흰쥐 생체시료 중 5-플루오로우라실 및 테가푸르의 안정성

장지현,박종국,강진형,정석재,심창구,구효정 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3

5-Fluorouracil (5-FU) is an antimetabolite anticancer agent active against many types of solid tumors. Tegafur (TF), a prodrug of 5-FU, is frequently used in combination with uracil as dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine. We studied the stability of 5-FU and TF in biological fluids of rats and determined their bioavailability (BA) and excretion into bile, and urine. The drug concentrations were analyzed by an HPLC method. At room temperature, there was a 14-30% decrease in the concentration of 5-FU and TF in bile, urine, and plasma specimen at 10 and 100 μg/ml over 240 min. No significant difference was noted among the sample types or between two different concentrations of 10 and 100 μg/ml. The decrease in drug concentration was significantly less in samples kept on ice (6-12%) for both drugs. These data indicate that biological fluid samples containing 5-FU or TF in plasma, urine, or bile should be placed on ice during the sample collection. Following these storage guidelines, samples were collected after administration 50 ㎎/㎏ of each drug via i.v. or oral route. BA was 1.5 folds greater for TF (60%) than that of 5-FU (42%). Approximately 0.52 and 3.3% of the i.v. doses of 5-FU and TF was excreted into bile, respectively. Renal clearance of 5-FU was about 16% of its total body clearance. These results suggest that instability of 5-FU and TF in biological fluids should be considered in pharmacokinetic or pharmacogenomic studies.

강의 현대화 추진 및 활용방안 연구

구경완,이근복,장종국,김재홍,김영환,최제영,이승훈 永同大學校 1997 硏究論叢 Vol.3 No.1

본 연구는 각종 첨단 기자재를 활용한 강의 현대화 방안을 모색함으로서 공학교육의 효율성을 도모하고 학생들의 학습동기를 유발하여 창조적 능력을 갖츤 전문기술 인력을 양성하는 데 도움을 주고자 하는 것이다. 이를 위하여 현행 공학교육의 현황과 문제점을 분석하고 강의 현대화 사례를 조사하여 본 연구의 기초자료로 삼고자 하였으며, 학부·전공별 강의 현대화 추진 실태분석 및 개선방안을 모색한 후 이상의 연구결과를 종합하여 향후의 강의 형대화 추진방향을 걸정하였다. This study aims to help bring up the well-skilled and creative engineers by searching the modernization of education using various high technology facilities. For this, we analyzed the general condition and problems of current engineering education and surveyed the case study of the modernization of education as basic study. After analyzing the existing situation of promotion searching the proper improvement methods of it, we proposed the new direction of the modernization of education from now on.

범게, Orithyia sinica 유생의 생존과 성장에 미치는 암모니아와 아질산의 영향

구자근,김종만,장차환,지정훈,강주찬 한국어병학회 2004 한국어병학회지 Vol.17 No.1

범게, Orithyia sinica 유생을 대상으로 암모니아와 아질산에 대한 생존 및 성장에 관한 실험을 실시하였다. 암모니아 노출 실험구에서 zoea기 유생은 노출 20일후, 대조구가 80%의 생존율을 나타내었지만 10㎎/L 이상의 실험구에서는 37-45%의 생존율을 나타내었고, megalopa기 유생에서도 유사한 경향을 나타내었다. 암모니아가 범게 유생의 성장에 미치는 영향을 조사한 결과, zoea기 유생은 20㎎/L 이상의 농도에서 megaloparl 유생은 50㎎/L 이상의 농도에서 유의한 차이를 나타내었다. (P<0.05). 아질산 노출 실험에서는 zoea기 유생과 meglaopa기 유생에서 농도와 노출기간에 비례하여 생존율이 감소하였으며, 특히 150㎎/L 이상의 아질산 농도에 노출된 zoea기 유생가 megalopa기 유생은 대조구와 비교하여 유의한 성장 지연을 나타내었다(P<0.05). This study investigates the influence of waterborne ammonia and nitrite on the zoea and megalopa stage larvae of tiger crab, Orithyiu sinicu under laboratory condition, focusing on the effects on survival and growth as deleterious responses of toxicant. Survival rate of zoea stage larvae exposed to control levels, and to 5, 10,20 and 50 ㎎/L total ammonia-N, using a continuous flow system for 20 days was 80, 77, 45, 40 and 37%, respectively. Growth rate of zoea stage larvae exposed to 20 and 50 ㎎/L total ammonia was significantly lower than in controls after 20 days (P< 0.05). Survival rate and growth rate of megalopa stage larvae exposed to ammonia also decreased at greater than 10 and 50 ㎎/L, respectively. In the nitrite exposure experiment with zoea and megalopa stage larvae of tiger crab, survival rate was decreased in a concentration and exposure period-dependent way. The growth rate of zoea and megalopa stage larvae of tiger crab exposed to nitrite decreased at greater than 150 ㎎/L nitrite concentration.

온실재배와 노지재배한 금산 깻잎의 품질 특성과 향기성분

현광욱,구교철,장정호,이재곤,김미리,이종수 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2004 한국식품저장유통학회지 Vol.11 No.1

깻잎을 이용한 건강 식품을 개발하고자 먼저 깻잎의 주산지인 금산에서 5월 온실재배한 깻잎과 8월 노지재배한 깻잎들의 품질특성과 향기성분을 조사하였다. 시료깻잎 모두 4.0%의 조단백질과 0.8%의 조지방을 함유하고 있었고, 플라보노이드의 함량은 온실재배 깻잎 25.2%, 노지재배 깻잎 26.5%로 시료깻잎간에 큰 차이는 나타나지 않았으며 조사포닌 함량도 2,7%와 2,8%로 비슷하였다. 시료깻잎의 효소 활성은 오직 알칼리성 단백질 분해효소 활성만이 8월 노지재배 깻잎에서만 물 추출물 7.1 unit, 에탄올 추출불 11.8 unit을 보였고 기타 효소 활성은 없었다. 8월 노지재배 깻잎의 조직감 특성으로 먼저 견고성과 탄력성 등은 잎의 상층부와 중층부 보다 잎받침을 포함하는 하층부에서 높았고 응집성은 하층부가 약간 약하였으며 5월 온실재배 깻잎은 씹힘성이 다서 낮았을 뿐 노지재배 깻잎과 비슷하였다. 5월 온실재배와 8월 노지재배 깻잎에는 1-octen-3-ol, linalool, β-caryorhyllene, α-caryophyllene, α-famesene, perilla ketone, nerolidol, eugenol. α-cadinol 등 14종∼15종의 향기성분을 함유하고 있었고 주요한 향기성분은 perilla ketone 이었다. Quality and flavor compounds of perilla leaves cultivated in greenhouse(May) and field (August) in Geumsan province were investigated and compared. All perilla leaves contained 4.0% crude protein and 0.8% crude lipid. C겨de flavonoid contents of perilla leaves cultivated in greenhouse and field showed 25.2% and 26.5%, respectively and each crude saponin content was cultivated in field. Hardness and chewness of bottom parts of field-perilla leaves were higher than those of top and middle part, whereas the cohesiveness of top parts and middle parts of perilla leaves were higher than that of bottom part. Furthermore, texture properties of greenhouse-perilla leaves were similar with those of field-perilla leaves except chewness. Nine kind of flavor compounds such as 1-octen-3-ol, linalool, β-caryophyllene, α-caryophylene, α-franesene, perilla ketone, nerolidol, eugennl, α-cadinol were identified in greenhouse-perilla and field-perilla leaves, showing that main flavor compound was perilla ketone.

취업증진을 위한 기사자격증 취득 및 위업자료의 체계적 구축 및 운용 방안

김성일,구경완,장종국,사공성대,황재효,류승헌 永同大學校 1997 硏究論叢 Vol.3 No.1

국가기술자격증 취득을 위한 효과적인 강의 지도를 실시하고, 이와 병행하여 기업체의 구인정보와 취업 대상자의 진로 의사 정보를 정확하게 파악하여 데이터베이스화하고 기업체에 본 대학을 상세히 홍보함으로써 취업증진을 도모한다. We make effective lectures for obtaining a national technical qualification and construct the database of job information that contain the information about companies and students respectively. Also We propagate Youngdong University to the companies for promoting the employment of students.

선천성 양측성 폐정맥 협착증의 심초음파 및 심도자 및 혈관조영술 소견

정남식,하종원,윤정한,김병옥,장양수,조승연,조범구 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.4

렌덤함수를 이용한 모의시험 출제 알고리듬 설계 : 멀티미디어를 기반으로하는 전자분야 기사 CD 타이틀 제작 A Development of CD Title for a Field of Electronic Engineering of the National Technical Qualification 1,2 Based on the Multimedia ToolBook

사공성대,구경완,김성일,장종국 永同工科大學校 1996 硏究論叢 Vol.2 No.1

본 연구는 전자분야의 여러 기사 자격증 취득에 효과적인 학습을 도모하기 위하여 멀티미디어 툴북을 기반으로 하는 CD 타이틀을 제작하고, 나아가 실용화하는데 있어 효율적인 문제 선택과 학습 능력을 배양하기 위한 모의시험의 문제선택 알고 리듬을 랜덤함수를 사용하여 개발한 것이다. For a effective study to acquire a national technical qualification 1, 2 of a field of electronic engineering, this work developes a CD title based on the multimedia toolbook, and for practical use, we design an algorithm for the setting questions for the trial examination using a random function which gives a effective choice of problems and offers students ability of heuristic study.

증점제를 사용한 고유동콘크리트의 기포조직과 내동해성에 관한 실험적 연구

김무한,권영진,강석표,여동구,김용로,장종호 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

Recently, lots of studies for high flowing concrete have been suggested under practical use that it is only a way to solve the confronted problem. However, most studies have been concentrated on the manufacture method and properties of fresh concrete, but there is few studies for the durability of hardened concrete, specially for the freezing and thawing. It is generally known that the frost resistance of concrete is much affected by the air content in concrete and by the air void system. The frost resistance is also believed to vary with the strength of concrete. The purpose of this experimental study is to make a comparison between high flowing concrete using viscosity agent and ordinary concrete about the effect of the viscosity agent, air content and curing method on the frost resistance. As the result of tutus study, the frost resistance have not effect the viscosity agent but effect the different of curing methods.

류마치스양 관절염의 예후에 미치는 인자에 관한 임상적 고찰

김인,김정만,이승구,장한,신장철 최신의학사 1988 最新醫學 Vol.31 No.1

인슐린 비의존성 당뇨병에 동반된 심상성 천포창 1 례

이상준,박진용,임태형,윤영호,권순대,남창욱,허규찬,박근용,구본식,김상표,장종억 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

저자들은 인슐린 비의존형 당뇨병 환자에서 통증성 구강내 미란 및 전신성 수포성 미란을 동반한 심상성 천포창 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Various skin conditions such as diabetic dermopathy, necrobiosis lipoidica diabeticorum, bullosis diabeticorum, granuloma annulare occur frequently in diabetes, although common lesions may be associated by chance. Pemphigus vulgaris(PV) is a blistering skin disease seen predominantly in elderly patients. This disorder is characterized by the loss of cohesion between epidermal cells with the resultant formation of intraepidermal blisters. These blisters rupture easily, leaving denuded areases that may crust and enlarge peripherally. In half or more of patients, lesions begin in the mouth: approximately 90% of patients have oromucosal involvement at some time during the course of their disease. But the relationship of this disorder with diabetes is not clear. We experienced a case of pemphigus vulgaris associated with NIDDM in 67 years old woman who was admitted due to painful oral ulcer and control of blood glucose, so we present this case with a review of literatures.