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생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구
민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.
민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.
생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구
김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.
정기적인 통합레크리에이션 활동이 정신분열증 환자의 대인관계 개선에 미치는 영향
김동건,이문숙,조민행 한국특수체육학회 2003 한국특수체육학회지 Vol.11 No.3
The purpose of this study was to investigate the effect of regulaly performed inclusive recreation on the improvement of interpersonal relationship in the schizophrenic patients. There were thirty-three schizophrenic patients who were randomly selected and divided in 2 groups, inclusive recreation participation group(male:10, female:6) and recreation participation group(male:9, female:8). The subjects participated in program, twice a week for 3 months. The major findings obtain from this study were followings. First, participation groups showed a significant increase in interpersonal relationship. Second, inclusive recreation participation group showed a significant increase compared to division recreation participation group in terms of interpersonal relationship. Third, there were significant associations between demographic variables(health and terms of admission into a hospital) and interpersonal relationship in inclusive recreation participation group.
Hang-Min Cho,In-Jae Jeong 한국산업경영시스템학회 2012 한국산업경영시스템학회 학술대회 Vol.2012 No.춘계
This paper deals with a planning problem for reentrant hybrid flow shop with serial stages consisted of parallel machines. In a reentrant operation, a product may revisit some stages several times and then it may cause the congestion of work in process (WIP) or equipment idleness. Preemptive goal programming based heuristics are proposed to maximize of throughput and to minimize of delayed customer demands in the hybrid flow shop.
A Multi-objective Constraint Programming for Centralized Production-distribution Planning
Hang-Min Cho,In-Jae Jeong 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This research deals with the production-distribution planning system in a supply chain environment. We consider multi-objectives for the plan including minimization of production cost, transformation cost, backorder cost and inventory holding cost. Also we consider realistic constraints such as the capacity of factory, distribution center, inventory and transportation vehicle, balance of inventory, backorder, etc. We propose a method that transforms the supply chain planning problem into constraint programming so that is can handle multiple objectives. A small example is presented to illustrate the proposed algorithm.
조항민(Hang-Min Cho),정인재(In-Jae Jeong) 한국산업경영시스템학회 2012 한국산업경영시스템학회 학술대회 Vol.2012 No.-
This paper deals with a planning problem for reentrant hybrid flow shop with serial stages consisted of parallel machines. In a reentrant operation, a product may revisit some stages several times and then it may cause the congestion of work in process (WIP) or equipment idleness. Preemptive goal programming based heuristics are proposed to maximize of throughput and to minimize of delayed customer demands in the hybrid flow shop.
RKO 대장암 세포주와 MCF-7 유방암 세포주에서 Sodium Butyrate와 5-aza-2’-deoxycytidine에 의한 종양세포 성장억제 상승작용
조항주(Hang Joo Cho),박순철(Sun Cheol Park),김기환(Kee Whan Kim),강원경(Won Kyung Kang),조현민(Hyun Min Cho),김정수(Jeong Soo Kim),김영애(Young Ae Kim),안창혁(Chang Hyeok An) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.5
Purpose: It is known that DNA methylation is associated with histone acetylation status in regulation of gene expression. In this study, we investigate the effect of demethylating agents and histone deacetylase (HDAC) inhibitor on the tumor suppression and the combined effect of two agents according to methylation status in human colon and breast cancer cell lines. Methods: In this study, the RKO colorectal cancer cell line, MCF-7 breast cancer cell lines were considered. For each cell line, we used HDAC inhibitor sodium butyrate (SB), demethylating agent 5-aza-2’-deoxycytidine (5-aza-DC) and a combination of both agents. We estimated the percentage of cell survival using the XTT method and experimented with the augmentative effects of both agents. Results: In RKO cell line in which most of the genes are methylated, 74% of cell survival was shown for 5-aza-DC treatment and 83% of cell survival for SB treatment. In MCF-7 cell line that approximately half of the genes are methylated, 82% cell survival was shown for 5-aza-DC treatment and 63% cell survival for SB treatment. We observed that the survival fraction is lower after the combined treatment of 5-aza-DC and SB than that of 5?aza?DC or SB alone in both RKO (53%) and MCF-7 (49%) cell lines (P<0.001). Conclusion: For highly methylated genes, 5-aza-DC is more effective on the tumor suppression than SB. On the other hand, if the methylation of the promoter region is at low density, SB is noted to be more effective than 5-aza-DC. Furthermore, the combined treatment of 5-aza-DC and SB is more effective than using each agent alone.
조정민(Hung-Min Cho) 한국생활환경학회 2008 한국생활환경학회지 Vol.15 No.4-1
Lead is environmental and public health hazard of global proportions. In the world's most developed countries, it is estimated that a large proportion of children suffer from lead poisoning. The purpose of this study is to ascertain factors influencing blood lead level in Korean childhood. Participants were selected from the children under the age of 6 to be accepted participation in the studyin Paju, Gyeonggi province. In total 59 participants were recruited. Parents of participants were interviewed by questionnaires and 5 ㎖ of venous blood were drawn from each participant. The mean blood lead level of subjects was 80 μ/㎗. The maximal blood lead level was 6.96 μ/㎗. According to results from multiple regression analysis, playing with toy including lead, dust in house, number of outdoor activity as well as housing, accounted for 41 % of the variance in blood lead level of participants Community - wide lead poisoning prevention and educational activities should be promoted, including the encouragement of personal hygiene and the management of environment.