홍삼복용이 유산소운동시 발생된 과산화지질(MDA)에 미치는 영향

최종환,김현주,기미영 忠北大學校 平生體育硏究所 1999 平生體育硏究所 論文集 Vol.11 No.-

This study was performed to investigated the effect of 8 weeks red-ginseng intaking on MDA(malondialdehyde) produced during aerobic exercise in the college women(20-25 yrs). Eight volunteers agreed to participate in the study. The subjects who joined this study were asked to take 2.7g of red-ginseng powder capsule per day before the meal for 8 weeks(3 times/day). MDA(from blood samples) were collected at rest, just after the submaximal exercise, and 30 minutes after the exercise (cycle ergometer riding) at the beginning and the end of the 8-weeks program. For data analysis, mean and standard deviation scores were calulated and paired T-tests were used. After 8 weeks of ginseng intaking, college students showed the decreased MDA in serum and plasma significantly at rest, just after the exercise, and 30 minutes after the exercise. Therefore, this study indicates that ginseng intaking, as an antioxidant, may be useful for removing MDA produced during aerobic exercise.

유리단 국소의치 장착 후 M.K.G.에 의한 하악운동 형태 및 속도의 변화

최현미,조주온,이상돈,송광엽,박찬운 全北大學校 齒醫學硏究所 1992 전북치대논문집 Vol.10 No.1

The purpose of this study is to evaluate the effects of distal extension partial denture on the mandibular movement patterns and velocity. The subjects are 10 patients who have unilateral or bilateral distal extension edentulous area in maxillary and/or mandibular arches. Their mandibular movement patterns and velocity had been measured by Mandibular Kinesiograph(M.K.G.-K6 diagnostic system, Myo-tronics Inc. Seattle. WA. U.S.A.) once just before the treatment and 8 times every week since the dentures were placed. The data have been analyzed statistically by means of ANOVA and Tukey test. The results have been obtained as follows : 1. The placement of the dentures has reduced the amount of vertical and antero-posterior displacement in the habitual mandibular movement significantly(p<0.01). 2. The maximum opening and closing velocity and the mean opening and closing velocity showed no significant change with the placement of the partial dentures(p>0.01). 3. The velocity trace of maximum opening-closing movement has been more regularized and well-coordinated, and the number of clicks decreased continuously after placement of the dentures and showed stable patterns since the 5th week(p<0.01). 4. The left deviation has been decreased significantly after the placement of the dentures and showed no significant change since the 4th week. The right deviation has also been reduced, but there was shown no difference after the 1st week(p<0.01). 5. The crossover pattern has been most frequently observed in the frontal plane and the sagittal plane. It has not been changed with the denture placement and stabilized uniformly.

한국인 제2형 당뇨병 환자의 골격근에서 인슐린 신호전달체계의 결함

최준혁,이관우,김효정,이동훈,이종우,김정은,엄현채,김경미,최성이,정윤석,김현만 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 제2형 당뇨병에서 나타나는 인슐린 저항성은 간, 지방, 근육 같은 말초조직에서 인슐린의 작용이 떨어지는 것을 말한다. 제2형 당뇨병의 발생기전에 인슐린 저항성과 인슐린 분비능 저하가 같이 관여함은 잘 알려진 사실이다. 인슐린의 세포내에서의 저항성을 규명하기 위한 인슐린의 세포내 신호전달체계에 대한 연구가 활발히 진행되고 있으며 몇몇 연구에서 인슐린 저항성을 가진 골격근육에서 IRS와 관련된 PI3-kinase의 활성감소와 Akt kinase의 활성감소를 보고하고 있으나 아직까지 명확하게 그 기작이 설명되어지지 않고 있다. 본 연구에서는 정상성인, 제2형 당뇨병 환자를 대상으로 경구당부하검사 및 인슐린 클램프검사를 시행하고 인슐린 클램프 검사시 대상인의 근육을 채취하여 인슐린 신호전달 체계(IR-β, IRS, Akt(PKB, Rac) kinase, GSK-3)를 연구하였다. 방법: 연구대상자는 한국인으로서 경구당부하검사상 정상인 및 당뇨병 환자 각각 11명, 9명을 대상으로 하였으며, 정상인은 건강인으로 과거력상 당대사에 영향을 줄 질환이 없고, 현재 당대사에 영향을 줄 약물 복용 및 다른 소견이 없는 경구당부하검사상 정성 내당능을 보이는 대상자로 하였다. 당뇨병환자는 모두 제2형 당뇨병 환자로 이환기간이 만 5년 이내인 경우로 하고, 인슐린으로 치료하는 대상자는 제외하도록 하였다. 대상자의 연령, 체질량지수, 체지방량, 공복시 총콜레스테롤, 중성지방, 고밀도지단백 콜레스테롤 및 HbA1c, 인슐린, C-peptide를 측정하였고, "HOMA model"을 이용하여 베타세포의 기능와 인슐린저항성 정도를 평가하였다. 정상혈당클램프 검사(euhlycemic hyperinsulinemic clamp test)를 시행하고 인슐린 투입 전과 인슐린 투입 30분후, 두차례에 걸쳐 대퇴부 근육생검을 실시한후 western 법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 측정하였다. 결과: 정상인 11명과 당뇨병 환자 9명을 대상으로 하였으며 대상자의 평균 연령, 평균 체질량지수, 체지방량, 허리/엉덩이 둘레의 비(waist hip ratio; WHR)는 두 군간에 차이가 없었다. 평균 공복혈당은 정상군 98.0±0.3㎎/dL, 당뇨병군 208.1±16.5㎎/dL(p<0.05), HbA1c는 정상군 5.4±0.5%, 당뇨병군 9.2±0.6%(p<0.05)였다. "HOMA model"을 이용한 베타세포의 기능과 인슐린저항성은 정상군 56.4±8.5%, 1.4±0.2, 당뇨병군 72.2±52.3%(p<0.01), 10.2±6.3(p<0.01)였으며 정상혈당클램프 검사상 포도당 이용률은 정상군 8.2±0.6㎎/㎏/min, 당뇨병군 3.7±1.1㎎/㎏/min(p<0.01)로 정상군과 당뇨병군간에 유의한 차이를 나타내었다. Western blot법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 인슐린 투입전과 인슐린 투입 30분후 측정하였을 때 IR-β에서는 정상군이 103.9±2.3에서 241.3±18.6, 당뇨군이 108.9±2.2에서 198.7±6.3으로 증가하였다(p=NS). 이는 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 통계적인 차이가 없었다. IRS에서는 정상군이 111.6±7.3에서 295.6±17.2, 당뇨군이 114.5±6.1에서 222.0±23.2로 증가하였으며(p<0.05), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 24% 감소하였다. Akt kinase에서는 103.4±6.0에서 416.8±29.5로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 43% 감소하였다. GSK-3에서는 정상군이 107.7±6.7에서 595.7±28.1, 당뇨군이 104.3±4.8에서 443.3±12.9로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 25% 감소하였다. 결론: 제2형 당뇨병 환자에서 정상인과 비교하여 인슐린 자극후 IR-β는 인산화량의 증가정도가 큰 차이가 없었으나, IRS, Akt kinase, GSK-3에서는 인산화량의 증가 정도가 감소되는 것으로 보아 상위 인슐린 신호전단체계부터 결함이 있는 것으로 생각된다. Background: The glucose uptake rate is the limiting step in glucose utilization and storage. The failure of insulin to stimulate glucose uptake in muscle appears to be a primary defect of insulin resistance. This study was undertaken to examine the effect of physiological hyperinsulinemia on the phosphorylation of the insulin receptor (IR-β), insulin receptor substrate (IRS), Akt kinase and GSK-3 in isolated skeletal muscle, in people with type 2 diabetes(n=9) and control subjects(n=11). Methods: 75g OGTT and euglycemic hyperinsulinemic clamp test were done. And vastus lateralis muscle was obtained before and 30 min into the euglycemic clamp. Western blots were performed for tyrosine phosphroylation of insulin receptor substrate (IRS) and phosphorylation of the insulin receptor(IR-β), Akt and GSK-3. Result: There were no statistical differences in the mean age, BMI and body fat between the control subjects and diabetic patients. The fasting blood sugar and HbA_1c in controls and diabetic patients were 98.0±0.3 and 208.1±16.5ng/dl, and 5.4±0.5 and 9.2±0.6%, and 1.4±0.2 in the control subjects, and 72.2±52.3%(p<0.01) and 10.2±6.3(p<0.01) in the diabetic patients, respectively. The insulin resistance from the euglycemic hyperinsulinemic clamp test were 8.2±0.6㎎/㎏/min and 3.7±1.1ng/㎏/min in the control subjects and in the diabetic patients, respectively(p<0.01). Compared with the normal controls, insulin-stimulated IR phosphorylation was no different to that in the diabetic patients. However, insulin-stimulated IRS phosphorylation, insulin-stimulated Akt phosphorylation and insulin-stimulated GSK-3 phosphorylation were reduced in the diabetic patients compared with the normal controls by 24, 43 and 25%, respectively(p<0.05). Conclusion: In Korean type 2 diabetic patients, the insulin resistance may be due to the impairment of the upstream insulin signal molecular network. Further studies will focus on determining whether these signaling defects are the cause of the development of insulin resistance, or secondary to the altered metabolic state, associated with type 2 diabetes mellitus (J Kor Soc Endocrinol 17:685∼697, 2002).

컴프리 葉의 조직배양에서의 植物體 再分化에 미치는 식물호르몬의 영향

車賢哲,崔賢美 단국대학교 1993 論文集 Vol.27 No.-

This study was conducted in order to regenerate plants from leaf explants and callus induced from the leaves of comfry (Symphytum peregrium). Calli were induced from leaf blade on MS medium supplemented with 1.0 mg/l 2,4-D and 1.0~2.0 mg/l kinetin. The shoot formation from leaf explants was initiated on MS medium supplemented with IAA in combination with kinetin. The root was also induced on MS medium supplemented 0.5-1.0 mg/l IAA and 0.1-2.0mg/l kinetin. The organogenesis from callus was formed to roots on B5 medium supplemented with kinetin, BAP, 2iP, irrespective to their kind and quantity Plantlets were regenerated from callus in B5 medium containing kinetin in combination with IAA or Containing BAP in combination with IAA. The optimum concentration of growth regulator for plant regeneration was estimated to be 2.0 mg/l BAP.

감식초가 고콜레스테롤 식이를 한 흰쥐의 혈중 지질 성분에 미치는 영향

정소형,김주현,정용진,최미자 동아시아식생활학회 1999 동아시아식생활학회지 Vol.9 No.4

This study was performed to evaluate the effect of persimmon vinegar on serum lipid components in the hypercholesterolemic Sprague-Dawley male rats. Forty rats were divided into four groups and fed diets containing 1% cholesterol for 4 weeks. Experimental diets added to distilled water, 1.5%, 3%, and 7% persimmon vinegar(PV) as drinking water. Concentration of total cholesterol, LDL and HDL cholesterol, triglyceride in serum and activity of AST, ALT in serum were assayed. Average food intake, weight gain and FER of experimental rats were not significantly different by contents of persimmon vinegar. Concentration of total cholesterol and LDL cholesterol in serum were lowest in 7% persimmon vinegar group. However concentration of HDL cholesterol in serum was highest in 3% persimmon vinegar group. Concentration of triglyceride in serum was significantly lower in persimmon vinegar group than control group. Activities of AST and ALT in serum were lowest in 7% persimmon vinegar group. The results in this study suggest that persimmon vinegar is effective in lowering serum triglyceride level.

갑상선 수질암종과 유두암종의 동시 발생된 1례

고진우,김도형,김미경,김현옥,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

저자들은 태생학적 기원, 면역조직화학적, 분자생물학적으로 완전히 별개의 암종인 갑상선 수질암종과 유두암종이 동시에 동일한 갑상선에 발생하는 매우 드문 사례를 경험하였고 이러한 현상이 우연한 동시 발생인지, 공통의 줄기세포 기원인지 혹은 공통의 암 유발인자에 의한 것인지는 여전히 논쟁의 여지를 남겨두고 있다. It is generally believed that the origins of medullary and papillary carcinoma of thyroid are embryologically different. So mixed medullary-papillary thyroid carcinomas are rare. The two separate tumors of the present case may be coincidental double primaries. It can be assumed that at least some of the mixed papillary and parafollicular cell carcinomas are results of collision of carcinomas derived from two embryogenetically different cell types. Recently, we experienced a case of mixed medullary-papillary thyroid carcinomas. A 50-year-old woman was found to have mixed medullary thyroid carcinoma and papillary thyroid carcinoma on the same lobe with lymph node metastases. We report a this case with literature review

Hypertensive Crisis During Excision of Retroperitoneal Mass in Patients with Abdominal Aortic Aneurysm-A Case Report-

( Mi Hyeon Lee ),( Joo Hyun Jun ),( Eun Mi Choi ),( Eun Mi Kim ),( Young Ryong Choi ),( Pil Hyun Jeon ),( Seung Hwa Baek ),( Mi Hwa Chung ),( Wha Ja Kang ) 경희대학교 경희의료원 2016 慶熙醫學 Vol.31 No.1

Paragangliomas are rare tumors that arise from extra-adrenal chromaffine tissues and that secrete catecholamine. The abnormal secretion of catecholamine can cause cardiovascular complications such as severe hypertension, cardiomyopathy, cardiac arrhythmia, and aortic aneurysm rupture. In particular, the risk of mortality and morbidity increases if the patient has not been diagnosed or if the preparation for a possible hypertensive crisis has been insufficient. Moreover, it can lead to high risks of cardiovascular complications if the patient has a concomitant disorder such as aortic aneurysm. We report a case of preoperatively undiagnosed paraganglioma that caused a hypertensive crisis during the surgical removal of a retroperitoneal mass and the repair of an infra-renal abdominal aortic aneurysm (AAA) and left common iliac artery aneurysm.

Antioxidant Activity of Extract from Paeonia lactiflora

Hyeon Mi Jo(조현미),Sin Park(박신),Eun Bi Choi(최은비),In Ho Choi(최인호) 한국약용작물학회 2022 한국약용작물학회 학술대회논문집 Vol.2022 No.1

Distribution of Seawater Thermal Energy and the Available Amount of OTEC in the Waters of Gangneung Green City

Mi-Yeon Choi,Deok-Su Moon,Young-Seok Kim,Hyeon-Ji Jung,Hyeon-Ju Kim 한국해양환경·에너지학회 2012 한국해양환경공학회 학술대회논문집 Vol.2012 No.11

Nanogenerators: Fully Rollable Transparent Nanogenerators Based on Graphene Electrodes (Adv. Mater. 19/2010)

Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19

<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>