정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

평판하 연기선단의 가시화

한용식,김명배,오광철,유상필 한국화재소방학회 2001 한국화재소방학회논문지 Vol.15 No.1

수평 평판과 충돌하는 제트에 의해 생성되는 연기유동을 관찰하기 위해 질소가스에 kerosene연기입자를 뛰워 유동장을 가시화하였다. 광원으로는 아르곤-이온 레이져 평면광이 사용되었다. Kerosene smoke의 산란 광에 의한 수직평면 상(image)과 수평평면 상을 고속 CCD 카메라와 비디오 카메라로 녹화하였으며, 얻어진 영상으로부터 연기 선단의 순간속도 및 평균속도를 측정하였다. The flow induced by a vertically impinging circular jet under a horizontal plate is investigated by visualization technique, using kerosene smoke in nitrogen gas to visualize the vortex flow and impinging flow. The light source was the sheet beam of Ar-Ion laser. The vertical and horizontal images scattering of kerosene smoke were recorded by the high speed CCD camera and the video camera. The instantaneous velocity of the smoke front were measured from the acquisited images.

알콜의존 환자에서 음주욕구를 유발하는 조건화자극에 대한 연구

한귀원,김명정,김성곤,변원탄 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

DSM-IV에 의하여 알콜 의존으로 진단되어 입원 중인 18세에서 65세 사이의 남자로서 과거 3주이상의 단주 경험이 있는 환자 110명을 대상으로 음주 욕구를 유발하는 조건화 자극의 종류와 빈도를 조사하였다. 먼저 예비조사를 통하여 환자들로부터 수집한 알콜연관자극들 중에서 흔한 내적 및 외적 자극 각각 25가지씩, 모두 50가지를 선정한 후, 대상 환자로 하여금 50가지의 알콜연관자극 중에서 자신에게 해당하는 자극을 모두 선택하게 하였다. 그 후 각 알콜연관자극의 빈도와 유형별 빈도를 조사하고 환자의 인구학적 특성, 음주력, 불안 및 우울 척도 등과 관련하여 검토하였다. 그 결과는 다음과 같다. 1) 조건화 자극을 내적 및 외적 알콜연관자극으로 분류하였을 때, 내적 자극은 신체 상태, 긍정적 기분 상태 그리고 부정적 기분 상태로, 외적 자극은 즐거운 상황, 불쾌한 상황, 알콜과 연관된 상황 및 기타 상황으로 분류되었다. 2) 1인당 선택한 문항의 평균 수는 14.1±8.6개로 내적 자극이 7.5±4.8개, 외적 자극이 6.5±4.4개이었으며 각 자극을 하나라도 선택한 사람은, 내적 자극은 대상군 모두가 선택하였고 외적 자극은 대상군의 99.1%가 선택하였다. 부정적 기분 상태와 불쾌한 상황은 각각 97.3%, 88.2%로서 가장 높은 빈도를 보였고 긍정적 기분 상태와 즐거운 상황도 각각 42.7%, 71.8%로서 높은 빈도를 보였다. 신체 상태에 관한 자극은 대상군의 68.2%가, 알콜과 연관된 상황에 관한 자극은 68.2%가, 그리고 기타 상황에 관한 자극은 49.1%가 선택하였다. 3) 음주 욕구를 증가사켰던 내적 자극 중 높은 빈도로 선택된 문항들은 화가 날 때(71%), 외로울 때(47%),고민이 될 때(45%), 시장기가 돌 때(45%), 잠이 안올 때(45%) 등이었고, 외적 자극 중에서 높은 빈도로 선택된 문항들은 가족이나 친척들과 갈등이 있거나 다투는 경우(53%), 잔치, 초상, 계 등 사회적인 모임이 있을 경우(52%), 하는 일이 잘 되지 않을 때(49%), 직장에서 혹은 친구와 갈등이 있거나 다투는 경우(42%)등이었다. 4) 환자의 나이와 신체 상태의 알콜연관자극 간에는 유의한 정상관관계가 있었고, 문제 음주로 인해 처음 정신과에 입원한 나이와 신체 상태의 알콜연관자극 간에도 유의한 정상관관계가 있었으며, 교육 수준과 신체 상태의 알콜연관자극 사이에는 유의한 역상관관계가 있었다. 그리고 입원횟수와 부정적 기분 상태의 알콜연관자극 사이에는 유의한 정상관관계가 있었다. 그러나 첫 음주 시작 나이, 문제 음주 시작 나이, 문제 음주 지속 기간, 최대 단주 기간, 병원 치료 후 평균 단주 기간, 개인의 특성 불안과 우울 점수 등과 알콜연관 자극의 유형 간에는 유의한 상관관계가 없었다. 또한 직업 유무별, 사회경제 상태별, 음주가족력 유무별, 결혼 상태별, 종교별 및 음주 양상별로 본 알콜연관자극의 유형별 선택 문항 수에 있어서도 통계적으로 의미있는 차이는 없었다. Conditioned stimuli provoking alcohlol craving in the alcoholics were surveyed in 110 hospitalized male patients with the diagnosis of alcohol dependence according to DSM-IV who had had 3 weeks or more of successful periods of alcohol abstinence after the onset of alcohol dependence. A preliminary study of preparing a list of 50 alcohol related cues(ARCs) was performed by collecting ARCs from 50 alcoholic patients, choosing the more frequent stimuli and rearranging those into 25 internal and 25 external ARCs. And then, each of the 110 subjects was asked to choose all the ARCs which provoked alcohol craving in the past to survey the frequency of the ARCs and their relevance with regards to a number of variables such as certain demographic data, alcohol history and anxiety and depression. The results were as follows ; 1) The ARCs were divided into internal and external ARCs ; the internal ARCs were categorized into positive affects, negative affects and somatic conditions and the external ARCs into pleasant situations, unpleasant situations, alcohlol-related situations and other situations. 2) Total mean number of ARCs per person was 14.1±8.6, that of internal ARCs being 7.5±4.8 and that of external ARSc being 6.5±4.4. All the subjects chose at least one of the internal ARCs and 99.1% chose one or more external ARCs. ARCs of negative affects and unpleasant situations were chosen by 97.3% and 88.2% of the subjects respectively, whereas, those of positive affects and pleasant situations were chosen by 42.7% and 71.8% respectively, showing unexpectedly high frequency. ARCs pertaining to somatic conditions were chosen by 68.2% of the subjects, those of alcohol-related situations were chosen by 68.2% and those of other situations by 49.1%. 3) Frequently chosen items of internal ARCs were when I was angry (71%),' when I was lonely'(47%), 'when I was distressed'(45%), 'when I was hungry'(45%) and 'when I had trouble sleeping' (45%). Those of external ARCs were 'when I had an argument or conflict with a relative' (53%), 'when I was at a social meeting such as party or funeral ceremony'(52%), when the things were not going to work out' (49%), 'when I met a friend whom I liked'(49%) and 'when I had an argument with a friend or people at work' (42%). 4) Positive correlations were seen between age and ARCs of somatic conditions and between age at the first psychiatric hospitalization and ARCs of somatic conditions. However, negative correlation was found between educational level and ARCs of somatic conditions. Number of psychiatric hospitalization was positively correlated with ARCs of negative affects. But there were no significant correlations in age at the first drink, age of onset of alcohol related problems, duration of alcohol related problem drinking, maximal length of abstinence, usual duration of abstinence after hospital treatment and score of trait anxiety and BDI. No significant difference was noted in the mean number of ARC subtypes between different groups divided by other demographic or clinical variables such as status of job, social class, family history of alcohol dependence, status of marriage, religion and drinking patterns.

효율적인 원격교육을 위한 웹 메일시스템의 설계 및 구현

한명성,이완주 용인대학교 학생생활연구소 2000 학생생활연구 Vol.8 No.-

In this thesis, I implement a wed-based mail system using PHP language and IMAP protocol. The web-based mail system will be useful not only as the effective mail system in the environment such as school with many students but little computers, but also as the assistance of the distance education program spread in our educational circumstance. The web-based mail system do not adopts POP protocol but IMAP protocol appropriate to use in "line"essage processing. IMAP protocol designed for "online" application thus, shows better performance in the circumstance of "online" such as the web-based mail system then POP protocol Therefore, 1 can guarantee that the web mail system based on IMAP protocol has the better capacity then based on IMAP protocol. Also, using the script language PHP, highlighted as a wed programming language for the next generation with the fast speed and security, it is designed to be able to respond quickly over a number of user. The web-based mail system provides various functions for user's conveniences such as controling mailbox of producing, deleting and changing, various functions for MIME message decoding controling addresses, registrating spam mail beside the basic functions like reading, sending, replying and deleting. The personal informations such as password and text informations registrating in spam mail and address control became more stabilized and secure through the database. This system is implemented in Solaris circumstance using Apache web server, but it can be used in all the circumstances of Unix, NT and Linux because most of web sever provides PHP 1anguage.

生態親和的 飼育環境 制御方式 確立을 위한 누에 核多角體病 發生要因 分析

韓明世,林鐘聲 慶北大學校農業科學技術硏究所 1997 慶北大農學誌 Vol.15 No.-

世界的으로 養蠶地域에서 큰 피해를 주는 核多角體病은 養蠶現場에서 蠶室 蠶具類의 철저한 포르말린 소독에도 불구하고 예방효과가 疑問視되는 경우가 발생하며, 이는 병원체의 存否 만으로 본 疾病의 蔓延이 설명될 수 없기 때문이라는 사실을 實驗病理學的으로 立證하였다. 核多角體病의 發生을 助長하는 不良 環境要因을 파악하기 위하여 1979년부터 1993년 까지 15년간 한국 일본 필리핀 등지에서 57건의 사육사례를 조사하였다. 環境狀態와 發病事例의 연관성을 분석하므로써 發病生理와 관련된 環境要因을 해명한 결과, 고름병 發生頻度는 상엽육과 인공사료육 간에 비슷한 경향을 나타내었고, 잠실 잠구류의 消毒방법에서는 포르말린 消毒 與否에 따른 차이가 인정되지 않았다. 交雜種은 原種보다 核多角體病 발생율이 다소 높은 수준이었으며, 특히 애누에때 부터 장기간 通氣不良인 사육환경에서는 發病率이 현저하게 높았다. 또한, 1993년부터 1997년 까지 5년간의 實證試驗에서는 蠶室 및 蠶具類의 청소와 사육실의 强制循環式 換氣로 사육환경을 개선하므로써 人體에 有害한 농약을 사용하지 않고도 누에 核多角體病 발생을 효율적으로 제어할 수 있음을 立證하였다. For the prevention of worldwide prevalent disease of nuclear polyhedrosis virus (NPV), environmental conditions and their incidence of grasserie was investigated through 57 cases of silkworm rearing from the year of 1979 to 1993 in the countries of Korea, Japan, and Philippines. Relationship between the occurrence of NPV and environmental factors were also analysed from the aspect of causal pathogenesis. Unfavorable foactors related to the prevalence of NPV disease was reconfirmed by the assay of experimental rearing. Silkworms reared on mulberry leaves or artificial diet appeared similar result on the occurrence of grasserie. Disinfection by formalin and simple sweeping or washing was not significantly different on the occurrence of NPV disease. Following insufficient ventilation on the younger larvae, from the 1st to 3rd instar, the disease by NPV at the later stage was remarkably emphasized those insidence. An experimental rearing from 1993 to 1996 demonstrated the prevention of NPV disease by simple cleaning of sweeping under the condition of air forced ventilation, the customal practice of disinfection with formalin or any other chemical agents could be omissible.

혈압 및 혈관손상에 대한 Candesartan과 Cilnidipine의 병용투여 효능 평가

정상혁,한주희,명창선 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

This study was designed to evaluate the effect of candesartan combined with cilnidipine on high blood pressure in spontaneous hypertensive rats (SHRs) and vascular injury induced by cuff-placed neointimal hyperplasia model. To measure blood pressure, low and high doses of candesartan (0.765 and 1.53 mg/kg/day) and cilnidipine (0.96 and 1.92 mg/kg/day) alone or in combination were orally administered in telemetered-SHRs for 2 weeks. To examine the protective action of vascular injury, high doses of candesartan (1.53 mg/kg/day) and cilnidipine (1.92 mg/kg/day) alone or in combination was orally administered for 2 weeks in cuff-induced neointimal hyperplasia model of C56BL/6 mice. As a result, high doses of candesartan and cilnidipine in combination decreased in systolic blood pressure (SBP) and mean arterial pressure (MAP) as compared with monotherapy of high dose of each drug, but not statistically significant. In vascular injury model, candesartan and cilnidipine in combination decreased BrdU-positive cells in neointima and vascular smooth muscle cell proliferation as compared with monotheray of each drug. Thus, these results indicate that the combination of candesartan with cilnidipine is effective for the protection of vascular injury, suggesting this combination to be a valuable tool for the management of vascular remodelling such as restenosis.

초정밀 공작기계용 스핀들의 설계제작 및 특성 평가

한복수,박성환,명태식,권경우 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

Precision machining widely bases on the technology connected with machine tools, machining and others. The prototype was designed in the base of the analysis of the precision air bearing spindle which have greate influence upon the machining accuracy of the precision machine. The contents in this study are as follows. 1) Design and manufacture of the spindle system, 2) Performance test of the system. The spindle system is made of aero-static, which has the excellent rotation accuracy was designed and manufactured. As a result of the test (static vibration, dynamic vibration, spindle rotation), the air spindle system was stability. We think that this system can apply to the ultra-precision machine tools.

放射線 照射에 衣한 人蔘貯藏에 關한 硏究 : 第2報, 감마線 照射가 人蔘粉末製品의 貯藏中 理化學的 特性에 미치는 영향 Part Ⅱ, Effect of Gamma Irradiation on the Physicochemical Properties of Ginseng Powder during the Storage

成絢淳,朴明漢,李光承,趙漢玉 한국응용생명화학회 1982 Applied Biological Chemistry (Appl Biol Chem) Vol.25 No.2

紅蔘 및 白蔘粉末製品에 對한 放射線(^(63)Co-r 線) 照射 및 照射線量과 長期貯藏이 理化學的 特性과 外觀品質 變異에 미치는 영향을 25℃에서 4個月間 저장하면서 조사하였다. 兩試料 모두에서 照射線量과 長期貯藏에 따른 變異가 거의 없었다. 理化學的 特性에서 水分, pH, 아미노態窒素, buthanol extract, 還元糖등과 사포닌분획별 패턴에도 大窒없었으나 白蔘粉末의 경우 특히 50% ethanol extract의 收率이 약간 增加되는 傾向을 보였다. 外觀品質의 경우 50% ethanol extract의 色濃度에서는 大差없었으나 粉末自體의 色度에서는 試料間에 약간 差異가 있었다. 紅蔘粉末의 경우 L値와 a値는 減少되었고 b値는 增加되어 茶褐色化 되는 傾向이었고 白蔘粉末에서는 L値가 減少되고 a値와 b値는 線量에 따라 增加되나 貯藏其間에서는 減少와 增加를 보여 濃黃色化되는 傾向이 었으나 識別可能程度의 色度變異범위는 아니었다. 全體的으로 品質의 安定性을 維持하고 있음을 보여주었다. The effect of the physiochemical properties of red and white ginseng powder after ^(60)Co-r ray irra diationduring the storage fer 4 months at 25℃ was investigated. The storage periods and the treatment of irradation at various doses on ginseng powders had no significant effects on the proximate composition and color density of ginseng extract with 50% ethanol. No changes in the contents of saponin and its HPLC patterns were found during the storage. However, a little increase was found in the yield of 50% ethanol extract and Hunter's color value of powder. But generally it was found to be stable in the physicochemical properties of red and white ginseng powder by irradiation of the intensity during the storage.

우리나라 일부 여고생과 여대생의 건강 위험 행태 분석

한성현,최민자,이선희,이명선,이혜진 한국모자보건학회 2000 한국모자보건학회지 Vol.4 No.1

조선업 근로자의 누적외상성질환 실태와 누적외상성질환 범용 작업위험도 평가도구를 이용한 작업분석

한상환,백남종,박동현,장기언,이명학,박종태,김대성,이연숙,백경자,신용수,송동빈 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.4

Cumulative trauma disorders were surveyed in a cross-sectional study of 100 male shipyard workers an 43 male office workers. And baseline checklist for risk assessment of cumulative trauma disorders was applicated in a ship making process. Cases of cumulative trauma disorders were defined using physical examinations and electronic diagnostic mathods. Data on demographics, individual factors(medical condition), work organization and psychosocial aspects of work were obtained by questionnaire. Association between the above factors and cumulative trauma disorders were assessed by multiple logistic regression models. 29(29%) participants of male shipyard workers and 4(9.2%) study subjects of male office workers met our case definitions for cumulative trauma disorders. The myofascial pain syndrome of neck muscles(12% of participants) and carpal tunnel syndrome(5% of participants) were the major two medical conditions in shipyard workers. The odds of male shipyard workers for cumulative trauma disorders to male office workers was 3.15 after adjustment of age(95% C. I. : 2.25-5.44). And the variables such as duration of present job, HIVD condition, and surges in workload were associated at least one of the cumulative trauma disorders in the final models(p<0.05). This study indicates that workrelated upper extremity musculoskeletal disorders are relatively common among shipyard workers, and shows that the psychosocial factors is not likely to be related to the occurrences of these disorders in heavy workers. Also we developed baseline checklist for risk assessment of cumulative trauma disorders. The checklist was unique in that its expected users were industrial hygienists and occupational healthing nurses who did not have much ergonomic background and in that it was targeted to Korean workers in various types. As the first application of the checklist, shipyard workers were evaluated.