경연 대회를 통한 초ㆍ중고생의 창의력 신장 효과에 관한 연구

이희복,육근철,류해일,김현섭,김희수,박달원,유병환,김선효,김여상,서광수,변두원,서명석,배성효,박종석,심규철,이성희 공주대학교 과학교육연구소 2001 과학교육연구 Vol.32 No.1

미래 사회를 대비하기 위한 개인의 개성을 존중과 창의적인 능력을 지닌 인간을 양성을 목적으로 충청남도 지역의 초 ㆍ 중고등학생들을 대상으로 한 창의력 경연대회가 공주대학교 과학교육연구소에서 개최되었다. 충청남도 초 ㆍ중 ㆍ 고등학생들을 대상으로 실시한 창의력 경연대회는 창조적 아이디어를 내어 스스로 문제를 해결해 나갈 수 있는 교육 프로그램을 제공하는 좋은 기회였음이 확인되었으나, 일부의 팀에서만 참신하고 재미있는 아이디어들이 제안되었다. 여학생의 참가자 수가 상당히 증가하였으며, 대체적으로 입상권의 학생들의 상당 부분이 여학생이라는 것이 특이할만하다. 학년이 올라감에 따라서 창의적인 아이디어를 내는 양이나 질에 있어서 뒤떨어지는 것으로 분석되었으며, 토론 학습의 적응력이 미흡하고 발표력 및 청취력에 있어서도 떨어지는 것으로 나타났다. 따라서 중 ㆍ고등학교의 학교교육에서도 학생들에게 프로젝트형 탐구학습 프로그램의 적용은 물론 토론식 수습을 통한 학생들의 사고의 전환의 기회를 제공해야 할 것으로 사료된다. The creativity competition was held to foster the creativity of elementary and secondary school students in the Institute of Science Education, Kongju national University. It was found that the creativity competition effected on the improvement of inventing creative ideas and problem solving activities. But, only some competitors participated in semifinal and final contests, presented original and interesting ideas. More female students participated in competition than last year. More female participants were awarded a prize than males. Totally, participants were defective in discussion and communication, and presentation and listening ideas. Increasing grades correlated inversely with creativity and originality. There is need of inquiry project teaming programs and presenting opportunities of conversion of thinking by discussing instructions in school

가토에서 Pentoxifylline, Asprin 및 Heparin이 피부피판의 생존 및 출혈 경향에 미치는 영향

하주원,백승,박홍주,오희균,유선열 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.5

The skin flap, which has been frequently used in the maxillofacial soft tissue defects, can be failed due to insufficient blood supply to the flap. To increase its survival rate, antithrombotic agents has been used. The agents have, however, been restrictly used because of their side effects, such as bleeding tendency or hematoma formation on the operation site. The present study aimed to the effect of pentoxifylline, aspirin, and heparin on the skin flap survival rate and bleeding tendency. Twelve adult white rabbits, weighing about 2.0 ㎏, were used. Five random skin flaps, which is 1㎜ thickness, were prepared on the dorsal surface of each rabbit by using 1.5×7.5㎝ prefabricated template. The animals were divided into 4 groups on the basis of drugs used: Control group, animals in which no drug was given (n=3); Pentoxifylline group, animals in which pentoxifylline was given intraorally (n=3); Aspirin group, animals in which aspirin was given intravenously (n=3), and Heparin group, animals in which heparin was given intravenously (n=3). On the 3rd and 7th day after operation, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured to evaluate the bleeding tendency. The animals were sacrificed on the 7th day and the mean skin falp survival rate of each group was measured. The results obtained were as follows : The skin flap survival rates of pentoxifylline (84.3±7.9%) and heparin (79.5±10.9%) groups were significantly increased, compared with control group (68.0±10.8%)(P<0.05). The survival rate of aspirin group (73.0±11.1%) was not increased. In bleeding tendency, the PT values were prolonged in heparin and aspirin groups at the 3rd day after operation (P<0.05), and prolonged in order of heparin group, aspirin group, and pentoxifylline group at the 7th day after operation. The aPPT values in heparin and aspirin groups were also prolonged at the 3rd day after operation (P<0.05), and prolonged in order of Aspirin group, Heparin group, and Pentoxifylline group at the 7th day after operation. These results suggest that pentoxifylline may be the most useful drug among three drugs to increase skin falp survival rate and less increase the bleeding tendency.

가토에서 Pentoxifylline, Aspirin 및 Heparin이 피부피판의 생존 및 출혈 경향에 미치는 영향

하주원,백승,박홍주,오희균,유선열 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.2

The skin flap, which has been frequently used in the maxillofacial soft tissue defects, can be failed due to insufficient blood supply to the flap. To increase its survival rate, antithrombotic agents has been used. The agents have, however, been restrictly used because of their side effects, such as bleeding tendency or hematoma formation on the operation site. The present study aimed to the effect of pentoxifylline, aspirin, and heparin on the skin flap survival rate and bleeding tendency. Twelve adult white rabbits, weighing about 2.0 kg, were used. Five random skin flaps, which is 1mm thickness, were prepared on the dorsal surface of each rabbit by using 1.5 X 7.5 cm prefabricated template. The animals were divided into 4 groups on the basis of drugs used: Control group, animals in which no drug was given (n=3); Pentoxifylline group, animals in which pentoxifylline was given intraorally (n=3); Aspirin group, animals in which aspirin was given intravenously (n=3). On the 3rd and 7th day after operation, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured to evaluate the bleeding tendency. The animals were sacrificed on the 7th day and the mean skin flap survival rate of each group was measured. The results obtained were as follows : 1. The skin flap survival rates of pentoxifylline (84.3±7.9%) and heparin (79.5±10.9%) groups were significantly increased, compared with control group (68.0±10.8%)(ㅔ<0.05). The survival rate of aspirin group (73.0±11.1%) was not increased. 2. In bleeding tendency, the PT values were prolonged in heparin and aspirin groups at the 3rd day after operation (p<0.05), and prolonged in order of heparin group, aspirin group, and pentoxifylline group at the 7th day after operation. The aPPT values in heparin and aspirin groups were also prolonged at the 3rd day after operation (p<0.05), and prolonged in order of Aspirin group. Heparin group, and Pentoxifylline group at the 7th day after operation. These results suggest that pentoxifylline may be the most useful drug among three drugs to increase skin flap survival rate and less increase the bleeding tendency.

키토산과 견사 단백질 복합체의 특성

김희숙,원용돈,류병호 한국식품영양학회 1996 韓國食品營養學會誌 Vol.9 No.4

기능성 다이어트 식품을 개발을 목적으로, 키토산과 견 피브로인의 복합체를 만들고 성질을 조사하였다. 키토산은 대동새우로부터 추출하였고, 견사 피브로인 섬유는 누에로부터 추출하였다. 견사의 특성을 알아보기 위하여 용해도를 조사한 결과, 용해도는 8M LiBr이상의 농도와 40℃ 이상에서 가장 높았다. 견사 피브로인의 아미노산 조성은 천연견사 및 용해시킨 피브로인과 같았다. 키토산, 견사 피브로인 복합체의 아미노산 조성은 glycine, alanine, serine, tyrosine, threonine 및 glutamic acid 순서를 많았다. 또한 IR 스펙트럼 결과, 키토산·견사 피브로인 복합체는 배합비율에 따른 스텍트럼상의 차이는 거의 없었다. In order to develop the functional diet food, characteristics of chitosan and silk fibroin composite was designed. Chitosan extracted from a prawn and silk fibroin was prepared from silkworm. The silk fibroin was dissolved rapidly in the 8M LiBr at a temperatrue of more than 40℃. Amino acid composition of fibroin composite revealed the same pattern that of native silk fibroin and regenerated silk fibroin. Predominant amino acid of chitosan-fibroin composite contained glycine, alanine, serine, tyrosine, threonine, and glutamic acid in order. According to the basis on the infrared spectrum, chitosan-silk fibroin composite is not distinguished differents composite ratio of chitosan and silk fibroin.

구개부에 발생한 다형선종의 처치

하주원,백승,송종운,박충열,이용욱,박홍주,오희균,유선열,김옥준 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

Pleomorphic adenoma of the palate is the most common of all intraoral salivary tumors. It can occur at any age but it presents most commonly in the 40∼60 age group, and there is no significant sex preponderance. It grows slowly and is usually painless, firm, well-circumscribed nodule. Because of high rate of recurrence, extra-capsular excision including the overlying mucosa and margin of normal tissue is recommended. We report 10 cases of palatal pelomorphic adenoma which have been successfully treated by extra-capsular excision. The surgical defects smaller than 3㎝ in diameter were covered with palatal acrylic splint for the secondary healing. The larger defects were repaired using palatal island flap in 3 cases, rotation flap and buccal fat graft in each 1 case. No patient showed any recurrence or malignant change during the mean follow-up period of 4 years and 9 months. These repair methods seem to be simple, reliable and uncomplicated procedures in the palatal surgical defects.

단순 비만 지표로서의 목둘레의 분별점

강지현,유병연,서희선,심경원 대한비만학회 2002 The Korean journal of obesity Vol.11 No.2

연구배경 : 목둘레는 인슐린저항성과 관련된 여러 질환과 연관되어 있으며 인슐린저항성의 위험이 증가되어 있는 환자들에서 목둘레가 임상적인 선별검사로 유용하게 쓰일 수 있으리라고 제시되어진 바 있다. 따라서 본 연구에서는 목둘레와 비만 관련 지표 및 인슐린저항성의 지표로서의 HOMA score 와의 상관관계를 알아보고, 비만 환자를 예측할 수 있는 최적의 목둘레 분별점을 알아보고자 하였다. 대상 및 방법 : 건양대학병원 종합검진센터에 내원하여 건강검진을 받은 성인 남녀 대상자 364명 (남자 199명, 여자 165명) 중 249명 (남자 136명, 여자 113명) 실험군(test group)로 하여 receiver output curve (ROC) 분석을 통해 체질량지수 25 kg/㎡에 대한 최적의 (optimal) 민감도와 특이도를 가지는 목둘레 분별점을 구하였으며, 나머지 115명 (남자 63명, 여자 52명)을 유효군 (validation group)으로 하여 실험군에서 얻어진 목둘레 분별점을 적용하여 그 유효성을 알아보았다. 또한 묵둘레와 비만 관련 지표 및 인슐린저항성의 지표로서의 HOMA score와의 상관관계를 알아보았다. 결과 : 목둘레는 남녀 대상군 모두에서 허리둘레, 엉덩이 둘레, 엉덩이허리둘레비, 체질량지수, 체지방률, 공복시 혈중 인슐린, HOMA score와 강한 양의 상관관계를 보였으며 실험군에서 비만 환자를 예측할 수 있는 최적의 목둘레의 분별점은 남자에서는 36.6 cm 여자에서는 32.3 cm 였다. 이때의 민감도는 남자 81.92%, 여자 91.5%, 특이도는 남자 77.4%, 여자 69.7%, 정확도는 남자 80.2%, 여자 85%였다. 또한 실험군에서 얻어진 목둘레의 분별점을 유효군에 적용한 결과 남자에서는 민감도 91.9%, 특이도 53.9%, 정확도 76.1%로 나타났으며 여자에서는 민감도 81.25%, 특이도 85%, 정확도 82.69%로 나타났다. 결론 : 본 연구는 측정이 간편한 단순 비만 지표로서의 목둘레와 흔히 사용되는 비만 관련 지표 및 인슐린저항성과의 관련성을 밝혔으며 비만환자를 예측하기 위한 방법으로서 남자 36.6 cm, 여자 32.3 cm라는 목둘레의 분별점을 제시하였다. 향후 보다 일반화할 수 있는 보완 연구가 이루어져야 할 것으로 생각된다. Background : Neck circumference has been reported to be related to the other anthropometric measures of obesity and also associated with the metabolic disorders related to insulin resistance. The measurement of neck circumference could be useful in clinical screening for persons at an enhanced risk for insulin resistance. The aim of this study was to determine whether a single measure of neck circumference might be correlated with other obesity indices and HOMA score and to define neck circumference cutoff levels for obesity. Methods : We examined 364 consecutive persons (199 men and 165 women), who visited konyang university hospital health examination center during August, 2002. To find the optimal, maximal sensitivity and specificity for neck circumference, the receiver output curve (ROC) analysis of cutoff points against BMI (25 kg/㎡) was performed using the test group (136 men and 113 women). We validated the cutoff level using validation group (63 men and 52 women). Other obesity indices and fasting glucose and insulin were measured to find the correlation between neck circumference. Results : Neck circumference was significantly correlated with waist circumference, hip circumference, waist hip ratio, BMI, total body fat percent, fasting insulin and HOMA score. Neck circumference 36.6 cm for men and 32.3 cm for women was the best cutoff levels for determining the subjects with BMI over 25 kg/㎡. In the validation unrelated group, the test characteristics were acceptable with 91.9% sensitivity, 53.9% specificity, and 76.1% accuracy for men, and 81.25% sensitivity, 85% specificity, and 82.69% accuracy for women. Conclusion : Neck circumference as a simple and easy screening method for obesity was strongly correlated with the other conventional obesity indices and HOMA score as a index of insulin resistance and we defined neck circumference cutoff level for obesity according existing BMI cutoff levels.

ASTM F813-07 의료용디바이스를 위한 생체재료의 직접촉 세포배양측정에 대한 표준지침서

김순희 ( Soon Hee Kim ),백미옥 ( Mi Ock Baek ),소정원 ( Jung Won So ),노혜원 ( Hye Won Roh ),이나리 ( Na Ri Lee ),김문석 ( Moon Suk Kim ),유규하 ( Gyu Ha Ryu2,),조양하 ( Yang Ha Cho ),이승진 ( Seung Jin Lee ),강길선 ( Gilson Khang 한국조직공학·재생의학회 2007 조직공학과 재생의학 Vol.4 No.4

We provided standard practice for direct contact cell culture evaluation of materials for medical devices in this report. This practice introduced a reference method of direct contact cell culture testing. This method of direct contact cell culture may be used in the construction of medical materials and devices for test the cytotoxic potential of materials. Researcher for medical devices could use this practice to compare other cytotoxicity tests or directly to evaluate materials. Cell or materials could be sometimes modified depending on use in offered extend of this practice.

조기위암의 임상적 연구

박태준,양은수,류종철,박태군,이희승,신원창,이진호,김관엽 인제대학교 1994 仁濟醫學 Vol.15 No.1

1989년 9월부터 1993년 7월까지 인제대학교 의과대학 상계백병원에서 실시한 위내시경 소견이 조기위암이며 내시경 직시하 생검결과 선암으로 판명되어, 근치적 위절제술을 시행받은 23명의 환자에서 임상적 특징을 알아보고, 문헌고찰과 함께 보고하는 바이다. The incidence and mortality rate of stomach cancer ranks well ahead of all malignancies in Korea. The prognosis is excellent in early gastric cancer of which the overall 5 years survival rate of 85∼95% is comparative with that of advanced gastric cancer of 15∼49%. So early detection with very sensitive mordality of gastroscope and surgery is the only premise to decrease the mortality rate of gastric cancer. This report deals with the clinical aspects of 23 cases of early gastric cancer, which were confirmed with histopathologic examination of resected stomach during the 4 years from September 1989 to July 1993 at Sanggye Paik hospital, Seoul, Korea. Out of 23 cases of early gastric cancer, 14 cases were male, 9 cases were female, and the male to female ratio was 1.6 : 1. The most common type of early gastric cancer was talc type(43.5%), IIc and its combined type comprised most of them(87.0%). The most prevalent sloe of lesion was gastric angle(43.5%) and the most common direction was lesser curvature(73.9%) 19 cases of 23(78.3%) were between 1∼3cm in size, and there was no statistical significance between the size of the lesion and lymph node metastasis. Of the 9 cases with mucosal lesion, there were 2 cases with lymph node metastasis(22.2%), but 7cases(50.0% ) of 14 cases with submucosal lesion presented lymph node metastasis. Diagnostic accuracy of endoscopy on detection of early gastric cancer was 17 cases(73.9%) of total 23 cases in our study. As with other report, histopathulogic examination of resected stomach revealed adenocarcinoma, tubular type as the most common type. Frequent complaint of patients with early gastric cancer was epigastric pain(65.2%), and duration of the symptom was less than 12 months in 17 cases(73.1%) of 23 patients with early gastric cancer.

삼출성 중이염 환자에서의 혈중 및 아데노이드 면역글로불린 E의 면역혈청학적 연구

장혁순,강성호,유창수,김성현,이병돈,박영진,윤세동,안희영,강주원 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Otitis media with effusion (OME) is one of the most common disease in children but its pathogenesis is not clear. In particular the role of allergy has revealed conflicting support with widely varing opinions as to its importance. Within recent years, striking biochemical and immunochemical analytic techniques have opened a new approach the study of otitis media with effusion. So we focused on distributions of IgE in adenoid tissue and serum IgE levels. Authors compared the serum IgE and the distribution of IgE in adenoid tissue between the 20 patients underwent tonsillectomy, adenoidectomy and ventilating tube insertion and control group of 11 patients underwent tonsillectomy and adenoidectomy. The results were as follows; 1. In the distribution of IgE in adenoid tissue, there was a significant increase in the group of patients with OME compared to the control group (P<0.01). 2. In the analysis of serum IgE levels, the levels of IgE in the OME patients an control group were higher than normal level, although the level of IgE in the OME patients were less than that of control group, there was no significance P>0.05).

카올린으로부터 질화알루미늄 분말 합성

이윤복,서기원,류봉기,김광호,박희찬,장윤식 釜山大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.50 No.-

카올린으로 부터 수화염기성황산알루미늄을 제조하고, 이것을 탄소열환원질화하여 질화알미늄 분말을 합성하였다. 수화염기성황산알루미늄은 카올린으로 부터 제조된 수화황산알루미나 0.5M 및 요소 5M인 용액으로 부터 얻은 것이 가장 미세하였다. 탄소열환원질화법으로 질화알미늄을 합성할 때 활성화탄과 염기성황산알루미늄의 질량비가 2인 조성이 가장 적합하였으며, 이 때 얻어진 질화알미늄은 0.3-1㎛의 submicron급 분말이었다. Aluminum nitride powder was synthesized by carbothermal reduction-nirtridation using kaolin- derived hydrated basic aluminum sulfate. The hydrated basic aluminum sulfate powder produced from the solution of 0.5M hydrated aluminum sulfate and 5M urea showed very fine particles. The aluminum nitride showed the submicron powder of 0.3-1㎛ in the optimum condition with 2.0-weight ratio of activated charcol to hydrated basic aluminum sulfate.