verification phase are identical. Ku-Wang suggested a new protocol that advances this problem. Kim-Kim-Hwang also suggested a new SAKA protocol and confirmed that their protocol has same safeness and better performance compared to the other SAKA protocols. In this paper, we reanalyze the safeness of SAKA protocols and find out that Kim-Kim-Hwang protocol has not only better performance but also better safeness. Diffie-Hellman의 키 인증 기법에 대한 제 3자 공격 (man-in-the middle attack)에 강한 간단한 인증키 동의 프로토콜인 SAKA (Simple Authenticated Key Agreement Protocol)가 제안된 바 있다. SAKA는 초기에 Seo-Sweeney에 의해 제안되었으며 이 방법은 침입자가 중간에 메시지를 가로채서 정당한 사용자임을 가장할 수 있는 단점이 있다. Tseng은 이 단점을 개선한 방안을 제안하였는데 이것도 키 확인 메시지 두 개의 값이 같을 경우 공격을 받을 수 있음이 밝혀졌다. Ku-Wang은 Tseng 방법의 문제점을 개선한 알고리즘을 제안하였다 그리고 Kim-Kim-Hwang은 새로운 SAKA 알고리즘을 제안하고 이것이 기존 SAKA 프로토콜들과 안전성은 동일하면서도 성능이 개선된 것임을 밝힌바 있다. 본 논문에서는 안전성 분석의 재고찰을 통하여, Kim-Kim-Hwang의 방법이 기존 SAKA 프로토콜들보다 성능면에서뿐만 아니라, 안전성 면에서도 우수함을 밝힌다.

각종 난치성 혈액 질환에서의 비혈연간 골수이식

김동욱,한훈,김정아,김희제,민창기,엄현석,최정현,이종욱,한치화,홍영선,최일봉,신완식,민우성,김학기,김춘추,김원일,김동집 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

목적: 비혈연간 골수이식은 혈연내에 적절한 골수공여자가 없는 만성골수성백혈병, 고위험군의 급성별혁병, 면역억제치료에 실패한 재생불량성빈혈 및 각종 난치성 조혈모세포질환의 완치를 위한 표준적인 치료방법으로 정착되고 있다. 혈연간 표준적인 동종 이식에 비하여 비혈연간 이식시에는 생착부전, 이식편대숙주반응과 감염이 더 빈번하게 발생하며, 국내에서는 아직까지 체계적인 임상연구결과가 보고된 바 없었다. 이에 본 센터에서는 1995년 10월 이후로 약 20개월간 26예의 비혈연간 골수이식을 시행하였으며 3개월 이상의 추적관찰이 가능하여 이식초기 합병증의 관찰 및 분석이 가능하였던 20예의 환자를 대상으로 이식성적 및 문제점을 보고함으로써 새롭게 확대되고 있는 이 분야의 임상연구 및 진료의 활성화를 꾀하고자 한다. 방법: 각종 혈액 종양질환으로 비혈연간 이식을 시행한 총 26예의 환자중 3개월이상의 추적관찰이 가능하였던 20예를 대상으로 후향적으로 임상경과를 분석한 후 생존 분석을 시행하였고, 환자의 연령, 성별, 질병의 상태, 조식 적합 항원의 일치정도, 이식편대 숙주 반응의 유무와 생존기간과의 상관관계를 살펴보았다. 또한 표준위험군과 고위험군으로 나누어 생존율을 비교하였고 이식과 관계된 생착 부전, 이식편대숙주반응, 감염의 발생과 양상 그리고 그 합병증을 관찰하였다. 결과: 1. 환자와 공여자간에 HLA 불일치가 20예 중 4예에서 있었으며, 생착여부의 확인이 가능했던 17예 중 16예에서 생착이 확인되어 94.1%의 생착율을 보였다. 2. 급성이식편대숙주반응은 62.5%(10/16예)에서 발생하였으며 111도 이상의 급성의 이식편대숙주 반응은 25%(4/16예)에서 발생하였다. 만성이식편대숙주반응은 40%(2/5예)의 환자에서 발생하였으며 이들 모두 국소형으로 중증의 진행형 만성이식편대숙주반응이 관찰된 환자는 없었다. 3. 호흡기 합병증은 10예(50%)에서 발생하였으며 감염성 폐렴을 포함한 호흡기 합병증이 가장 흔한 일차적인 사망 원인이었다. 호흡기 합병증이 발생했던 10예중 6예가 감염에 의한 폐렴이 의심되었고 나머지 4예는 특발성 간질성 폐렴이었다. 4. 8.5개월의 중앙추적기간 중 35%의 생존율을 관찰할 수 있었고, 생존기간은0.5개월에서 15개월 (중앙치:4개월)이었다. 한편 고위험군은 25%(3/12예), 표준위험군은 50%(4/8)의 생존율을 관찰할 수 있었다. 5. 가장 흔한 사망 원인은 감염성 폐렴을 포함한 호흡기 합병증(6예)이었고, 이외의 사망 원인으로는 급성 이식편대숙주반응과 다장기부전이 각각 2예, 생착 부전, 간정맥 폐쇄, 그리고 재발이 각각 1예였다. Unrelated bone marrow transplantation(UBMT) has been increasingly recognized as the standard treatment for cure of chronic myelogenous leukemia, high risk acute leukemia, aplastic failed on immunotherapy, and the variety of refractory hematologic diseases in patients lacking a related donor. However, as compared to HLA identical sibing transplantation, UBMT carries higher incidence of graft failure, graft versus host disease(GVHD), and infection. In our center, 26 patients underwent UMBT between October 1995 and June 1997. The minimum follow-up of 3 months was possible in 20 patients, for whom early complications and clinical outcomes were assessed. The median age of the 20 patients was 24 years. 8 patients had standard risk disease and 12 patients had high risk disease. All patients received various preparative regimens including total body irradiation according to disease and disease status. 19 patients received CsA + short course MTX for GVHD prophylaxis. One patient received marrow that was depleted of T cells ex vivo using avidinbiotin column. The class I loci were typed by serological methods and HLA-A, HLA-B and HLA-DRB1. 3 additional pairs were one minor mismatched at the HLA-B locus. Another one patients was one major mismatched at the DRBI alleles. 17 patients were evaluable for engraftment. Successful enfraftment was confirmed in 16 patients(94.1%). Only one patient who was performed one major DRBI mismatched transplants experienced graft rejection. 16 patients were evaluable for acute GVHD. The overall incidence of acute GVHD developed in 4 patients(25%). Five patients were evaluable for the development of Ⅳ acute GVHD developed in 4 patients (25%). Five patients were evaluanle for the development of chronic GVHD. 2 patients(40%) developed limited chronic GVHD. Respiratory complications including pulmonary infection developed in 10 patients(50%) and these complications were the most common primary cause of death. Of these 10patients, 6 had pneumonia due to fungus(4 patients), pacterial (1 patient), and CMV infection (1 patient) and 4(20%) had idiopathic interstitial pneumonitis and/or adult respiratory distress syndrome. The duration of median follow- up was 8.5 months and 7 of 20 patients(35%) are alive at the time of this analysis with survival duration of 0.5 to 15 months(median survival duration: 4 months). The overall survival was 25% (3/12 patients) in high risk group and 50%(4/8 patients) in standard group. From these results, we can predict that the incidence and severity of GVHD in Korea are lesser than multiracial countries and the long-term survival of patients with standard risk disease can approach that of HLA matched sibling transplants. For the past two years, the performance of UBMT has been rapidly increasing and it will be possible to analyze much larger number of patients soon in Korea. In the future the problems of graft failure, GVHD, and infection due to long lasting immunocompromised status will need to be overcome by continued medical research. In addition, the volunteer donor pool will have to be expanded by the promotion of the national awareness of its need.

시스템 다이내믹스를 이용한 간호단위별 간호인력 산정에 관한 연구

김문실,성영희,권경자,김도형,김정아,신덕신,유인자,유재국,이현숙 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: The purpose of the study was to forecast manpower by building the nursing manpower-staffing model(surgical-medical nursing unite). Method: The system dynamics approach was adapted to build a simulation model for calculating medical-surgical nursing manpower-staffing. The model was built up on Venism 5.0b DSS. Result: The results in the basic circumstance are in following. The level of nursing service quality, patientsatisfaction, and nurse job satisfaction maintains higher at medical-surgical nursing unit of the tertiary hospitals with the ratio of bed to nurse 2.5:1-3.0:1 than at any other situations. The level of nursing service quality, patient satisfaction, and nurse job satisfaction maintains higher at madical nursing unit of the secontary hospotals with the ratio of bed to nurse 3.0:1 and at surgical nursing unit of the secondary hospitals with the ratio of bed to nurse 3.0:1-3.5:1 than at any other situations in the fundamental from. The results in the simulation circumstance are in following, As author raises the operating rate of bed into 95-100%, and cut skilled nursing staff down, the level of nursing-service quality, patient satisfaction, and nurse job satisfaction drops slightly. Conclusion: In terms of economic efficiency on tertiary hospotals, the ratio of bed to nurse for the best reasonable medical-surgical nursing manpower-staffing is 3.0:1. In terms of economic efficiency on secondary hospitals, the ratio of bed to nurse for the best reasonable medical nursing manpower-staffing is 3.0:1 and surgical nursing manpower-staffing is 3.5:1

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

신규간호사와 프리셉터가 인지하는 프리셉터의 교수효율성 비교

김지양,김영선,김춘실,박현숙,신미영,윤연숙,조유숙,박미미,유문숙 한국간호과학회 간호행정학회 2009 간호행정학회지 Vol.15 No.2

Objective: The purpose of this study was to compare preceptors and new graduate nurses on their perception of preceptor teaching effectiveness. Methods: The participants were 90 new nurses and 90 preceptors who worked in A medical center. The data were collected from July 1 to September 30, 2008. A cross-sectional descriptive survey was done using a structured questionnaire. Results: New nurses' perception (4.07±.44) of the preceptor teaching effectiveness was significantly higher than perception of the preceptors (3.57±.37). Fifty five percent of new graduate nurses reported a lack of coherence in the preceptor's practice guidelines. For 5 causal factors classified on the teaching effectiveness, the factor of 'Professional knowledge and ability' showed the highest score, but 'Interpersonal and communication skill' got lowest score for both group. Preceptors responded that they did not have enough time to teach well because of their heavy workloads. Conclusions: These results suggest that the preceptors need appropriate compensation and education opportunities, and new graduate nurses need consistent education by the teaching professionals. Therefore, it is important to give preceptors full charge of the preceptorship. Also, it will be necessary to develop education programs to enhance interpersonal and communication skill for preceptors and new nurses.

The Butanol Fraction of Bitter Melon (Momordica charantia) Scavenges Free Radicals and Attenuates Oxidative Stress

Kim, Hyun Young,Sin, Seung Mi,Lee, Sanghyun,Cho, Kye Man,Cho, Eun Ju The Korean Society of Food Science and Nutrition 2013 Preventive Nutrition and Food Science Vol.18 No.1

To investigate radical scavenging effects and protective activities of bitter melon (Momordica charantia) against oxidative stress, in vitro and a cellular system using LLC-$PK_1$ renal epithelial cells were used in this study. The butanol (BuOH) fraction of bitter melon scavenged 63.4% and 87.1% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals at concentrations of 250 and $500{\mu}g/mL$, respectively. In addition, the BuOH fraction of bitter melon effectively scavenged hydroxyl radicals (${\cdot}OH$). At all concentrations tested, the scavenging activity of the BuOH fraction was more potent than that of the positive control, ascorbic acid. Furthermore, under the LLC-$PK_1$ cellular model, the cells showed a decline in viability and an increase in lipid peroxidation through oxidative stress induced by pyrogallol, a generator of superoxide anion ($O_2{^-}$). However, the BuOH fraction of bitter melon significantly and dose-dependently inhibited cytotoxicity. In addition, 3-morpholinosydnonimine (SIN-1), a generator of peroxynitrite ($ONOO^-$) formed by simultaneous releases of nitric oxide and $O_2{^-}$, caused cytotoxicity in the LLC-$PK_1$ cells while the BuOH fraction of bitter melon ameliorated oxidative damage induced by $ONOO^-$. These results indicate that BuOH fraction of bitter melon has protective activities against oxidative damage induced by free radicals.

교합면 우식병소의 다양한 진단법에 관한 비교연구

김재곤,김영진,김영신,백병주 大韓小兒齒科學會 2001 大韓小兒齒科學會誌 Vol.28 No.4

교합면의 열구는 우식이 발생하기 쉬운 위치이며, 특히 초기우식병소는 건전해 보이는 법랑질 하방에서 진행되는 경우가 많고, 주위 건전 법랑질과 잘 구별되지 않아서 주기적인 검사에도 불구하고 우식의 치료 시기를 놓치는 경우가 종종 있다. 초기 우식을 조기에 진단할 경우 불소도포, 식이조절, 치태조절 능력개선 그리고 타액분비 촉진 등의 방법으로 그 병리적 과정을 차단하고, 조기에 치료할 수 있다는 관점에서 조기 진단은 중요시 되고 있다. 본 연구는 발거된 치아에서 교합면 우식을 검출하기 위해 두가지 전통적인 진단법인 시진, 방사선 검사법에 대하여 레이저 형광측정법을 이용한 새로운 우식진단기구인 Diagnodent (Biberach , Germany)의 민감도, 특이도 그리고 정확도를 비교함으로서 교합면 초기 우식 병소에 대한 가장 신뢰성 있는 진단 방법에 대하여 평가하고자 하였으며 다음과 같은 결론을 얻었다. 1. Diagnodent는 건전치에서 7.8, 초기우식에서 25.4, 법랑질 우식에서는 30.5 그리고 상아질 우식에서는 53.8의 평균값을 나타냈다. 2. 염료를 이용한 치아조직표본검사와 스피어만과 피어슨 상관계수에서 Diagnodent(0.736, 0.619)와 시진(0.664, 0.666)에서 높은 상관성을 나타냈고 방사선 촬영검사(0.333, 0.335)에서 가장 낮은 상관성을 나타냈다(P<0.01, 전체). 3. 교합면 우식진단의 정확도는 Diagnodent의 민감도와 특이도가 가장 높았고 방사선 검사가 34%로 가장 낮았다. 4. 초기 우식의 경우, Diagnodent의 민감도와 특이도가 가장 높았고 법랑질 우식의 경우, 시신의 민감도가 가장 높았으며 Diagnodent의 특이도가 가장 높았다. 상아질 우식의 경우, Diagnodent의 민감도와 특이도가 가장 높았으며 시진의 민감도가 가장 낮았다. The aims of this study were to compare the accuracy, sensitivity and specificity of cnventional visual examination, radiography and a new laser fluorescence method, KaVo Diagnodent, for the detection of occlusal caries lesions. One hundred sound human premolars and molars which had no restorations or interproximal cavities were tested by three methods. Tooth lesions depth was assessed at histologic examination using Caries detector dye The following results were obtained. 1. Diagnodent show 7.8 in sound tooth, 25.4 in initial caries, 30.5 in enamel caries, and 53.8 in dentin caries with average score 2. Spearman and Pearson relation coefficient was high between tooth-specimen test with dye and Diagnodent(0.736, 0.619), visual examination(0.664, 0.666), and was low between tooth-specimen test with dye and radiographic examination(P<0.01, total) 3. Accuracy of occlusal caries was highest on Diagnodent(65%) and lowest on radiographic examination(35%) 4. In initial caries, the sensitivity and specificity of Diagnodent method was the highest. In enamel caries, the sensitivity of visual examination was the highest and specificity of Diagnodent method was the highest. In dentinal caries, the sensitivity and specificity of Diagnodent method was the highest and sensitivity of visual examination was the lowest.

The Butanol Fraction of Bitter Melon (Momordica charantia) Scavenges Free Radicals and Attenuates Oxidative Stress

Hyun Young Kim,Seung Mi Sin,Sanghyun Lee,Kye Man Cho,Eun Ju Cho 한국식품영양과학회 2013 Preventive Nutrition and Food Science Vol.18 No.1

To investigate radical scavenging effects and protective activities of bitter melon (Momordica charantia) against oxidative stress, in vitro and a cellular system using LLC-PK₁ renal epithelial cells were used in this study. The butanol (BuOH) fraction of bitter melon scavenged 63.4% and 87.1% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals at concentrations of 250 and 500 ㎍/mL, respectively. In addition, the BuOH fraction of bitter melon effectively scavenged hydroxyl radicals (ㆍOH). At all concentrations tested, the scavenging activity of the BuOH fraction was more potent than that of the positive control, ascorbic acid. Furthermore, under the LLC-PK₁ cellular model, the cells showed a decline in viability and an increase in lipid peroxidation through oxidative stress induced by pyrogallol, a generator of superoxide anion (O₂^-). However, the BuOH fraction of bitter melon significantly and dose-dependently inhibited cytotoxicity. In addition, 3-morpholinosydnonimine (SIN-1), a generator of peroxynitrite (ONOO^-) formed by simultaneous releases of nitric oxide and O₂^-, caused cytotoxicity in the LLC-PK₁ cells while the BuOH fraction of bitter melon ameliorated oxidative damage induced by ONOO^-. These results indicate that BuOH fraction of bitter melon has protective activities against oxidative damage induced by free radicals.

어머니의 구강보건관리행태가 초등학교 아동의 치아우식에 미치는 영향

김영남 ( Young Nam Kim ),송윤신 ( Yun Sin Song ),김윤신 ( Yun Sin Song ) 한국치위생학회 2012 한국치위생학회지 Vol.12 No.1

Objectives : By analyzing the affects of the mother`s oral care to the caries experiences of the elementary school children, To looking for the way to prevent dental caries in the primary school, to provide baseline data to perform the associated oral health education. Methods : Between the 3,676 children`s dental check-up data and the 2,934 survey of parents from 9 elementary schools in the the Gyeonggi Province, the exactly matching data of 2,358 pairs, children versus mothers, were analyzed during the period, 2009 May 4 to July 20, By using the PASW 18(SPSS-PC 18), Frequency analysis of the collected data, and cross-analysis, ANOVA, Bonferroni post-analysis was performed. Results : The findings of the study were as follows. 1. In children, the ratio(DMF rate)of the dental caries experience in permanent teeth, appeared higher for men than women. Divided by grade level, the ratio of caries experience in the permanent teeth(DMF rate) generally appear higher in older than young. Thus between the child`s gender and grade level by the ratio of caries experience in the permanent teeth(DMF rate) showed the statistically significant differences (p<0.05). 2. Between the socioeconomic characteristics of mothers and the children`s level of dental caries experiences, not showed the statistically significant difference.(p>0.05). 3. The significant difference showed between the dental caries levels of the children and the mother`s oral health care behavior - a toothbrush replacement period, mother`s broken teeth, mothers guidances of the brushing after snacks for children(p<0.05). Conclusions : The mother`s oral health attitudes and behaviors can affect to their children`s oral care habits. Therefore The mother themselves should have the right proper habit of oral health care, so that in oral health care mothers should be the model for their children. Institutionally more systematic and detailed oral health educational program in conjunction with the family is needed.(J Korean Soc Dent Hygiene 2012;12(1):145-156)

젊은 노년층의 운동지속의지에 대한 참여동기와 참여만족의 영향력

김범수(Kim, Bum-Soo),원영신(Won, Young-Sin),고대선(Ko, Dae-Sun) 한국웰니스학회 2017 한국웰니스학회지 Vol.12 No.3

본 연구의 목적은 젊은 노년층의 운동참여에 대한 참여동기, 참여만족이 지속적참여의지에 영향을 주는 요인이 무엇인지를 밝히는 것이다. 연구대상은 60-70세 노년층으로 총 305부의 설문지를 실제 분석 자료로 사용하였다. 자료처리는 Window용 SPSS 통계 Package 15.0 Version을 이용하여 빈도분석, 기술통계, 상관관계, 위계적 회귀분석 방법을 실시하였다. 위계적 회귀분석 결과는 다음과 같이 나타났다. 첫째, 노인들의 참여만족에 영향을 주는 요인으로 배우자와 내적동기가 가장 중요하다는 것을 알 수 있다. 위계적 순서로는 내적동기가 가장 높으며, 배우자가 그 다음 순으로 중요도 순위가 결정된다. 둘째, 노인들의 지속적참여의지에 영향을 주는 요인으로 내적동기, 무동기, 참여만족이며, 그 중 내적동기가 가장 높으며, 참여만족, 그리고 무동기 순으로 중요도 순위가 결정된다. The purpose of this study was examined effect of participation motivation and participation satisfaction on exercise adherence intention of young-old age. The subjects were a total 305 people that they were participate in the regular exercise. The collected data were analyzed frequency, descriptive statistics, correlation and hierarchical regression analysis using the SPSS-Win 15.0 program. The results of hierarchical regression analysis were appeared as follows. According to the results of hierarchical regression analysis, significant factors influencing participation satisfaction were spouse and intrinsic motivation. Secondly, according to the results, significant factors influencing exercise adherence intention were intrinsic motivation, amotivation, participation satisfaction. It is important that exercise adherence intention is main factor to intrinsic motivation on the young-old elderly.