열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

자궁경부 종양에서 Nested PCR을 이용한 인유두종 바이러스 16형 및 18형의 검출과 임상적 의의

최규연,이종국,최승도,배동한,김휘준,김민관 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

The aim of this study is to estimate the prevalence of HPV types(16, 18) in cervix of gynecologic patients and to elucidate the relationship of HPV types(16, 18) and clinical characteristics. Human papilloma virus(HPV) has attracted attention as one of the viruses linked to human cancers. Numerous clinical, epidemiological, and molecular studies indicate that certain genital HPV types are associated with cervical carcinoma. Of 100 types of HPV identified today, at least 40 have been found in the anogenital mucosa. A classification of these types into three groups with differing pathogenicity has been proposed: HPV type 6, 11, 42, 43, and 44 are detected more frequently in benign lesions such as condylomata; HPV type 31, 33, 35, 51, 52, and 58 are found more often in low grade squamous intraepithelial lesions than invasive lesions; and HPV 16, 18, 45, and 56 are predominant in high grade squamous intraepithelial lesions and invasive carcinoma. To detect HPV types prevalent in carcinoma of the uterine cervix, a type-specific, sensitive polymerase chain reaction(PCR)-based assay for HPV types 16, 18 was applied to 18 cervical carcinomas(15 squamous cell carcinomas and 3 adenocarcinomas), 21 cases of cervical intraepithelial neoplasia(CIN), and 42 samples of cervicitis and histologically normal. DNA extraction from cervical swab was done using DNAzol™(MBI, USA) and Nested PCR was done using HPV detection kit(Bioneer, Korea). The amplified product was analyzed directly on the basis of the site of ethidium bromide-stained band visible after agarose gel electrophoresis. The results were as follows 1. The positivity rates of HPV type 16 and HPV type 18 were 12.5%(90/718), 2,5%(18/718). so, HPV 16 positive cases(12.5%) was five folds as HPV 18 positive cases(2.5%) 2. Forty eight percents(39/81) of HPV 16 or HPV 18 positive cases were CIN, microinvasive cancer. 3. Age, Gestation number, Clinical stage, Histologic cell type in relation to HPV types were not statistically significant.

紡絲工程에서의 Emulsion Fume 處理를 위한 充塡塔 適用에 관한 硏究

최동훈,박진식,장성호,김일배,서정민,김장호 동아대학교 환경문제연구소 1996 硏究報告 Vol.19 No.2

This study was carried out to interpret hydraulic behavior and component analysis of the emulsion fume, laboratory work of mass transfer in the packing tower which packed 50mm plastic Hiflow-ring. The results from experiment are as follows : 1. The component of emulsion fume is Cyclododecane, 1-Tridecene, 4-Nonene 5-butyl. The kinds of Alkene contained approxymately 76.23 percent. 2. To compare with conventional packing, 50mm Hiflow-ring could save energy because of low pressure drop under high load. 3. The unique magnituteds of packing witch was used are as follows. Cv = 5.18 × 10^(-4) , m = 0.683, n=0.462 so we can predict efficiency which occurres. 4. To require plant of the packing tower in the gas capacity factor 2.7 (Kg^(1/2) m^(-1/2) s^(1))

양수검사에서 small supernumerary marker chromosomes(sSMCs) 발견과 산전상담

문성택,김윤숙,전섭,최승도,선우재근,배동한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

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자연친화적 과학계발활동 프로그램의 적용이 과학에 대한 태도에 미치는 효과

최은경,문성배 부산대학교 사범대학 과학교육연구소 2006 科學敎育硏究報 Vol.33 No.-

This study organized a Nature Friendly Science Improvement Activity Program designed for the middle school students', and applied it to the relevant students, and then analyzed the effect of e program on science-related attitudes. The science club students in G middle school in Busan were sampled as the objects of the study consisting of one experiment group and one control group. The Nature Friendly Improvement Activity Program was applied to the experiment group as a club activity which was conducted every second Saturday from April to November. T-test for the pre-test was used to examine the homogeneity between groups, and t-test for the post-test was used to see the effects of applying a Science Improvement Activity Program on science-related attitudes between two groups. The following were the results of this study: First, the students participated in the Science Improvement Activity showed an increase in the science-related attitudes compared with those who didn't. At first, the experiment and control groups had the same level of sdence-related attitudes, but the former indicated a higher level of improvement in attitudes than the latter after taking part in the program, and showed a significant difference in the development of science-related attitudes regarding that of the control group. Second, women showed an effective increase in the science-related attitudes compared with men. Various activities with easily usable materials will be effective to enhance the science-related attitudes for women. Third, by applying a Nature Friendly Improvement Activity Program, science-related attitudes in the inactive group reluctant to participate science events were more positively established than those in the active group. These results of this study led to the following suggestions: It is expected that the development of various activities for science improvement will be effective in enhancing the science-related attitudes. And it is also expected that the development of activity programs and their active application should be done in order to provide science education according to each student's capacity from various angles in school.

Bacillus stearothermophilus가 생산하는 Xylanase의 정제 및 특성

배성호,최용진 한국산업미생물학회 1991 한국미생물·생명공학회지 Vol.19 No.6

토양 분리균인 B. stearothermophilus가 생산하는 xylanase를 ammonium sulfate 분획, DEAE-Sepharose CL-6B ion exchange chromatography, Sephadex G-100 gel 여과 및 열처리 등의 과정을 거쳐 단일 단백질로 분리 정제하였다. 170,000의 분자량을 지닌 본 정제 xylanase는 pH 8과 pH 10 사이의 넓은 최적 pH를 보였으며 55℃에서 최대 활성을 나타내었다. 55℃에서 2시간의 열처리에 의해서도 활서의 손실이 거의 없을 정도로 열에 매우 안정하였으며 Co^2+와 Mn^2+에 의해서 현저한 활성화 효과를 보였다. 또한 larchwood xylan의 가수분해 산물로 주로 xylobiose와 xylotriose를 생성하였으며 약간의 xylose도 생성하였다. 따라서 본 정제효소는 endo-xylanase(EC 3.2.1.8)로 분류할 수 있었다. An extracellular xylanase of Bacillus stearothermophilus was purified to a single protein through a sequency of operations including ammonium sulfate fractionation, DEAE Sepharose CL-6B ion exchange chromatography, Sephadex G-100 gel filtration and heat treatment. The purified enzyme had a moleular weight of 170,000, the pH and temperature optima for the enzyme activity were pH 9.0 and 55℃, respectively. The activity was enhanced by Co^2+ and Mn^2+, and inhibited by Hg^2+. Pattern of hydrolysis demonstrated that the xylanase was an endo-splitting enzyme able to break down larchwood xylan at random giving xylobiose and xylotriose as the main end products.

여성 골반재건술과 요실금수술에서 복강경의 역할

문성택,김윤숙,전섭,최승도,선우재근,배동한 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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폐경 전후 여성의 신체활동 및 생활습관과 골 밀도 수치와의 관련성

배성욱,남철현,홍성철,최연희,이정옥,양숙희 대한보건협회 2002 대한보건연구 Vol.28 No.3

To evaluate the degree of bone mineral density according to physical activity, lifestyle in pre- and postmenopausal women. The subjects were 951 premenopausal and 1,167 postmenopausal women who have examined in health promotion center of Yeungnam University Hospital in Daegu city from January, 1999 to Januaty, 2001. The test for bone mineral density. The physical activity and life style were evaluated by questionaire through interview. The results were summarized as follow. 1) The prevalence rates of reduced bone mineral density and osteoporosis in premenopausal women were 23.8% and 1.6%, respectively. However, these values were increased to 46.1% and 28.1% in postmenopausal women. 2) The regular exercise was revealed to have preventive effect for osteoporosis in pre- and postmenopausal women. Among the types of exercise, the most effective exercise was bowling and moderately effective exercise was swimming on prevention of osteoporosis, however, bare hand physical exercise was not significant effect on bone mineral density. 3) The risk for reducing bone mineral density was decreased in women who have higher educational background and income in pre- and postmenopausal. The bone mineral density was highest in white color worker and lowest in blue color worker. 4) The premenopausal women who favor meat were revealed higher bone mineral density than the women who favor vegetable. The women who have drunk none or small amount of alcohol were revealed increased bone mineral density and smoking was a risk factor for osteoporosis. These results suggested that to prevent osteoporosis, the systemized program for promoting anti-osteoporotic factor have to be developed and apply from the thirties whom have maximal bone mineral density.

초등교육용 온라인 멀티미디어 코스웨어 개발을 위한 설계 전략

배종수,최성우 서울교육대학교 과학교육연구소 1997 科學과 數學敎育 論文集 Vol.23 No.-

양성갑상선종물 환자에서 갑사선 호르몬 억제요법과 갑상선 호르몬과 항갑상선제 병합요법의 치료효과 비교

최성남,공병호,배현철,오연상,신순현 중앙대학교 의과대학 의과학연구소 1998 中央醫大誌 Vol.23 No.1

Traditionally, patients with nontoxic benign thyroid nodule has been treated with levothyroxine. The successful treatment of T4 suppressive therapy, however, has been observed in 50 % of patients with thyroid nodules oven though the treatment were continued more than 1 year. The side effects such as osteoporosis, left ventricular hypertrophy has been observed. Therefore, we performed this study to evaluate the efficacy of the new treatment modality (levothyroxine and methimazole combination) in the treatment of thyroid nodule. Study population was 67 patients having nontoxic benign thyroid nodule. Serum TSH, fT4, T3 and thyroid nodular volume were measured at pretreatment and post-treatment periods. The benign thyroid lesion was confirmed by FNAC (fine needle aspiration cytology). The factors can be influenced on therapeutic response were also studied. The patients were divided into two groups. One group had been treated with levothyroxine only and the other with levothyroxine and anthithyroid drug combination. 47 patients had been treated with levothyroxine only. The other 20 patients had received combination therapy with levothyroxine and methimazole. The mean age and sex ratio, pretreatment nodular volume, TSH, fT4 and total T3 level measured at pretreatment and post-treatment had no stastistical difference between two groups. The combination therapy group had been treated for 8.4 ± 2.6 months and T4 suppressive therapy group for 11.1 ± 4.8 months (P=0.03). Pretreatment TSH concentration was 0.99 ± 0.60 μIU/ml in T4 suppressive therapy group, 1.43 ± 1.21 μIU/ml in combination therapy group. (P=0.023) But the value of serum TSH in both groups was in normal range. The responder group was 17 patients and the response rate was 85 % in combination therapy group and 25 and 53 % in T4 suppressive group. In the combination therapy group, the volume reduction was more greater. (71.5% in combination group, 18.1 % in T4 group) In conclusion, combination therapy can reduce treatment duration, enhance therapeutic response rate for the treatment of benign thyroid nodule. The exact mechanism of methimazole on thyroid nodule wan not not clearly known. Perhapse, the influence of methimazole on the transcription factor may be involved Further study in this regard is needed in the future.