여성과 남성 공공근로사업 참여자의 (재)취업 결정요인

윤홍식,김광혁 한국사회복지정책학회 2006 사회복지정책 Vol.24 No.-

골아세포 MC₃T₃-E₁의 증식과 기능에 Insulin Like Growth Factor Ⅰ, Ⅱ 및 부갑상선 호르몬이 미치는 영향

윤현구,정호연,양인명,김성운,김진우,김광원,김영설,최영길,서광식 대한내과학회 1992 대한내과학회지 Vol.42 No.1

MC₃T₃-E₁골아세포군을 이용하여 IGF-Ⅰ과 Ⅱ를 투여하고 DNA합성과 골아세포기능을 측정하기 위해 PTH에 대한 C-AMP반응정도, alkaline phosphatase 활성도를 측정하여 다음과 같은 결과를 얻었다. 1) IGF-Ⅰ과 Ⅱ는 모두 DNA합성이 어느 농도까지는 증식효과를 나타내지만 그 이후에는 억제되는 양상을 보였다. 2) PTH에 대한 골아세포의 C-AMP반응으로 증가되었지만 IGF-Ⅰ과 Ⅱ의 투여시 농도변화에 따른 의미있는 변화는 없었다. 3) 본 실험의 조건에서 alkaline phosphatase 활성도는 증가되지 않았다. 이상의 결과로 MC₃T₃-E₁ 골아세포에 IGF-Ⅰ과 Ⅱ는 세포의 증식을 자극하여 PTH는 C-AMP생성을 촉진하는 효과가 있었다. The effect of insulin-like growth factor (IGF) Ⅰ and Ⅱ on cloned MC₃T₃-E₁ cells that had osteoblastic activity was examined by [³H] thymidine incorporation into DNA, cyclic AMP responsiveness to parathyroid hormone (PTH), and alkaline phosphatase activity. IGF Ⅰ and Ⅱ stimulated the growth and proliferation of osteoblastic cells at 20ng/㎖ and 50ng/㎖, respectively. We next examined the effect of IGF-Ⅰ and Ⅱ on the expression of osteoblastic activity. Adenylate cyclase response of PTH to IGF-Ⅰ and Ⅱ-treated cells showed maximal stimulation at 10 and 50㎚PTH, respectively, but IGF Ⅰ and Ⅱ induced limited activity of osteoblastic function. In conclusion, IGF-Ⅰ and Ⅱ were potent stimulators to the growth of osteoblastic cells but did not have an immediate effect on expression of osteoblastic function in this experiment.

농업수리시설물 유지관리시스템 개발을 위한 지리정보시스템 (GIS)과 GPS 이용

윤광식,최진용,김종옥 公州大學校 産業開發硏究所 1998 産業開發硏究 Vol.6 No.-

A facility management system using GIS and GPS for the feasible maintenance of irrigation structures was developed. Digital map of irrigation network was constructed using geographic Information system, Arc/Info. Locations of irrigation structures were surveyed with GPS. The surveyed data were corrected with post-processing DGPS and imported to GIS for the digital map construction. Database related to maintenance record were built and interface program between DIS and database were developed suing object-oriented language JABA?. User-friendly menu system enable querying maintenance record also developed and imbedded into the system.

6-hydmxydopamine 파킨슨병 모델에서 Apomorphine의 투여에 따른 회전운동 변화의 시간적 추이

홍근식,김병곤,전범석,윤병우,이광우,노재규,이상복,명호진 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

한국어 단음 인식을 위한 자기구조화 신경망의 확장

진광식,윤태성 國立 昌原大學校 産業技術硏究所 1995 産技硏論文集 Vol.9 No.-

In this study, speech recognition experiments for 10 Korean digits(from 0 to 9) are performed using nelcepstrum and SOFM(Self-Organized Feature Map). Especially, the feature map for each digit was composed of 4 parts. 3 parts are for the initial, medial and final phonemes, and 1 part is for the whole phone. We did not do the exact segmentation for each phoneme extraction. But, with the proposed feature map, the patterns for 10 digits are classified well. In the recognition experiment, 10(digits)3??(speakers)??10(utterances)=300 data were tested and 150 data of them are used as training data. In case of training data, the recognition rate is 98.6% and for other test data, 92.6%. These results are much better than those of the conventional SOFM(training data:82.29%, other test data:85.95%).

퍼지 전문가 시스템을 이용한 BLDC 전동기의 자동조정 PID 속도제어에 관한 연구

진광식,윤태성,권세현 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

This paper proposes the rule-based expert system with auto-turning of PID controller gain and shows the efficiency of fuzzy expert system for the speed control of BLDC motor. The PID controller gain tuned using RZN(refined ZN) formula to initial tuning and fuzzy expert system to subsequent tuning. The fuzzy expert PID control method proposed in this paper results in the reduction of overshoot, the rapid response and the robustness for disturbances and noise.

센서 융합을 이용한 자율이동로봇의 위치추정

정석윤,진광식,윤태성 國立 昌原大學校 產業技術硏究院 2004 産技硏論文集 Vol.18 No.-

Accurate position estimation is required for mobile robot navigation. To estimate current position, mobile robot uses sensors. As one sensor or two sensors system is insufficient to estimate accurately, it is necessary to use sensor fusion method. Mobile robot can obtain redundant and complementary information by using sensor fusion method. It is possible to estimate current position more accurately than one sensor or two sensors system. Sensor fusion system is composed of vision sensor, ultrasonic sensors and encoder sensor. Personal computer and interface board control three different sensors. Extended Kalman Filter(EKF) method using three different sensors is proposed for sensor fusion. The validity of the proposed sensor fusion method is proved by experimental results in indoor environment.

농업용 저수지의 부영양화와 수질관리방안

이광식,윤경섭,김형중,김호일 한국환경농학회 2003 한국환경농학회지 Vol.22 No.2

1990년부터 2001년까지 농업용수 수질측정망 조사자료를 분석하고, Chl-α 농도와 유효저수량/만수면적비를 이용하여 498개 저수지에 대하여 유형을 분류하고, 각 유형에 대한 수질개선방안을 제시하기 위하여 본 연구를 수행하고 다음과 같은 결론을 얻었다. 우리 나라 농업용 저수지의 Chl-α 농도는 유효저수량/만수면적비(ST/WS)에 민감하게 반응하였으며, ST/WS비가 클수록 Chl-α 농도는 감소하는 경향을 나타내었는데, 저수지의 부영양화를 억제하기 위해서는 ST/WS비를 최소 5~6 m 이상, 가능하면 10m 이상이 되도록 건설ㆍ보수하는 것을 좋을 것으로 판단된다. 우리나라 저수지를 Chl-α 농도 25 mg/m³, ST/WS비 5m를 기준으로 유형을 분류하고 그 특성을 고찰한 결과 ST/WS비가 작고 부영양화가 진행된 종합정비형인 Ⅰ형 저수지는 호소의 지형학적 특성과 외부에서의 부하가 모두 복합적으로 부영양화에 영향을 준 것으로 판단되며, 동일한 형상이라도 부영양화가 진행되지 않은 호내정비형인 Ⅱ형 저수지는 상대적으로 외부 유입이 적은 것으로 나타났다. 반면에 지형학적 특성상 수질관리에 유리한 ST/WS비가 큰 관리형인 Ⅳ형 저수지는 대부분이 부영양화가 아직 진행되지 않았으며, 유역으로부터 높은 부하량을 나타내는 유역정비형인 Ⅲ형는 부영양화가 이루어 졌으나 전체 저수지의 약 5% 미만으로 극히 드문 것으로 나타나 ST/WS비가 큰 경우 상대적으로 외부유입으로 인한 부영양화는 작은 것으로 나타났다. 수질개선사업우선순위(안)는 Ⅰ형(종합정비형) → Ⅲ(유역정비형) → Ⅱ형(호내정비형) → Ⅳ형(관리형)의 순으로 정비해 나가는 것이 바람직할 것으로 판단된다. 또한 농업용수 수질기준 항목 중 COD 농도를 유기오염 지표뿐 아니라 부영양화를 나타내는 지표로써도 함께 고려하여 세분화한 결과 현행 8 mg/L에서 10 mg/L 이상을 대책기준, 6~10 mg/L을 우려기준, 6 mg/L이하는 안전기준으로 세분하고, 이에 따라 수질개선사업을 실시하는 것이 효율적일 것으로 판단된다. A total of 498 agricultural reservoirs ranging from 164 × 10³ to 253 × l0^(6) ㎥ in storage volume were investigated from 1990 to 2001 with respect to Chl-a, COD concentration and pollutant loading of BOD, TN, and TP. The lakes and reservoirs could be classified to 4 types using the relationships between the ratio of storage volume per water surface area(ST/WS) and Chl-a concentration. It is recommended that the improvement of polluted lakes should be performed in the order of integrated consolidation type→watershed consolidation type→in-lake consolidation type→management type and reservoir should be constructed to be over 5∼6 m in depth(STWS ratio) for preventing the eutrophication of agricultural reservoirs. We propose that water quality criteria for agricultural water is changed from less than 8 ㎎/L to less than 6㎎/L for safety value, 6-10 ㎎/L for concern value, and more than 10 mg/L for countermeasure value in COD concentration, respectively.

인간 재조합 인터루긴-32 면역조절작용에 대한 유세포 분석

이광수,김영관,채정일,심정현,김은미,강형식,김수현,윤도영,명평근 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

Xenotransplantation of porcine organs has the potential to overcome the severe shortage of human tissues and organ available for human transplantation. however, it remains various hurdles for clinical xenotransplantation. In pig and mouse xenotransplantation, porcine xenograft evoke a strong cellular rejection response in immunocompetent host and grafts are destroyed within a week. This cellular immune response could involved both T cells and NK cells. A number of groups have shown that human NK cells can recognize and damage porcine endothelial cells. In addition, human T cells can respond to porcine endothelial cells through both direct and indirect mechanisms. Cellular rejection of porcine tissues requires T cells, particularly CD4^(+) cells. A new cytokine recombinant human interleukin-32α,β(IL-32α,β) has a role innate and acquired immune system. In order to investigate the role of recombinant mouse IL-18 and recombinant human IL-32α,β in xenograft rejection, we transplanted the PK(15) cells to C57BL/6 mice with or without intraperitoneal injection of recombinant mouse IL-18 or recombinant human IL-32 α,β. It was analyzed the population of NK cell, T cell and B cell in the C57BL/6 mice transplanted with PK(15) cells and recombinant mouse IL-18 or recombinant human IL-32α,β by flow cytometry analysis. As a result, lymph node and thymus of PK15/IL18, PK15/IL32α and PK15/IL32β injected group were increased to T cell activation population than normal injected groups. CD8^(+) T cells were decreased in lymph node of PK15/IL18, PK15/IL32α and PK15/IL32β injected groups. CD4^(+) T cells were increased in lymph node cell of PK15/IL32α and PK15/IL32β injected group and also, B cell population were increased in lymph node cell and spleen of PK15/IL18, PK15/IL32α and PK15/IL32β injected group. Therefore, we suggest that recombinant mouse IL-18 and recombinant human IL-32α,β suppress xenograft rejection in cellular xenotransplantation.

Segmented TMA T-loop spring에 의한 견치 후방이동시의 응력분포에 관한 광탄성법적 분석

유필식,윤영주,김광원 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.2

본 연구는 교정치료를 시행함에 있어 전치부 crowding을 해결하기 위한 견치의 단독견인 방법중 새로운 segmented TMA T-loop spring으로 견치 후방견인시 치근단과 그 주위 치조골에서의 응력상태를 알아보기 위해 시행되었다. PL-3 epoxy resin으로 광탄성 모형을 제작하여 B/L ratio가 0.25, 0.5, 0.75인 위치로 T-loop을 위치시키고 각 위치에서 5mm, 3mm, 1mm activation하였다. 이후 광탄성 응력 해석장치를 이용하여 견치견인시 치근단과 그 주위 치조골에서의 초기 응력 상태를 광탄성법으로 분석한 바, 다음과 같은 결론을 얻었다 1.T-loop 위치에 상관없이 activation량이 감소할수록 상악 1소구치 발치부위에 응력이 감소하였고 상악 1대구치의 함입응력은 증가하였다. 2.5mm activation시 T-loop위치가 구치부쪽으로 이동할수록 상악 1소구치 발치부위에 응력이 증가하였다. 3.3mm activation시 T-loop위치가 구치부쪽으로 이동할수록 상악 1소구치 발치부위와 상악 1대구치 협측 근심치근 근심면하방 1/2부위에 응력이 증가하였다. 4.1mm activation시 T-loop위치가 견치쪽으로 이동할수록 상악 견치의 근심치근면 상방과 치근첨 하방의 응력이 증가하였다. 5.B/L ratio가 0.25이고 3mm activation시 상악견치의 치체이동이 나타났다. 이상의 결과를 종합해볼 때 segmented T-loop spring의 근,원심 위치와 activation량을 조절하여 원하는 치아이동과 고정원 조절이 가능하다고 사료된다. The segmented TMA T-loop spring, used for reciprocal space closure and described by Burstone, was used to achievebodily movement of canine. Photoelastic analysis is a technique for the transformation of Internal stress into visiblelight patterns. The two-dimensional photoelastic stress analysis was performed, and stress distribution was recorded byphotography. The purpose of this study was to visualize photoelastically the distribution of forces transmitted to the alveolus and surrounding structures using new segmented TMA T-loop spring for canine retraction. The resuts were as follows: 1.Decreased activation produced decreased stress of upper 1st. premolar extraction site and increased intrusive stress of upper 1st. molar, regardless of T-loop position. 2.At 5mm activation, More posterior positioning of T-loop produced an increased stress in upper 1st. premolar extraction site. 3.At 3mm activation, More posterior positioning of T-loop produced an increased stress in upper 1st. premolar extraction site and menial lower half of upper 1st. molar mesio-buccal root. 4.At 1mm activation, More anterior positioning of T-loop produced an increased stress in upper menial and blew apex area of upper canine root. 5.0.25 B/L ratio and 3mm activation produced bodily movement of canine. To summarize, desired tooth movement and anchorage requirement is possible byaltering the activation and mesio-distal position of the T-loop spring.