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이준식,안순철,박영민,김대현,하태권,노경태,박진욱,Deok Rim Heo,손희광,정인덕,이은경,신용규 대한면역학회 2011 Immune Network Vol.11 No.1
Background: Dendritic cell (DC)-based vaccines are currently being evaluated as a novel strategy for tumor vaccination and immunotherapy. However, inducing long-term regression in established tumor-implanted mice is difficult. Here, we show that deoxypohophyllotoxin (DPT) induces maturation and activation of bone marrow-derived DCs via Toll-like receptor (TLR) 4 activation of MAPK and NF-κB. Methods: The phenotypic and functional maturation of DPT-treated DCs was assessed by flow cytometric analysis and cytokine production, respectively. DPT-treated DCs was also used for mixed leukocyte reaction to evaluate T cell-priming capacity and for tumor regression against melanoma. Results: DPT promoted the activation of CD8+ T cells and the Th1 immune response by inducing IL-12 production in DCs. In a B16F10 melanoma-implanted mouse model, we demonstrated that DPT-treated DCs (DPT-DCs) enhance immune priming and regression of an established tumor in vivo. Furthermore, migration of DPT-DCs to the draining lymph nodes was induced via CCR7 upregulation. Mice that received DPT-DCs displayed enhanced antitumor therapeutic efficacy, which was associated with increased IFN-γproduction and induction of cytotoxic T lymphocyte activity. Conclusion: These findings strongly suggest that the adjuvant effect of DPT in DC vaccination is associated with the polarization of T effector cells toward a Th1 phenotype and provides a potential therapeutic antitumor immunity.
Lee, Jun-Sik,Kim, Dae-Hyun,Lee, Chang-Min,Ha, Tae-Kwun,Noh, Kyung-Tae,Park, Jin-Wook,Heo, Deok-Rim,Son, Kwang-Hee,Jung, In-Duk,Lee, Eun-Kyung,Shin, Yong-Kyoo,Ahn, Soon-Cheol,Park, Yeong-Min The Korean Association of Immunobiologists 2011 Immune Network Vol.11 No.1
Background: Dendritic cell (DC)-based vaccines are currently being evaluated as a novel strategy for tumor vaccination and immunotherapy. However, inducing long-term regression in established tumor-implanted mice is difficult. Here, we show that deoxypohophyllotoxin (DPT) induces maturation and activation of bone marrow-derived DCs via Toll-like receptor (TLR) 4 activation of MAPK and NF-${\kappa}B$. Methods: The phenotypic and functional maturation of DPT-treated DCs was assessed by flow cytometric analysis and cytokine production, respectively. DPT-treated DCs was also used for mixed leukocyte reaction to evaluate T cell-priming capacity and for tumor regression against melanoma. Results: DPT promoted the activation of $CD8^+$ T cells and the Th1 immune response by inducing IL-12 production in DCs. In a B16F10 melanoma-implanted mouse model, we demonstrated that DPT-treated DCs (DPT-DCs) enhance immune priming and regression of an established tumor in vivo. Furthermore, migration of DPT-DCs to the draining lymph nodes was induced via CCR7 upregulation. Mice that received DPT-DCs displayed enhanced antitumor therapeutic efficacy, which was associated with increased IFN-${\gamma}$ production and induction of cytotoxic T lymphocyte activity. Conclusion: These findings strongly suggest that the adjuvant effect of DPT in DC vaccination is associated with the polarization of T effector cells toward a Th1 phenotype and provides a potential therapeutic antitumor immunity.
RG-II from Panax ginseng C.A. Meyer suppresses asthmatic reaction
( In Duk Jung ),( Hye Young Kim ),( Jin Wook Park ),( Chang Min Lee ),( Kyung Tae Noh ),( Hyun Kyu Kang ),( Deok Rim Heo ),( Su Jung Lee ),( Kwang Hee Son ),( Hee Ju Park ),( Sung Jae Shin ),( Jong Hw 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.2
In asthma, T helper 2 (TH2)-type cytokines such as interleukin (IL)-4, IL-5, and IL-13 are produced by activated CD4+ T cells. Dendritic cells played an important role in determining the fate of na?ve T cells into either TH1 or TH2 cells. We determined whether RG-II regulates the TH1/TH2 immune response by using an ovalbumin-induced murine model of asthma. RG-II reduced IL-4 production but increased interferon- gamma production, and inhibited GATA-3 gene expression. RG-II also inhibited asthmatic reactions including an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration in lung tissues, airway luminal narrowing, and airway hyperresponsiveness. This study provides evidence that RG-II plays a critical role in ameliorating the pathogenic process of asthmatic inflammation in mice. These findings provide new insights into the immunotherapeutic role of RG-II in terms of its effects in a murine model of asthma. [BMB reports 2012; 45(2): 79-84].
Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma
( Jun Ho Park ),( Jong Won Kim ),( Chang Min Lee ),( Yeong Dae Kim ),( Sung Woon Chung ),( In Duk Jung ),( Kyung Tae Noh ),( Jin Wook Park ),( Deok Rim Heo ),( Yong Kyoo Shin ),( Jong Keun Seo ),( Yeo 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.5
Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane), belonging to a family of natural compounds that are abundant in broccoli, has received significant therapeutic interest in recent years. However, the molecular basis of its effects remains to be elucidated. In this study, we attempt to determine whether sulforaphane regulates the inflammatory response in an ovalbumin (OVA)-induced murine asthma model. Mice were sensitized with OVA, treated with sulforaphane, and then challenged with OVA. Sulforaphane administration significantly alleviated the OVA-induced airway hyperresponsiveness to inhaled methacholine. Additionally, sulforaphane suppressed the increase in the levels of SOCS-3 and GATA-3 and IL-4 expression in the OVA-challenged mice. Collectively, our results demonstrate that sulforaphane regulates Th2 immune responses. This sutdy provides novel insights into the regulatory role of sulforaphane in allergen- induced Th2 inflammation and airway responses, which indicates its therapeutic potential for asthma and other allergic diseases. [BMB reports 2012; 45(5): 311-316]
Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015
Yang, Jeong-Sun,Park, SungHan,Kim, You-Jin,Kang, Hae Ji,Kim, Hak,Han, Young Woo,Lee, Han Saem,Kim, Dae-Won,Kim, A-Reum,Heo, Deok Rim,Kim, Joo Ae,Kim, Su Jin,Nam, Jeong-Gu,Jung, Hee-Dong,Cheong, Hyang- U.S. Department of Health and Human Services * Cen 2015 Emerging Infectious Diseases Vol.21 No.11
<P>In May 2015, Middle East respiratory syndrome coronavirus infection was laboratory confirmed in South Korea. Patients were a man who had visited the Middle East, his wife, and a man who shared a hospital room with the index patient. Rapid laboratory confirmation will facilitate subsequent prevention and control for imported cases.</P>