지상발표 : 단세포군 항체를 이용한 인체 α - fetoprotein 의 효소면역 측정에 관한 연구

노동영,김진복,정홍근,서판길,김승원 대한소화기학회 1985 대한소화기학회지 Vol.17 No.2

유방암에서 PET 의 응용

노동영 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.1

유방암

노동영 한국과학기술원 유전공학연구소 1995 생명공학동향 Vol.3 No.2

유방암의 예후인자로서 젊은 연령에 대한 고찰

노동영,No, Dong-Yeong 한국건강관리협회 2004 한국건강관리협회지 Vol.2 No.1

Purpose:It has been known that the prognosis of a young woman's breast cancer is Poorer than the other woman However, the effect of age on the prognosis is not well-defined We performed this study to investigate age as a prognostic factor of breast cancer. Materials and Methods : A retrospective study was conducted for 3209 breast cancer patients who underwent operations in Department of Surgery, Seoul National University Hospital from January 1981 to December 2000. Patients were divided into two groups, young age(≤35) and old age(>35) groups. And tumor stage, histopathologic characteristics(such as histology, nuclear grade, histologic grade, hormonal receptor, etc), overall survival and disease free survival rates were compared between age groups. Results . The age ranged from 17 to 88 years. 396 patients(12.3%) were included in young age group(median=32) and 2813 Patients(87.7%) in old age group(median=47).There are more advanced stages and poor nuclear grades in young age group(p=0.000, p=0.003), By log-rank test, the young age group had poorer overall survival and disease free survival rates(p<0.05, p=0.0002). Although, the young age group had more advanced TMN stages(p=0.000) and poorer nuclear grade than the old age group(p=0.003) in multi variate analysis, the age was not a significant independent prognostic factor. (P=0.642)Conclusion: Our study showed that the age was not a significant independent prognostic factor.

Phospholipase-C와 발암 신호 전달

노동영 암연구센터 1996 암연구의최신지견 Vol.1996 No.-

북한 핵문제와 우주군축

노동영 한국항공우주정책⋅법학회 2017 한국항공우주정책·법학회지 Vol.32 No.2

Nuclear issue is a good example showing globalization of the international regime. The history showed nuclear weapons may cause the extinction of human races when the first nuclear bombs fell down to Japan in August, 1945 and people became increasingly eager to achieve peace. Military buildup for national security is a matter of existence in the international society. However, disarmament or arms control to secure international peace and safety which is also the purpose of the Charter of the United Nations may be the most important task for us to realize peace of the mankind. Today, disarmament, together with amicable settlement of international conflicts and collective security system, is an important means to maintain and promote international peace and safety. It might be our permanent task to realize complete disarmament but, as the Preamble of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) expressed general and complete disarmament, the international society has clarified its effort for complete disarmament. Thus, taking a look into the international regime on the nuclear issue and progress related to the nuclear issue in North Korea, the study was intended to introduce the globalization of the nuclear issue, review the international effort for nuclear disarmament based on the concept of the ‘common heritage of the mankind’ and with respect to the United Nations Committee on the Peaceful Uses of Outer Space (COPUOS) and controls over nuclear weapons, and then evaluate the North Korean nuclear issue, which is in direct relation with South Korea and international laws, in terms of the space law and disarmament acts. The collective security system along with policies to prevent dissemination of nuclear weapons should also be emphasized and implemented to cope with the North Korean nuclear issue. 핵문제는 국제레짐(resime)의 지구화를 보여주는 좋은 예이다. 1945년 8월 일본에 최초로 핵폭탄이 투하되면서 핵무기가 인류를 절멸시킬 수 있다는 역사를 통해 평화에 대한 갈망은 더욱 절실해졌다. 자국의 안보를 위한 군비증강은 국제사회에서 자존의 문제이지만, UN헌장의 목적이기도 한 국제평화와 안전을 유지하기 위해 군축 또는 군비통제는 전 인류의 평화 실현과 직결된 가장 중요한 과제일 것이다. 오늘날 군축은 국제분쟁의 평화적 해결, 집단안전보장제도와 함께 국제평화와 안전을 유지·촉진하는 중요한 수단이다. 완전한 군축 실현이 항구적인 인류의 과제일 수는 있으나, NPT 서문에서 일반적이고 완전한 군축이 표현된 것처럼 국제사회는 완전 군축을 위한 노력을 천명하고 있다. 따라서 핵문제에 대한 국제레짐과 북한의 핵문제에 대한 주요 경과를 살펴봄으로써 핵문제의 지구화 현상을 소개하고, 핵 군축을 위한 국제사회의 노력을‘인류의 공동유산’개념과 우주공간 평화이용위원회 및 핵무기의 통제를 중심으로 검토한 후, 대한민국과 국제법에 직결된 사안인 북한의 핵문제를 우주법 내지 군축법적인 관점에서 평가해 보고자 한다. 또한 북한의 핵문제를 위해서는 비확산·반확산정책과 함께 집단안전보장제도가 지속적으로 강조·시도되어야 할 것이다.

Ambulatory Surgery for Breast Lesions

노동영 대한외과학회 2001 대한외과학회 학술대회 초록집 Vol.2001 No.5

Array CGH를 이용한 DNA 복제 수 변화에 대한 분석에 따른 유방암의 예후 인자에 대한 후보 유전자로서의 COL18A1

노동영,황기태,정중기,허승철,정인목,안영준,안혜성,장미수,김정아,한원식 한국유방암학회 2010 Journal of breast cancer Vol.13 No.1

Purpose: We tried to select and validate the candidate gene for the prognostic marker of breast cancer by comparing the analysis of copy number variation (CNV) between normal breast tissues and breast cancer tissues by performing array comparative genomic hybridization (CGH). Methods: Array CGH was performed with using the fresh frozen tissues of 77 breast cancer patients. We selected the clones with more than a 20% frequency of gain or loss, and the clones with gain or loss in more than 2 consecutive clones. We finally selected the clones that were statistically significant on the survival analysis. We searched for the candidate gene that belonged to the candidate clones and we selected the final candidate gene that is assumed to be most related to the carcinogenesis of breast cancer by searching for information of the individual gene. We performed RT-PCR to validate the RNA expression of the final candidate gene with using the breast tissues of another 20 breast cancer patients. Results: Eleven (10 in the gain group and 1 in the loss group) clones were finally selected as candidate clones. The significant CNVs with gain were found in the regions of 1q23.1, 1q41, 1q44, 5p15.33, 8q21.3, 15q26.3, 17q12 and 21q22.3 and the significant CNV with loss was found in 14q32.33. COL18A1 (21q22.3) was selected as the final candidate gene and the RT-PCR results revealed that the expression of COL18A1 was up-regulated in the cancer tissues of 18 of the other 20 (90%) breast cancer patients. Conclusion: We selected COL18A1 (21q22.3) as the candidate gene for the prognostic marker of breast cancer by comparing the analysis of CNVs from the array CGH. The RNA of COL18A1 was over-expressed in breast cancer tissue, as determined by RT-PCR.

Breast Cancer Genes

노동영 가톨릭대학교 가톨릭암센터 2000 암심포지움 Vol.- No.1

유방암의 유전자는 20세기들어 분자생물학의 발달과 함께 어느 암보다 다양하게 밝혀져 있다. 유방암의 유전자도 타 암종과 마찬가지로 암유전자와 암억제유전자로 대별될 수 있겠다. 그 중에서도 가장 획기적인 발견은 유전성 유방암에서 1990년 17번 염색체에서 위치를 찾고, 1994년과 1995년에 각각 발견한 BRCA-1과 BRCA-2의 클로닝일 것이다. 최근에 성장인자 수용체에 관련된 유전자, 특히 c-erbB2 유전자에 관한 지식이 많아지고 Herceptin이라는 이 유전자의 산물에 대한 항체가 개발되고 유방암의 치료에 효과가 증명되면서 암유전자는 종양표지자로의 가치 외에 치료에 응용되는 새로운 장을 열게 되었다. 더욱이 새로운 세기에 들어서면서 인간의 염색체 유전자의 서열이 모두 밝혀지게 되고 DNA chip과 microarray의 기술이 괄목하게 향상되어 이런 추세라면 향후 10∼20년에는 현재와는 비교할 수도 없는 많은 유전자 정보를 가지고 인체의 질환을 대하게 될 것이다. 여기서 언급해야 할 유방암의 발생, 성장, 전이에 관계된 암유전자는 성장인자 수용체와 관련된 유전자들로부터 암억제유전자 등 수 십여 가지가 있지만, 본 연구자는 그 중에서도 성장인자와 관련된 암 유전자와 효소들에 대하여 연구하여 왔는 바 이번 기회에 몇 가지 암 유전자의 예후와 관련된 일반적인 소개와 함께 아직은 잘 밝혀져 있지 않은 암 신호 전달 체계에 관한 연구 결과들을 주로 논의코자 한다. 전체적인 이해를 위해서 중요한 것은 유전자가 단독으로 작용하는 것이 아니라, 여러 유전자들이 서로 교신을 하며 각각의 발현을, 나아가서는 암종의 발생을 촉진 또는 억제한다는 것이다.

수술 전 항암화학요법을 전후한 유방암 종양수용 체(ER, PR, HER-2)의 발현 변화

노동영 한국유방암학회 2007 Journal of breast cancer Vol.10 No.3

Purpose: We aimed to assess the concordance of the immunohistochemical profiles of core biopsy before administrating neoadjuvant chemotherapy with that of the surgical specimens after a definitive operation for breast cancer. Methods: We retrospectively reviewed the estrogen receptor (ER), progesterone receptor (PR), and HER-2 expressions in 130 consecutive patients who received neoadjuvant chemotherapy and were followed by surgery during the period between February 2002 and March 2006. The pathologic complete tumor response rate for this group was 4.6% (6/ 130). Both the pre- and post-operative immunohistochemical profiles were available in 32 of the 124 patients (25.8%). Immunohistochemical staining was done on the core biopsies before chemotherapy and on the surgical specimens after operation. Results: There were 12 markers from 11 patients that were altered out of the 96 total markers (ER, PR, or HER-2) from 32 patients: 2 ER (2/12, 16.7%), 4 PR (4/12, 33.3%), and 6 HER-2 (6/12, 50.0%). One patient simultaneously had changes in the expressions of PR and HER-2. Conversion of the hormone receptor status occurred in 3 patients (3/32, 9.4%): this was positive to negative in two, and vice versa in one. In addition, there were 6 conversions (6/32, 18.8%) of the HER-2 status from negative to positive. Conclusion: The hormone receptor status changed in 9.4% of the 32 patients and the HER-2 status changed in 18.8% of the 32 patients after neoadjuvant chemotherapy. We have concluded that conducting only a single immunohistochemical study about ER, PR, and HER-2 may not be enough to exactly estimate the tumor marker status in the neoadjuvant setting.