간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

Assessment of Alcohol Level in Inebriated Victims of Sexual Assault using Ethyl Glucuronide

Young?Hoon Jo,Mia Kwon,Joon-Bae Lee,Jeong A Ko 한국분석과학회 2022 학술대회논문집 Vol.2022 No.5

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

산불진화정보 관리를 위한 Mobile GIS 공간 데이터 압축기법 개발

조명희,이명보,이시영,김준범,권봉겸,허영진 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.2

최근 무선 인터넷 및 통신기술의 눈부신 발달과 LBS(location based service)개념을 기반으로 한 mobile GIS 기술 개발은 대규모 산불 발생시 정확한 현장 파악과 신속한 상황보고 뿐만 아니라 사고 예방과 분석·평가에 이르기까지 의사결정지원시스템으로 자리를 잡고 있다. 본 연구에서는 지상진화대의 정확한 위치와 이동상황을 실시간으로 파악하여 안전한 진화작업 유도 및 산불진화 환경정보를 제공을 목적으로 mobile GIS 기술 기반의 산불진화정보 관리시스템을 설계하고 네트워크 부하감소를 위하여 '.gci'라는 공간 데이터 압축기법을 개발하여 면, 선, 주기 데이터에 대하여 51~62%의 높은 압축률을 구현하였다. 따라서 대규모 산불 발생시 일어날 수 있는 안전사고를 미연에 방지하고 사고 발생시 신속한 후속조치로 안전하고 과학적인 산불진화 업무를 수행할 수 있도록 하였다. Recently GPS and mobile GIS technologies based on LBS (location based service) have played an important role as DSS (decision supporting system) for domestic forest fire extinguishment policies. In this study forest fire extinguishments information management system based on mobile GIS technique was designed to seize the exact location on wireless network so that it helps to guide the safe and efficient extinguishments affairs and provide the extinguishments environment toward ground fighting teams and the central forest government in real time. Moreover, possibly to operate this system, the foundation technologies by the name of `. gci such as the spatial data compression method, the spatial data transmission method over wireless network and the spatial analysis interface on PDA should be mainly considered. Especially, in this study the spatial data compression method having high compression rate from 51% to 62% for each polygon, line, and point data, without the loss of data was developed.

肝臟損傷이 肝의 Superoxide Dismutase에 미치는 影響

孫健英,曺準承 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

간장손상시 간의 superoxide dismutase의 변화를 알아보기위하여 흰쥐에게 CCl_4를 투여하거나 또는 총담관을 결찰하고 시간경과에 따른 간장의 superoxide dismutase 변동을 관찰하여 다음과 같은 결과를 얻었다. 정상흰쥐 간세포에서의 superoxide dismutase 분포는, 세포질에는 세포 총 superoxide dismutase의 95.2%. mitochandria에는 4.8%가 분포되어 있었다. CCl_4단회 투여시에는, 세포질 superoxide dismutase는 투여후 6시간네 감소되기 시작하여 24시간에 최저치를보이다가 이후 증가하여 72시간에는 대조군의 약 82%까지 회복되는 경향이었고, mitochondrial superoxide dismutase는 투여후 12시간에 감소하기 시작하여 24시간에 최저치를 나타내고 이후 증가하여 72시간에는 대조군의 약 79%까지 회복되는 경향이었다. CCl_4간격투여시에는 세포질, mitochondrial superoxide dismutase 모두 투여후 9일까지 감소되어 회복되지 않았다. CCl_4 간격투여시에는 세포질, mitochondrial superoxide dismutase 모두 투여후 6일까지는 감소되어 있었으나 9일에는 다소 회복되는 경향이었다. 그리고 총담관 결찰시에는 의의있는 변동을 볼 수가 없었다. 이상의 결과로 보아 CCl_4에 의한 간손상시에는 간세포내 superoxide dismutase가 감소하며 세포질의 superoxide dismutase 감소가 mit-ochondrial superoxide dismutase의 감소보다 빨리 일어나나, 담관결찰시에는 이 효소의 변동이 없는 것을 알 수 있었다. To study the influence of liver injury on hepatic superoxide dismutase in rats, superoxide dismutase was determined in rat liver after either CCl_4 injection or common bile duct ligation. In normal rat liver cells, 95.2% of total cellular superoxide dismutase was distributed in cytosol and 4.8% was in mitochondria, respectively. In single injection of CCl_4, cytocolic superoxide dismutase was decreased at 6 hours after injection and revealed minimum value at 24 hours, thereafter increased to 82% of the control level at 72 hours. Mitochondrial superoxide dismutase was decreased at 12 hours after injection and revealed minimum value at 24 hours while increasing to 79% of the control level at 72 hours after injection. In 2 day-interval injection of CCl_4, both cytosolic and mitochondrial superoxide dismutase showed decreased levels until 9 days after the first injection and did not recover. In 3 dua-interval injection of CCl_4, both cytosolic and mitochondrial superoxide dimutase showed decreased levels until 6 days after the first injection and recovered to 75% and 64% of the control at 9 days, respectively. No significant changes were noted after common bile duct ligation. All of these findings are compatible with the views that cellular superoxide dismutase decreases in CCl_4-induced liver injury and decrease of cytosolic superoxide dismutase precedes that of mitochondrial superoxide dismutase. But superoxide dismutase did not change after the ligation of common bile duct.

연골양 한관종 1예

김기준,김영조,정병수 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Chondroid syringoma, also called cutaneous mixed tumor, is a solitary, well-demarcated, firm intradermal or subcutaneous nodule which mainly occurs on the head and neck. Histopathologically, the tumor is composed of pleomorphic components of both epithelial and mesenchymal elements. Chondroid syringoma has been argued about, with differentiation toward eccrine or apocrine units. We report a case of chondroid syringoma in a 51-years-old male patient who has a solitary, 1.0 × 0.7㎝ in sized, firm, erythematous nodule on his nose.

Koebner 현상이 동반된 전신성 광택태선 1예

김기준,김시용,김영조,최규철,정병수 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

Lichen nitidus is a rare chronic dermatitis of unknown etiology. It is characterized by round, flat-topped, flesh-colored papules 2 to 3 mm in diameter that may occur in groups but do not coalesce. The lesions of lichen nitidus are usually localized to the upper extremities, genitalia, chest, and abdomen, but less commonly, they may be generalized. Although the eruption is usually asymptomatic, it is sometimes mild pruritic, and the Koebner phenomenon may be observed very exceptionally. We reported a case of generalized lichen nitidus with Koebner phenomenon.

脂肪組織에 있어서 Glucose-〔U〕-^14C의 脂質에의 編入에 대한 人蔘成分의 影響

郭再濚,曺準承 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.2

攝食 및 絶食狀態에서 또는 여기에 人蔘을 投與함으로써 脂肪組織에 있어서 glucose의 脂質生合成에의 利用이 어떻게 變動하는 가를 觀察하기 위하여 白蓼根의 methanol 抽出成分을 分離 乾燥하고 이것을 體重 100g當 5㎎ 을 生理的食監水 0.5㎖에 녹여서 쥐에게 4日間 注入하고 對照群에는 같은 量의 食監水만 投與해서 다시 이것들을 正常 攝食群과 24時間 絶食群으로 各各 나누어서 人蓼抽出物 또는 生理的食監水를 마지막 投與한 한 時間 뒤에 體重 100g當 glucose-(U)-^14C 4μC와 carrier로써 D-glucose 100㎎를 法入하고 3時間後에 腹腔內의 脂肪組織을 摘出하여 이의 脂質量과 이에 編入된 glucose의 放射性 炭素量을 測定하였다. 脂肪組織中의 脂質含量은 人蓼投與로써 攝食時에는 뚜렷한 增減이 없었으나 絶食時에 있어서 그 減少를 적게 하였다. 投與한 放射性 glucose는 脂肪組中의 脂質에 활발히 編入되었으며 또한 이것은 絶食狀態나 人蓼投與로써 變動하였다. 卽 放財性 glucose의 脂質에의 編入率은 攝食群에 비하여 絶食群에서 約 1.9倍로 높았으며, 여기에 人蓼을 投與한 攝食群에는 多少 增加의는 傾向이었으나 絶食群에서는 約 1.3倍로 若干 높았었다. 그러나 人蓼을 投與한 編入率은 人蓼을 投興하지 않는 絶食群의 그것에 比하여 約 3分의 1이나 낮은 값이었다. 脂肪組織에서의 이러한 현상들은 血淸脂質에 대해서도 유사한 경향을 나타내었다. To investigate effects of ginseng extract on the incorpcration of glucose-(U)-^14C into lipid of adipose tissue in rats, a methanol extract of the roots of dried ginseng was prepared. The extract was injected into the peritoneal cavity of rats in single daily dose of 5㎎ in 0.5㎖ of saline solution per body weight of 100gm for 4 days, and the control group was injected with 0.5㎖ of saline. The two groups were divided into the feeding and the fasting (24 hours). After one hour following the final administration of ginseng extract and saline respectively, all rats were injected with 4μCi of glucose-(U)-^14C mixed with 100gm of glucose, per body weight of 100gm. Three hours later, the amount of lipid content was checked, and the radioactivity of lipid ^14C was measure with gas flow counter. The lipid content of adipose tissue was not so notable increasing effect in the normal feeding with ginseng. However, under the fasting group, the decreasing rate of lipid content was minimized with ginseng administration. The utilization rate of glucose-(U)-^14C into lipid of adipose tissue showed a slight increase under a normal feeding with ginseng. However, it decreased under fasting with ginseng administration. These effects of ginseng administration in the adipose tissue appeared almost same effects in the rat serum.

여름철 참나무속의 이소프렌 배출속도 비교에 관한 연구

김조천,김기준,홍지형,선우 영,임수길 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.1

In order to compare the NVOC (Natural Volatile Organic Compound) emission rates from oak trees, the emission rates of isoprene were quantitatively measured in situ based on tree species and region. As a result, the emission rates from Quercus serrata T. were found to be 1000 times greater than those from Quercus acutissima C. However, the emission rates at the Chiri and Gumsung mountain sites did not show any significant differences in summer. Cuvette tests using four different oak species also supported that there was a tremendous difference in emission rates between Quercus serrata T. and Quercus acutissima C. It was found that the emission rates from the trees were highest on the order of Quercus serrata T., Quercus aliena B., Quercus acutissima C. and Quercus variabilis B.