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RG-II from Panax ginseng C.A. Meyer suppresses asthmatic reaction
( In Duk Jung ),( Hye Young Kim ),( Jin Wook Park ),( Chang Min Lee ),( Kyung Tae Noh ),( Hyun Kyu Kang ),( Deok Rim Heo ),( Su Jung Lee ),( Kwang Hee Son ),( Hee Ju Park ),( Sung Jae Shin ),( Jong Hw 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.2
In asthma, T helper 2 (TH2)-type cytokines such as interleukin (IL)-4, IL-5, and IL-13 are produced by activated CD4+ T cells. Dendritic cells played an important role in determining the fate of na?ve T cells into either TH1 or TH2 cells. We determined whether RG-II regulates the TH1/TH2 immune response by using an ovalbumin-induced murine model of asthma. RG-II reduced IL-4 production but increased interferon- gamma production, and inhibited GATA-3 gene expression. RG-II also inhibited asthmatic reactions including an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration in lung tissues, airway luminal narrowing, and airway hyperresponsiveness. This study provides evidence that RG-II plays a critical role in ameliorating the pathogenic process of asthmatic inflammation in mice. These findings provide new insights into the immunotherapeutic role of RG-II in terms of its effects in a murine model of asthma. [BMB reports 2012; 45(2): 79-84].
Jun Young Park,Yun Jung Nam,Young Ho Lee,Su Min Hwang,A Ram Kim,Tae Seok Ko,Tae Wan Kim,Sun-Hee Woo,Tae Wook Jung,Sei Joon Park 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Cereal seeds, sorghum, foxtail millet, hog millet, adlay, and corn are traditionally used as health assistant as well as energy supplying food in Korea. While beneficial phytochemicals to human have revealed in cereals, the information on peptides from cereals is far less accumulated than major reserve protein. Here, we analyzed peptide profiles using surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF MS) in cereal seeds for construction of peptide information and attempted to develop peptide biomarkers for cereal identification. To optimize the analysis condition of SELDI-TOF MS, the effect of dilution factor on binding affinity to protein chips was tested using CM10 and Q10 arrays. Peptide clusters were significantly different at the level of 0.01 p-value. Peak spectra were the most stable in 1:50 of dilution factor in both chip arrays. Numbers of detected peak of 5 cereal seeds were 131 in CM10 and 74 in Q10 array. Each cereal was grouped as a cluster and well discriminated into different cluster in the level of 0.01 p-value. Numbers of potentially identified peptide biomarkers are 11, 13, 9, 5 and 12 in sorghum, foxtail millet, hog millet, adlay and corn, respectively. This study demonstrates that each cereal seed have own distinguishable specific peptides although their function are not identified yet in this study. In addition, the proteomic profiling using SELDI-TOF MS techniques could be a useful and powerful tool to discover peptide biomarker for discrimination and assess crop species, especially under 20 kDa.
Clinical Practice Guideline for Cardiac Rehabilitation in Korea
Chul Kim,성지동,Jong Hwa Lee,김원석,Goo Joo Lee,Sungju Jee,Il-Young Jung,Ueon Woo Rah,Byung Ok Kim,Kyoung Hyo Choi,Bum Sun Kwon,Seung Don Yoo,Heui Je Bang,Hyung-Ik Shin,김용욱,Heeyoune Jung,Eung Ju Kim,Jung Hw 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.3
Objective Though clinical practice guidelines (CPGs) for cardiac rehabilitation (CR) are an effective and widely used treatment method worldwide, they are as yet not widely accepted in Korea. Given that cardiovascular disease is the second leading cause of death in Korea, it is urgent that CR programs be developed. In 2008, the Government of Korea implemented CR programs at 11 university hospitals as part of its Regional Cardio-Cerebrovascular Center Project, and three additional medical facilities will be added in 2019. In addition, owing to the promotion of CR nationwide and the introduction of CR insurance benefits, 40 medical institutions nationwide have begun CR programs even as a growing number of medical institutions are preparing to offer CR. The purpose of this research was to develop evidence-based CPGs to support CR implementation in Korea. Methods This study is based on an analysis of CPGs elsewhere in the world, an extensive literature search, a systematic analysis of multiple randomized control trials, and a CPG management, development, and assessment committee comprised of 33 authors—primarily rehabilitation specialists, cardiologists, and thoracic surgeons in 21 university hospitals and two general hospitals. Twelve consultants, primarily rehabilitation, sports medicine, and preventive medicine specialists, CPG experts, nurses, physical therapists, clinical nutritionists, and library and information experts participated in the research and development of these CPGs. After the draft guidelines were developed, three rounds of public hearings were held with staff members from relevant academic societies and stakeholders, after which the guidelines were further reviewed and modified. Principal Conclusions CR involves a more cost-effective use of healthcare resources relative to that of general treatments, and the exercise component of CR lowers cardiovascular mortality and readmission rates, regardless of the type of coronary heart disease and type and setting of CR. Individualized CR programs should be considered together with various factors, including differences in heart function and lifestyle, and doing so will boost participation and adherence with the CR program, ultimately meeting the final goals of the program, namely reducing the recurrence of myocardial infarction and mortality rates.
악성경과를 보이는 수막종 : Clinical Experiences of 8 Cases
김동규,정희원,한대희 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.4
Meningiomas are conventionally regarded as benign tumors that can be easily excised. However, some groups of meningiomas grow very fast and recur more frequently than "classic" meningiomas. Authors reviewed eight cases of meningiomas that showed aggressive clinical behavior. These comprised 5 males and 3 females. Age ranged from 21 to 65 years, with an average of 37 years. The histopathological diagnosis of 8 cases were : 6 hemangiopericytic type. 1 papillary type, and 1 syncytial type meningioma. They recurred frequently during the short-period of time in spite of gross total resection of the mass. Two of these patients were dead as a result of recurrence. The common findings of computed tomography scan were hyperdensity on precontrast scan(7/8). irregular tumor margin(5/8). penetrating fronds of tumor into the brain(5/8), central necrosis(5/8), and absence of calcifications. We suggest that the meningiomas, showing radiological and pathological features of aggressiveness, should be removed completely and be treated with radiation therapy.
Two Dimensional Code System Using Genome-wide InDel Markers for Rice Cultivar Identification
Hyang Mi Park,Yul Ho Kim,Jung Pil Suh,Tae Young Hwang,DongWoo Lee,Sunghoon Lee 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Sequence diversity was accumulated through evolution and breeding process. A set of 595 PCR-based novel insertion/deletion (InDel) markers was designed in order to widen the genetic basis for national rice breeding programs. The markers were generated by analyzing of 40 Korean cultivars and published genome sequences of rice(Oryza sativa L. spp japonica). We selected 112 markers spread across all rice chromosomes among the 595 InDel markers, and they showed polymorphic between rice cultivars, which are 284 Korean japonica and Tongil varieties. Due to their simplicity in design and robustness in genotyping, these InDel markers have been routinely used in quantitative trait loci (QTL) mapping studies and marker assisted selection programs for rice. Moreover, the PCR amplification type of InDel markers was converged to digital code, 0 or 1 and then finally represented as one- and two dimensional bar-code system, which could easily differentiate genetically highly homologous japonica rice cultivars. The developed InDel markers uniquely discriminated among each of the Korean cultivars. Therefore, the systems we developed may be valuable tools in discrimination from cultivars
황선혜 ( Sun Hye Hwang ),정숙영 ( Sook Young Jung ),임대현 ( Dae Hyun Lim ),손병관 ( Byong Kwan Son ),김정희 ( Jeong Hee Kim ),양준모 ( Jun-mo Yang ),오인보 ( In Bo Oh ),김양호 ( Yang Ho Kim ),이지호 ( Ji Ho Lee ),이근화 ( Keun Hw 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4
Purpose: The diagnosis of allergic rhinitis (AR) is based upon the concordance between a history of allergic symptoms and diagnostic tests. This study is to investigate the epidemiology of AR by using data from National Health Insurance Corporation (NHIC) and data according to the AR definition in general students health screening. Methods: We examined medical insurance claims data of NHIC from 2004 to 2010 according to age, area, and gender. We investigated the results of Korean International Study of Asthma and Allergies in Childhood questionnaires and skin prick tests of 14,133 students participated in health screening from 2010 to 2012. Results: The prevalence of AR according to the NHIC data was elementary school students (24.34%); middle school students (13.75%) and high school students (12.17%). The prevalence of AR was higher in boy than in girl, annually. In health screening, the prevalence of AR was elementary school students (19.50%±0.26); middle school students (23.19%±0.30) and high school students (24.11%±0.31). The prevalence of AR had peaking at the age late teens (P<0.0001) and was higher in boy (26.49%±0.38) than in girl (17.43%±0.35) (P<0.0001). Sensitization rate of allergen in students with AR was house dust mite (86.71%±0.48); pollen (41.26%±1.01) and molds (14.80%±0.52). Conclusion: The prevalence according to the AR definition tended to be increased with aging in Korean children. There are some differences in the prevalence of AR in the data of NHIC and health screening study. Further investigation will be needed to reveal the causes of this difference.