Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Yan, Bing Chun,Park, Joon Ha,Kim, Sung Koo,Choi, Jung Hoon,Lee, Choong Hyun,Yoo, Ki-Yeon,Kwon, Young-Geun,Kim, Young-Myeong,Kim, Jong-Dai,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Cellular and molecular neurobiology Vol.32 No.8

<P>In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.</P>

도시지역 응급센터를 내원한 약물중독 환자

유지영,최옥경,김무수,정구영 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Acute drug intoxication is a important part of emergency medicine. The outcome of intoxicated patients depends upon a kind of drug, a dose of drug, the time of initial management and the knowledge of variable drugs. Our study was made on 249cases of acute drug intoxication, who visited to emergency department of Ehwa Wonams University Mokdong Hospital during 15months from June 1994 to August 1995. The patients of early 10 months period were treated in department in IM and patients of late 5 months period treated in department of EM. The results were as follows : 1) Total nember of patients was 249 which is 0.59% fo total ED patients. The male to female ratio was 1:2 (81pts : 168 pts) The age distribution showed the highest incidences in 2nd (35%) and 3rd (23%) decades. 2) The most patients (78%) were visited to ED within 4 hour after drug ingestion. 3) The most common drug which activated charcoal was indicated was sedatives and hynotics (63%) The most common drug which activated charcoal was contraindicated was strong acid-alkali (4%) 4) The total mortality of intoxicated patients was 8%. 5) The outcomes of the patients( early 10 months vs. late 5 months) : the percentage of admission was 20% vs 24%, discharge against admission was 36% vs 46% discharge was 21% vs 22%, transfer to other hospital was 22% vs 9%

알카리성 부여제 도포에 의한 중성화된 콘크리트의 알카리성 회복성능에 관한 실험적 연구

김무한,권영진,강석표,유재강,이강우 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

Concrete is the most commonly used material in construction field and it is the permanent construction material with respect to civil property. But, if concrete loses its alkalinity by CO2 gas, it loses its structural characteristics and results in total collapse in construction field. Therefore. it is needed to be studied the alkali-recovery performance by alkalization agent on carbonated concrete by accelerated carbonation test. In this paper, we investigate recovery performance by impregnating alkalization agent in carbonated concrete, then we evaluate alkali maintenance performance by pH survey in each kinds of finishing materials. The results of this paper can be summarized as follows. 1)Carbonated concrete under pH 10 was recovered its alkalinity to pH 11 at first stage by spreading alkalization agent on its outer surface. 2)After spreading alkalization agent, there is a difference due to types of moreover effect of anti-rust paint and ordinary cement paste were excellent.

Vibrio vulnificus에 의한 패혈증 3예

김신무,김유현,신상희,오재세,강숙희,윤여안,이화재,김영옥 대한임상병리사협회 1986 임상병리사회지 Vol.18 No.1

COX 모델을 이용한 생존자료분석에서 Proportionality 가정 검정의 의의

이무송,유근영,노동영,최국진 대한암학회 1991 Cancer Research and Treatment Vol.23 No.4

천연골재 및 재생골재콘크리트의 Na₂SO₄침식에 의한 화학저항성에 관한 실험적 연구

김규용,이정율,박유신,강석표,김무한 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

Now a day, the more Proportion of concrete used in practice is exposed to serious chemical attack Chemical reactions that involve formation of expansive products in hardened concrete can lead to certain harmful effects. In this study, it is to compare and investigate the chemical resistance of natural and recycled aggregate concrete by attacked Na₂SO₄according to W/C ratio. The result of this study is that the chemical resistance of recycled aggregate concrete is lower than natural aggregate concrete. But it is developed the chemical resistance by decreasing the W/C ratio.

ρ군의 대 부분군에 대한 표현정리

김영무,유원석 금오공과대학교 산업기술개발연구원 2000 産業技術開發硏究 Vol.16 No.-

In this paper, we give further properties of fully invariant subgroups and large subgroups of p-groups and obtain a representation theorem for large subgroups of p-groups.

메치실린 내성 황색 포도상구균(MRSA)에 대한 소독제 및 항생제의 살균력 효능

이화중,나영천,유석근,김동철,김신무 大韓成形外科學會 2002 Archives of Plastic Surgery Vol.29 No.6

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

메치실린 내성 황식 포도상구균(MRSA)에 대한 소독제 및 항생제의 살균력 효능

이희중,나영천,유석근,김동철,김신무 大韓成形外科學會 2002 Archives of Plastic Surgery Vol.29 No.6