提川郡 荷川里-月窟里 地域의 地質構造와 岩石學的 硏究

Ok Joon Kim(金玉準),Kang Min Yu(兪剛民) 대한자원환경지질학회 1977 자원환경지질 Vol.10 No.1

The study area is located in between Hacheonri and Weolgulri, Jecheon-gun where the formations of Okcheon group and Chosun group come in contact and the stratigraphy and geological age of the Okcheon group have been debated among previous workers. The dolomitic limestone which distributed at Cheongam and Dumusil is clarified as the Hyangsanri dolomite formation and the quartzite distributed at Cheongam and Howeunri as Taehyangsan quartzite formation. The newly named Soorumsan schist interbedded in the Great Limestone Series was previously classified Seochangri formation. It is also classified that the formation formerly named as Seochangri was divided into newly named Manji schist which seems to be correlated to Kemyeongsan and Munjuri formation. The formation formerly named as Buknori is clarified as Hwanggangri formation. The Samtaesan formation has been clarified as the lower and upper limestone beds which belong to the Great Limestone Series. The area divided into two groups, that is, Okcheon system of Pre-cambrian age occupies western part and the Great Limestone Series of Chosun system of Cambro-Ordovician age eastern part of this area. Okcheon system consists in ascending order of Manji schist, Hyangsanri dolomite, Taehyangsan quartzite, Munjuri schist, and Hwanggangri formation of meta-tillite. The Great Limestone Series of Chosun group consists in ascending order of lower limestone, Soorumsan schist, Hoosanri quartzite and upper limestone formations. Busan augen gneiss seems to be igneous origin. Unmetamorphosed shale interbed can be traced in the Soorumsan schist. Previous study (Kims, 1974) reveals that meta-volcanic rocks are distributed from south to north alone contact zone of the Okcheon and Chosun groups, and it has been confirmed that the meta-volcanics crop out continuously from the adjacent southern quardrangle into the southern part of the area studied, intruding along the fault zone between the Okcheon and Chosun groups which seems to be upthrust as in the area south. This evidence coincides with Kims’ work (1974) which states that the Precambrian Okcheon group is largely overturned and thrusted over the Chosun group.

골격성 3급 부정교합자의 임상적 특성에 따른 심리상태

김선옥 ( Sun Ok Kim ),진미영 ( Mi Young Jin ),유병철 ( Byeng Chul Yu ) 한국치위생학회(구 한국치위생교육학회) 2015 한국치위생학회지 Vol.15 No.2

Objectives: The purpose of the study is to investigate the psychological state of the patients according to skeletal class Ⅲ malocclusion symptoms. Methods: The subjects were 200 skeletal class Ⅲ malocclusion patients. The questionnaire consisted of general characteristics, clinical manifestation, and T score of Korean version of self-rated Symptom Checklist-90-Revision modified by Jae-hwan Kim. The data were analyzed using SAS version 9.2 and t-test, ANOVA, and ANCOVA were used. Clinical manifestation included subjective recognition and radiological analysis. The subjective recognition of the patients consisted of self-satisfaction of the appearance, phonation, mastication, and temporomandibular joint pain. T score consisted of somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism. Results: The most serious factor in 9 scales was the severe TMJ pain by ANCOVA. Male patients had a higher T score in phobic anxiety, psyochoticism, somatization and depression than female patients. Those having low appearance satisfaction had the problem in interpersonal sensitivity. Obsessive-compulsive symptoms were conspicuous in phonation difficulty and temporomandibular pain. Conclusions: The patients with skeletal class Ⅲ malocclusion have more satisfaction with appearance, pronunciation, and phonation than those with skeletal class Ⅲ malocclusion and overjet. Proper dental treatment will improve the communication and quality of life.

Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer

오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-

Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.

관상동맥 질환에서 SDF-1α의 농도

김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.

소비자의 라이프 스타일에 따른 패션행동양식에 관한 연구

정유정,박옥련,하종경,김서주 경성대학교 2000 論文集 Vol.21 No.1

A study is to divide consumer's spending pattern into life style and fashion behaviour, analyzing the interrelation of fashion behaviour according to life style, which brings about the following summarized results. First, as a result of the analysis of consumer's life style, most reveal to be an independent pioneering group and there is no significant difference between clients and staffs. Second, by analysis result from consumer's fashion behaviour pattern, it appears that factors as for sale promotion and quality enhancement have a meaningful variable. In case clients are concerned, buying ability, fashion sense and purchasing method have something meaningful. In addition, as to all customers and staffs, it turns out that a type of spending for pleasure and a type of independent pioneering have something to do closely with fashion sense.

상부 조기 위암 환자의 복강경하 상부 위절제술 3례 경험

조규석,김형철,박경규,이문수,송옥평,임철완,신웅진,주종우,유기원 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Background : The reported incidence of early gastric cancer located in the upper portion of the stomach has been increasing with the recent advances in its diagnosis and screening. Recently, we have successfully performed laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without pyloroplasty on three patients with early gastric carcinoma localized to the upper third of the stomach. We describe our modification of this procedure in this report. Method : After creating an surgical pneumoperitoneum, the stomach was mobilized using laparoscopic coagulating shears. Upper half of the greater curvature and three-quarters of the lesser curvature were then dissected along with regoinal D2 lymphadenectomy. This was followed by a 5 cm, longitudinal mini-laparotomy in the upper abdomen, and the construction of the exteriorized stomach with a gastric tube measuring 20 cm long and 4 cm wide. Reconstruction with an esophagogastrostomy was performed using a circular stapler. Result : No post-operative morbidity or mortality was observed in this small series of patients. The average operative time was 250 minutes (range 220-300 minutes), and the average blood loss was 150 ml (range 90-180 ml). The mean number of lymph nodes harvested during these laparoscopic proximal gastrectomies was 24 nodes (range 22-25 lymph nodes). The average postoperative hospital stays was 7.5 days (range 7-8 days). Conclusion : Our technique of laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without phloroplasty offers a minimally invasive technique with the potential of impoving the post-operative quality of life patients with an early-stage proximal gastric cancer.

다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

다중 쓰레드 기반의 병렬처리서버용 안티바이러스 엔진

유주영;김미애;박은옥;박유미;최주영;최은정;김명주 서울여자대학교 컴퓨터과학연구소 2004 정보기술논문지 Vol.2 No.-

악성코드에 대한 보다 바람직한 예방은 클라이언트측이 아닌 서버측에서 이루어지는 것이다. 본 논문에서는 새로운 개념 의 서버용 안티바이러스 엔진인 SAVE 1.0을 설계 구현하여 제시한다. SAVE는 기본적으로 1개의 AV모니터와 다수의 AV에이전트로 구성되어 있는데 다중 CPU를 장착한 병렬처리서버의 특징을 직접 활용하기 위하여 관리자가 다중쓰레드 기법을 직접 지정할 수 있도록 하고 있다 악성코드를 5가지 부류로 구분하여 바이러스 시그너쳐 DB를 구축 제공함으로써 부류별 진단을 지정할 수 있도록 하고 있으며 실시간 네트워크 패킷 검사를 통한 악성코드 유입 점검 기능도 제공한다. 웹 기반의 관리자 인터페이스는 뛰어난 사용자 편의성을 제공하고 있다. 성능실험결과 악성코드 검색율은 국내외 상용제품과 비교해서 매우 우수한 것으로 나타났으며 검색속도에 있어서도 서버의 CPU 수 증가에 거의 선형 비례하여 향상되는 특징을 보이고 있다. It is more desirable to prevent and detect the malicious codes in server system rather than in client PCs. In this paper, we suggest a new anti-virus engine, SAVE 1.0, which is executed on a parallel processing server. SAVE consists of 1 AV monitor and several AV agents. A system administrator can control the degree of multi-thread directly in order to enhance the utilization of parallel processing servers. Virus signature DBs in SAVE are classified into 5 categories, which support system administrator's options to use the classifier or not. By real-time checking of network packets, the influx of malicious codes can be prevented. Web-based GUI is one of the convenient functions provided in SAVE. In performance tests, we have confirmed that SAVE has higher virus detection ratio than any other AV engine, and SAVE has a desirable feature as an software of parallel processing servers since the performance of SAVE is improved almost linearly as the CPUs in a parallel processing server increases.

제천군(提川郡) 하천리(荷川里)-월굴리(月窟里) 지역(地域)의 지질구조(地質構造)와 암석학적(岩石學的) 연구(硏究)

김옥준,유강민,Kim, Ok Joon,Yu, Kang Min 대한자원환경지질학회 1977 자원환경지질 Vol.10 No.1

The study area is located in between Hacheonri and Weolgulri, Jecheon-gun where the formations of Okcheon group and Chosun group come in contact and the stratigraphy and geological age of the Okcheon group have been debated among previous workers. The dolomitic limestone which distributed at Cheongam and Dumusil is clarified as the Hyangsanri dolomite formation and the quartzite distributed at Cheongam and Howeunri as Taehyangsan quartzite formation. The newly named Soorumsan schist interbedded in the Great Limestone Series was previously classified Seochangri formation. It is also classified that the formation formerly named as Seochangri was divided into newly named Manji schist which seems to be correlated to Kemyeongsan and Munjuri formation. The formation formerly named as Buknori is clarified as Hwanggangri formation. The Samtaesan formation has been clarified as the lower and upper limestone beds which belong to the Great Limestone Series. The area divided into two groups, that is, Okcheon system of Pre-cambrian age occupies western part and the Great Limestone Series of Chosun system of Cambro-Ordovician age eastern part of this area. Okcheon system consists in ascending order of Manji schist, Hyangsanri dolomite, Taehyangsan quartzite, Munjuri schist, and Hwanggangri formation of meta-tillite. The Great Limestone Series of Chosun group consists in ascending order of lower limestone, Soorumsan schist, Hoosanri quartzite and upper limestone formations. Busan augen gneiss seems to be igneous origin. Unmetamorphosed shale interbed can be traced in the Soorumsan schist. Previous study (Kims, 1974) reveals that meta-volcanic rocks are distributed from south to north along contact zone of the Okcheon and Chosun groups, and it has been confirmed that the meta-volcanics crop out continuously from the adjacent southern quardrangle into the southern part of the area studied, intruding along the fault zone between the Okcheon and Chosun groups which seems to be upthrust as in the area south. This evidence coincides with Kims' work (1974) which states that the Precambrian Okcheon group is largely overturned and thrusted over the Chosun group.

정신분열병과 Neuregulin 1 유전자의 연합연구

박동연,이유상,조은영,조승희,장용이,전현옥,장수연,윤세창,김종원,홍경수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : The authors recently found a suggestive evidence of linkage of chromosome 8p21-12 to schizophrenia in Korean multiplex families. Neuregutin 1 (NRGI) was identified in this locus as a positional and functional candidate gene for Schizo-phrenia, through several independent studies with European and Chinese populations. The purpose of this study is to determine whether NRGl is associated with schizophrenia in Korean population. Methods : Three SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177) and two microsatellites markers (478B14-848,420M9-1395) located at the 5' end of NRGI were genotyped for 242 unrelated schizophrenia patients and the same num-ber of normal controls. Genetic association was tested by χ²-test (df=1). Not only for the whole patients group but also for asubgroup of patients with auditory hallucination. This subtype showed stronger linkage with chromosome 8p12 in the prior study of the authors with multiplex families. Results : G allele of SNP8NRG241930 was significantly in excess in the subgroup of patients with auditory hallucination compared to the control group (p=0.03, 0R=1.76). We also found that 3 SNPs haplotype TTC (p=0.04, 0R=0.58) and five markers haplotype TTC53 (p=0.01,0R=0.49) were associated with schziophrenia with a protective effect. Three SNPs haplotype CGT which is a part of the at-risk haplotype of the Icelandic schizophrenia families was found in excess in the patients group but no significant association was observed. Conclusion : NRGI might either play a mle in the predisposition to schizophrenia or be in linkage disequilibrium with a causal locus of this illness.