열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

부신피질 자극호르몬 단독결핍 1례

박경식,이승현,최석영,박태규,이동화,이찬우,정성복,이인규 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

부신피질 자극호르몬 단독결핍은 국내에서 7례만이 보고된 희귀 질환이며 병인 및 경과 등 아직 불분명한 측면이 많다. 이는 질환지체의 희귀성도 있지만 치료후 자연경과에 대한 장기적인 추적검사가 이루어진 경우가 드물기 때문이기도 하다. 저자들은 비특이적인 전신증상을 주소로 내원한 폐경기후의 56세 여자 환자에서 자가면역질환의 증거없이 고프로릭틴혈증을 보인 부신피질 자극호르몬 단독결핍 1례를 경험하고 1년간의 부신피질호르몬 대치요법후 추적검사를 실시하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated ACTH deficiency is a rare disorder which shows secondary adrenal insufficiency with normal states of other pituitary hormones. A 56-year-old postmenopausal woman complaining general weakness and intermittent mental confusion presented negligible serum cortisol and ACTH level with hyperprolactinemia and mild hyponatremia. Rapid ACTH stimulation test did not show significant increase of serum cortisol level. Combined pituitary stimulation test showed negligible response of cortisol and ACTH, and slightly decreased response of prolactin and gonadotropin. But the responses of TSH and GH were normal. There was no evidence of organic pituitary of hypothalamic lesion in brain MRI and antithyroid autoantibody was not detected in serum. After receiving 12 months of glucocorticoid replacement therapy, she skipped the medicine for 3 weeks and we performed follow-up endocrinologic tests. Serum ACTH and cortisol level was also negligible and prolonged ACTH simulation test showed normal response of serum cortisol. CRF stimulation test showed no response of serum ACTH. Basal prolactin level was decreased to near normal and combined pituitary stimulation test showed normal response of prolactin with slightly blunted response of TSH and GH. We concluded that the case was nonautoimmune origined isolated ACTH deficiency which was accompanied by hyperprolactinemia and resultant deficiency of gonadotropin, so we report this case with review of literatures.

시멘트 및 고성능AE감수제가 고유동콘크리트의 유동특성에 미치는 효과에 관한 실험적 연구

박선규,반성수,우영제,김규용,김무한 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

The fluidity of high flowing concrete can be affected by numerous parameters which characterize either the cement or the admixture. The reactivity of a cement as determined by its chemical compositions (especially its C₃A content), its fineness and its content in sulfates and alkalies obviously plays a key role in rheology of high flowing concrete in fresh state. Specific properties of high range water reducing AE agent used to enhance the workability of high flowing concrete also exert important influence. The purpose of this experimental study is to investigate and analyze the effect of cement and high range water reducing AE agent in fluidity, setting, compressive strength of high flowing concrete. As a result, we found that fluidity of high flowing concrete is affected greatly by kind of cement and high range water reducing AE agent, also, there is harmonic character between high belite cement and polycarbonic acid high range water reducing AE agent.

한의 진단의 추론 형식과 실재성

박경모,최승훈,안규석 현곡학회 1997 제3의학 Vol.2 No.1

FEA와 다이나모메터를 이용한 자동차 디스크 브레이크의 열적 거동에 관한 연구

박범식,손영지,장성규,전언찬 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-

While braking cars, a large amount of energy is taken into the brake system in a short period of time. This leads to some problems ; cracking of the disc, non-uniform wear of pad and disc, fade. Thus it is important to measure the contact thermal behaviour precisely between disc and pad. The measurements must be considered to design the brake system. The paper describes methods to analysis the problem of the thermal behavior on the ventilated disc with ANSYS-a program of FEA and a brake dynamometer. According to this way, the paper can present the error between the data by the dynamometer and the results of analysis by ANSYS.

접촉수소화에 의한 이산화탄소의 화학적 고정화

박종래,박남국,서성규 여수대학교 1998 論文集 Vol.12 No.2

The chemical fixation of carbon dioxide by hydrogenation over supported Ni catalysts was studied using an atmospheric pressure flow reactor. The mole ratio of carbon dioxide and hydrogen as a reactants was 1:4. The effect of reaction and reduction temperature, loading amount, and support type was examined to the catalytic activity. Also, the physico-chemical properties of catalyst were investigated by XRD(X-ray diffractometer), H₂-TPR(temperature programmed reduction) and NH₃-TPD(temperature programmed desorption). The conversion of CO₂and the selectivity of CH₄were increased with increasing of the reaction and reduction temperature, loading amount, and decreasing of the support acidity.

DNA Chip과 고정화 기술

박현규,지홍석,임성춘,장호남 한국화학공학회 2002 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.40 No.3

DNA chip 기술은, 인간 DNA 염기 서열상의 이상징후와 관련된 질병을 진단하거나 신약 개발을 위하여 특정 DNA 발현의 분석 등에 응용될 수 있다. 현재, DNA chip을 제작하고 DNA hybridization 반응 신호를 감지하는 방법에는 다양한 기술들이 있다. 본 글에서는 급성장하고 있는 DNA 칩의 전반적인 원리, 제조기술, 그리고 DNA를 chip에 고정화 시키는 기술을 중점적으로 소개하고자 한다. 또한 젊은 나이에서의 당뇨 발병과 관련된 유전자인 MODY의 유전자 변이를 진단하는 oligonucleotide DNA chip의 예를 보여주고자 한다. The application of DNA chip technology includes the diagnosis of various human diseases associated with DNA sequence anomalies and the comprehensive analysis of expressed sequences with regard to newer drug designs. There are a variety of options for making DNA chips and detecting hybridized signals. Here, we take a close look at the principles and manufacturing technologies of this rapidly growing area, highlighting the DNA immobilization technology on the chip. Finally we present an example of oligonucleotide chip for the analysis of multiple MODY gene mutations, which are related with diabetes of the young.

적층구성이 다른 복합재의 드릴 가공에 관한 연구

정성택,박종남,조규재,심재기 한국공작기계학회 2002 한국공작기계학회 추계학술대회논문집 Vol.2002 No.-

In recent days the more use of CFRP composite is in the airplane, automobile, and sport goods , etc., the more necessity of research on it in this engineering. In this research, the CFRP composite specimen are fabricated by 48 CFRP plies with 6 stacking sequences, and the specimens are drilled with 4 tools. The results are analyzed with consideration of cutting force, type of tools and fabrication condition. The specimens with each drilling conditions are also investigated with SEM. The optimal drilling conditions such as drill types and cutting force with respect to the fabricating condition are studied.

크레인 정밀 정지위치결정을 위한 입력성형기법 개선

배규현,홍성욱,박상원 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

Input shaping is widely accepted to be a useful tool for removing residual vibration in cranes. The UMZV(unity magnitude zero vibration) input shaper is often employed for cranes driven by on-off type motors. However, the UMZV input shaper makes the cranes move slightly further than expected from the original command while it can remove the residual vibration out of the cranes. This paper deals with a method of input shaping scheme which can compensate the position inaccuracy as well as remove the residual vibration of cranes. The proposed method is illustrated through a numerical simulation.

CFRP복합재료의 적층각에 따른 가공 특성

정성택,박종남,김선진,조규재 한국공작기계학회 2002 한국공작기계학회 춘계학술대회논문집 Vol.2002 No.-

In recent days the more use of CFRP composite is in the airplane, automobile, and sport goods, etc., the more necessity of research on it in this engineering. In this research, the CFRP composite specimen are fabricated by 48 CFRP plies with 8 orientation angles, and the specimens are drilled with 3 tools. The results are analyzed with consideration of cutting force, type of tools and fabrication condition. The specimens with each drilling conditions are also investigated with SEM. The optimal drilling conditions such as drill types and cutting force with respect to the fabricating condition are studied.