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박희원(HW Park),손건부(KB Sohn),이원기(WK Lee),양문호(MH Yang) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.10
저자들은 46세의 경산부에서 발생한 자궁경부임신을 조기진단하여 자궁전적출술을 시행하여 병리조직학적으로 확진된 자궁경관임신의 1예를 경험하였기에 문헌적고찰과 함께 이에 보고하는 바이다. Cervical pregnancy is a rare complication of gestation. The cdiagnosis of cervical pregnancy is rarely made clinically, prior to Curettage or instrumentation. Once the diagnosis of cervical pregnancy is made, conservative vaginal treatment shoud be attempted first. If conservative treatment fail, hysterectomy must be performed without delay. A case of cervical pregnancy confirmed by microscopic study postoreratively is presented with a brief review of literatures concerned.
Yoon soo Park,Hyun Jin Tae,Jeong Hwi Cho,In Shik Kim,Taek Geun Ohk,Chan Woo Park,Joong Bum Moon,Myoung Cheol Shin,Tae Kyeong Lee,Jae Chul Lee,Joon Ha Park,Ji Hyeon Ahn,Seok Hoon Kang,Moo Ho Won,Jun Hw 대한해부학회 2018 Anatomy & Cell Biology Vol.51 No.2
Cardiac arrest (CA) is sudden loss of heart function and abrupt stop in effective blood flow to the body. The patients who initially achieve return of spontaneous circulation (RoSC) after CA have low survival rate. It has been known that multiorgan dysfunctions after RoSC are associated with high morbidity and mortality. Most previous studies have focused on the heart and brain in RoSC after CA. Therefore, the aim of this research was to perform serological, physiological, and histopathology study in the lung and to determine whether or how pulmonary dysfunction is associated with low survival rate after CA. Experimental animals were divided into sham-operated group (n=14 at each point in time), which was not subjected to CA operation, and CA-operated group (n=14 at each point in time), which was subjected to CA. The rats in each group were sacrificed at 6 hours, 12 hours, 24 hours, and 2 days, respectively, after RoSC. Then, pathological changes of the lungs were analyzed by hematoxylin and eosin staining, Western blot and immunohistochemistry for tumor necrosis factor (TNF-). The survival rate after CA was decreased with time past. We found that histopathological score and TNF- immunoreactivity were significantly increased in the lung after CA. These results indicate that inflammation triggered by ischemia-reperfusion damage after CA leads to pulmonary injury/dysfunctions and contributes to low survival rate. In addition, the finding of increase in TNF- via inflammation in the lung after CA would be able to utilize therapeutic or diagnostic measures in the future.
Jun Young Park,Yun Jung Nam,Young Ho Lee,Su Min Hwang,A Ram Kim,Tae Seok Ko,Tae Wan Kim,Sun-Hee Woo,Tae Wook Jung,Sei Joon Park 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Cereal seeds, sorghum, foxtail millet, hog millet, adlay, and corn are traditionally used as health assistant as well as energy supplying food in Korea. While beneficial phytochemicals to human have revealed in cereals, the information on peptides from cereals is far less accumulated than major reserve protein. Here, we analyzed peptide profiles using surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF MS) in cereal seeds for construction of peptide information and attempted to develop peptide biomarkers for cereal identification. To optimize the analysis condition of SELDI-TOF MS, the effect of dilution factor on binding affinity to protein chips was tested using CM10 and Q10 arrays. Peptide clusters were significantly different at the level of 0.01 p-value. Peak spectra were the most stable in 1:50 of dilution factor in both chip arrays. Numbers of detected peak of 5 cereal seeds were 131 in CM10 and 74 in Q10 array. Each cereal was grouped as a cluster and well discriminated into different cluster in the level of 0.01 p-value. Numbers of potentially identified peptide biomarkers are 11, 13, 9, 5 and 12 in sorghum, foxtail millet, hog millet, adlay and corn, respectively. This study demonstrates that each cereal seed have own distinguishable specific peptides although their function are not identified yet in this study. In addition, the proteomic profiling using SELDI-TOF MS techniques could be a useful and powerful tool to discover peptide biomarker for discrimination and assess crop species, especially under 20 kDa.
박정희(JH Park),조행원(HW cho),우신희(SH Woo),박금자(KZ Park) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.10
Toxemia of pregnancy is still leading cause of maternal mortality during 3 years period from 1964 to 1966, 438 cases of toxemia of pregnancy have been encountered among total deliveries of 1040 cases in Ewha Womans University Hospital, Seoul. 1) The incidence of toxemia was varies, ranging from 3.4 to 12.2%(7% in average). Severe Preeclampsia was 50.5% of the toxemias, mild one of 44% and eclampsia of 5.3% It showed no any tendency to decrease for past 3 years. Both primigravidas and multigravidas were equally the same as 3.6% in the frequency of toxemia. February was the peak in the incidence. Toxemia was apt to occur in multiple preganancy, approximately 4 times single pregnancy. 2) Toxemic maternal death was 3 cases (0.68%); 2 eclampsias and 1 preeclampsia. The cause of death was that 2 cases died of pulmonary edema, one case of cerebral hemorrhage. Prognosis of eclampsia in general was poor. Over all toxemic death during past 4 years(1964-1968.3)was still high as leading cause of meternal death(55%). 3) Fetal death was 5%. The longer duration of gestation, the higher fetal death(40% loss during 38-41weeks) born in toxemia. 4) Fetal weight born in toxemia was 2850gms, and 390gms lesser than those born in non toxemic mother. 5) The majority of toxemias were lacking prenatal cares except 18% of the cases. Both the quantitative and qualitative prenatal care was re-emphasized. 6) Complications of the toxemia were 9 cases of postpartum hemorrhage & 4 abruptio placentae. 7) Most of the toxemic cases (2/3) were delivered well conservatively or spontaneously or whith low forceps aided. Cesarean section was performed on 8% of the cases usually following 24-48 hours, intensive medical treatment, such as Magnesium Sulfate, Serpacil, Apresolin, diuretics or sedatives etc. The stillbirths(1.6%) were succesfully induced by means of intrauterine catheter insertion. Oxytocic induction was rarely insituteed(only 1 case).
송용상,전혜원,이재훈,김재원,박창수,박노현,박충학,강순범,이효표 대한부인종양 콜포스코피학회 1994 Journal of Gynecologic Oncology Vol.5 No.2
Twenty two patients with primary invasive carcinoma of the vulva were treated at Seoul National University Hospital from 1980 to 1991 and their clinicopathological profiles were analyzed retrospectively. The median age of the patients was 50 years(32-81 years). The most frequent presenting symptom was a palpable lump or mass observed in 14 patients(63.6% ), followed by pruritis in 12 patients(54.5% ) and pain in 10 patients(45.5%). As a standard therapy, radical vulvectomy with bilateral inguinofemoral lymphadenectomy was performed in 17 patients and simple vulvectomy was done in one patient. Eight patients of them had reconstructive surgery with local cutaneous(5 patients) or myocutaneous(3 patients) flaps. Chemotherapy or radiotherapy was performed in 3 patients and one patient rejected the treatment. Nineteen patients(86.4%) had squamous cell carcinoma, 2(9.1%) had adenocarcinoma of the Bartholins gland, and one(4.5%) had melanama. of 18 surgically treated patients, 5 were stage I (27.8%), 7 were stage 11(38.8%), 2 were stage Ill(11.1%), 3 were stage Wa(16.7k) according to FOGO surgical staging, and one had melanoma of Clark's level IV. Two(11.1% ) of them had lymph node metastasis There was no caw of primary mortality but morbidity was observed in 16 patients(88.9%). The 5 year survival rate of 18 surgically treated patients was 65.3%(median follow--up 47 months). This experience suggests that more conservative surgery should be considered in the management of selected patients with primary invasive vulvar cancer.
박순서(Soon Seo Park),서철원(Cheol won Suh),박종범(Jong Beom Park),박지운(Ji Woon Park),임소덕(Soo Duk Lim),허주령(Joo ryung Huh),남순열(Soon Yuhl Nam),김상윤(Sang Yoon Kim),이호규,장혜숙(Hye sook Chang),김태원(Tae Won Kim),이제환(Je Hw 대한두경부종양학회 1999 대한두경부 종양학회지 Vol.15 No.2
Objectives: To study the clinical features of the primary nasal/nasopharyngeal non-Hodgkin's lymphomas and to evaluate the implication of immunophenotyping as a prognostic factor. Patients and Methods: From January 1990 to December 1997,41 patients(median age, 41 years) of primary nasal/nasopharyngeal non-Hodgkin's lymphoma were studied. The clinical records and paraffin-embedded tissue blocks were reviewed retrospectively. The histologic features, immunophenotypic findings(pan-T, pan-B, CD3, CD56) and Epstein-Barr virus in situ hybridizatios were examined. The prognostic factors for clinical outcome were evaluated in these patients. According to Ann-Arbor system, there were 30 patiets(73%) with stage IE, 4(10%) with stage IIE, 3(7%) with stage IIIE, 4(10%) with stage IVE lymphoma. Among the patients with stage IE/IIE, 4 patients received local radiation alone, 4 received chemotherapy alone, 25 received combination chemotherapy and radiotherapy and 1 refused treatment. The patients with stage IIIE/IVE were given combination chemotherapy and radiotherapy. Results: Immunophenotyping were performed in 40 patients and staining results were as follows: 3(7%) patients with B cell, 17(42%) with T cell, 18(44%) with NK/T cell(CD56 positive), and two patients with unclassifiable result. Epstein-Barr(EB) virus in situ hybridization were performed in 28 patients and 23(82%) patients had positive EBV-encoded RNAs(EBERs). 21(55%) patients achieved a complete remission. There was no difference in complete remission between radiation alone and combination therapy. With median follow-up of 30 months, 5-years disease free survival of complete responders was 60% and 5-years overall survival rate was 36%. Multivariate analysis showed that better overall survival was related with absence of B symptoms, ECOG performance ≤1 and non-NK cells. Conclusion: Most of all cases were positive for EBER. Since NK/T phenotype carried the worst prognosis, analysis for CD56 expression should be done. Further prospective studies were warranted to evaluate the role of chemotherapy in stage IE/IIE.
조직학적으로 확진된 자궁경부 상피내종양 및 침윤암 1000예에서 평가한 자궁경부 세포진검사의 위음성률에 관한 연구
김희수,백희수,손찬우,이기헌,심재욱,박종택,전종수,박인서,김희숙,박종숙 대한부인종양 콜포스코피학회 1995 Journal of Gynecologic Oncology Vol.6 No.1
The cervical smears represent the most effective technique to detect and prevent cancer of the uterine cervix, its false-negative rate is still a reason of concern among pathologists and gynecologists. This study was performed to determine the false - negative rate in cervical smears and to evaluate the causes for false negatives. The histologically confirmed consecutive 1,000 cases of Squamous Intraepithelial Lesion(SIL) and Squamous Cell Carcinoma(SCC) of the uterine cervix from the surgical files of Department of Pathology, Cheil General Hospital, from January 1992 to June 1993 were collected. All cervical smears of 1,000 cases, which obtained prior to pathologic diagnosis made, were evaluated based on cyto-histologic correlation. The false negatives were identified and cervical smears were reviewed. The reasons for false negatives were analysed as well. 'I'he results are as follows : 1. Histologic diagnoses of 1,000 cases include 252 cases of Low grade SIL(LSll.), 484 cases of High grade SlL(HSIL) and 284 cases of SCC. 2. 60 cases were identified as false negatives. The false - negative rate was 6%(60/1000). Those 60 cases of false negatives were 31 cases(51.7%) of LSIL, 23cases (38.3) of HSIL and 6 cases(10%) of SCC. 3. False- negative rate were 12.3%6(31/252) of LSIL, 4.8%(23/484) of HSII. arid 2.1%(6/284) of SCC. 4. In 58 of 60 eases reviewed, the sampling error were 75.9%(44/58) and screening error were 24.1%(14/58). 5. Sampling error were 65.9%(29/44) of LSIL and 2.3%(1/44) of SCC. 6. Screening error were 4 cases of LSIL, 6 cases of HSIL and 4 cases of SCC. In conclusion, the major of false negatives was sampling error and the major lesion of false negativity and sampling error was LSIL. These findings suggest that LSIL should require further investigation by colposcopy, cervicography and HPV Test in order tx reduced the false-negative rate. The supporting of sufficient clinical informations, good supervision and training of cytotechnologist, use of automated cytologic screening system in order to reduced false-negative rate in HSIL and SCC.