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Tuyen N. M. Hua,오지웅,김소현,Jayson M. Antonio,Vu T. A. Vo,Jiyeon Om,최종환,Jeong-Yub Kim,Chan-Woong Jung,Myung-Jin Park,정양식 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Glioblastomas (GBMs) are characterized by four subtypes, proneural (PN), neural, classical, and mesenchymal (MES) GBMs, and they all have distinct activated signaling pathways. Among the subtypes, PN and MES GBMs show mutually exclusive genetic signatures, and the MES phenotype is, in general, believed to be associated with more aggressive features of GBM: tumor recurrence and drug resistance. Therefore, targeting MES GBMs would improve the overall prognosis of patients with fatal tumors. In this study, we propose peroxisome proliferator-activated receptor gamma (PPARγ) as a potential diagnostic and prognostic biomarker as well as therapeutic target for MES GBM; we used multiple approaches to assess PPARγ, including biostatistics analysis and assessment of preclinical studies. First, we found that PPARγ was exclusively expressed in MES glioblastoma stem cells (GSCs), and ligand activation of endogenous PPARγ suppressed cell growth and stemness in MES GSCs. Further in vivo studies involving orthotopic and heterotopic xenograft mouse models confirmed the therapeutic efficacy of targeting PPARγ; compared to control mice, those that received ligand treatment exhibited longer survival as well as decreased tumor burden. Mechanistically, PPARγ activation suppressed proneural–mesenchymal transition (PMT) by inhibiting the STAT3 signaling pathway. Biostatistical analysis using The Cancer Genomics Atlas (TCGA, n=206) and REMBRANDT (n=329) revealed that PPARγ upregulation is linked to poor overall survival and disease-free survival of GBM patients. Analysis was performed on prospective (n=2) and retrospective (n=6) GBM patient tissues, and we finally confirmed that PPARγ expression was distinctly upregulated in MES GBM. Collectively, this study provides insight into PPARγ as a potential therapeutic target for patients with MES GBM.
Bhadra, B.N.,Seo, P.W.,Jun, J.W.,Jeong, J.H.,Kim, T.W.,Kim, C.U.,Jhung, S.H. Elsevier 2016 Microporous and mesoporous materials Vol.235 No.-
<P>SSZ-39 and mordenite zeolites were obtained from the conversion of zeolite Y in the presence of the same reaction precursors (organic templates, NaOH, water, etc.) under a wide range of reaction conditions. The applied templates were N,N-dialkyl-2,6-dimethyl-piperidinium-OH and -I (alkyl: ethyl or methyl). Curiously, SSZ-39 and mordenite were obtained from hydroxides and iodides, respectively, showing firstly the importance of the anion in the selective crystallization of zeolites. Reactions were also performed at the same set of pH values (achieved by adding small amounts of NaOH to the iodide-based precursors) to investigate the effect of basicity; the results did not vary appreciably with the pH of the synthesis precursors. Based on the phase conversion (MOR - > AEI or ANA with increasing reaction time and pH), the selective formation of SSZ-39 and mordenite from hydroxides and iodides, respectively, could be explained in terms of zeolite-promoting and -preventing anions (hydroxide and iodide, respectively). The phase conversion of zeolites could be explained on the basis of the maximum pore size of zeolites, rather than the framework densities. The obtained zeolites (SSZ-39 and mordenite), in their protonated forms, were employed in ethanol dehydration and direct ethylene-to-propylene conversion, and the results showed that the two zeolites have potential application in acid catalysis. In particular, the SSZ-39 with an AEI structure can be applied in the direct production of propylene from ethylene or ethanol. (C) 2016 Elsevier Inc. All rights reserved.</P>
전국 주요 시장에서 시판 중인 진주담치에 함유된 마비성 패독에 관한 조사 연구
이채언,이종태,조규일,정귀원,문덕환,신해림,김공현,배기택,김용완,백낙환 인제대학교 1990 仁濟醫學 Vol.11 No.1
마비성 패독(paralytic shellfish poison)은 강력한 자연계 신경독으로 먹이연쇄를 통해 패류에 축적되며 이를 인간이나 동물이 섭취할 경우 마비성 패류 중독(paralytic shellfish poisoning)을 발생하게 된다. 마비성 패류 중독은 미국, 캐나다 및 일본 등지에서 비교적 호발하고 있으나, 우리나라의 경우 최초의 공식 보고는 1986년 4월 부산지역에서 발생된 집단 중독례로 원인 패류는 진주담치(blue mussel, Mytilus edulis)였다. 본 조사자들은 1989년 4월부터 7월까지 전국 주요 시장 38개소에서 시판 중인 진주담치를 수거하여 mouse bioassay를 이용하여 마비성 패독 함유량을 산정하였기에 보고하고자 한다. Bioassays on paralytic shellfish poison(PSP) in blue mussels(Mytilus edulis) were earned out. The subject matters were collected from 38 markets of 26 places throughout the country, during the period of April to July, 1989. At the time of collection, they were classified into two groups by their sites produced either natural or cultured. As a result, it was identified that two subject matters which were collected from markets of both Boryong and Chinhae contained PSP. The PSP toxicity scores were 47.97㎍/100gm meat in Boryong, 48.84㎍/100gm meat in Chinhae respectively, which are much lower than the level of lethal dose. Hewever it is noticeable that blue mussels in markets contained PSP, which may increase the risk of paralytic shellfish poisoning. From the view point of public health, control measures for preventing paralytic shellfish poisoning are necessary.
액체금속로 증기발생기에서 대규모 누출 소듐-물 반응 사고시 중후반기 압력거동특성 연구
정지영,어재혁,정경채,김병호,김태준,남호윤,박남국 한국공업화학회 2005 응용화학 Vol.9 No.1
In order to investigate the pressure transient at the later phase of a large leak sodium-water reaction event in KALIMER(Korea Advanced Llquid MEtal Reactor), an experimental study has been carried out. The experiment was performed to simulate the long-term system transient response of a large leak sodium-water reaction event due to double ended guillotine failure of three tubes in a 1/10 scale-down mock-up test facility with sufficient considerations of the quasi-steady state features of the SWR event.
이상태,정관용,최상원,오남희,방정환,김정우 여수대학교 1999 論文集 Vol.14 No.2
For obtaining of disinfectant surfactant from amino acid mixtures, we treated the butchery wastes which contain much protein by sodium hydroxide hydrolyzing method. The composition and concentration of amino acid mixture were anaslyzed by high perfomance liquid chromatography. The disinfectant agent with Tetrammine copper(Ⅱ) sulfate monohydrate [Cu(NH₃)₄²+]SO₄·H₂O was synthesized by using amino acid. The sterilizing power of the new synthesized disinfectant agent (diammine aminato copper(Ⅱ) complexes) was compared with formaline(CH₂O) and different type copper complex(ET),which is used generally. The sterilizing effect to Edwardsilla sp, Escherichia coli, Salmonella typhi, Bacillus spp, Staphyloccus aureus. Pseudomonas anguilliseptica. Edwardsilla tarda, showed that the new synthesized disinfectants were better than others. The testing of ecological safety effect was applied to toxicity of Rotifer, Altimia and gold fish. The toxic result indicated of the new synthesized disinfectant agent is excellent safe in ecological field.
Kang, Y.K.,Jeong, J.H.,Lee, N.Y.,Lee, Y.T.,Lee, H. Pergamon Press 2010 Polyhedron Vol.29 No.12
The reaction between ZnCl<SUB>2</SUB> and N,N-bis[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-1-phenylethylamine (bdmppea) affords [(bdmppea)ZnCl<SUB>2</SUB>], whose structure has been determined by X-ray crystallography. The [(bdmppea)ZnEt<SUB>2</SUB>] complex in situ prepared by the reaction between [bdmppea] and ZnEt<SUB>2</SUB> exhibited high activity toward the polymerization reaction of rac-lactide at room temperature. However, its activity decreased sharply with decreasing temperature. Stereospecificity of this catalyst characterized by heterotacticity (P<SUB>r</SUB>) was determined by homonuclear decoupled NMR spectroscopy, which value was ∼0.58.
Yamada, M.,Oeda, A.,Jung, J.,Iijima, M.,Yoshimoto, N.,Niimi, T.,Jeong, S.Y.,Choi, E.K.,Tanizawa, K.,Kuroda, S. Elsevier Science Publishers 2012 Journal of controlled release Vol.160 No.2
A bio-nanocapsule (BNC) is a hollow nanoparticle consisting of an approximately 100-nm-diameter liposome with about 110 molecules of hepatitis B virus (HBV) surface antigen L protein embedded as a transmembrane protein. BNC can encapsulate various drugs and genes and deliver them specifically to human hepatic cells based on the ability of HBV to recognize human hepatocyte, which is integrated in the N-terminal region of L protein. However, it is elusive whether the cellular attachment and entry into hepatic cells of BNC utilize the early infection mechanism of HBV. In this study, we have found that while all human hepatic cells show distinct affinities for BNC compared to non-hepatic cells, primary hepatocytes shows the highest efficiency for cellular binding and incorporation of BNC. Amounts of BNCs bound weakly and strongly to cell membranes and those entered into the cells varied significantly depending on the types of human hepatic cells. The weak and strong binding modes of BNC are likely mediated through binding to two distinct HBV receptors (heparin-mediated low-affinity and unidentified high-affinity receptors), which play major roles in the early infection mechanism of HBV. The rates of cellular uptake of BNC are similar to those reported for HBV. The BNCs incorporated into the cells are swiftly sorted to either early endosomes or macropinosomes and then to late endosomes and/or lysosomes. These findings strongly suggest that BNC is bound to and incorporated into human hepatic cells according to the early infection mechanism of HBV.