중증 근무력증 52례에 대한 임상적 고찰

박건주,하정상,이준,도현철,박승권,서상덕,기병수,김진국 영남대학교 의과대학 1996 Yeungnam University Journal of Medicine Vol.13 No.1

1985년 8월부터 1996년 1월까지 중증근무력증으로 진단받은 환자 52례에 대한 임상적 고찰을 통하여 다음과 같은 결론을 얻었다. 1. 전체 환자 중 남자가 19례(35.8%), 여자가 33례(64.2%)이넜고 11세에서 20세 사이가 12례(23%)로 가장 높은 빈도를 보였다. 2. 환자의 초기증상으로는 안검하수, 복시 등의 안구증상이 37례(71.2%)로 가장 많았고 modified Osserman의 분류에 따라서도 가장 증상이 가볍고 약물치료에 잘 반응하는 1군이 36례(69.3%)로 가장 많았다. 3. 환자가 호소하는 증상의 비특이성과 회복과 재발을 거듭하는 질병의 특성으로 인해 발병이후 진단될 때까지의 시간은 비교적 오래 걸렸고 1년이상 경과하며 진단된 경우도 16례(30.8%)나 되었다. 4. 자가면역질환이 7.6%에서 동반되었는데 갑상선기능 항진증이 2례(3.8), 인슐린의존형 당뇨 2례(3.8%)였고 종격동 전산화 단층촬영소견에서 흉선의 비대가 의심되었던 환자는 6례(11.5%), 흉선종이 발견 되었던 경우는 3례였다. 5. 환자의 치료는 대부분 항콜린에스테라제나 부신피질호르몬을 병용하는 내과적 치료를 하였으며 약물의 치료에 반응이 미비하거나 악화되는 경우 혹은 종격동 전산화 단층촬영상에서 흉선의 이상 소견이 보인 경우에 2례(3.9%)에서는 흉선절제술이, 1례(1.9%)에서는 혈장여과요법이 추가 되었고 흉선절제술과 혈장여과요법이 같이 병합 치료된 경우도 3례(5.9%)있었다. 6. 전체 환자중 2명에서 자연치유의 경과를 보였으며 이들은 모두 1군이였다. 그리고 흉선절제술과 부신피질 호르몬 투여로 완치된 예가 1례있었다. The authors experienced 52 patients with myasthenia gravis who were diagnosed at the Department of Neurology, Yeungnam University Hospital from August 1985 to January 1996. The following results were obtained through diagnostic evaluation and treatment. 1. The ratio of male to female was 1:1.7 and the most prevalent age group was second decade. 2. The most common initial presentation symptom was ocular(71.2%) and the peak incidence group was stage I(69.3%) according to the modified Osserman's classification. 3. In 16 patients(30.8%), it took more than a year to diagnose due to symptoms which were relapsed and remitting. 4. Of 52 patients, 2 cases were associated with thyroid disease(3.8%) and 2 with insulin-dependent diabetes mellitus(3.8%). 5. All of those who received anticholinesterase and corticosteroid therapy were improved with the exception of 5 cases which were improved after thymectomy and/or plasmapheresis. 6. Spontaneous remission was occured in 2 cases(3.8%) of ocular myasthenia gravis. And 1 case of group II was cured through thymectomy and long-term corticosteroid therapy.

청소년의 성과 연령에 따라 자아정체감 발달에 영향을 미치는 생태학적 변인들의 구조분석

박아청,이승국 한국교육학회 대구·경북지회 2000 교육학논총 Vol.20 No.2

The purpose of this study is to determine through what media and how much ecological variables affect the ego-identity formation among adolescents. In particular, their media and amount of influence are analyzed according to sex and age of the youths. For this investigation, spousal relationship, socioeconomic status of the family, peer relationship, and student-teacher relationship are taken for external variables; parental expectation from their childrens education, parental attitude to child rearing, family support, peer support, and ego identity for internal variables. A random sample of 767 secondary school male and female students and 767 parents was investigated through questionnaires for the nine variables mentioned above. The results of the questionnaires were analyzed by covariance structure analysis, and path analysis and Lisrel-pc 8.03 statistical analysis program were applied to determine cause-and-effect relations among the variables. After reviewing previous studies, the following conclusions were derived: First, in regard to the media through which these ecological variable are affecting the ego identity development, female adolescents are susceptible to spousal relationship, socioeconomic status of the family, and parental attitude to child rearing, parental expectation from their childrens education, parental attitude to child rearing, and peer support, but male adolescents are not noticeably affected by these variables. While parental expectation from education affect peer support positively for male adolescents, these variables have no effect on female adolescents. Second, with respect to sexual differences, female adolescents are affected by familial factors more notably than male adolescents are. Third, in regard to the media through which these ecological variable are affecting the ego identity development, the middle school students are susceptible to spousal relationship, parental expectation from their childrens education, parental expectation from their childrens education, and peer support, but the high school students are not noticeably affected by these variables. While socioeconomic status of the family, and peer support affect peer support, and the ego identity positively for the high school students, these variables have no effect on the middle school students. Finally, as for the age differences, it was found that as they grow older, student-teacher relationship and peer support have a stronger influence than familial factors do.

만성폐쇄성 폐질환 환자에서 적혈구 항산화효소의 변화

국기용,이만재,조희충,임영국,박일,김원식,이승일,이병래 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disordesrs. Enhandng the intracellular content of antioxidant enzymes can provide means of limiting biological damage caused by oxygen free radicals. Many investigations have examined the potential of various oxyradical scavengers to modulate oxyradical injury. The oxygen free radicals play a role in the pathogenesis of chronic obstructive pulmonary disease. To investigate the pulmonary oxyradical injury and the protective role of antioxidant enzymes, author measured the amount of thiobarbituric acid reactants, the activiteies of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase) and the sulfhydryl groups in serum and red blood cells from the chronic obstructive pulmonary disease groups and the normal controls. The thiobarbituric acid reactant in chronic obstructive pulmonary disease groups was increased than the controls in both serum and red blood cells, and the superoxide dismutase activity in red blood cells was no statistically difference in both groups. But, the glutathione peroxidase and catalase activities were lowered in chronic obstructive pulmonary disease groups than the controls. The sulfhydryl groups in serum and red blood cells were no statistically difference in both groups. These results suggest that the increased thiobarbituric acid reactant in chronic obstructive pulmonary disease groups mean oxygen radical toxicity, and the decreased glutathione peroxidase and catalase activities may play a role in cellular injury.

저혈량성 쇼크를 동반한 자발성 복직근초 혈종

박상현,오동렬,김형국,김세경,박승현 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: Intermediate myasthenia syndrome(IMS) is thought to have clinical importance because it may cause sudden respiratory failure during the recovery phase of a cholinergic crisis of organophosphate poisoning. We designed this study to identify the prevalence, the inducing agent, clinical predictor, and the proposed treatment of IMS. Methods: Patients who had admitted with the diagnosis of acute organophosphate poisoning from 1992 to 1998 at two teaching hospitals were enrolled in this study. We selected the cases of IMS based on a review of medical records using modified He' s criteria. Results: Twelve(12) out of 110 patients with acute organophosphate poisoning were diagnosed for a prevalence at 10.9%. The drug inducing IMS were identified as dichlorvos, fenthion, EPN, methidathion, and phosphamidon. The occurrence of IMS was not related to either the initial treatment with atropine and pralidoxime, or the level of serum cholinesterase. Complications were pneumonia, sepsis, pancreatitis, and pseudomembranous colitis, etc. Eleven(11) patients were discharged without sequelae, and one patient was discharged as a hopeless case. Conclusion: This study suggests that IMS is not rare, so close observation is required to detect IMS in organophosphate-poisoning patients. Also, more studies are required to find predictors and treatments.

특성 길이를 이용한 평직 복합재 볼트 체결부의 강도 예측

박승범,변준형,안국찬 한국안전학회 2003 한국안전학회지 Vol.18 No.4

A study on predicting the joint strength of mechanically fastened woven glass/epoxy composite has been performed. An experimental and numerical study were carried out to determine the characteristic length and joint strength of composite joint. The characteristic lengths for tension and compression were determined from the tensile and compressive test with a hole respectively. The characteristic lengths were evaluated by applying the point stress failure criterion to a specimen containing a hole at the center subjected to tensile loading and a specimen containing a half circular notch at the center subjected to compressive load. The joint strength was evaluated by the Tsai-Wu and Yamada-Sun failure criterion on the characteristic curve. The predicted results of the joint strength were compared with experimental results.

3차원 비디오 자동 동작분석 시스템 개발

박성순,양창수,장준원,이경일,우철호,백승국 한국운동역학회 1998 한국운동역학회지 Vol.8 No.2

The purpose of this study was to develope both hardware and software of automatic 3-dimensional video motion analysis system. In this image capture system, the vedeo image was stored as a file in CD-Rom directly, the refore it was possible to analyze motion without VCR. Reflective markers were used to digitize automaticaly. C-language and MS-Visual Basic 5.0 ] anguage were utiliged in this software to analyze motion. The conclusions were as follows; 1. The vedeo information at sixty frames per second could be captured accurately as a image with a resolution photography of 640×480-24 bit. 2. It was possible to digitize both manually and automatically utilizing reflective marks attached the body. 3. The automatic 3-dimensional video motion analysis system, which was developed in this study not only increased accuracy but also reduced digitizing time so much.

레이저 다이싱 장비의 구조 동특성이 빔 안정성에 미치는 영향

박형욱,노승국,박종권,이혜진,최석우 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

Inherent merits fabricating thin wafers motivated the development of laser dicing machines. In this study, the dynamic characteristics of the prototype of a laser dicing machine has been evaluated using ANSYS based modal and harmonic analysis. The computation shows that the supporting structure of the laser tube which is a guide of laser beams is stable in terms of the dynamic stiffness. But, the thickness of the beams supporting the upper structure of a laser dicing machine has to be increased.

하안면 고경 변화의 인지도에 관한 연구

박승현,김영진,국윤아 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.3

교정치료 결과 나타나는 안모의 개선에 대하여 환자들이 느끼는 인지도에 관한 정보를 교정의사들이 이해하여야 하며, 진단과 치료계획 수립 시 이에 대한 기준이 중요하다. 이에 본 연구는 하악의 수직적 변화를 통해서 야기되는 측모 및 정모의 변화를 인지할 수 있는 최소한의 수직적 변화량을 알아보고자 보기좋은 안모를 갖는 가상의 안모를 컴퓨터 영상으로 정모와 측모를 만들고 하안면부인 stomion에서 chin까지 1, 2, 3, 4 mm변화시킨 디지털 영상을 이용하여 40명의 미술학도를 관찰자로 인지도 조사를 하였다. 그 결과는 환자가 수직고경의 변화를 인지하게하기 위해서는 측모에서 최소한 2 mm 이상, 정모에서 3 mm 이상의 변화가 필요하였으며, 하악의 수직적 변화에 대한 인지도는 정모의 변화보다는 상대적으로 측모의 변화에서 높았다. 또한 치료 전이나 치료과정에서 환자가 접하게 될 수 있는 안모 변화에 대한 사전 정보는 변화에 대한 인지율을 현저하게 높여 주었다 Understanding the level of a person's perception of changes that have occurred on the face after orthodontic treatment is critical to the process of orthodontic diagnosis and treatment planning. The purpose of this study was to determine the level of perception of profile and frontal changes in lower facial height. Forty students attending art school participated in a study evaluating the level of a participant's perception of changes in the lower facial height. Participants compared computer-graphic frontal and profile photographs with balanced proportions and photograph simulations of 1, 2, 3, and 4 mm changes in lower facial height from stomion to the chin. At least a 2 mm change in lower facial height for the profile view and 3 mm in the frontal view was needed to be perceived after orthodontic treatment. The level of a person's perception of the change in lower facial height was more sensitive in the profile view than in the frontal view, and information about facial changes given prior to evaluation enhanced the level of perception.

분석결과 검증 및 신뢰성 확보를 위한 실험실간 협력 실험

박혜진,고광용,한국탁,김일중,이용재,김성헌,이규승 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.2

The residual study of pesticide has been used in various areas, such as food safety, environmental protection, establishment of tolerance, and explaining the pathway and reaction mode of pesticides, and its importance was expected to increase further more. The aspect of food safety, the pesticide residue survey have been practiced at many organizations, but there were no verification of analytical results at present. In this experiment, we focused on instrumental stability, including response of each instrument and the recovery ratio of each organization's method. As samples for this experiment, we prepared cucumber and sesame, and chose 4 pesticides (bifenthrin, chlorpyrifos, diazinon, and ethoprophos), which were mostly detected from pesticide residue survey and widely used for each crop. The standard deviation of peak areas in the chromatogram of each pesticide were under 1.212 %, so it showed that most instruments were stable. The relationship of recovery ratio of each organization were over 0.996 for every pesticide and each organization. Finally, the analytical results for pesticide residue from each participated organization were not statically significant and we could put confidence in the result from each organization.

성견에서 표면처리된 교정용 마이크로임플랜트의 골 접촉률 및 동요도

박승현,김성훈,류준하,강윤구,정규림,국윤아 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

The purpose of this study was to evaluate the mobility and ratio of the bone-implant contact (BIC) of a sandblasted, large grit and acid-etched (SLA) orthodontic micro-implant. Methods: Ninety-six micro-implants (48 SLA and 48 machined) were implanted in the upper and lower buccal alveolar bone, and palatal bone of four beagle dogs. Two weeks after surgery, orthodontic force (150 - 200 g) was applied. Two beagles were sacrificed at 4-weeks and the other two at 12-weeks. Histomorphometric comparisons were made between the SLA experimental group and the machined micro-implant as a control group to determine the ratio of contact between the bone and implant. Micro-implant mobility was also evaluated using Periotest. Results: Periotest values showed no statistically significant difference in the upper alveolar and palatal bone between groups except for the lower buccal area. BIC in the upper buccal area showed no significant difference between groups both at 4-weeks and 12-weeks. However, both the groups showed a significant difference in BIC ratio in the rest of the experimental areas between 4 weeks and 12 weeks. The experimental group showed active bone remodeling around the bone-implant interface compared to the control group. Conclusions: There were significant differences in the BIC and the Periotest values between the surface-treated and machined micro-implants according to bone quality in the early stage. 본 연구는 비글견에 식립된 sandblasted, large grit and acid-etched (SLA) 표면처리된 교정용 마이크로임플랜트와 평활면 마이크로임플랜트에 교정력을 가한 후 시간 경과에 따른 동요도와 골접촉률의 차이를 규명하기 위해 시행되었다. 비글 성견 네 마리를 이용하여 상, 하악 협측과 구개측 골에 대해 SLA 표면처리된 표면처리군 48개, 평활면의 비처리군 48개의 마이크로임플랜트 96개를 식립하고 2주의 치유기간 후 교정력(150 - 200 g)을 지속적으로 가했으며 식립 4주 후에 두 마리를 희생시키고, 12주 후에 나머지 2마리를 희생시켰다. 표면처리군과 비처리군 간의 마이크로 임플랜트의 동요도와 골과 임플랜트 간 접촉률을 조직학적인 측면에서 측정 비교하여 다음과 같은 결과를 얻었다. 상악 협측과 구개측에서는 표면처리군과 비처리군의 동요도에서 유의성 있는 차이가 없었으나 하악협측에서는 표면처리군이 유의하게 안정적인 동요도를 보였다. 마이크로임플랜트와 인접골 간 접촉률은 상악 협측에서는 4주와 12주 모두 표면처리군과 비처리군 간에 유의한 차이가 없었으나 하악 협측과 구개측의 경우 4주와 12주 모두 표면처리군이 비처리군에 비해 유의하게 높은 접촉률을 보였다. 표면처리군은 비처리군에 비해 임플랜트 주변에서 활발한 골개조가 관찰되었으며 모든 군에서 이물반응은 관찰되지 않았다. 본 연구를 통해 SLA 표면처리된 마이크로임플랜트는 평활면 마이크로임플랜트에 비하여 식립 초기에는 식립 부위에 따라 유의하게 높은 인접골 간 접촉률과 동요도의 안정성을 보임으로써 다양한 크기와 방향의 교정력의 적용이 가능할 것이라 생각한다.