Thiamine결핍 유도후 쥐 전뇌의 성상교세포 Glial Fibrillary Acidic Protein(GFAP) 면역화학 활성도에 대한 변화

김승현,김희태,김주한,김명호,황세진,김명권,백태경 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

Reliability Considerations of Hybrid Power Systems for Critical Facilities

Choi, Se Jin · Ham, Young Hwan · Kim, Myung Chin 충북대학교 컴퓨터정보통신연구소 2008 컴퓨터정보통신연구 Vol.27 No.2

본문참고

Complication of Intraoperative Radiation Therapy (IORT) in Gastric Cancer

김명세(Myung Se Kim),김성규(Sung Kyu Kim),송선교(Sung Kyo Song),김홍진(Hong Jin Kim),권굉보(Koing Bo Kwan),김흥대(Heung Dae Kim) 대한방사선종양학회 1992 Radiation Oncology Journal Vol.10 No.2

영남대학교 의료원 치료방사선과에서 1988년 6월 15일에 위함 환자의 수술중 방사선치료를 시작한 이래 1992년 8월 30일까지 총 58예에서 시도하여 그중 53예에서 IORT를 실시하였으며, 정기적인 추적검사에서 한명의 국소개발 환자도 보고되지 않고 있다. 출혈(3예), 장관폐쇄(3예), 폐혈증(2예), 골수기능저차(1예)를 포함한 총 9예(17%)의 합병증이 보고되었고, 이중 6예(13%)가 사망하였다. IORT(1500cGy), 외부 방사선치료 (-4500cGy)와 강한 항암제를 병합치료 하였음에도 불구하고 주등(수술과 항암제 치료)의 25.2%, 김등(수술 불가능한 환자에서 항암제 투여)의 18%, 리등(수술)의 18.5%, Kraming등(IORT 2800-3500cGy)의 35.3%에 비해 낮은 합병증을 보여 IORT가 위암의 치료에 공헌할 수 있음을 시사하였다. 그러나 비교적 높은 치사율(11.3%)은 더욱 세심한 수술수기 및 수술 후 환자의 치료가 필요하며 외부 방사선치료와 항암제치료의 적절한 시기 조절 및 치료선량의 가감이 필요할 것으로 생각된다. Local control is the important prognostic factor in cancer treatment because local control decrease the relative risk of metastatic spread and increase distant metastasis free survival. IORT is the modality which could increase local control without increasing complication, combined with curative operation. Eventhough we could achieve significant deacreased local failure by IORT and curative resection, it should not be committed as a main treatment modality without proving acceptable complications. Therapeutic Radiology Department of Yeungnam University Medical Center have tried 58 IORT from June 15, 1988 and performed 53 IORT in patients with gastric cancer. No local failure had been reported including interstinal obstrution, hemorrhage, sepsis, and bone marrow depression. These complications could be comparable to Jo's 25.2% (chemotherapy + operation), Kim's 18% (chemotherapy only in inoperable patients), because our treatment regimen is consisted of IORT (1500cGy), external irradiation (--4500cGy) and extensive chemotherapy (FAM, 5FU + MMC, BACOP). Our data encouraged us to re-inforce further IORT in stomach cancer treatment.

전화조사의 체계적 편향 - 2007년 대통령선거 여론조사들에 대한 메타분석 -

김세용,허명회,Kim, Se-Yong,Huh, Myung-Hoe 한국통계학회 2009 응용통계연구 Vol.22 No.2

For 2007 Korea presidential election, most polls by telephone surveys indicated Lee Myung-Bak led the second runner-up Jung Dong-Young by certain margin. The margin between two candidates can be estimated accurately by averaging individual poll results, provided there exists no systematic bias in telephone surveys. Most Korean telephone surveys via telephone directory are based on quota samples, with the region, the gender and the age-band as quota variables. Thus the surveys may result in certain systematic bias due to unbalanced factors inherent in quota sampling. The aim of this study is to answer the following questions by the analytic methods adopted in Huh et al. (2004): Question 1. Wasn't there systematic bias in estimates of support rates. Question 2. If yes, what was the source of the bias? To answer the questions, we collected eighteen surveys administered during the election campaign period and applied the iterated proportional weighting (the rim weighting) to the last eleven surveys to obtain the balance in five factors - region, gender, age, occupation and education level. We found that the support rate of Lee Myung-Bak was over-estimated consistently by 1.4%P and that of Jung Dong-Young was underestimated by 0.6%P, resulting in the over-estimation of the margin by 2.0%P. By investigating the Lee Myung-Bak bias with logistic regression models, we conclude that it originated from the under-representation of less educated class and/or the over-representation of house wives in telephone samples. 2007년 12월의 대통령선거 과정에서 행해진 수많은 전화 여론조사에서 이명박 후보가 일관되게 앞자리를 지켰다. 많은 수의 여론조사가 시행되는 경우 개별 여론조사의 표본추출오차는 상쇄되어 소멸한다. 그러나 일정한 편향은 많은 수의 조사가 실행된다 하더라도 잔존하므로 중요한 문제가 아닐 수 없다. 우리나라의 전화조사는 지역, 성과 연령대를 고려한 할당추출(quota sampling)을 사용하며 대부분 전화번호부를 표집 틀로 한다. 조사 거절률도 높은 편이다. 이에 따라 조사표본들이 할당변인 외의 인구사회적 속성에서 모집단을 잘 대표하지 못할 수 있다. 이 연구의 목적은 허명회 등 (2004)의 연구 방법른을 2007년에 수행된 대통령선거 여론조사 L8개 사례에 적용하여 다음 물음에 답하는 데 목적이 있다. - 물음 1. 각후보에 대한 선호도 또는 지지율에 체계적 편향이 있지 않았는가? - 물음 2. 편향이 있었다면, 그 원인이 어디에 있는가? 첫째 물음에 답하기 위하여 2007년 11월 이후 시행된 11개 사례 자료에 지역, 성과 연령대 외에 직업과 학력까지 고려한 반복비례가중법(rim weighting)을 적용해보았다. 그 결과, 이명박 후보의 지지율이 평균 1.4%P 과다 추정되었던 것으로 나타났다. 반면, 정동영 후보의 지지율은 평균 0.6%P 과소 추정되었고 이에 따라 두 후보간 지지율 차이가 2.0%P (= 1.4+0.6) 과다하게 추정되었던 것으로 보여진다. 둘째 물음에 답하기 위하여 위의 11개 사례 자료에서 이명박 후보 지지를 종속변수로 하는 로지스틱 회귀 분석을 하였다. 그 결과, 전화조사 표본에서의 저학력자 과소 및 가정주부의 과다가 이명박 편향의 원인이 되는 것으로 밝혀졌다.

대체골재의 종류에 따른 수중불분리성 콘크리트의 특성 연구

김명식,신현필,박세인 釜慶大學校 2001 釜慶大學校 論文集 Vol.6 No.-

In this study, three kinds of fine aggregate (river sand, sea sand, crushed sand) were used and four different s/a (38%, 40%, 42%, 45%) were applied separately to this experiment for getting the conclusion written below. Regardless of fine aggregate kinds and casting-curing condition, maximum unit weight is obtained at 40% of s/a and also to be seen in case of crushed sand. Because the for that specific gravity of crushed sand is higher comparatively than that of river sand and sea sand. Higher compressive strength is measured following the order of river sand, crushed sand, sea sand regardless of variation of s/a, casting-curing condition and age. Max. compressive strength is obtained when s/a is 42% regardless of fine aggregate kinds. Although, according to references, the optimum s/a of underwater antiwashout concrete is given as 40% the optimum s/a of underwater antiwashout concrete is proven to be 42% from the view point of compressive strength.

CORBA 디자인 패턴에 관한 연구

김정현,박세명,최항묵 인제대학교 2001 仁濟論叢 Vol.16 No.1

소프트웨어의 객체지향 패러다임이 줄 수 있는 가장 큰 이점은 다형성(polymorphism)을 통한 재사용성(reusability)이다. 이러한 재사용성은 구현측면에서 코드의 재사용, 그래픽 사용자 인터페이스의 재사용, 분산 시스템에서의 인터페이스의 재사용에서는 잘 이루어지고 있으나, 설계단계에서의 재사용성은 아직 부족한 실정이다. 본 연구에서는 이러한 객체지향 설계단계에서 재사용할 수 있는 디자인 패턴(Design Pattern)으로서 분산 객체 환경인 CORBA 시스템 설계 시 적용할 수 있는 새로운 CORBA 디자인패턴을 제안한다. Designing object-oriented software is hard, and designing reusable object-oriented software is even harder. Design should be specific to the problem at hand but also general enough to address future problem and requirement. Expert Designers reuse solutions that have worked for them in the past. This solution is Design Pattern. The propose of this paper is to record experience in designing distributed-object CORBA software as CORBA design pattern.

칼라 영상 분할에 의한 차량번호판 영역 추출

김상균,박세명,최흥국,최항묵 인제대학교 1998 仁濟論叢 Vol.14 No.1

Extracting a license plate is an essential stage in the automatic car identification. Because car images are usually degraded and processes for the images are a computationally intensive job, it is difficult to extract a license plate correctly from the images. In this paper, we propose an extraction method of a license plate region based on color image segmentation. To segment the color image, we use a distributed genetic algorithm and transformed Hue-Saturation-Intensity color space as a measure of distance. The method offers robustness in dealing with deformation of car images and inherent parallelism to improve processing time. A test with car images on the roads shows an extraction rate of 93.8%. This result suggests that the proposed method works well with real-world situations, and is pertinent to be put into practical use.

대학생들의 운동참여제약 척도 개발

김철원,김성찬,이세형,양명환 濟州大學敎 體育科學硏究所 1995 체육과학연구 Vol.1 No.-

The purpose of this study was to develop the Exercise Involvement Constraints Scale for college students in Korea. The subjects of this study were 232 college students who were involved in physical activity classes(tennis and table tennis)at the Cheju National University. The Questionnaire consisted of a list of 44 reasons for not participating in exercise. Items were selected by reviewing related literature and on the bases of two pilot studies. First, 12-factors were extracted by the principle-components factor analysis from the correlation matrix of the subscales. Eliminations were made to those items that failed to load at least 40 on their intended factor, or emerged with a strong cross-loading(.30 or above)on a nonintended factor. From this modification, 31 items were appiled to further analysis. Second, using 31-items, exploratory factor analysis with normal varimax rotation were repeated in order to provide a more complete picture of factor structure. The results of the factor analysis reveals 8 factors that in total explain 63.7% of the variance among the subscale items. These factors were motivation, sport facilities, exercise skill, time, activity barriers, fatigue from exercise, involvment change, and lack of will power. In order to a more valid instrument, using the statistical methods of stepwise multiple regression analysis, elimination were made to three items from motivation subscale. Thus, final scale consisted of 8 subscale with 28 items. Finally, subscale and scale reliability was examied using Cronbach's coefficients alpha. Alpha reliabilites ranged from .67 to .88. As a result of these analysis, it was conclude that the Exercise Involvement Constraints Scale(EICS) was a valid and reliable instrument to measure reasons for did not participating to exercise and physical activity.

국내 환자에서 분리된 Orientia tsutsugamushi에서 doxycycline 내성

김은실,김미경,이혜명,길세희,정문현,이진수,강재승 대한감염학회 2008 감염과 화학요법 Vol.40 No.5

Background : Doxycycline has been the drug of choice for the treatment of scrub typhus. However, scrub typhus with poor response to doxycycline was first reported in Thailand in 1996. To date, it is not known whether doxycycline resistant scrub typhus is present in Korea. To investigate the doxycycline resistance of scrub typhus in Korea, we performed an experiment to evaluate the degree of growth inhibition of Orientia tsutsugamushi at the minimal inhibitory concentration (MIC) of doxycycline. Materials and Methods : 37 isolates of Orientia tsutsugamushi were collected from Korean patients with scrub typhus during 10 year period (from 1997 to 2007). 34 isolates consisted of Boryong serotype or related serotypes. These strains were stained with FS15, a monoclonal antibody against the linear epitope on the protein located at the outer membrane of O. tsutsugamushi. Three isolates were confirmed as serotype Gilliam, which was stained by anti-Gilliam antibody. The antibody-stainable 35 isolates were incubated in media containing 0.1 and 0.2 ug/mL of doxycycline for 3 days. Then the growth indices of Orient/a were measured by flow cytometry. If the growth index was greater than 10%, the isolate was tentatively classified as an isolate resistant to doxycycline and its MIC was measured. Results : Demographic and treatment data were similar to the results of previous reports. Infection was mainly observed in Inchon and the Chungcheongnam province. No patient showed delayed response to antibiotics. Of 35 hospitalized patients, 4 (11.4%) were managed at the intensive care unit and 1 (2.9%) died of nosocomial pneumonia. All the 2 patients whose isolates were serotype Gilliam Yonchon/Ikeda-like strain were managed at the intensive care unit. Six of the 34 isolates from Korean patients exhibited growth indices greater than 10% at the MIC of doxycycline; however, the MICs of these isolates did not exceed 0.2 ug/mL. One isolate of serotype Gilliam showed an MIC of 0.0125 ug/mL, which seemed to be underestimated due to weak fluorescence of the anti-GiIIiam antibody. Conclusions : Although the number of tested isolates is small, insensitivity of scrub typhus to doxy-cycline is not a major reason for treatment failure in Korea. Serotype Gilliam, especially Yochon/Ikeda-like strain may be associated with severe form of scrub typhus. More studies concerning the antibiotic susceptibility for serotype Gilliam are warranted.

상이한 분할조사가 마우스의 체중과 말초혈액에 미치는 효과

김성규,김명세,신세원 영남대학교 의과대학 1987 Yeungnam University Journal of Medicine Vol.4 No.2

동일한 시간, 선량, 분할 인자를 가진 두개의 서로 다른 분할 조사군과 부여된 전체 선량이 같은 경우를 비교한 결과는 아래와 같다. 암, 수 성별에 따른 차이점은 없었다. 체중의 변화는 분할당 선량 보다는 조사에 소요된 기간과 더 연관됨을 보였다. 혈색소의 변화는 시간, 선량, 분할 인자와 부여된 전체 선량과는 관련이 적었다. 백혈구의 변화는 전체 조사 선량 보다는 시간, 선량, 분할 인자에 더 관련이 있었다. 감별 백혈구와의 변화는 비교적 초기에 임파구의 비율 감소가 나오는 시간, 선량, 분할 인자나 전체 조사 선량 사이의 큰 차이는 없었으며 조사가 지속될수록 점차 경미한 변화를 보였다. Using same TDE factors, the authors studied the effects of whole abdominal irradiation on body weight and peripheral blood picture in 30±3 day old mice. Fractions of 100 and 200 cGY were given five times a week to the final TDF factors 17, 33, and 49. Total 80 mice were irradiated with orthovoltage x-ray machine. Our results can be summarized as follows: There were no significant differences by sex. Body weight was progressively decreased by the duration for irradiation, but no remarkable difference by fractional dose. Hemoglobin level showed no remarkable change by fractional dose or TDF factors. Leukopenic changes showed that severity of decrease seems to be more related to TDF factors. There Were no significant changes of differential count by TDF factors of total doses.