아세톤-물 혼합용매에서 trans-[Co(en)_2Cl_2]^+, trans-[Co(N-eten)_2Cl_2]^+, trans-[Co(N-meen)_2Cl_2]^+, trans-[Co(tn)_2Cl_2]^+ 착이온의 가용매 분해반응에 대한 압력과 용매조성의 영향 : 반응메카니즘과 자유에너지 변화사이클 및 Excess 자유에너지 Excess Free Energy & Free Energy Cycle and Reaction Mechanism

朴裕哲,趙靈濟 慶北大學校 物理化學硏究所 1986 硏究論文集 Vol.7 No.-

아세톤-물 혼합용매에서 trans-[Co(AA)_2Cl_2]^+ 착이온의 가용매분해반응속도를 전도도법과 분광광도법을 사용하여 1∼2000 bar의 압력범위에서 측정하였다. 여기서 AA는 에틸렌디아민(en), N-에틸에틸렌디아민(N-eten), N-메틸에틸렌디아민(N-meen)과 트리메틸렌디아민(tn)을 각각 의미한다. 속도상수에 대한 압력의 영향으로부터 구한 활성화 체적은 AA가 en, N-eten, N-meen 및 tn 일때 각각 -0.2∼0.9㎤mole^-1, -0.2∼0.6㎤mole^-1, -0.8∼6.0㎤mole^-1, 0.7∼7.0㎤mole^-1이었다. 이들 착이온의 가용매분해반응성은 excess 자유에너지와 자유에너지 사이클로부터 얻은 결과를 비교하여 검토하였다. 가용매분해반응성은 압력이 감소할수록, 그리고 아세톤의 함량이 증가할수록 S_N1 경향성이 증가하였다. 또한 가용매 분해반응의 메카니즘에 미치는 하전분리 효과도 고찰하였다. The rates of solvolysis of trans-[Co(AA)_2Cl_2]^+ in which AA indicates ethylenediamine(en), N-ethylethylenediamine(N-eten), N-methylethylenediamino(N-meen) and trimethylenediamine(tn) respectively have been investigated using conductometric and spectrophotometric methods at various pressure up to 2,000 bar in acetone-water mixture. The activation volumes(ΔV^≠) obtained from the pressure effect on rate constants were -0.2∼0.9㎤mole^-1 for en, -0.2∼0.6㎤mole^-1 for N-eten, -0.8∼6.0㎤mole^-1 for N-meen and 0.7∼7.0㎤mole^-1 for tn. The rates of solvolysis of these complexes were analyzed by comparing with the results obtained from excess free energy(G^E) and free energy cycle. It was found that S_N1 character was increased with decreasing the pressure and increasing the content of acetone in the mixture solvent. In addition to that, the effect of charge separation on the mechanism of solvolysis was discussed.

남성화 암쥐의 모리스 수중 미로 수행력 : 성에 따른 공간기억력과 테스토르테론 효과의 차이

신성현,박제민,정우영,박문일,서유나,김성곤,강철중 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objectives : It is widely accepted that gonadal steroids are involved in organization and activation of sexual dimorphism in the brain areas related with spatial leaming. This study aimed to test the following hypothesis : 1) spatial memory is affected by sex, 2) this difference is related with brain differentiation by exposure to testosterone in the neonatal period, and/or 3) the sexual difference of spatial memory is the result of the interaction between organization of sexual dimorphism in the brain and the circulating testosterone after growing up. Methods : Testosterone enanthate 100 ㎍, ('androgenized') orvehicle ('control') was randomly administered to 28 female and 25 male rat pups within 24 hour of birth. The escape latencies (EL) in Morris water maze were measured in 15 and 16 week of age with vehicle ('baseline') and with 10 μmol/kg of testosterone ('with testosterone'), respectively. Each session Consis-ted of 10 trials, and means of the last 5 trials were analyzed. Results : The baseline EL of the males were significantly shorter than females regardless ofneonatal exposure to testosterone. With testosterone, EL of the androgenized females were significantly shorter than control females and comparable to those of males. Conclusion : Neonatal exposure to testosterone in female rats may develop a tesosterone-dependent male-like spatial leaming system.

중증 만성정신질환자 수의 추산 : Through Two Community Surveys 두 지역사회 조사를 중심으로

홍진표,김윤,배재남,정유진,강영호,양병국,김용익,김병후,이철,조맹제 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

국내 중증 만성정신질환자 수를 추정하기 위하여 일 농촌 및 대도시 지역의 지역의료보험 및 의료보호 대상자 중 1993년 1년간 의료기관에서 정신증 상병(ICD-9 code 상 290-299) 및 알콜 남용/중독, 성격장애 및 정신박약 진단하에 치료를 받은 적이 있는 사람에 대해 설문조사를 실시하였다. 연구자들이 개발한 진단도구를 이용하여 진단을 평가하고, Strauss-Carpenter scale 등을 이용하여 기능 장애를 평가하고 유병기간 등을 조사하였다. 결과를 요약하면 다음과 같다. 1) 진단평가상 정신분열병군(61.1%)이 가장 많았으며, 정동장애군(23.7%), 알콜장애군(11.2%), 기질성 정신장애군(4.0%)의 순서이었다. 2) 직업활동정도는 진단군별로 차이가 많았다. 지난 1년간 직업활동이 6개월 미만이거나 전혀 없는 환자 비율이 정신분열병군은 67.2%, 알콜장애군 52.0%, 정동장애20.8%의 순으로 정신분열병군이 가장 불량하였다. 3) 사회활동도 진단군별로 차이가 많아서 지난 1년간 의도적, 사회활동이 없는 비율이 정신분열병군이 가장 높았고(72.3%), 알콜장애군(32.0%), 정동장애군(20.7%)의 순이었다. 4) 국내 의료보험 및 사회복지시설 이용 자료 등을 토대로 본 조사 결과를 적용한 결과 국내중증 만성 정신질환자의 수는 약 8만 7천명으로 추산되었다. Objectives: The purpose of this study was to estimate the number of serious and persistent mentally ill patients in Korea. Methods : Study populations were recruited from medical insurance data of two district areas ; one rural and the other urban areas. Subject were all mentally ill who had ever visited any hospital in 1993 and were diagnosed as having psychosis, personality disorder and drug abuse. We conducted a home visiting survey applying semi-structured diagnostic interview, assessing the level of social adjustment with Strauss-Carpenter Scale, and past psychiatric history by the trained researchers, in October and November,1994. Results : According to diagnostic assessment schizophrenic patients constituted the major portion(61.1%) of study subjects. The distribution of occupational functions and social contacts was variable according to diagnosis. Most schizophrenic patients were unemployed or worked less than 6 months in the previous year(67.2%), and showed poor social contact(72.3%). But affective disorder patients were relatively independent in job maintenance and social relationship. Alcoholic patients lay between those of schizophrenic and affective disorder groups. It was estimated that about 87,000 adult Koreans were suffering from chronic mental disorders which seriously interfere with their daily life. Conclusions : Serious and persistent mentally ill patients were common in Korea. Community support program should be provided for them.

3-MCPD의 생식˙발생독성에 관한 연구

곽승준(Seung Jun Kwack),김순선(Soon Sun Kim),최요우(Yo Woo Choi),이규식(Gyu Seek Rhee),손경희(Kyung Hee Sohn),이이다(Rhee Da Lee),채수영(Soo Young Chae),정용현(Yong-Hyun Chung1),유일재(Il Je Yu1),박귀례(Kui Lea Park) 한국독성학회 2004 Toxicological Research Vol.20 No.2

3-Monochloro-1,2-propanediol(3-MCPD) is a toxic compound, often present in different foods containing acid hydrolyzed(AH) protein, like seasonings and savory food products. The purpose of the present study was to investigate the effects of 3-MCPD on male fertility, sperm and testosterone secretion. In vivo male fertility test was performed for observing the adverse effects of 3-MCPD on the function of male reproductive system and pregnancy outcome. 0.01, 0.05, 0.25, 1 and 5 mg/kg b.w. of 3-MCPD was given daily by gavage to groups of 15 adult male SD rats for 4 weeks. At the end of pre-treatment period, males were mated overnight with normal females. Following morning, males demonstrating successful induction of pregnancy were sacrificed on that day to assess sperm parameters and histopathology of reproductive organs. The resulting pregnant females were sacrificed on day 20 of gestation to evaluate pregnancy outcome. As a result, four-week paternal administration with 3-MCPD resulted in adverse effects on male fertility and pregnancy outcome without remarkable histopathological changes in testes and epididymides; sperm motility, copulation index and fertility index were markedly decreased in the treated group and numbers of live fetuses showed steep dose-response curves. Also, spermatogenesis was investigated in this experiment. However, no<br/> effect was observed on production of sperm in testes treated with 3-MCPD for 4 weeks. Hormone assay was performed for observing the effects of 3-MCPD on testosterone and luteinizing hormone (LH) in blood and testes of male SD rats and cultured primary Leydig cell. In result, significant changes of related hormones did not observed by treatment of 3-MCPD. These results indicated that paternal treatment with 3-MCPD induced spermatotoxic effect, which caused an antifertility on male.

Epidemiological Characterization of Opportunistic Mycoses between the Years 2006 and 2010 in Korea

( Je Seop Park ),( Seung Hak Cho ),( Seung Ki Youn ),( Young Seok Bak ),( Young Bin Yu ),( Young Kwon Kim ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1

In order to perform an epidemiological characterization of opportunistic mycosis infections, we collected health insurance data between the years 2006 and 2010 from the Health Insurance Corporation and analyzed the data to determine the prevalence of opportunistic mycoses and treatment management of opportunistic mycoses. The prevalence within the study increased consecutively by 0.02% to 0.12% every year. The annual prevalence of opportunistic mycoses increased from 2.437% in 2006 to 2.709% in 2010. The average annual prevalence was 2.605%. Candidiasis occurred the most frequently, followed by aspergillosis, zygomycosis, and cryptococcosis. The regions with the highest incidences were the capital areas, Gyeonggi and Seoul. By sex, the prevalence in females (4.851%) was 14 times higher than that in males (0.352%). Interestingly, the adults from the 20- to 49-year-old age group showed higher prevalence than children and the elderly. The average duration of hospitalized treatment was 17.31 days and of outpatient treatment was 2.21 days; 3,577 hundred million won was used in total for medical expenses. This study provides useful data to study trends of opportunistic mycoses.

Radiation impacts on morphological and qualitative properties in common buckwheat (Fagopyrum esculentum) and tatary buckwheat (Fagopyrum tataricum) seeds

Je-Hyeok Yu,Min-Heon Yun,Seon-Mo Yang,Dong-Seop Kim,Young-Ho Yun,Kyung-Ho Ma,Eun-Ho Son,Sok-Young Lee,Hong-Sig Kim,Sun-Hee Woo 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Breeding and cultivation techniques are being treated very severely regarding ecological and physiological development in buckwheat. This study was conducted to focus on the diversity occurring in the cultivated and tartary buckwheat and provide an overview of the characteristics and genetic resources activities. Morphological results showed that the height of common buckwheat ranges from 82-90cm, common buckwheat induced by 200Gy ranges from 52-75cm, common buckwheat induced by 300Gy ranges from 43-56cm, common buckwheat induced by 400Gy ranges from 33-60cm whereas the tartary buckwheat hight ranges from 65-87cm, and while it exposed to various radiation (200Gy, 300Gy and 400Gy), the obtained height ranges from 73-92cm, 55-80cm and 60-75cm respectively. However, the stems from the both cultivar are hollow and that’s why, the plant is very prone to lodging. The leaf color of common buckwheat was green, 200Gray, 300Gy 400Gy common buckwheat light green and green, whereas the tartary buckwheat green and bottle-green, 200Gray 300Gy 400Gy tatary buckwheat bottle-green, common buckwheat (control, 200Gy, 300Gy, 400Gy) stem color is light green and pink, flower color is white, tartary buckwheat (control, 200Gy, 300Gy, 400Gy) flower color is light green. The stem color from tartary buckwheat showed (200Gy, 300Gy, 400Gy) light green and light red color. The results revealed that the two buckwheat cultivars showed diversified characteristics.

트리 기반의 다대다 신뢰적 멀티캐스트를 위한 효율적인 혼잡 제어 기법

유제영(Je-Young Yu),강경란(Kyungran Kang),이동만(Dongman Lee) 한국정보과학회 2003 정보과학회논문지 : 정보통신 Vol.30 No.5

혼잡 제어는 에러 제어와 함께 신뢰적 멀티캐스트의 핵심적인 기능이다. MTCP나 TRAMCC와 같은 기존의 트리 기반의 혼잡 제어 기법은 일대다 신뢰적 멀티캐스트를 위하여 설계되어 다대다 신뢰적 멀티캐스트에 적용할 경우 몇몇 문제점들이 나타난다. 본 논문에서는 트리 기반의 다대다 신뢰적 멀티캐스트 프로토콜을 위한 효율적인 혼잡 제어 기법을 제안한다. 제안하는 기법은 혼잡 윈도우 기법을 기반으로 하며 전송률 제어기를 추가적으로 사용한다. 수신자들의 처리 부담을 최소화하기 위하여 추가적인 피드백 없이 에러 복구를 위한 피드백을 혼잡 제어를 위하여 이용하며, 동적으로 네트워크의 상태의 변화를 반영하는 ACK 타이머와 NACK 타이머 및 빠른 전송률 복구 기법 등을 통하여, 세션 내의 흐름들 간의 공평성을 제공한다. 네트워크 시뮬레이터를 사용해서 제안하는 기법이 세션 내의 흐름 간 공평성에 있어서 기존의 TRAMCC보다 효과적인 것을 보였으며, TCP-친화성, 응답성, 확장성에 있어서 만족할 만한 성능을 보임을 확인하였다. 그리고, 신뢰적 멀티캐스트 프로토콜인 GAM에 통합 구현하여 실험실 내 시험 네트워크 상에서 실험을 수행하였다. Congestion control is a key task in reliable multicast along with error control. However, existing tree-based congestion control schemes such as MTCP and TRAMCC are designed for one-to-many reliable multicast and have some drawbacks when they are used for many-to-many reliable multicast. We propose an efficient congestion control mechanism, TMRCC, for tree-based many-to-many reliable multicast protocols. The proposed scheme is based on the congestion windowing mechanism and a rate controller is used in addition. The feedback for error recovery is exploited for congestion control as well to minimize the overhead at the receivers. The ACK timer and the NACK timers are set dynamically reflecting the network condition changes. The rate regulation algorithm in the proposed scheme is designed to help the flows sharing the same link to achieve the fair share quickly. The performance of the proposed scheme is evaluated using ns-2. The simulation results show that the proposed scheme outperforms TRAMCC in terms of intra-session fairness and shows good level of responsiveness, TCP-friendliness, and scalability. In addition, we implemented the proposed scheme by integrating with GAM that is one of many-to-many reliable multicast protocols and evaluated the performance in a laboratory-wide testbed.

개회충 유충 감염에서 발생되는 호산구성 폐질환의 특성

김유진 ( Yu Jin Kim ),경선영 ( Sun Young Kyung ),안창혁 ( Chang Hyeok An ),임영희 ( Young Hee Lim ),박정웅 ( Jung Woong Park ),정성환 ( Seong Hwan Jeong ),이상표 ( Sang Pyo Lee ),최동철 ( Dong Chull Choi ),정영배 ( Young Bae Je 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.1

연구배경: 개흡충증은 한국에서 호산구증다증과 호산구성 폐질환을 일으키는 흔한 원인의 하나이다. 우리는 개흡충증에 의한 호산구성 폐질환의 특장을 분석하였다. 방법: 2001년 9월 1일부터 2006년 3월 30일까지 개회충 2기유충에 의한 호산구증다증으로 진단 받은 141명의 환자들을 대상으로 하였다. 본 연구를 위해 단순 흉부 방사선 촬영. 흉부 컴퓨터단층촬영, 기관지내시경, 기관지폐포세척술과 각종 혈액학적 검사를 시행하였다. 개회충증의 진단은 개회충 2기유충의 순수 분비배설 항원을 사용하였다. 결과: 141명의 환자 중 32명이 개회충에 의한 호산구성 폐질환으로 진단되었다. 젖빛유리양상이 컴퓨터단층촬영에서 지배적으로 23/32명(71.9%)이었다. 13/32명(40.6%)은 무작위적 구역적 분포를 보였다. 흉수액이 9/32명(28.1%)에서 관찰되었다. 28/32명(87.5%)이 호흡기 증상을 호소하였다. 11/32명(34.4%)은 호흡기 증상과 소화기 증상을 동시에 호소하였다. 12/32명(37.5%)에서 간에 국소의 저음영의 침윤을 보였다. 결론: 개회충에 의한 호산구성폐질환의 임상적, 방사선적 특성은 다발성의 결절성 또는 경화성의 젖빛유리음영이 양폐 상하엽에 무작위적 분포를 하는 것이다. 앞으로 우리나라에서 호산구 증다증과 폐침윤을 보이는 성인에서 감별진단을 위해 개회충증의 가능성을 고려해야 할 것으로 판단된다. Background: Toxocariasis is a common cause of eosinophilia and eosinophilic lung disease in Korea. We analyzed the characteristics of eosinophilic lung disease in toxocariasis. Method: One hundred and forty one patients with eosinophilia caused by a toxocara larval infection were evaluated from September 1, 2001 through March 30, 2006. The plain chest x-ray, chest CT(computed tomography), and bronchoalveolar larvage(BAL) were examined. A diagnosis of toxocariasis was made by ELISA using that secretory-excretory antigen from the T. canis larvae. Results: Toxocarial eosinophilic lung diseases was diagnosed in 32 out of 141 patients. Ground glass attenuation was the main feature on the CT scans in 23 out of 141 patients (71.9%). Thirteen patients (40.6%) had a random in zonal distribution on CT. Pleural effusion was observed in 9 patients (28.1%). Twenty eight patients (87.5%) complained of respiratory symptoms. Eleven patients (34.4%) had gastrointestinal symptoms and 12 patients (37.5%) had liver infiltration. Conclusions: The most common findings of the chest CT in patients with toxocariasis was a randomly distributed ground grass attenuation. A toxocara infection should be considered in a differential diagnosis of patients who exhibit pulmonary infiltration with eosinophilia in Korea. (Tuberc Respir Dis 2007; 62: 19-26)

Pneumobilia 가 동반된 간세포암종에서 간동맥 화학색전술 후 비암성 간 내에 발생한 간농양 1 예

김영철,이성구,박영민,이소영,김용균,정규원,배시현,김부성,정연주,선희식,유수은,박두호,변병훈,최종영,신제현,홍창균 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.2

Transcatheter arterial chemoembolization (TACE) is widely used to treat inoperable hepatocellular carcinoma and metastatic tumor of the liver. Among the complications occurring after TACE, liver abscess formation in HCC is a fatal complication. The reported incidence of this complication ranges from O% to 3.3%. Moreover, liver abscess formation in non - tumorous parenchyma is very rare. The pathogenic mechanism of this complication has been linked to several factors but retrograde enteric bacterial contamination of the biliary tract appears to be the most commonly implicated cause. The major risk factors of the biliary tract infection are pneumobilia, portal vein thrombosis, bilo - enteric anastomosis and biliary obstruction. We report a rare case of liver abscess formation in non - tumorous liver parenchyma after TACE for the treatment of hepatocellular carcinoma in a patient with pneumobilia(Korean J Hepatol 2001;7:189-194)

메시지 기반 인터페이스 공동 개발을 위한 메시지 관리 시스템

유제영(Je-young Yu),박진희(Jinhee Park) 한국정보과학회 2008 정보과학회 컴퓨팅의 실제 논문지 Vol.14 No.6

대형 시스템은 각 컴포넌트가 여러 다른 개발자에 의하여 개발된다. 개발 과정에서 컴포넌트 간의 인터페이스 관리의 효율성은 전체 개발 효율에 큰 영향을 미친다. 특히, 개발 초기 과정에서는 컴포넌트가 새롭게 정의되거나 변경되는 경우가 많다. 컴포넌트의 새로운 정의나 변경은 컴포넌트 간의 인터페이스의 생성이나 변경을 필요로 한다. 이러한 인터페이스의 변경에 대한 관리가 효율적으로 이루어지지 않는 경우, 관련된 컴포넌트를 개발하는 서로 다른 개발자들이 서로 다른 인터페이스를 기반으로 개발을 진행하는 경우가 발생한다. 이는 개발의 효율이 저하되는 문제를 일으킨다. 이러한 문제를 해결하기 위하여 메시지 관리시스템은 메시지 기반의 인터페이스 관리를 위한 수단을 제공한다. 또한, 메시지에 대한 코드 생성을 통하여 구현의 편의성을 제공해 주며, 메시지 관리 시스템 내에 정의된 메시지 정보를 이용하여 인터페이스 설계 명세서(IDD)를 자동으로 생성해 준다. 문서 자동 생성은 메시지 변경으로 인한 실제 인터페이스와 문서와의 불일치를 방지한다. 또한, 메시지 관리 시스템은 전체 시스템의 각 컴포넌트 간 메시지를 관리함으로써 각 컴포넌트 간 메시지 흐름에 대한 종합적인 정보를 수집하는 것이 가능하다. 이러한 정보는 컴포넌트간 메시지 흐름의 병목 현상의 발생을 미리 방지하거나, 전체 시스템 성능의 조율을 지원하는데 응용할 수도 있다. In Large scale system, components are developed by many different developers. In such a development environment, efficiency of the development depends largely on effectiveness of interface management. In the early stage of development, many components are newly defined or modified quite often. These definitions and modifications of components cause the change of interfaces between components. If changes of interfaces are not properly managed, many developers may implement components based on different version of interfaces. This causes decrease in efficiency of development. “Message Definition and Management System (MDMS)” provides the means to cope with the inefficiency of unmanaged interface definitions and changes. MDMS automatically generates source code and Interface Design Description (IDD). The automatic generation of source code and IDD prevents the disagreement between code and documents. Furthermore, MDMS shows the overall view of message flow for a system. Based on this information, we can optimize the system identifying message bottleneck and apply to support for the performance tuning of the system.