정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Melville의 "Benito Cereno" 연구

한기욱 인제대학교 1992 仁濟論叢 Vol.8 No.2

This thesis contends that Herman Melville is deeply concerned about social dimensions of American life, and that his method of integrating such dimensions in his works is truly original. "Bonito Cereno", a masterpiece of 19th century American literature, shows well how deeply and persistently Melville explores his contemporary social problems such as slavery and expansionism. In "Bonito Cereno", however, Melville brings into focus not so much the problem of slavery per se as his Yankee protagonist(captain Delano)'s inability to perceive the mutiny of Black slaves. As the main action, the bulk of which is narrated from captain Delano's point of view, unfurls itself, the reader is increasingly involved in what is wrong with captain Delano's mind. That is to say, an overriding emphasis is structurally put on the particular nature of Delano that makes him immune to obvious symptoms of Black revolt. In fact, the underlying problem in "Bonito Cereno" is why captain Delano cannot recognize the revolt of slaves with all the evidences of insurrection on San Dominick, the Spanish slaveship. The answer of the text to that question seems to lie in his "singularly undistrustful good nature". But captain Delano's narrative itself males it clear that such a simple and innate good nature is not incompatible with the most outrageous proslavery ideology. Actually both his misgiving toward Spanish captain Bonito Cereno and his indulgent "genial" attachment to Babo the black rebel reveal that Delano's innocence and benevolence cannot be separated from his racist preconceptions with which the entire narrative of Delano is imbued. Delano's practical mind and attitude is another important factor to obstruct his recognition. Delano's way of dealing with what he observes and feels is typical of a pragmatic thinker such as Benjamin Franklin. Delano does observe and feel a lot of things but proceed instantly t? classify what he senses, cutting out what he instinctly feels irrelevent to his practical usage. After the task of classification has been done, the process of reasoning out as if to solve a mathematical problem is taken up. Melville shows subtlely that such a pragmatic way as Delano's of dealing with the outside world, when combined congenially with his "singularly undistrustful good nature", is the principal cause of the failure of recognizing the revolt and, at the same time, functions in itself as a real power to subdue it. Indeed, it is in the characterization of Delano as a typical Yankee spirit with an American innocene' which contains mental qualities capable of dominating other peoples with an 'undistrustful good nature', that Melville reveals himself a rigorous realist.

韓國産 夜行性 맵시벌科(벌目: 벌亞目)의 分類學的 硏究

이종욱,정종철,김기범,김정한,배지득,남상호 대전대학교 기초과학연구소 2002 自然科學 Vol.13 No.2

영남대 생물학과에 소장되어 있는 표본과 2001년 4월~2002년 6월 사이에 채집한 표본을 대상으로 하여 한국산 야행성 맵시벌의 분류학적 연구와 출현 현황 및 숙주 관계의 분석을 실시하였다. 분류학적 연구 결과 Gauld(1970)가 영국산 야행성 맵시벌을 대상으로 한 연구에서 기록한 Mesochorinae아과, Tryphonin-ae아과, Ctenoplematinae아과, Ophioninae아과의 4아과외에 Metopinae (Metopius속)를 추가하여 한국산 야행성 맵시벌류는 총 5아과 13속을 기록하였다. 또한 한국산 야행성 맵시벌의 출현 현황을 분석한 결과 야행성으로 잘 알려진 Mesochorinae아과의 Mesochorus속, Tryphoninae아과의 Netelia속과 Ophioninae아과가 전체 야행성 맵시벌 증 95%를 차지하였다. 속별 출현현황을 살펴보면 Netelia속이 393개체가 출현하여 가장 많은 수를 나타내었으며 Ophi-on속, Mesochorus속, Enicopilus속도 전체 출현 분류군 중 높은 비중을 차지하였다. 월별 현황을 살펴보면 전반적으로 4월에서 11월 사이에 걸쳐 나타나는데, Op-hioninae아과는 5월과 7월에, Tryphoninae아과는 6월에 집중적인 출현 빈도를 보였다. 숙주의 분류군에 따른 야행성 맵시벌의 기생 양상을 살펴보면 대부분이 나비목을 대상 숙주로 하고 있으며 Mesochorinae아과와 Ctenopelmatinae아과는 벌목에도 많은 종이 기생하는 것으로 나타났다. 특히 Mesochorinae아과의 Cidaphus속은 위생 해충으로 분류되는 기생파리과(Tachinidae)에도 기생하는 것으로 나타나 위생 해충을 구제할 수 있는 천적 분류군으로 연구될 수 있는 가능성을 보였다. 숙주의 식성에 따라 살펴보면 부식성의 먹이를 섭식하는 부식성(saprophagus) 숙주, 곤충의 유충을 섭식하는 식충성(entomophagus)인 숙주가 소수 출현하였고 기생생활(parasite)을 하는 숙주도 다수 출현하였으나 대부분의 야행성 맵시벌의 기생 대상 숙주는 주로 식물을 해하는 식식성 곤충(phytophagus)으로 나타났다. Nocturnal Ichneumonidae, which was called yellow-brown ichneumonoid, included several subfamilies adapted for nocturnal activity. Taxonomic study of nocturnal ichneumonoid has been investigated by Gauld(1975) but examination of Korean nocturnal ichneumonoid has not been provided until now. This present study: the taxonomic revision, Appearance state and Host-parasite relation analysis of nocturnal ichneumonoid, were examined using Korean peninsula specimens. As the result. approximately 13 genera referable to 5 subfamilies appeared regularly in light trap. Genus MetopiudSubfamily Illetopinae) were newly recorded in nocturnal ichneumonoid. Tryphoninae and Ophioninae, which were dominant in appearance taxa! occupied 96% of total numbers of individuals, and majority of them were taken from May to November. Nocturnal ichneumonoid are parasitoids of part of immature holometabolous insects(Coleoptera, Diptera, Hymenoptera, Lepidoptera). Lepidoptera is the most common hosts of nocturnal group except Mesochorinae and Ctenopelmatine. In large number of Mesochorinae are koinobiont hyperparasitoids of ectoparasitic or endoparasitic BraconiddHymenoptera), and, less frequently, of Tachinidae(Diptera1. Also, Ctenopelmatinae are koinobiont endoparasitoids of Symphyta and, rarely, Lepidoptera. Majority of nocturnal ichneumonoid hosts are phytophagous, feeding plant taxa, and many host of Mesochorinae taxa are parastoids, and a few host are saprophagus or entomophagus.

서울대학교치과병원 소아치과를 내원한 교정환자의 분포양상에 대한 연구

구용한,현홍근,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

과거에 비해 소아 및 청소년기에 교정치료를 시작하는 경우가 증가하고 있으며 따라서 소아치과에서 교정치료가 차지하는 비율 역시 증가하는 추세이다. 이러한 변화에 맞추어 소아치과에 내원하는 교정환자의 분포 양상을 파악하기 위하여 본 연구를 시행하였다. 2006년 1월부터 2008년 12월까지 서울대학교 치과병원 소아치과를 내원한 환자 중 교정 진단 받은 792명을 대상으로 조사를 진행하였으며 다음과 같은 결과를 얻었다. 1. 교정 진단을 받은 환자의 연령 분포는 8세가 22%로 가장 많았고 7세(19%), 9세(16%) 순서로 나타났다. 2. 골격 분포는 골격성 1급 부정교합이 52%로 가장 많았고 3급(29%), 2급(19%)순서로 나타났으며 연령이 낮은 경우 3급 부정교합 환자의 비율이 높은 경향을 보였다. 3. 총 792명의 환자 중 28%인 218명에서 전치부 반대교합을 보였으며 연령이 낮은 경우 그 비율이 높은 경향을 보였다. Distribution of orthodontic patients in pediatric dental clinics has increased recently. So it is worth to study about the present status of orthodontic patients in pediatric dental clinics. The purpose of this study was to recognize the characteristics and orthodontic patterns of orthodontic patients in pediatric dental clinics. The material consisted of distribution and orthodontic analysis records of 792 new patients in the department of pediatric dentistry, Seoul National University Dental Hospital, from 2006 to 2008. Results were as follows 1. In age distribution, 8-year-olds group comprised 22%, 7-year-olds 19%, 9-year-olds 16%, 10-year olds 15%, 11-year-olds 11%, and other age groups comprised 18%. 2. In skeletal patterns, skeletal class Ⅰ patients comprised 52%, class Ⅱ 29%, and class Ⅲ 19%. 3. In vertical facial types mesofacial comprised 41%, brachyfacial 35%, and dolichofacial 24%. 4. Out of 792 patients 218 patients(28%) showed anterior cross-bite, and the occurrence ratio of anterior cross-bite increased as the age decreased.

HFC-134a와 대체냉매 HFC-152a에 CF_3I를 혼합한 자동차냉매 특성

권일욱,박찬수,홍경한,문기선,최운수,서의경,윤갑식,이종인,하옥남 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.1

These days, an attention of environment has been increasing all over the world. to prevent the green house effect and destruction of an ozone layer, an ozone destruction potential(ODP) be zero and a refrigerant for low global warming potential(GWP) is needed. HFC-134a, in which hydrogen is mixed instead of chlorine is a refrigerant used for automobile conditioners and its destruction potential is ecologically zero. However, it is not considered as a perfect substitutive refrigerant as its GWP is high. It is studied refrigerant mixtures in which HFC-134a, HFC-152a and CF_3I with low GWP and zero ODP are mixed by experimentally and concluded as follows; 1. with the variation of speed of compressor outside temperature and flow rate, the heat of evaporator and compressor and coefficient of performance was varied, and influenced the air conditioner. 2. The pressure of evaporator was decreased with increasing the speed of compressor and that of the refrigerant HFC-134a was higher 21% than that of azotrope refrigerant mixed with CF_3I. The overall capacity of condensor and evaporator was increased and HGC-134a was higher than azotrope refrigerant mixed with CF_3I 3. The capacity of evaporator with the refrigerant HFC-134a was higher 6% than azotrope refrigerant mixed with CF31 and the required power with zaotrope refrigerant mixed with CF_3I was higher 11% than that of HFC-134a. 4. The COP of the refrigerant FHC-134a was higher 31% in 1000RPM. when outside temperature was increased, COP was decreased. 5. Performance of HFC-134a is better than azotrope refrigerant mixed with CF_3I but prefered zaotrope refrigerant mixed with CF_3I considering the environment.

Cathepsin D가 타액선종양에 미치는 영향에 관한 면역조직화학적 연구

라기욱,조한국 慶熙大學校 大學院 1995 高凰論集 Vol.16 No.-

The purpose of the present study was to evaluate the localization of cathepsin D, and then further to prove the correlation with other clinical parameters, and to survey carcinogenesis and the role of various type of the tumor cells in the salivary gland tumors. 5 cases of normal minor salivary gland as controls, 14 cases of pleomorphic adenoma, 7 cases of mucoepidermoid carcinoma, 4 cases of adenoid cystic carcinoma, 1 case of acinic cell carcinoma and 4 cases of adenocarcinoma NOS from files of Dept. of Oral Pathology, School of Dentistry, Kyung Hee University were reexamined. The tissue sections obtained from paraffin-embedded blocks were stained with Hematoxylin-eosin, and immunostained with rabbit anti-human cathepsin D antibody using labeled streptavidin-biotin complex peroxidase method. The results were as follows : 1. The expression of cathepsin D revealed more frequently in malignant salivary gland tumors than that in benign salivary gland tumors, and particularly marked in mucoepidermoid carcinoma. 2. 11 cases of 14 cases of pleomorphic adenoma were positive immunoreactivity cathepsin D, and chiefly localized in ductal cells and tumor cell proper. 3. 7 cases of mucoepidermoid carcinoma were positive immunoreactivity to cathepsin D. Because this protease localized generally in the intermediate cells and the lining cells of pseudocysts, it suggests that these cells could have different biologic behavior compared with mucous cells, epidermoid cells and clear cells. 4. 3 cases of 4 cases of adenoid cystic carcinoma were positive immunoreactivity to cathepsin D. As the cathepsin D localized in peripheral cells of tumor parenchymes in a case of the recurred lesion, it proposes that tumor cells could more progressively infiltrate into adjacent stroma. 5. In one case of acinic cell carcinoma, cathepsin D showed positive immunoreactivity weakly in the clear cells. 6. 3 cases of 4 cases of adenocarcinoma NOS were positive immunoreactivity to cathepsin D. And tumor cells revealing abnormal mitotic features and pleomorphism were more markedly immunoreactive response.

수직적 안모형태와 치아성숙도의 상관관계에 대한 연구

구용한,현홍근,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

본 연구는 수직적 안모형태와 치아성숙도의 관계를 평가하고 이러한 연관성에 대한 사춘기 성장의 영향을 평가하기 위한 것이다. 이번 연구를 위해 7세에서 9세, 13세에서 15세 환자 1306명을 Ricketts의 VERT index를 이용하여 수직적 안모 형태를 분류하였고 환자들의 치령을 Demirjian법으로 평가하여 다음과 같은 결과를 얻었다. 1. 모든 군에서 치령이 역령과 비교 시 통계적으로 유의한 수준에서 크게 측정되었다. 2. 사춘기 연령군에서 brachyfacial type의 경우가 dolichofacial type 보다 치아성숙도가 크게 나타나는 경향을 보였다. 여성의 경우는 통계적으로 유의성있게 차이가 나타났으며, 남성의 경우는 통계적 유의성은 보이지 않았다. 3. Brachyfacial type의 경우 사춘기전 군들과 비교 시 사춘기 군들에서 치아성숙도가 유의성있게 높게 나타났으며, dolichofacial type의 경우는 연령층간 치아성숙도의 차이를 보이지 않았다. The purpose of this investigation was to study the relationship between vertical facial pattern and dental maturation in children in pubertal and pre-pubertal periods. The material consisted of lateral head films and panoramic radiographs of 1306 patients. The subjects were selected according to Ricketts's VERT index and other including criteria. These subjects were divided by VERT index to brachyfacial group and dolichofacial group. In each selected subject, dental age was determined according to Demirjian's dental maturity score. All subjects were distributed according to age, vertical facial type and sex, mean and standard deviation of chronological age, dental age and age difference were determined in each group. And the data were analysed to find the difference of tooth maturation by facial pattern. Findings of this study include: 1. In all groups, dental age was determined higher than chronological age in statistically significant level. 2. Compared by vertical facial pattern, in pubertal age groups, it seems that subjects with brachyfacial type presented the tendency to have an advanced dental maturation, only in female group. 3. Compared by pubertal period, brachyfacial groups presented more advanced dental maturation in pubertal groups than pre-pubertal groups.

휴대전화의 전자파가 생쥐의 뇌에서 NMDA receptor의 발현에 미치는 영향

정기윤,한상욱 순천향대학교 기초과학연구소 2004 순천향자연과학연구 논문집 Vol.10 No.2

NMDA Receptor plays a role in long term memory and anxiety. Repeated exposure to the magnetic field is likely to contribute insomnia, memory systems, nervosity and uncoordinated behavior. The brain region, hipppocampus play a prominent role in learning and memory, thalamus relays information form the sensory organ, hypothalamus control the secretion of hormones for growth, reproduction, metabolism and temperature regulation. The cerebellum is the regulating center of the behaivor by controling skeletal muscle. Charged calcium ion influx through NMDA receptors maybe influenced by exogenous magnetic field. As a neurotransmitter receptor, NMDA receptor gene expression system may be affected by the abnormal permeability of the calcium ion. To compare cellular phone magnetic effects between brain regions and between NMDA receptors. We measured the RNA quantity of NR1, NR2A, NR2B, NR2C, NR2D. samples are exposed 9 hours/day for three months. In cerebellum, NR2A and NR2B are expressed 20 and 55 times more then the unexposed mouse tissue respectively. The others are suppressed ad a half of the control. In hippocampus, all of the NR expressions are enhanced several hundred times then the control. In thalamus, NR2C and NR2D are expressed 3times and 5 times more then the control respectively. The others are expressed nearly as same level as the control. In hypothalamus, all of the NR expressions are suppressed at 1/3 of the control.

타액선종양에서 c-erbB-2 종양단백질의 발현과 cathepsin D의 분포에 관한 연구

라기욱,조한국 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.1

The purpose of the present study was to evaluate the expression of c-erbB-2 oncoprotein and localization of cathepsin D, and then further to prove the correlation with other clinical parameters, and to survey carcinogenesis and the role of various type of the tumor cells in the salivary gland tumors. A total of 30 salivary gland tumors(pleomorphic adenoma, n=14 ; mucoepidermoid carcinoma, n=7 ; adenoid cystic carcinoma, n=4 acinic cell carcinoma, n=1 ; adenocarcinoma, n=4) and 5 cases of normal minor salivary- gland as controls were retrieved from files of Dept. of Oral Pathology, School of Dentistry, KyungHee University. The tissue sections obtained from paraffin-embedded blocks were stained with Hematoxylin-eosin, and imrnunostained with rabbit anti-human c-erbB-2 oncoprotein antibody and rabbit anti-human cathepsin D antibody using labeled streptavidin-biotin complex peroxidase method. The results were as follows ; 1. 14 cases of pleomorphic adenoma were stained negatively to c-erbB-2 oncoprotein. But 11 cases of them were positive immunoreactivity to cathepsin D, and chiefly localized in ductal cells and tumor cell proper. 2. 3 cases and 7 cases of mucoepidermoid carcinoma were positive immunoreactivity to c-erbB-2 oncoprotein and cathepsin D, respectively. Because these proteins localized generally in the intermediate cells and the lining cells of pseudocysts, it suggests that these cells could have different biologic behavior compared with mucous cells, epidermoid cells and clear cells. 3. 4 cases of adenoid cystic carcinoma were negative immunoreactivity to c-erbB-2 oncoprotein, and 3 cases of them were positive irnmunoreactivity to cathepsin D. As the cathepsin D localized in peripheral cells of tumor parenchymes in a case of the recurred lesion, it proposes that tumor cells could more progressively infiltrate into adjacent stroma. 4. 1 case of acinic cell carcinoma was negative immunoreactivity to c-erbB-2 oncoprotein, but cathepsin D showed positive immunoreactivity weakly in the clear cells. 5. 1 case and 3 cases of adenocarcinoma NOS were positive immunoreactivity to c-erbB-2 oncoprotein and cathepsin D, respectively. And tumor cells revealing abnormal mitotic features and pleomorphism were more markedly immunoreactive response. 6. After all, c-erbB-2 oncoprotein and cathepsin D partly seem to play an important role in the initiation and progression of salivary gland tumors or in the malformation of glandular cells. The case of only cytoplasmic immunoreactivity without membranous immunoreaction to c-erbB-2 oncoprotein was showed mostly in the ductal cells of normal salivary gland, benign salivary gland tumor and malignant salivary gland tumor. For that reason it suggests that cytoplasmic immunoreactivity could have no connection with progression and maintenance of salivary gland tumors.

광대역 엑세스 망을 위한 연결 제어 프로토콜의 연동 모델

김춘희,차영욱,한기준 安東大學校 工業技術硏究所 1999 공업기술연구논문집 Vol.6 No.1

B-ISDN 환경에서 전송 시스템은 가입자망과 국간 중계망으로 구성되며, 가입자망 내에 도입된 광대역 엑세스 망은 다양한 유형의 가입자들을 서비스 노드로 집선하는 기능을 수행한다. ITU-T의 SG13에서는 광대역 엑세스 망과 서비스 노드 사이에서 ATM 자원의 동적인 할당 및 해제를 위하여 연결제어 프로토콜의 표준화를 수행하고 있다. ATM 연결의 설정을 위한 연결 제어 프로토콜과 신호 프로토콜의 연동 기능은 서비스 노드에서 수행되며, ITU-T에서는 순차적 연동 모델을 채택하고 있다. 순차적 연동 모델은 SN에서 각 프로토콜의 절차가 순차적 방식으로 연동되므로 연결 지연이 크다. 본 논문에서는 광대역 엑세스 망의 도입으로 인한 연결 설정 지연을 최소화하기 위하여 병렬형으로 수행되는 연동 모델을 제시하였다. 그리고 순차적 연동 모델과 본 논문에서 제안한 병렬형 연동 모델의 연결 설정 지연 및 완료비에 대하여 시뮬레이션을 수행하였다. 시뮬레이션에서 사용된 워크로드 파라미터는 RACE MAGIC 프로젝트의 결과를 적용하였다. In B-ISDN environment, various subscribers are concentrated into a service node via a broadband access network. The SG13 of ITU-T is standardizing a connection control protocol which provides dynamic allocation of ATM resources between an access network and a service node. To establish an ATM connection, interworking functions between the connection control protocol and the signaling protocol are performed at the service node. ITU-T adopts a sequential interworking model. In this paper, we propose a parallel interworking model which minimizes the overall connection setup delay by introducing the access network. Using the simulation, we compare our proposed parallel model with the existing sequential model in terms of connection setup delay and completion ratio. The workload parameters of RACE MAGIC project are applied to the analysis and simulation.