경련이 동반된 저산소성 허혈성 뇌병증 소아의 특성

정숙영(Sook Young Jung),황선혜(Sun Hye Hwang),김동현(Kim Dong Hyun),전용훈(Jun Yong Hoon),손병관(Byong Kwan Son),권영세(Young Se Kwon) 대한소아신경학회 2013 대한소아신경학회지 Vol.21 No.3

목 적 : 저산소성 허혈성 뇌병증 환아를 경련군과 비경련군으로 나누어 특성을 비교, 분석하고자 하였다. 방 법: 1999년 6월 1일부터 2011년 12월 31일 기간 동안 인하대학병원 소아청소년과에 입원한 환아 중 저산소성 허혈성 뇌병증을 진단받은 총 55명을 대상으로 의무기록 분석을 통해 후향적으로 조사하였다. 결 과:대상 환아 55명 중 경련군은 34명, 비경련군은 21명이었다. 남녀비는 경련군은 1:1, 비경련군은 2.5:1 이었다. 경련군의 발병 평균 연령은9.7개월(범위 : 0-158개월)이었고, 비경련군은 10개월(범위 : 0-108개월)이었다. 위험인자는 경련군에서는 신생아 가사가 6명(17.7%), 비경련군에서는 미숙아가 5명(23.8%)로 가장 많은 부분을 차지하였다. 임상 증상은 두 군 모두에서 호흡곤란이 주로 나타났다. 영상검사에서 두 군 모두 대뇌 피질 병변이 가장 많았다. 사망하거나 신경학적 후유증이 남은 경우는 경련군에서 23명(67.7%), 비경련군에서 16명(76.3%)으로 나타났다. 두 군 모두에서 위험요인들 간의 통계학적으로 유의한 차이는 없었다. 결 론 : 본 연구에서는 저산소성 허혈성 뇌병증 경련군과 비경련군의 특성에서 유의한 차이는 없었지만 저산소성 허혈성 뇌병증은 신생아의 사망 또는 영구적 뇌손상을 주로 일으켰다. 그러므로 저산소성 허혈성 뇌병증의 조기 진단과 치료가 영구적 뇌손상을 최소화할 수 있을 것이다. Purpose : This study was aimed to evaluate the clinical features of hypoxic ischemic encephalopathy(HIE) in children with and without seizures. Methods : Fifty five children who had been diagnosed as HIE at Inha University Hospital from June 1999 to December 2011 were enrolled in this study. Subjects were divided into two groups by the presence of seizures and their medical records were retrospectively analyzed. Results : Among the 55 cases, 34 patients (61.8%) had seizures, while 17 patients (32.2%) did not have them. Male to female ratio was 1:1 for the 'seizure' group and 2.5:1 for the 'no seizure' group. The onset age was 9.7 months (range: 0-158 months) for the 'seizure' group and 10 months (range : 0-108 months) for the 'no seizure' group. The most common risk factor was birth asphyxia (17.7%) for the 'seizure' group, and prematurity (23.8%) for the 'no seizure' group. The most common symptom other than seizure was respiratory arrest for both groups. On radiologic imaging studies of the brain, main causative lesion was most commonly observed in the cerebral cortex in both groups. The neurologic deficits or death were detected in 67.7% of the 'seizure' group, and 76.3% of the 'no seizure' group. There were no statistically significant differences in risk factors between the two groups. Conclusion : Although the characteristics between patients with and without seizures from HIE revealed no significant differences, HIE still can result in death or permanent disability in children. Therefore, permanent brain damage may be minimized by early suspicion and treatment in these patients.

현대 패션컬렉션에 표현된 키치메이크업의 색채 연구

임정미(Jung Mi Lim),정숙영(Sook Young Jeong) 한국인체미용예술학회 2015 한국인체미용예술학회지 Vol.16 No.1

In modern society, people's desire to get more attention from others with a different look has risen. As a result, more innovative and experimental styles have been tried. In addition, personalized kitsch makeup has developed into a trend in modern fashion collections. This study aimed to analyze the color characteristics, scheme and image of kitsch makeup which reflects the taste and propensity of modern people, focusing on fashion collections from 2010 S/S to 2013 F/W. Regarding the color characteristics of kitsch makeup, 'YR' and 'Bk' were high in eye makeup, followed by 'R', 'PB' and 'Y'. In terms of the tone of the eye makeup, on the contrary, 'v' was the highest, followed by 'lt', 'd' an d'dk'. In terms of the color of base makeup, 'YR' was the highest, followed by 'Y'. In terms of the tone of the base makeup, 'P' was the most common. In lip makeup, 'R' accounted for the greatest portion, followed by 'YR' and 'RP'. In terms of the tone of color, 'v,' with high chroma, was most frequently used. In terms of the coloring of kitsch makeup, contrast was very high. Regarding color images, 'gorgeous', 'modern' and 'dynamic' images were frequently found, which means that bold, stylish and dynamic images were expressed with unique and diverse colors.

들깨의 볶음 조건에 따른 들기름의 산화 안정성 변화

김영언(Young Eon Kim),김인환(In Hwan Kim),이영철(Young Chul Lee),정숙영(Sook Young Jung),조개선(Jae Sun Jo) 한국응용생명화학회 1996 Applied Biological Chemistry (Appl Biol Chem) Vol.39 No.5

The oxidative stabilities of perilla oil increased as roasting temperature and time increased. Induction period of the perilla oil from unroasted perilla seed was 3.9 days, but that of the oil from perilla seed roasted at 210℃ for 30 min was 55 days. The electron donating ability(EDA) on DPPH by perilla oils increased as the roasting temperature and time increased. EDA of the unroasted perilla oil was 24% but that of the perilla oil roasted at 210℃ for 30 min was 64%. These results suggested that the reducing compounds were formed during the roasting process. The fluorescence intensity in perilla oil increased as the roasting temperature and time were increased. This result indicated that Maillard reaction has occurred during the roasting process and the reaction products seemed to provide stability to perilla oil.

들깨의 볶음 조건에 따른 들기름의 성분 및 관능적 특성 변화

김영언(Young Eon Kim),김인환(In Hwan Kim),정숙영(Sook Young Jung),조재선(Jae Sun Jo) 한국응용생명화학회 1996 Applied Biological Chemistry (Appl Biol Chem) Vol.39 No.2

The main objectives of this study was to characterize physicochemical properties, oxidative stability and sensory property of perilla oil obtained by various roasting temperature and time. Roasting temperature of perilla seed was conducted from 150℃ to 210℃ at the increment of 20℃, and roasting time was 10, 20 and 30 min. Yield of perilla oil was increased as the roasting temperature and time were increased. The content of linolenic acid, a major fatty acid in perilla oil, was 60%. There was no differences in fatty acid composition upon the roasting conditions. Unsaturated fatty acid was contained more than 88% of the total fatty acids. Contents of phosphorus in perilla oils were decreased as the roasting temperature and time were increased. Phosphorus contents were significantly decreased at 190℃ for 30 min and 210℃ for 20∼30 min. Tocopherol contents were unchanged at the roasting conditions of present study and gamma-tocopherol was shown to be the major tocopherol. Sensory evaluation of perilla oil roasted in various conditions showed significant differences in taste, color, flavor and palatability. The perilla oil roasted at 190℃ for 20 min had the best palatability.

들깨의 볶음 조건에 따른 들기름의 산화 안정성 변화

김인환,이영철,정숙영,조재선,김영언,Kim, In-Hwan,Lee, Young-Chul,Jung, Sook-Young,Jo, Jae-Sun,Kim, Young-Eon 한국응용생명화학회 1996 Applied Biological Chemistry (Appl Biol Chem) Vol.44 No.3

들깨를 여러 볶음조건에서 처리한 후 착유한 들기름의 저장중 산화안정성 변화를 살펴보았다. 이때 들깨의 볶음온도는 $150,\;170,\;190,\;210^{\circ}C$로 볶음시간은 10, 20, 30분으로 하였다. 전체적으로 들깨의 볶음온도가 높고 볶음 시간이 길어질수록 착유한 들기름의 산화안정성은 높아졌다. 들깨를 볶지 않고 착유한 들기름의 유도기간은 3.9일이었으며 $210^{\circ}C$에서 30분 볶아 착유한 들기름의 유도기간은 55일이었다. 들기름의 DPPH에 대한 전자공여작용은 들깨의 볶음온도가 높고 볶음시간을 길게하여 착유한 들기름일수록 증가하는 경향을 보였다. 들깨를 볶지 않고 착유한 들기름의 전자공여능이 24%로 나타난 반면 $210^{\circ}C$에서 30분 볶아 착유한 들기름은 64%이었다. 그리고 들기름의 fluorescence는 들깨의 볶음온도가 높고 볶음시간을 길게 하여 착유한 들기름일수록 증가하였다. The oxidative stabilities of perilla oil increased as roasting temperature and time increased. Induction period of the perilla oil from unroasted perilla seed was 3.9 days, but that of the oil from perilla seed roasted at $210^{\circ}C$ for 30 min was 55 days. The electron donating ability(EDA) on DPPH by perilla oils increased as the roasting temperature and time increased. EDA of the unroasted perilla oil was 24% but that of the perilla oil roasted at $210^{\circ}C$ for 30 min was 64%. These results indicated that the reducing compounds were formed during the roasting process. The fluorescence intensity in perilla oil increased as the roasting temperature and time were increased. This result indicated that Maillard reaction has occurred during the roasting process and the reaction products seemed to provide stability to perilla oil.

모유 수유아에서 발생한 구루병 경련의 임상양상

강빈(Ben Kang),정숙영(Sook Young Jung),김순기(Soon Ki Kim),이지은(Jee Eun Lee),손병관(Byong Kwan Son),권영세(Young Se Kwon) 대한소아신경학회 2012 대한소아신경학회지 Vol.20 No.3

목 적 : 모유 수유에 의한 비타민 D 결핍성 구루병에 관한 연구들이 활발히 진행되고 있는 반면에 이때 발생하는 경련에 관한 연구는 없다. 이에 저자들은 완전 모유 수유에 의해 비타민 D 결핍성 구루병이 있었던 환아에서 발생하는 경련의 임상양상 대하여 알아보고자 하였다. 방 법 : 2000년 1월부터 2010년 12월까지 인하대병원 소아청소년과 외래를 방문하였거나 입원하였던 환아 중 완전 모유수유를 하면서 구루병을 진단 받았던 환아들을 대상으로 후향적으로 조사하였다. 경련군과 비경련군으로 나눈 후, 두 군간의 임상적 특성과 생화학적 검사 결과를 비교 분석하였고, 경련 발생의 상대 위험도를 평가하였으며, 경련군에서 발생한 경련의 임상 양상에 대해 조사하였다. 결 과 : 완전 모유수유를 하면서 구루병을 진단받은 17명의 환아중 9명(53.0%)에서 경련이 발생하였고, 8명(47.0%)에서는 경련이 없었다. 두 군의 진단당시 평균 연령은 각각 4.1±2.0개월, 9.3±2.7개월로 경련군에서 통계적으로 의미 있게 낮았다( P<0.0001). 혈액 검사에서 혈청 Ca 수치는 각각 5.7±1.0 mg/dL, 9.5±0.9 mg/dL으로 경련군에서 통계적으로 의미 있게 낮았다( P<0.0001). 혈청 25-OHD3 수치는 각각 5.7±0.8 IU/L, 15.3±4.2 IU/L으로 경련군에서 통계적으로 의미 있게 낮았다( P<0.0001). 경련 발생의 상대 위험비는 저칼슘혈증이 있있을때가 8배였고, 혈중 25-OHD3 수치가 8 ng/mL 미만일 때가 17배였다. 경련은 5분 미만의 전신 발작 또는 1분 미만의 부분 발작 형태로 다회성으로 나타났으나, 향후 간질이 발생하거나 항경련제를 투여받거나 비정상적인 신경 발달을 보인 환아는 없었다. 결 론 : 완전 모유 수유아에 의한 비타민 D 결핍성 구루병 환아에서 발생하는 경련은 저칼슘혈증에 의해 발생하고, 저칼슘혈증은 혈중 25-OHD3 농도의 영향을 받는다. 또한, 체내에서 칼슘 요구량이 많은 급성장 시기의 모유 수유아에서는 경련이 다른 시기 보다 쉽게 발생할 수 있다. 완전 모유 수유아에 의한 비타민 D 결핍성 구루병 환아에서 발생하는 경련은 다회성으로 발생했으나 예후는 양호했다. 추후, 보다 많은 환아들을 대상으로 하는 대규모 전향적 연구가 필요하다. Purpose : This study was aimed to evaluate the clinical features of seizures in breastfed children with vitamin D deficient rickets. Methods : Seventeen children, breastfed and diagnosed as vitamin D deficient rickets at Inha University Hospital from January 2000 to July 2010, were retrospectively investigated. Subjects were divided into two groups according to the presence/absence of seizures. Demographic and biochemical results were compared and statistically analyzed between the two groups, and the relative risk for seizure occurrence was estimated. Clinical features of seizures were also analyzed. Results : Out of the 17 subjects, nine patients (53.0%) had seizures, while eight patients(47.0%) did not. The mean age for the two groups were 4.1±2.0 months and 9.3±2.7 months, respectively, which was statistically different between the two groups ( P<0.0001). Serum calcium(Ca) and 25-hydroxyvitamin D3 (25-OHD3) levels were significantly lower in the 'seizure' group(5.7±1.0 vs. 9.5±0.9 mg/dL, P<0.0001; 5.7±0.8 vs. 15.3±4.2 IU/L, P<0.0001). The relative risk for seizure occurrence was 8 times higher in hypocalcemia and 17 times higher in 25-OHD3<8 ng/mL. Seizures occurred several times as generalized or focal types, but none of them developed epilepsy nor showed developmental abnormalities later on. Conclusion : Seizures in breastfed children with vitamin D deficiency rickets are mainly due to hypocalcemia, which is affected by 25-OHD3 levels. Seizures may also occur more frequently in children in the stages of rapid growth. Although seizures occurred multiple times, future outcomes were favorable. Further large-scaled prospective studies are required in the future.

한국 소아의 알레르기비염 역학

황선혜 ( Sun Hye Hwang ),정숙영 ( Sook Young Jung ),임대현 ( Dae Hyun Lim ),손병관 ( Byong Kwan Son ),김정희 ( Jeong Hee Kim ),양준모 ( Jun-mo Yang ),오인보 ( In Bo Oh ),김양호 ( Yang Ho Kim ),이지호 ( Ji Ho Lee ),이근화 ( Keun Hw 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4

Purpose: The diagnosis of allergic rhinitis (AR) is based upon the concordance between a history of allergic symptoms and diagnostic tests. This study is to investigate the epidemiology of AR by using data from National Health Insurance Corporation (NHIC) and data according to the AR definition in general students health screening. Methods: We examined medical insurance claims data of NHIC from 2004 to 2010 according to age, area, and gender. We investigated the results of Korean International Study of Asthma and Allergies in Childhood questionnaires and skin prick tests of 14,133 students participated in health screening from 2010 to 2012. Results: The prevalence of AR according to the NHIC data was elementary school students (24.34%); middle school students (13.75%) and high school students (12.17%). The prevalence of AR was higher in boy than in girl, annually. In health screening, the prevalence of AR was elementary school students (19.50%±0.26); middle school students (23.19%±0.30) and high school students (24.11%±0.31). The prevalence of AR had peaking at the age late teens (P<0.0001) and was higher in boy (26.49%±0.38) than in girl (17.43%±0.35) (P<0.0001). Sensitization rate of allergen in students with AR was house dust mite (86.71%±0.48); pollen (41.26%±1.01) and molds (14.80%±0.52). Conclusion: The prevalence according to the AR definition tended to be increased with aging in Korean children. There are some differences in the prevalence of AR in the data of NHIC and health screening study. Further investigation will be needed to reveal the causes of this difference.

한국 소아의 알레르기비염 역학

황선혜 ( Sun Hye Hwang ),정숙영 ( Sook Young Jung ),임대현 ( Dae Hyun Lim ),손병관 ( Byong Kwan Son ),김정희 ( Jeong Hee Kim ),양준모 ( Jun Mo Yang ),오인보 ( In Bo Oh ),김양호 ( Yang Ho Kim ),이지호 ( Ji Ho Lee ),이근화 ( Keun Hw 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4

Purpose: The diagnosis of allergic rhinitis (AR) is based upon the concordance between a history of allergic symptoms and diagnostic tests. This study is to investigate the epidemiology of AR by using data from National Health Insurance Corporation (NHIC) and data according to the AR definition in general students health screening. Methods: We examined medical insurance claims data of NHIC from 2004 to 2010 according to age, area, and gender. We investigated the results of Korean International Study of Asthma and Allergies in Childhood questionnaires and skin prick tests of 14,133 students participated in health screening from 2010 to 2012. Results: The prevalence of AR according to the NHIC data was elementary school students (24.34%); middle school students (13.75%) and high school students (12.17%). The prevalence of AR was higher in boy than in girl, annually. In health screening, the prevalence of AR was elementary school students (19.50%±0.26); middle school students (23.19%±0.30) and high school students (24.11%±0.31). The prevalence of AR had peaking at the age late teens (P<0.0001) and was higher in boy (26.49%±0.38) than in girl (17.43%±0.35) (P<0.0001). Sensitization rate of allergen in students with AR was house dust mite (86.71%±0.48); pollen (41.26%±1.01) and molds (14.80%±0.52). Conclusion: The prevalence according to the AR definition tended to be increased with aging in Korean children. There are some differences in the prevalence of AR in the data of NHIC and health screening study. Further investigation will be needed to reveal the causes of this difference. (Allergy Asthma Respir Dis 2013;1:321-332)

동백나무(Camellia japonica) 잎의 열수추출 조건 확립

정진호(Jin Ho Chung),이형재(Hyoung Jae Lee),이숙영(Sook Young Lee),김광상(Kwang-Sang Kim),임요섭(Yo Sup Rim),신수철(Soo Cheol Shin),정경희(Kyoung Hee Jung),박근형(Keun-Hyung Park),문제학(Jae-Hak Moon) 한국식품과학회 2006 한국식품과학회지 Vol.38 No.6