노인정신장애 평가척도(Psychogeriatric Assessment Scale)의 한국판 표준화 연구

조맹제,박임순,신영민,김무진,정희연,정은기,최용성,조성진,서국희,함봉진 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

연구목적 : 본 연구는 치매와 우울증을 다차원적으로 평가할 수 있는 도구인 Psychogeriatric Assessment Scale(PAS)의 한국판(PAS-K)을 개발하기 위한 것이다. 방 법 : 번역, 역번역, 그리고 세차례의 예비조사를 통하여 PAS-K를 제작하였다. 60세 이상의 노인 291명(임상환자군 : 58명, 지역사회노인군 : 168명, 수용시설 거주자 : 67명)과 그들의 정보제공자들을 대상으로 PAS-K, Geriatric Depression Scale(GDS), Korean version of Mini-Mental State Examination(MMSE-K), Hamilton Rating Scale for Depression(HRSD), 그리고 Hachinski Ischemic Score 를 적용하고, Diagnostic Interview chedule(DIS-Ⅲ-R)을 사용하여 치매와 우울증을 진단하였다. PAS-K의 신뢰도와 타당도를 평가하고, 예민도와 특이도, Kappa값, 그리고 ROC커브 분석법을 이용하여 PAS-K의 6개의 소척도들(피검자면접 : 인지기능 장애척도, 우울척도, 뇌졸중척도, 정보제공자면접 : 인지기능 저하척도, 행동변화척도, 뇌졸중척도)의 최적 절단점을 구하였다. 결 과 : PAS-K는 높은 내적 일관성을 보였고, 검사자간 신뢰도도 만족할 만한 수준이었다. PAS-K의 소척도들을 다른 표준화된 검사도구들과 비교하였을 때 인지기능 장애척도와 인지기능 저하척도는 MMSE-K와, 우울척도는 GDS 및 HRSD와 유의한 상관관계를 보였으며, 뇌졸중척도는 Hachinski Ischemic Score와 통계적으로 의미있는 상관관계를 보였다. 최적절단점은 인지기능 장애척도 10점, 인지기능 저하척도 3점, 우울척도 5점, 피검자면접과 정보제공자 뇌졸중척도 모두 1점, 그리고 행동변화척도 2점으로 추정하였다. 결 론 : 본 연구를 통해 PAS-K의 신뢰도와 타당도가 검증되었고, 노인정신의학 역학연구나 보건분야에서 치매와 우울증의 임상경과관찰 및 일차 선별도구로서 유용하게 사용될 수 있게 되었다. Objectives : This study was designed to develop the Korean version of the Psychogeriatric Assessment Scale(PAS-K), a multidimensional screening tool for the dementia and depression. Methods : Through three times preliminary trials, the authors translated PAS into Korean. The PAS-K, Geriatric Depression Scale, Hamilton Depression Rating Scale, Hachinski Ischemic Scale and Mini-Mental State Examination-Korean version were administered to 291 subjects over the age of 60 and the same number of their informants(67 subjects were institutionalized, 168 subjects were in community, 58 subjects were psychiatric hospital patients). And the Diagnostic Interview Schedule(DSM-Ⅲ-R) was independently administered to exactly diagnose dementia and depression. The reliability and validity test, optimal cut-off point estimation for six each scale and ROC curve analyses were done to investigate the diagnostic validity of PAS-K. Results : Internal consistency and interrater reliability of the PAS-K were high. Concurrent validity of each scales of PAS-K was good in being measured with other standardized scales. The optimal cut-off points of each scale of the PAS-K were estimated as follows : 1) Stroke Scale of subject interview : 1, 2) Cognitive Impairment Scale of subject interview: 10, 3) Depression Scale of subject interview : 5, 4) Stroke Scale of informant interview : 1, 5) Cognitive Decline Scale of informant interview : 3, and 6) Behavioral Change Scale of informant : 2. conclusions : The PAS-K was valid and reliable screening tools for detecting dementia and depression. Therefore the PAS-K could be widely and extensively used in psychogeriatric epidemiological research or clinical setting of primary screening for dementia and depression.

노인에서 한국판 행동통제척도의 표준화 및 타당도 연구

김효진,이준영,정희연,나덕렬,조성진,조맹제,장성만 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.4

The aims of this study are to demonstrate the reliability and the validity of the Korean version of Behavioral Dyscontrol Scale (BDS-K.) and to present the normative values of BDS-K among the Korean elderly. The BDS-K was administered in a standardized manner to 1,389 healthy volunteers aged over 65 years recruited from the cornmunity. The elderly with serious neurological, medical or psychiatric disorders were excluded using screening tests. BDS-K showed good intemal consistency (Cronbach's alpha=0.812), test-retest reliability (r=0.88) and inter-rater reliability (r=0.99). Age and educational level were found to affect BDS-K score. Based on this result, normative values of BDS-K. were calculated by age and educational level. The validity of the BDS-K were demonstrated in comparison with MMSE-KC (r=0.72). BDS-K is reliable and valid instrument for measuring executive function of the elderly. The normative values suggested by this study can be widely used as reference values to objectively interpret BDS-K scores of the Korean elderly.

볼엔드밀 加工에서 남겨진 커습體積의 仕上加工 特性에 關한 연구

김명수,천상진,맹희영 서울産業大學校 1997 논문집 Vol.46 No.1

The polishing characteristics of machined surface after ball end milling are studied in this paper quantitatively to investigate the optimum machining time including polishing and milling process. The polishing experiments are formulated into the incremental changing task of sand paper meshes bounded by the allowable limit roughness for each abrasive grit size. Testpieces are prepared by milling the flat steel block to have the terraced surface for the different milling crossfeed and cutter size, and polishing device installed on a grinding machine table, which simulates the actual polishing work as specified stroke and acting pressure. The polishing efficiency is investigated during the polishing experiment, and then eventually polishing time is evaluated for the various kinds of conditions, and it is finally analyzed the total machining time which is estimated by adding the milling time to the polishing time of corresponding testpieces. Although the polishing work is shortened as the initial roughness of milled surface becomes small, the total machining time is revealed as the minimum value at a testpiece prepared by milling condition of 1.5mm crossfeed and 20mm cutter size, which means the most economic machining balance between milling and polishing work partitions.

드레인 전류 잡음원만을 고려한 스케일링이 가능한 바이어스 의존 P-HEMT 잡음모델

윤경식,이창석,맹성재,이진희,박철순 대전산업대학교 반도체기술연구소 1999 半導體技術硏究所報 Vol.1 No.-

게이트 길이가 0.2㎛인 P-HEMT에 대하여 드레인 바이어스 전류의 변화 및 게이트 폭에 대해 스케일링이 가능한 잡음모델을 제안하였다. 본 논문에서는 S-파라미터를 정확히 예측하기 위하여 x를 제외한 intrinsic 파라미터는 offset를 도입하여 정규화 한 후 스케일링을 하였다. 드레인 포화전류에 대한 드레인 전류의 비율과 게이트 폭을 변수로 하는 소신호 모델 파라미터의 맞춤함수를 구하였다. 또한, 잡음 파라미터를 정확히 예측하기 위하여 진성저항 잡음 온도 T_g, 게이트 단 전류 잡음원 등가잡음 컨덕턴스 G_ni 드레인 단 전류 잡음원 등가잡음 컨덕턴스 G_no를 잡음 모델정수로 사용하여 그 값을 추출하여 스케일링 하였다. 잡음 온도 T_g는 드레인 전류와 게이트 폭에 거의 추출되었다. 그러므로, G_no만을 잡음 모델정수로 하는 잡음모델과 T_g, G_ni, G_no를 잡음 모델정수로 하는 잡음모델을 측정값과 비교하여 본 결과 G_no만을 갖는 잡음모델도 측정된 잡음 파라미터와 잘 일치하였다. 따라서, 모델 정수 추출이 간단한 G_no 만을 갖는 잡음모델은 게이트 폭과 바이어스 전류에 대해 스케일링이 가능한 실용적인 잡음모델임을 확인하였다. Bias-dependent noise models of 0.2㎛ gate length P-HEMT's which are scalable with gate width are proposed. To predict S-parameters of the P-HEMT's the intrinsic parameters except for x subtracted the offsets introduced in this paper are normalized to the gate width and then scaled. The small-signal model parameters are expressed as fitting functions of the drain current to I_dss ratio and gate width. In addition, to estimate accurately noise parameters the noise temperature T_g of the intrinsic resistance, the equivalent noise conductance G_ni of the gate current noise source, and the equivalent noise conductance G_no of the drain current noise source are adopted as the noise model parameters. The extracted values of T_g are nearly independent of drain current and gate width and their average is arou

광주시내 업종별 음식점의 위생상태 및 식중독원인 세균의 분포 특성

이홍열,유맹자,정해진,김근영,정희종 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

업종별 음식점 주방의 위생상태는 일식>중식>한식의 순이었고 개인위생의 경우는 일식>한식>중식의 순이었는데 주방 및 종업원의 위생상태를 향상시키기 위해서는 음식점 규모의 대형화, 45℃ 이상의 온수공급, 주방시설의 표준화, 위생비닐장갑의 착용, 및 유니폼 착용이 신속하게 이루어져야 할 것이다. 업종별 대중음식점의 주방기구중의 세균분포는 전반적으로 일반세균수가 높게 나타났고 특히 대장균군수가 높게 나타났는데 음식물이 아니고 조리기구이긴 하지만 우리 음식점의 위생상 문제가 많은 것으로 생각된다. 미국 육군 Natick연구소가 제시한 음식물의 미생물 기준한계인 1 ×10??마리 이하, 대장균수가 100마리 이하와 비교할때 일반세균수의 경우는 아주 만족할만한 위생상태로 평가되었으나 대장균수는 개숫물의 경우 업종과 관계없이 높게 나타났고 행주와 칼의 경우 일식음식점에서만 높게 나타났으며 도마의 경우는 모두 100마리 이하로 양호한 위생상태로 평가되었다. 한식 전문음식점간의 세균수가 큰 차이를 보인 것은 규모와 운영방법이 서로 다르기 때문으로 앞으로 한식음식점에 대한 시설 및 환경개선에 대한 노력이 요구되었다. 또한 일식음식점간에는 일반세균수의 분포가 크게 다는 것으로 조사되었는데 특히 개숫물, 행주 및 도마중에 존재하는 미생물수가 크게 차이가 있었다. 등급별 한식음식점의 세균분포는 호텔급 음식점> 일반대중급 음식점> 여관급 음식점의 순으로 나타나 업소규모가 클수록 위생시설 및 위생습관의 수준이 높아 위생상태가 양호한 것으로 분석되었고 여관급음식점의 경우 위생상태가 낮은 것은 이용빈도가 낮은 것이 그 원인이 아닌가 생각되었다. Sanitary evaluation of kitchen area in different types of restaurants was the best at Japanese style restaurants and the worst aat Korean style restaurants. In personal hygiene Japanese style restaurant were evaluated as the best, but Chinese style restaurants were evaluated as the worst. Total and coliform bacterial counts were mostly showed high levels at all types of restaurants and especially this tendency was predominated in coliform counts. As compared to the standards suggested by U.S. Army Natick, however, total bacterial counts in all of supplies were evaluated as the satisfactory state. On the other hand, coliform counts in dish-washing water were much higher than the standard, which were not affected by the types of restaurant, and Japanese style restaurants were higher in wiping cloths and knives, but cutting boards were evaluated as satisfactory state with the counts less than 1.0 ×10².Bacterial counts in Korean style restaurants were greatly different depended on the size or type of restaurant. Total bacterial counts in Japanese style were also different among restaurants, especially in dish-washing water, wiping cloths, and cutting boards. According to the results of the evaluation of Korean style restaurant, bacterial distribution based on the class of restaurants, classified as hotel, motel, and public classes, hotel class restaurants showed lower levels of bacterial counts than public class. This result suggested that the larger and higher classes of restaurants maintained the satisfactory state without potential hazards.

일 농촌지역의 우울 증상에 관한 역학연구 -위험요인 및 요인구조분석

하양숙,홍진표,김한규,이군희,한경자,조맹제,김용익,송미순,박성애,김창윤 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 세계적으로 널리 사용되는 우울증 척도인 the Center for Epidemiologic Studies Depression Scale(CES-D)을 이용하여 지역사회 주민의 우울증상의 정도를 평가하고, 우울증상의 위험요인을 분석하고, 한국인에서 우울증상의 요인구조를 알기 위해 본 연구를 실시하였다. 방 법 : 경기도 일 농촌 지역의 30세 이상 주민에 대해 무작위 군집 집락 추출을 실시하였고, 훈련된 면담원들이 가정 방문을 통하여 면접 및 자기보고 검사인 CES-D를 실시하였다. 총 1,315명에서 응답을 하였고 응답율은 59.3%이었다. 결 과 : CES-D에 의한 우울증 점수는 0∼5점이 57%정도를 차지하였고, 평균 점수는 남자 7.8점 여자 9.5점으로 비교적 낮은 편이었다. ANCOVA 분석 결과 비결혼, 저학력, 여성이라는 위험요인은 독립적으로 우울증상을 악화시키는 요인이었으나 연령은 통계적으로 유의하지 않았다. CES-D 결과를 요인분석을 시행한 결과 4가지 요인이 추출되었는데 우울증상 및 신체증상이 한 개의 요인으로, 다른 나라에서 보고되지 않는 정서적 고통이 별도의 요인으로 추출되었다. 결 론 : 국내 역학 조사에서도 외국과 유사한 우울점수 및 위험요인이 확인되었으나 우울증의 요인에서는 특이한 요인이 추출되었다. 한국인에 독특한 우울 반응에 관한 추가 연구가 필요하다. Objectives :The rates, correlates, and factor structure of depressive symptoms in a Korean rural sample were examined using Korean version of the Center for Epidemiologic Studies Depression Scale(CES-D). Methods : Door to door visiting survey was conducted by trained interviewers. A random cluster sample of 1,315 respondents, aged 30 and over completed the CES-D scale along with additional sociodemographic questionnaire. Results : In this sample, mean CES-D score of male and female were 7.8 and 9.5, respectively which were lower than those reported previously. Symptoms of depression were most common among the less educated, non-married and female according to ANCOVA. Age was not a significant risk factor for depressive symptoms. Different factor structures emerged from this sample as compared to other studies using this approach. Somatic symptoms and affective symptoms were combined as one factor and emotional hardship emerged as a separate factor. Conclusion : Symptoms scores and risk factors were similar to the results reported in other countries but unique factor structures were found in this study. Further research is needed about the Korean depressive symptomatology and related areas.

한국어 판 구조화 임상면담도구 개발 : 신뢰도 연구

한오수,안준호,송선희,조맹제,김장규,배재남,조성진,정범수,서동우,함봉진,이동우,박종익,홍진표 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 정신장애의 정확한 진단과 평가는 임상에서뿐만 아니라 신뢰성 있는 연구를 위해서도 매우 중요하다. Structured Clinical Interview for DSM-IV(SCID)는 임상전문가들이 사용하는 진단도구로서, 비교적 짧은 시간에 정확한 진단을 내릴 수 있다. 본 연구는 한국어판SCID를 개발하고 그 신뢰도를 평가하기 위해 수행되었다. 방법: 국문학자가 포함된 번역위원회를 통하여 연구용판 SCID를 번역한 후, 정신과 의사 2인과 임상심리학자 1인에게 한국어판SCID 실시방법을 교육시킨 뒤 한국어판SCID를 이용한 면담의 평가자간 신뢰도 (interrater reliability)를 검증하였다. 면담 대상은 1999년 2월에서 3월까지 2개 병원 정신과에 치료중인 환자 90명(남:41명, 여:29명)이었다. 결과: 현재 장애(current disorder) 평가에서 주요 우울장애, 기분부전장애, 정신분열병, 알코올 남용 및 의존, 기타 물질 남용 또는 의존, 여러 불안장애들 및 섭식장애 등과 같은 대부분 장애의 kappa값은 .70이상으로 매우 높았다. 그 이외의 양극성 장애, 망상장애, 광장공포증, 감별 불능 신체화 장애 및 건강염려증의 kappa값도 .69에서 .40사이로 수용할 수 있는 정도였다. 평생 장애(lifetime disorder)에서는 양극성 장애(k=.69)와 감별 불능 신체화장애(k=.59)를 제외한 다른 모든 장애의 kappa값이 .70이상이었다. K-SCID 면담시 Ⅰ축 질환에 대하여 흔하게 다중 진단이 내려졌으며, 평균 진단 수는 1.5∼1.7개로 나타났다. 결론: 한국어판 SCID는 신뢰도가 높은 진단도구로 생각되며, 향후 정신질환의 정확한 진단과 임상연구에 유용하게 사용될 수 있다. Objectives: Accurate diagnosis and assessment for psychiatric disorders is crucial for research, as well as for clinical practice. Structured Clinical Interview for DSM-Ⅳ(SCID-RV) is a less time-consumimg and more accurate structured diagnostic interview form. It can be used by clinical professions and is known for a reliable diagnostic tool. Present study was conducted to develop Korean version of SCID-RV and to test the inter-rater reliability. Methods: The authors have translated original SCID-RV into Korean, and revised in parallel with sociocultural background of Korea. Ninety patients from two psychiatric hospitals, both outpatient and inpatient, were interviewed and rated independently by three raters. Results: The kappa coefficients for most of illnesses, such as major depressive disorder, dysthymia, schizophrenia, alcohol abuse and dependency, anxiety disorder and eating disorder were excellent(>0.70) in the evaluation of current disorders. And the kappa coefficients for bipolar disorder, delusional disorder, agoraphobia, undifferentiated somatoform disorder, and hypochondriasis were acceptable(>0.40) in the evaluation of current disorders. In the evalua-tion of lifetime disorders, the concordant rates of all the diagnoses except bipolar disorder and undifferentiated somatoform disorder were excellent. Lack of hierarchy in DSM-Ⅳ allows for multiple Axis I diagnoses. Mean numbers of Axis I diagnoses per subject assigned by the three raters were 1.5-1.7. Conclusions: Our findings confirm that SCID-RV yields highly reliable diagnoses. SCID-RV is recommended for accurate diagnosis in clinical practice and research on psychiatric disorders.

말쥐치기름 및 들깨기름의 攝取가 高콜레스테롤 食餌 흰쥐의 血淸 및 肝臟의 脂質成分에 미치는 影響

鄭承鏞,朴畢淑,徐孟姬,姜晋順,禹靜淑 慶尙大學校 1985 論文集 Vol.24 No.1

Hypercholesterolemic male rats of Sprague Dawley, divided into six groups, were fed for 3 weeks with the diets containing several different oils of 10,0, the mixtures of 5% perilla oil and 5% other oils. The concentration of the lipid peroxide, T-cholesterol, phospholipid and triglyceride in the serum and liver were measured along with the HDL-cholesterol concentration of the serum. The results were as follows: 1. The concentration of LPO in the serum of the rats fed with lO% perilla oil, with 5% perilla oil+5% lard and with 5% perilla oil+5% file fish oil was higher than those with any other oils. The concentration of that was significantaly high in the liver of the rats fed with 10% perilia oil, while it was considerably low with 10% olive oil. 2. The concentration of T-cholesterol in the serum of the rats fed with 10% perilla oil, with 10% file fish oil and with 5% perilla oil+5% file fish oil was lower than those with any other oils. 3. The concentration of HDL-cholesterol was low in the serum of the rats fed with 10% perilla oil, while it was high with 5% perilla oil+5% file fish oil and with 10% file fish oil. The concen tration of that for the T-cholesterol in the serum of the rats fed with 10% file fish oil and with 5% perilla oil+5% file fish oil was much higher than those with any other oils. 4. The concentration of T-cholesterol in the liver of the rats fed with 10% perilla oil was high, while it was low with 10f file fish oil and with any other oils. 5. The concentration of PL and TG in the serum of the rats fed with 10% perilla oil and with 10% file fish oil was lower than those with any other oils, but it was lower in the liver of the rats fed with 10% perilla oil than the mixtures of perilla oil and with 10% file fish oil.

Synthesis of spherical Prussian blue with high surface area using acid etching

Maeng, Hee Jin,Kim, Dae-Han,Kim, Nam-Woon,Ruh, Hyun,Lee, Dong Kyu,Yu, Hyunung ELSEVIER 2018 CURRENT APPLIED PHYSICS Vol.18 No.supp

<P>In this study, we report a hydrothermal synthesis method to control the shape of monodisperse PB from cube to sphere via selective acid etching. Polyvinylpyrrolidone (PVP), used as a surfactant, not only maintains a good dispersion of the particle without aggregation by stabilizing the PB particles during crystallization but also plays a key role in the etching process after mixing with strong acid. The size and shape of the resulting spherical PB particles were sensitive to the molar concentration of acid solution. Consequently, the spherical PB had a high specific surface area and the calcined PB exhibited superparamagnetic properties. The results show that the spherical PB can be utilized in applications such as magnetic-field-guided drug delivery, cell labeling, and contrast agents for magnetic resonance imaging. The chemical and physical properties of the obtained samples were characterized using X-ray diffraction, Brunauere-Emmette-Teller analysis, Raman spectroscopy, and scanning electron microscopy. (C) 2017 Elsevier B.V. All rights reserved.</P>

Rabbit gastric ulcer models

Jin Hee Maeng,Eunhye Lee,Don Haeng Lee,Su-Geun Yang 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.2

In this study, we examined rabbit gastric ulcer models that can serve as more clinically relevant models. Two types of ulcer model were studied: acetic acid-induced ulcers (AAU) and mucosal resection-induced ulcers (MRU). For AAU, rabbit gastric mucosa was exposed by median laparotomy and treated with bottled acetic acid. MRU was examined as a model for endoscopic mucosal resection (EMR). Normal saline was injected into the submucosal layer and the swollen mucosa was resected with scissors. Endoscopic mucosal resection (EMR) is frequently performed for treatment of early gastric cancers. This procedure inevitably leads to ulcers and bleeding. Bleeding control is the major concern in endoscopic mucosectomy, and some endoscopic hemostatic agents are currently under clinical and preclinical studies. MRU was developed as a model for these induced ulcers and the evaluation of the healing process. The clinical relevancy of those models was compared with that of rat models. Progressive healing was observed for 7 days based on histology. Rabbit models demonstrate round, deep ulcers with clear margins and well-defined healing stages that were difficult to define in rat models.