정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

단선사고보상기능을 갖는 능동전력필터에 관한 연구

한경희,박인석,이정준,오봉환 명지대학교 대학원 1999 대학원논문집 Vol.3 No.-

Recently, for increasing consumed power and informational society, confidence of power supply is demanded. Beside, owing to most of these loads are nonlinear, utility line is polluted by these components. therefore, it is demanded compensation of harmonic current. In times past, special order of harmonic current is only compensated by passive filter, but active power filter compensate whole harmonic current. Therefore, this paper propose uninterruptable power supply(UPS) with performance of active power filter.

離婚原因의 比較法的 硏究 : 英·美·獨·佛을 中心으로

韓琫熙 全北大學校 1972 論文集 Vol.14 No.-

Morphine의 血漿 Corticosterone增加作用에 對한 Clonidine의 抑制性 效果에 있어서 Monoamine性 神經系의 關聯性에 關한 硏究

韓泰熙,全普權,申萬鍊 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1

Buckingham suggested that the effects of opioid substances on CRF secretion are probably-due partially to direct actions on the hypothalamus and partially to alterations in the ratio of stimulatory and inhibitory signals received from higher centers i3 the brain. And there are several reports supporting that the inhibitory effect of clonidine on the morphine-induced increase of plasma corticosterone level may be mediate3 by its property as an alpha₂-adrenoceptor agonist. In this paper, tire influences of alteration of moncaminergic neuoronal activities on the inhibitory effect of clonidine on the morphine-induced increase of plasma corticosterone level were studied in male mice. The results obtained were summarized as follows; 1. Clonidine(100 and 500 ㎍/kg) slightly increased plasma corticosterone level in normal mice, and the increasing effect of clonidine was not affected by iproniazid(100 mg/kg) and p-chlorophenylalanine (400 mg/kg) but significantly enhanced by reserpine(2 mg/kg) and alpha-methyl-p-tyrosine(250 mg/kg). 2. Clonidine(100 and 50 0㎍/kg) showed the dose-depeiident inhibitory effect on the morphine-induced increase of plasma corticosterone level. 3. The inhibitory effect of clonidine(100 ㎍/kg) on the morphine-induced increase of plasma corticosterone level was not affected by iproniazid but moderately suppressed by reserpine, alpha-methyl-p-tyrosine, and p-chlorophenylalanine. 4. The inhibitory effect of clonidine(500 ㎍/kg) on the morphine-induced increase of plasma corticosterone level was cot affected by reserpine, iproniazid, alpha-methyl-p-tyrosine, and p-chlorophenylalanine. These results suggest that the inhibitory effect of clonidine on the morphine-induced increase of plasma corticosterone level are probably due partially to its direct action on the hypothalamo-adenohypophyseal system rather than due to its indirect (presynaptic) action on the morphine-induced changes of central moncaminergic neuronal activities.

「婚姻法改正의 方向과 課題」

韓琫熙 仁川大學校 法科大學 法學硏究所 1999 仁川法學論叢 Vol.2 No.-

터어키안 상부에서 발생한 뇌수막종의 미세수술적 치료

한대희,정영섭,김봉수,정희원,조병규,최길수,심보성 대한신경외과학회 1986 Journal of Korean neurosurgical society Vol.15 No.1

Suprasellar meningiomas are uncommon intracranial tumors representing approximately 4-10% of intracranial meningiomas and the total excision is sometimes hazardous because of surrounding vital structures. We have experienced four cases of this lesion during last three years and the masses were approached through frontoparietal craniotomy and lateral subfrontal approach and were removed completely with microsurgical technique. Visual disturbances were improved in three cases and unchanged in one case. The literatures are also reviewed.

신우신염으로 오인된 부종양증후군을 동반한 신세포암

한민철,김재헌,박성재,변동원,강덕희,심봉석 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.2

Renal cell carcinoma can presents wide range of signs and symptoms, and commonly associated with paraneoplastic syndrome. Paraneoplastic manifestations are present in up to 20% of patients with renal cell carcinoma. There is convincing evidence that renal cell carcinoma tumor cells elaborate proteins that serve as mediators of endocrine (ex ; ectopic production of parathyroid hormone-related protein or erythropoietin) as well as nonendocrine paraneoplastic syndromes. A paraneoplastic syndrome may be the various clinical presentation of renal cell carcinoma in a significant number of patients, therefore mimicked other general disease. We report a case of renal cell carcinoma associated with paraneoplastic syndrome mimicking pyelonephritis.

傳統的 離婚原因과 破綻主義에 關한 硏究(一) : 外國法을 中心으로 With Emphasis upon Foreign Laws

韓琫熙 全北大學校 1976 論文集 Vol.18 No.-

Divorce law reforms have been widely spread throughout the world since the 1960's. Because marital disruption is becoming one of the serious social problems of the present day. There has been much discussion among social scientists to find the best preventive solutions. In the end, they have found that the therapeutic approach instead of the judicial one, under the breakdown principle, is the best way to solve the problem. Under the above circumstances, the writer has researced the following major points in this study. In the second chapter of this study, he introduced briefly history of divorce in Roman law, Canon law and in the Reformation, in addition to that of the United Kingdom, the United States of America, France and Germany. In the third chapter of this study, he also introduced the various contents of the traditional grounds for divorce, i.e., adultery, desertion and cruelty in France, Germany, Great Britain, and the United States of America, the most important countries in civil and common law.

김치에 대한 중국 남녀 대학생의 인식 및 기호도 조사

한재숙,홍주희,서봉순,변재옥 동아시아식생활학회 2001 동아시아식생활학회지 Vol.11 No.1

The purposes of this study are to investigate perception and preference of Chinese college students for Korean Kimchi by a survey and sensory evaluation and to globalize and industrialize Kimchi in the world. A questionnaire survey was conducted on 588 students residing in Beijing. About 80% of all the participants knew what Kimchi was and 63.4% had eaten Kimchi before the survey. On their first impression of Kimchi, 43.6% of respondents answered that it was 'good', and 67.1% answered that their impression after eating Kimchi was 'good'. 51.4% of respondents, answered the nationality of Kimchi is 'Korea'. The most liked Kimchi is Baechu Kimchi, and they preferred the white stem of the Chinese cabbage. On their perception of Kimchi, 'Kimchi is a good side dish with cooked rice' was totally received point. The most well-known cooking method of Kimchi turned out to be Kimchi Chigae, As the results of sensory evaluation on several types cabbage Kimchies at room temperature, the most preferred Kimchi by the students was two-day old and made out of 5g red pepper. And two-day old Kimchi 10g red pepper and 2g shangchai added was preferred, too. But the six-day old Kimchi was disliked. The two-day old Kimchi made out of 10g red pepper preserved in the refrigerator was the most-liked. The dishes using Kimchi as the main ingredient are listed according to the students preference as follows : Kimchi Hundun, Kimchi Ddungchai, Kimchi Bokum, and Kimchi Ramen, and so on.

PLD 박막의 물리적 성질

한용진,조봉균,정재훈,이수빈,박해윤,이태기,채희백,홍진수 순천향대학교 기초과학연구소 1998 순천향자연과학연구 논문집 Vol.4 No.2

Thin amorphous carbon films were deposited by a Q-switched Nd;YAG 532nm with beam power density of ?? on the high purity graphite (99.7%). The pressure of vacuum chamber was ?? Torr. In order to estimate the quality of the Pulsed Laser Deposition films one of the most important optical properties, bandgap energy, was characterized by transmission and reflection in the range of the visible, and an optical direct bandgap energy of 2.45eV and indirect bandgap energy 0.36eV were obtained. Surface morphology of amorphous film was investigated by AFM (Atomic Force Microscopy). Its surface roughness is 70nm. Comparing our results with the published values in the literature we have confidence that our films show the good quality for optical properties.