정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Tabes Dorsalis의 핵자기공명영상 및 전기생리학적 소견

권기한,김성민,권석범,이병철,조광호,주정희 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

유아기의 신체활동과 발육ㆍ발달에 관한 연구

조성호,윤해철,권기욱 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This study was conducted for 216 infants (64 two-year-old males and 64 three-year-old males and 44 females) on the infant physical aptitude test, the infant educational program of the "H" sport center located in Kangdong-ku, Seoul. Both the physical fitness test and the exercise ability test were conducted for the two-year-old infants having 1-month exercise period and the three-year-old infants having a 18-month exercise period. As a consequence of inquiring into them by gender and y exercise period and of analyzing the relationship between physical fitness and exercise period, the following conclusion was obtained. 1. It could not be found that male infants' physical fitness varied significantly according to exercise period and that female infants' standing height and body weight varied significantly according to exercise period(p<.05). 2. It was shown that flexibility-sit and reach test of infants' exercise ability had a very significant difference according to exercise period for both male and female infants(p<.05). 3. It was found that foot and toe balance of infants' exercise ability showed a significant difference according to exercise period and that female infants showed a very significant difference(p<.05). 4. It was shown that in measuring power of infants' according to exercise period and it varied significantly for female infants(p<.05). 5. It was shown that in measuring muscular endurance, of infant's exercise ability, and sit-up infant's exercise ability had a very signigicant difference for both males and females according to exercise period(p<.05). And it was shown that V-form sit varied very significantly for both male and female infants(p<.05). 6. It was shown that as result of measuring agility of infant's exercise ability 25M-run varied very significantly for both male and female infants but that it varied more significantly for female infantstha for male infants(p<.05).

위암에서 근치적 절제술 후 전이 림프절 수가 예후에 미치는 영향

임호영,최진혁,김현수,남동기,김효철 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

Gastric cancer is the most common cause of cancer death in Korea, and the most important prognostic factor for patients with gastric cancer is the extent of TNM stage. Among TNM staging system, lymph node involvement (N) has been recognized as one of the significant prognostic indicators after curative resection. Recently, nodal stage of new AJCC TNM staging system has changed its emphasis on the location of metastatic lymph nodes to the number of metastatic lymph nodes. Thus, we attempted to analyze the survival difference based on the number of metastatic lymph nodes after curative resection of gastric cancer. Two hundred and forty two patients of curatively resected gastric cancer were retrospectively studied to identify the number of metastatic lymph nodes to influence prognosis. The following results were obtained. The results showed that there was a significant difference in the survival rate between the patients with 0-2 metastatic lymph nodes and those with ≥3 metastatic lymph nodes in adjuvant chemotherapy (FA) group (DFS; 36.7% vs. 23.4%, OS; 38.3% vs. 26.0%). In adjuvant chemoimmunotherapy (FA+poly-AU) group, there was a significant difference in the overall survival between the patients with 0∼2 metastatic lymph nodes and those with ≥ 3 metastatic lymph nodes(70.1% vs. 47.4%). The present report demonstrates the prognostic importance of the number of metastatic lymph nodes in gastric cancer after curative resection and a necessity of further evaluation of current nodal stage.

입원한 기분장애 소아청소년의 임상특성 : 주요 우울증과 양극성장애의 우울삽화 비교를 중심으로

임명호,조수철,백기청,이경규,김현우,홍강의 대한소아청소년정신의학회 2000 소아청소년정신의학 Vol.11 No.2

본 연구는 소아청소년에서의 우울증 및 조울증의 우울삽화에 대한 임상특성을 알아보고자 하였다. 1993년 3월 1일부터 1999년 10월 31일까지 ○○대학교 어린이 병원 소아청소년 정신과에 입원하였던 34명의 우울증 환아와 17명의 조울증 우울삽화 환아를 대상으로 병록지 기록을 통해서 이들의 사회인구학적 특성, 진단적 분류, 입원시 주 증상 및 문제점, 증상의 빈도, 주산기 모 병력과 아동기 발달력, 공존정신 질환 및 신경 심리학적 검사 가족의 임상적 특성, 가족 정신병리 및 가족 병력, 치료반응등에 대하여 조사하였다. 1) 우울증에서 남자의 비율이 여성의 경우보다 높았으며, 조울증 우울삽화에서는 남녀의 비율이 비슷하였다. 2) 평균 발병 연령은 조울증 우울삽화에서 14.1세, 우울중에서 12.8세로 우울증에서 일찍 발병하는 양상을 나타냈으며, 입원 횟수에 있어서는 조울증 우울삽화에서 우울증에 비해서 많았다. 3) 조울증 우울삽화와 우울증 모두에서 식물증상의 호소가 신체증상보다 많았으며, 자살사고 증상은 우울증에서, 공격적인 증상은 조울증 우울삽화에서 많았고, 정신병적 증상에서는 망상은 우울증에서 환각은 조울증 우울삽화에서 많이 나타났다. 4) 두 집단 모두에서 불안장애가 가장 많이 동반되었으며, 신체형 장애, 정신지체, 인격장애 등이 동반되었다. 5) 조울증 우울삽화와 우울증 모두 높은 가족력을 보였고, 특히 우울증은 아동 학대력과 가족의 부적절한 양육과 관련성을 보였다. 성인에서 조울증과 우울증이 분명한 임상적 차이를 갖고있는 것처럼 소아에서도 조울증 우울삽화와 우울증은 발병연령, 신체증상 및 식물증상을 비롯한 임상증상의 차이, 공존질환 등에서 서로 다른 임상 양상을 나타내었다. 중심 단어 : 주요 우울증ㆍ우울 삽화ㆍ임상 특성. The purpose of this study is to find out the characteristics of depressive episode about major depression and bipolar disorder in child and adolescent. The subjects of this study were 34 major depression patients and 17 bipolar disorder patients hospitalized at child and adolescent psychiatry in ○○ university children's hospital from 1st March 1993 to 31st October 1999. The method of this study is to review socio-demographic characteristics, diagnostic classification, chief problems and symptoms at admission, frequency of symptoms, maternal pregnancy problem history, childhood developmental history, coexisting psychiatric disorders, family psychopathology and family history and therapeutic response through their chart. 1) The ratio of male was higher than that of female in major depressive disorder while they are similar in manic episode, bipolar disorder. 2) Average onset age of bipolar disorder was 14 years 1 month and it was 12 years 8 months in the case of major depression As a result, average onset age of major depression is lower than that of bipolar disorder. 3) The patients complained of vegetative symptoms than somatic symptoms in both bipolar disorder and depressive disorder. Also, the cases of major depression developed more suicide idea symptom while the case of bipolar disorder developed more aggressive symptoms. In the respect of psychotic symptoms, delusion was more frequently shown in major depression, but halucination was more often shown in bipolar disorder. 4) Anxiety disorder coexisted most frequently in two groups. And there coexisted symptoms such as somartoform disorder, mental retardation and personality disorder in both cases. 5) The influence of family loading was remarkable in both cases. Above all, the development of major depression had to do with child abuse history and inappropriate care of family. It is apparent that there are distinctive differences between major depression and bipolar disorder in child and adolescent through the study, just as in adult cases. Therefore the differences of clinical characteristics between two disorders is founded in coexisting disorders and clinical symptoms including onset age, somatic symptoms and vegetative symptoms. KEY WORDS : Major depressive disorderㆍDepressive episodeㆍClinical characteristics.

중소 로프 제조업체를 위한 종합경영정보시스템 구축에 관한 연구

신철호,주기세 木浦海洋大學校 1997 論文集 Vol.5 No.1

In this paper, a new management information system(MIS) is developed for a small-sized rope manufacturing company. The system consists of two fields such as complex production control, and general control field. The complex production control field is divided into three modules of inventory, production and marketing control. The general control field is divided into two modules of payment and finance control, respectively. This system is developed for the small and medium-scale enterprise which mainly manufactures the rope, as an example, and is furthermore applicable to the computer integrated manufacturing(CIM) in the future. Also, this system is expected to contribute to increasing profits, efficiency of company management and is applicable to various kinds of small and medium-scale manufacturing enterprises by adjusting and costomizing the developed system.

LaCrO_(3) 후막의 가스 감도 특성

신정호,장재영,김정규,박기철 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

LaCrO_(3) thick film sensors were fabricated on an alumina substrate by screen printing method. The sensitivities for gases were investigated by varying the heat treatment temperatures of the films. The sensitivities of LaCrO_(3) thick film for Gallo and NH_(3) gases were better than for CO and NO gases. The best condition of heat treatment was 450℃ and the optimal operating temperature of LaCrO_(3) thick film for the highest sensitivity was 400℃. Sensitivities of LaCrO_(3) thick films about at 3000ppm for C_(4)H_(10) and NH_(3) gases were 85% and 95%, respectively.

외상성 뇌실출혈의 임상적 분석

김호진,변진수,허철,홍순기,김헌주,한용표 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

Intraventricular hemorrhage after blunt head trauma, which reflects the severity of head injury, is uncommon. A retrospective study of 109 traumatic intraventricular hemorrhage(TIVH) patients who were admitted between January 1, 1988 and December 31, 1993 was conducted. The results are as follows : 1) Incidence of TIVH and its associated mortality were 2.45% and 28.4%, respectively. 2) TIVH-associated radiological abnormalities were traumatic intracerebral hematoma(62.7%), skull fracture(42.7%), and traumatic subarachnoid hemorrhage(34.5%). 3) Amount of TIVH was related to traumatic intracerebral hematoma(p=0.0003) and traumatic subarachnod hemorrhage(p=0.0385). 4) The poorest prognostic indicator was associated abnormalities, especially corpus callosum or brainstem hemorrhage(p=0.0099). 5) TIVH-associated hydrocephalus was not related to the amount of TIVH(p=0.42), and poor prognosis(p=0.12). 6) Patients with TIVH showed better Glasgow coma scale and Glasgow outcome scale than TIVH-associated abnormalities.

제주도에 수송되는 황사의 사례분석

이기호,허철구 제주대학교 환경연구소 1995 환경연구논문집 : 제주대 Vol.3 No.1

This study is carried out to investigate the charactexistis of the yellow sand transported to Cheju dand on 1995 and its influence on the concentration of TSP at Cheju area. For this purpose, the collection of TSP is conducted by using a high volume air sampler and the analyses of weather maps is also performed. By the analysis of weather map, it can be seen that the yellow sand ocurred at Cheju area on March 1995 is tramporkd from the upstream of the Yellow River via Shanghai region The duration time far this case is 32 hours at Cheju area. Although the source regions of yellow sand occurred on April are not dearly inferred on the weather map, it can be confirmed that the bend of yellow sand is flowed to Cheju area f&wd by cyclone passage with cold fornt passing the Korean penmda. It can be also confirmes that the of 40-9 knots in the 700hPa layer and southward movement of cold core. circulation associated with the yellow sand is characterizd by the westerly to north-weaskly The concentration of TSP when the yebw sand occurrs is increased over 4 times than normal period.

酢酸菌의 遊離, 固定化 菌體를 이용한 豆乳중의 n-hexanal의 脫臭

류병호,김동석,배기철 경성대학교 1989 論文集 Vol.10 No.1

These study was designed to deordorize the off flavor of n-hexanal in defatted soybean milk using the free cells or immobilized cells of acetic acid bacteria, such as Acetobacter aceti, IFO 3281, Acetobacter pasturianus, IFO 13751, and Acetobacter aceti, IFO 13752. When a small amount of acetic acid bacteria was added in defatted soybean milk and incubated at 30℃ for 30min. Deordorization of n-hexanal showed significantly decrease by three kinds of acetic acid bacteria. The optimal conditions of free and immobilized cells for deordorization of n-hexanal was at 50℃-60℃ and, pH 6, and there was no significance difference between free cells and immobilized cells for the deordorization of n-hexanal. Three kinds of acetic acid bacteria was not inhibited activites until 3% sodium chloride and 4.0% sucrose under the same sanie conditions. The immobilized cells system was indicated to maintain the deordorization of n-hexanal for 180 hr.