Description and classification for facilitating interoperability of heterogeneous data/events/services in the Internet of Things

Yim, H.J.,Seo, D.,Jung, H.,Back, M.K.,Kim, I.,Lee, K.C. Elsevier Science Publishers 2017 Neurocomputing Vol.256 No.-

<P>The Internet of Things (loT) refers to an infrastructure that integrates things over standard wired/wireless networks and allows them to exchange information with each other. The loT is a very complex heterogeneous network, enabling seamless integration of these things is a huge challenge. A publish/subscribe method of integration can be formulated to solve the problems of interconnecting billions of heterogeneous things. In our work, an IoT framework that uses an abstraction layer that decouples an application from the service calls and network interfaces is required to send and receive messages on a particular thing. This paper provides definitions and classifications for heterogeneous data/events/services according to the properties of the things in order to integrate them into a framework for description. Based on these definitions and classifications, heterogeneous data/events/services in the loT were integrated via topic description through the Data Distribution Service (DDS) middleware standard for real-time publish/subscribe. This paper also concludes with general remarks and a discussion of future work. (C) 2017 Elsevier B.V. All rights reserved.</P>

Structural dynamics of keyword networks: Liquid crystal display and plasma display panel cases

Yang, H.,Jung, W.S. Elsevier Science Publishers 2016 Journal of Engineering and Technology Management Vol.40 No.-

<P>This study focuses on understanding scientific evolution by using keyword co-occurrence networks, where keywords appearing in a scientific article are linked with a weight equal to the number of co-occurrences. To characterize structural changes of the network, we examine distributions of sums of weights by node over time. In particular, a change of power-law behavior is utilized to explore scientific evolution, such as emerging scientific paradigms and advancing normal science. As an illustration of the method used, the development of Liquid Crystal Displays (LCDs) and Plasma Display Panels (PDPs) is tracked. We detect two-tiered power-law distributions in the initial stage of scientific growth in both technologies due to differences in research intensity between two groups. The groups of keywords more likely to attract researchers' interest than others are incrementally developed until the mid-2000s to overtake those prior. Finally, we can capture a merging point of the dichotomous structure of PDPs but LCDs maintain the structural separation throughout the adjustment area. We expect that this structural investigation of keyword co-occurrence networks provides an indicator to diagnose the research evolution in that field. (C) 2016 Published by Elsevier B.V.</P>

WITHDRAWN: Spectroscopic characterization of selected functionalized fullerenes - IR absorption and Raman scattering studies

Lewandowska, K.,Barszcz, B.,Graja, A.,Nam, S.Y.,Han, Y.S.,Kim, T.D.,Lee, K.S. Elsevier Science Publishers 2014 Materials chemistry and physics Vol.148 No.3

The Publisher regrets that this article is an accidental duplication of an article that has already been published in <Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 118, (2014) 204 - 209>, http://dx.doi.org/<10.1016/j.saa.2013.08.102>. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

Effect of tempering methods on quality changes of pork loin frozen by cryogenic immersion

Choi, E.J.,Park, H.W.,Chung, Y.B.,Park, S.H.,Kim, J.S.,Chun, H.H. Applied Science Publishers ; Elsevier Science Ltd 2017 Meat science Vol.124 No.-

<P>The quality characteristics of pork loin frozen by cryogenic immersion were examined, such as the drip loss, cooking loss, water holding capacity, moisture content, protein solubility, lipid and protein oxidation, color, and microstructure, and compared after different tempering methods: radio frequency (27.12 MHz), water immersion, forced-air convection, and microwave tempering. Forced-air tempering was the most time-consuming process, whereas electromagnetic energy methods (radio frequency and microwave) were the shortest. The tempering rate of radio frequency at 400 W was 5 and 94 times greater than that obtained with water immersion and forced-air tempering, respectively. The drip loss, water holding capacity, moisture content, color, and microstructure of pork samples all declined as a result of microwave tempering. By contrast, the least degree of changes in the drip loss, microstructure, and color of the pork loin samples was obtained with radio frequency tempering, suggesting its potential application in providing rapid defrosting without quality deterioration in the frozen meat industry. (C) 2016 Elsevier Ltd. All rights reserved.</P>

Teriyaki sauce with carvacrol or thymol effectively controls Escherichia coli O157:H7, Listeria monocytogenes, Salmonella Typhimurium, and indigenous flora in marinated beef and marinade

Moon, H.,Kim, N.H.,Kim, S.H.,Kim, Y.,Ryu, J.H.,Rhee, M.S. Applied Science Publishers ; Elsevier Science Ltd 2017 Meat science Vol.129 No.-

<P>An effective bactericidal cold-marinating method for beef products is described, exploiting the synergism between soy sauce and natural compounds (carvacrol, CV or thymol, TM) to reduce microbiological risks. Beef slices inoculated with Escherichia coli 0157:H7, Listeria monocytogenes, and Salmonella Typhimurium (3.1-3.5 log CFU/g) were marinated in a teriyaki sauce with or without CV and TM (0.3 and 0.5%). After 1, 3, and 7 days at 4 degrees C, indigenous microflora population, color, lipid oxidation, marinade uptake, and pH of marinated beef and leftover marinade samples were examined. Teriyaki sauce alone did not reduce or inhibit any of the target pathogens or indigenous bacteria, while 0.5% CV- or TM-containing teriyaki sauce inactivated all inocula without recovery within 7 days (p < 0.05). The pathogens relocated from the beef into the leftover marinade (3.0-3.4 log CFU/mL) were also completely inactivated. The treatment inhibited growth of indigenous aerobic bacteria (p < 0.05) and inactivated coliform bacteria. Physicochemical parameters were not significantly affected (p > 0.05). (C) 2017 Elsevier Ltd. All rights reserved.</P>

Identification and quantification of myosin heavy chain isoforms in bovine and porcine longissimus muscles by LC-MS/MS analysis

Kim, G.D.,Jeong, T.C.,Cho, K.M.,Jeong, J.Y. Applied Science Publishers ; Elsevier Science Ltd 2017 Meat science Vol.125 No.-

<P>To identify and quantify the myosin heavy chain (MHC) isoforms in porcine and bovine longissimus thoracis (LT) muscles, LC-MS/MS and label-free quantification were conducted. 2a, 2x, 2b and slow isoforms were identified in porcine LT muscle, whereas bovine LT muscle contained 2a, 2x and slow isoforms. The highest peak intensity (4432%) of MHC 2b was observed in porcine LT muscle, whereas the peak intensity of MHC 2a was the highest (71.15%) in bovine LT muscle (p < 0.05). MHC-based fiber compositions for porcine and bovine LT were also the highest in types BB (61.13%) and IIA (61.90%), respectively (p < 0.05). Spectral count and peak intensity had positive correlations with MHC-based fiber composition (p < 0.01), however the spectral count and peak intensity of total peptides were not acceptable for MHC quantification because of the limited reliability of the protein and common peptide, respectively. Therefore, the peak intensity of unique peptides would be the most acceptable trait for WHC quantification. (C) 2016 Elsevier Ltd. All rights reserved.</P>

Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice

Kim, S.J.,Lee, J.W.,Jung, Y.S.,Kwon, D.Y.,Park, H.K.,Ryu, C.S.,Kim, S.K.,Oh, G.T.,Kim, Y.C. Elsevier Science Publishers 2009 Journal of hepatology Vol.50 No.6

Background/Aims: Oxidative stress via generation of reactive oxygen species is suggested to be the major mechanism of alcohol-induced liver injury. We investigated the effects of glutathione peroxidase-1 and catalase double deficiency (Gpx-1<SUP>-/-</SUP>/Cat<SUP>-/-</SUP>) on liver injury and changes in the sulfur amino acid metabolism induced by binge ethanol administration. Methods: Ethanol (5g/kg) was administered orally to the wild-type and the Gpx-1<SUP>-/-</SUP>/Cat<SUP>-/-</SUP> mice every 12h for a total of three doses. Mice were sacrificed 6h after the final dose. Results: The Gpx-1/Cat deficiency alone increased malondialdehyde levels in liver significantly. Hepatic methionine adenosyltransferase (MAT) activity and S-adenosylmethionine levels were decreased, however, glutathione contents were not changed. Ethanol administration to the Gpx-1<SUP>-/-</SUP>/Cat<SUP>-/-</SUP> mice increased the elevation of serum alanine aminotransferase activity, plasma homocysteine levels, hepatic fat accumulation and lipid peroxidation compared with the wild-type animals challenged with ethanol. Also the reduction of MAT activity and S-adenosylmethionine levels was enhanced, but MATI/III expression was increased significantly. Conclusions: The results indicate that Gpx-1 and Cat have critical roles in the protection of liver against binge ethanol exposure. Augmentation of ethanol-induced oxidative stress may be responsible for the impairment of the transsulfuration reactions and the aggravation of acute liver injury in the Gpx-1<SUP>-/-</SUP>/Cat<SUP>-/-</SUP> mice.

The hydrogel template method for fabrication of homogeneous nano/microparticles

Acharya, G.,Shin, C.S.,McDermott, M.,Mishra, H.,Park, H.,Kwon, I.C.,Park, K. Elsevier Science Publishers 2010 Journal of controlled release Vol.141 No.3

Nano/microparticles have been used widely in drug delivery applications. The majority of the particles are prepared by the conventional emulsion methods, which tend to result in particles with heterogeneous size distribution with sub-optimal drug loading and release properties. Recently, microfabrication methods have been used to make nano/microparticles with a monodisperse size distribution. The existing methods utilize solid templates for making particles, and the collection of individual particles after preparation has not been easy. The new hydrogel template approach was developed to make the particle preparation process simple and fast. The hydrogel template approach is based on the unique properties of physical gels that can undergo sol-gel phase transition upon changes in environmental conditions. The phase reversible hydrogels, however, are in general mechanically too weak to be treated as a solid material. It was unexpectedly found that gelatin hydrogels could be made to possess various properties necessary for microfabrication of nano/microparticles in large quantities. The size of the particles can be adjusted from 200nm to >50@?m, providing flexibility in controlling the size in drug delivery formulations. The simplicity in processing makes the hydrogel template method useful for scale-up manufacturing of particles. The drug loading capacity is 50% or higher, and yet the initial burst release is minimal. The hydrogel template approach presents a new strategy of preparing nano/microparticles of predefined size and shape with homogeneous size distribution for drug delivery applications.

High antiangiogenic and low anticoagulant efficacy of orally active low molecular weight heparin derivatives

Park, J.W.,Jeon, O.C.,Kim, S.K.,Al-Hilal, T.A.,Jin, S.J.,Moon, H.T.,Yang, V.C.,Kim, S.Y.,Byun, Y. Elsevier Science Publishers 2010 Journal of controlled release Vol.148 No.3

Heparin, an anticoagulant that is widely used clinically, is also known to bind to several kinds of proteins through electrostatic interactions because of its polyanionic character. These interactions are mediated by the physicochemical properties of heparin such as sequence composition, sulfation patterns, charge distribution, overall charge density, and molecular size. Although this electrostatic character mediates its binding to many proteins related with tumor progression, thereby providing its antiangiogenic property, the administration of heparin for treating cancer is limited in clinical applications due to several drawbacks, such as its low oral absorption, unsatisfactory therapeutic effects, and strong anticoagulant activity which induces hemorrhaging. Here, we evaluated novel, orally active, low molecular weight heparin (LMWH) derivatives (LHD) conjugated with deoxycholic acid (DOCA) that show reduced anticoagulant activity and enhanced antiangiogenic activity. The chemical conjugate of LMWH and DOCA was synthesized by conjugating the amine group of N-deoxycholylethylamine (EtDOCA) with the carboxylic groups of heparin at various DOCA conjugation ratios. The LMWH-DOCA conjugate series (LHD1, LHD1.5, LHD2, and LHD4) were further formulated with poloxamer 407 as a solubilizer for oral administration. An in vitro endothelial tubular formation and in vivo Matrigel plug assay were performed to verify the antiangiogenic potential of LHD. Finally, we evaluated tumor growth inhibition of oral LHD administration in a SCC7 model as well as in A549 human cancer cell lines in a mouse xenograft model. Increasing DOCA conjugation ratios showed decreased anticoagulant activity, eventually to zero. LHD could block angiogenesis in the tubular formation assay and the Matrigel plug assay. In particular, oral administration of LHD4, which has 4 molecules of DOCA per mole of LMWH, inhibited tumor growth in SCC7 mice model as well as A549 mice xenograft model. LHD4 was orally absorbable, showed minimal anticoagulant activity and inhibits tumor growth via antiangiogenesis. These findings demonstrate the therapeutic potential of LHD4 as a new oral anti-cancer drug.

Nonstructural 5A protein activates β-catenin signaling cascades: Implication of hepatitis C virus-induced liver pathogenesis

Park, C.Y.,Choi, S.H.,Kang, S.M.,Kang, J.I.,Ahn, B.Y.,Kim, H.,Jung, G.,Choi, K.Y.,Hwang, S.B. Elsevier Science Publishers 2009 Journal of hepatology Vol.51 No.5

Background/Aims: The nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) has been implicated in HCV-induced liver pathogenesis. Wnt/β-catenin signaling has also been involved in tumorigenesis. To elucidate the molecular mechanism of HCV pathogenesis, we examined the potential effects of HCV NS5A protein on Wnt/β-catenin signal transduction cascades. Methods: The effects of NS5A protein on β-catenin signaling cascades in hepatic cells were investigated by luciferase reporter gene assay, confocal microscopy, immunoprecipitation assay, and immunoblot analysis. Results: β-Catenin-mediated transcriptional activity is elevated by NS5A protein, in the context of HCV replication, and by infection of cell culture-produced HCV. NS5A protein directly interacts with endogenous β-catenin and colocalizes with β-catenin in the cytoplasm. NS5A protein inactivates glycogen synthase kinase 3β and increases subsequent accumulation of β-catenin in HepG2 cells. β-Catenin was also accumulated in HCV patients' liver tissues. In addition, the accumulation of β-catenin in HCV replicon cells requires both activation of phosphatidylinositol 3-kinase and inactivation of GSK3β. Conclusions: NS5A activates β-catenin signaling cascades through increasing the stability of β-catenin. This modulation is accomplished by the protein interplay between viral and cellular signaling transducer. These data suggest that NS5A protein may directly be involved in Wnt/β-catenin-mediated liver pathogenesis.